Lexicon PharmaceuticalsLXRX
13F holders, Q1 2026 (March 31)136holders +11
25new positions
14sold out
5famous investors
$1.56avg. 13F price*
At the end of Q1 2026, 136 institutions reported holding Lexicon Pharmaceuticals Inc. (LXRX) in their 13F filings, up 11 from Q4 2025. 25 opened new positions and 14 sold out. The largest holders were Artal Group S.A. ($241.4M), FMR LLC ($70.3M) and Siren, L.L.C. ($69.1M). 5 famous investors held it, including Steve Cohen (0.0% of Point72 Asset Management's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Lexicon Pharmaceuticals Inc.
- CUSIP
- 528872302
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 25 | $4.9M |
| Exits | 14 | $815K |
All 13F filers, Q4 2025 → Q1 2026: 64,428,664 shares bought and 3,047,748 shares sold, net +61,380,916 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 136 holders
| Artal Group S.A. | 23.89% | Add +13.6% | 154,734,327 | $241.4M |
| FMR LLC | 0.00% | Add +19.1% | 45,056,338 | $70.3M |
| Siren, L.L.C. | 1.92% | Add +13.8% | 44,303,518 | $69.1M |
| Sessa Capital IM, L.P. | 0.53% | Add +497.1% | 17,912,961 | $27.9M |
| Vanguard Capital Management LLC | 0.00% | — | 9,519,167 | $14.8M |
| Point72 Asset Management | 0.02% | Add +2651.4% | 7,814,606 | $12.2M |
| Millennium Management | 0.01% | Add +2.5% | 4,944,731 | $7.7M |
| BlackRock, Inc. | 0.00% | Add +4.1% | 3,322,219 | $5.2M |
| Geode Capital Management, LLC | 0.00% | Add +26.8% | 3,169,111 | $4.9M |
| Jane Street Group, LLC | 0.00% | Add +54.6% | 2,665,938 | $4.2M |
| UBS Group AG | 0.00% | Reduce -17.4% | 2,483,182 | $3.9M |
| Marshall Wace, LLP | 0.00% | Add +88.2% | 2,376,304 | $3.7M |
| Susquehanna International Group, LLP | 0.00% | Add +75.7% | 2,121,164 | $3.3M |
| CIBC Bancorp USA Inc. | 0.00% | — | 1,800,000 | $2.8M |
| Renaissance Technologies | 0.00% | Add +508.0% | 1,600,500 | $2.5M |
| Vanguard Fiduciary Trust Co. | 0.00% | — | 1,332,284 | $2.1M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +24.3% | 1,311,298 | $2.0M |
| Two Sigma Investments, LP | 0.00% | Add +88.2% | 1,199,632 | $1.9M |
| Citadel Advisors | 0.00% | Reduce -36.0% | 1,094,901 | $1.7M |
| Goldman Sachs Group Inc. | 0.00% | Add +16.2% | 1,070,517 | $1.7M |
| State Street Corp. | 0.00% | Add +9.0% | 964,038 | $1.5M |
| Gsa Capital Partners LLP | 0.09% | Reduce -6.6% | 930,089 | $1.5M |
| Ishara Investments LP | 1.42% | Add +2.5% | 902,000 | $1.4M |
| Hennion & Walsh Asset Management, Inc. | 0.04% | Reduce -5.9% | 848,138 | $1.3M |
| Mackenzie Financial Corp. | 0.00% | New | 772,677 | $1.2M |
| ADAR1 Capital Management, LLC | 0.07% | New | 750,000 | $1.2M |
| Vanguard Portfolio Management LLC | 0.00% | — | 546,600 | $853K |
| Bank of America Corp. | 0.00% | Add +415.3% | 526,103 | $821K |
| Invesco Ltd. | 0.00% | Reduce -13.9% | 512,426 | $799K |
| Compagnie Lombard Odier SCmA | 0.01% | Add +24.4% | 510,000 | $796K |
| Northern Trust Corp. | 0.00% | Add +20.0% | 494,666 | $772K |
| Acadian Asset Management LLC | 0.00% | Reduce -30.4% | 445,288 | $693K |
| Tang Capital Management LLC | 0.03% | New | 399,700 | $624K |
| XTX Topco Ltd | 0.01% | Add +227.4% | 314,614 | $491K |
| Morgan Stanley | 0.00% | Add +13.9% | 219,862 | $343K |
| Catalyst Funds Management Pty Ltd | 0.05% | Add +415.9% | 207,900 | $324K |
| Headlands Technologies LLC | 0.03% | Add +40.6% | 191,322 | $298K |
| Group One Trading LLC | 0.01% | Reduce -17.5% | 185,006 | $289K |
| Citigroup Inc. | 0.00% | Add +81.5% | 166,398 | $260K |
| Ikarian Capital, LLC | 0.04% | No change | 164,674 | $257K |
| Brevan Howard Capital Management LP | 0.00% | New | 160,499 | $250K |
| Scotia Capital Inc. | 0.00% | New | 159,831 | $249K |
| Jain Global LLC | 0.00% | New | 154,800 | $241K |
| Hudson Bay Capital Management LP | 0.00% | Add +51.8% | 152,616 | $238K |
| Jacobs Levy Equity Management, Inc. | 0.00% | New | 130,020 | $203K |
| Bridgewater Advisors Inc. | 0.01% | New | 82,209 | $201K |
| HRT Financial LP | 0.00% | Add +4.5% | 122,780 | $191K |
| Cerity Partners LLC | 0.00% | Reduce -23.8% | 110,458 | $172K |
| Quadrature Capital Ltd | 0.00% | Add +499.4% | 110,379 | $172K |
| Quarry LP | 0.04% | Add +25.0% | 110,000 | $172K |
| Man Group plc | 0.00% | New | 108,806 | $170K |
| OMERS ADMINISTRATION Corp | 0.00% | Reduce -61.0% | 106,800 | $167K |
| Barclays PLC | 0.00% | Reduce -45.8% | 105,487 | $165K |
| AQR Capital Management | 0.00% | Reduce -33.5% | 96,234 | $150K |
| Vanguard Global Advisers, LLC | 0.00% | — | 93,641 | $146K |
| Schonfeld Strategic Advisors LLC | 0.00% | Add +473.0% | 75,110 | $117K |
| Bank of Nova Scotia | 0.00% | New | 73,707 | $115K |
| Bank of Montreal | 0.00% | No change | 70,000 | $109K |
| LPL Financial LLC | 0.00% | Reduce -19.8% | 69,783 | $109K |
| Jefferies Financial Group Inc. | 0.00% | Reduce -25.7% | 68,734 | $107K |
| Diametric Capital, LP | 0.03% | New | 67,841 | $106K |
| R Squared Ltd | 0.06% | Add +45.0% | 67,526 | $105K |
| Straight Path Wealth Management | 0.03% | No change | 62,666 | $98K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Reduce -17.4% | 54,965 | $86K |
| Fortis Group Advisors, LLC | 0.01% | No change | 50,000 | $81K |
| EntryPoint Capital, LLC | 0.02% | Add +44.3% | 48,498 | $76K |
| Boothbay Fund Management, LLC | 0.00% | No change | 44,315 | $69K |
| Wedbush Securities Inc. | 0.00% | No change | 40,850 | $64K |
| Jump Financial, LLC | 0.00% | New | 40,246 | $63K |
| CIBC Asset Management Inc | 0.00% | No change | 39,520 | $62K |
| ExodusPoint Capital Management, LP | 0.00% | Reduce -86.1% | 37,430 | $58K |
| University of Texas/Texas Am Investment Management Co. | 0.01% | No change | 35,714 | $56K |
| Graham Capital Management, L.P. | 0.00% | Reduce -69.0% | 34,027 | $53K |
| Prudential Financial Inc. | 0.00% | No change | 33,800 | $53K |
| Leonteq Securities AG | 0.00% | No change | 30,000 | $47K |
| KWB Wealth | 0.00% | No change | 40,640 | $47K |
| Pathstone Holdings, LLC | 0.00% | Reduce -0.7% | 29,774 | $46K |
| Pinnacle Associates Ltd. | 0.00% | No change | 29,015 | $45K |
| Bank of New York Mellon Corp | 0.00% | Add +43.6% | 27,459 | $43K |
| Security National Bank of Sioux City Iowa | 0.02% | No change | 26,650 | $42K |
| WINTON GROUP Ltd | 0.00% | New | 25,500 | $40K |
| Oppenheimer & Co. Inc. | 0.00% | No change | 23,500 | $37K |
| LMR Partners LLP | 0.00% | New | 23,305 | $36K |
| Victory Capital Management Inc. | 0.00% | Add +7.0% | 22,679 | $35K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | No change | 21,505 | $34K |
| Axq Capital, LP | 0.00% | New | 20,150 | $31K |
| Diker Management LLC | 0.03% | New | 20,000 | $31K |
| Invera Wealth Advisors, LLC | 0.02% | No change | 20,000 | $31K |
| Tiaa-Cref Individual & Institutional Services, LLC | 0.00% | — | 20,000 | $31K |
| Credit Agricole S A | 0.00% | No change | 18,975 | $30K |
| Quantessence Capital LLC | 0.14% | New | 18,581 | $29K |
| BNP Paribas Financial Markets | 0.00% | Add +159445.5% | 17,550 | $27K |
| CTC Alternative Strategies, Ltd. | 0.06% | New | 17,544 | $27K |
| Prelude Capital Management, LLC | 0.00% | New | 17,173 | $27K |
| Captrust Financial Advisors | 0.00% | Add +31.7% | 15,450 | $24K |
| HBK Sorce Advisory LLC | 0.00% | No change | 11,786 | $24K |
| Callan Family Office, LLC | 0.00% | No change | 14,090 | $22K |
| Truist Financial Corp. | 0.00% | No change | 14,000 | $22K |
| Cetera Investment Advisers | 0.00% | Reduce -11.0% | 12,633 | $20K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Reduce -8.4% | 12,388 | $20K |
| Chemistry Wealth Management LLC | 0.00% | No change | 12,000 | $19K |
| FWG Holdings, LLC | 0.01% | No change | 11,350 | $18K |
| Mariner, LLC | 0.00% | New | 11,072 | $17K |
| Perennial Investment Advisors, LLC | 0.00% | No change | 10,990 | $17K |
| State of Wyoming | 0.00% | Reduce -82.2% | 10,779 | $17K |
| Cwm, LLC | 0.00% | Reduce -21.1% | 10,402 | $16K |
| Talisman Wealth Advisors LLC | 0.01% | New | 10,000 | $16K |
| NBT Bank, N.A. | 0.00% | No change | 10,000 | $16K |
| Berger Financial Group, Inc | 0.00% | No change | 10,000 | $16K |
| Wells Fargo & Company | 0.00% | Add +775900.0% | 7,760 | $12K |
| SBI Securities Co., Ltd. | 0.00% | Add +35.2% | 4,081 | $6K |
| Advisory Services Network, LLC | 0.00% | New | 3,242 | $5K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 2,592 | $4K |
| PNC Financial Services Group, Inc. | 0.00% | No change | 1,461 | $2K |
| Physician Wealth Advisors, Inc. | 0.00% | No change | 1,412 | $2K |
| Rialto Wealth Management, LLC | 0.00% | No change | 1,313 | $2K |
| Avion Wealth | 0.00% | No change | 1,333 | $2K |
| Royal Bank of Canada | 0.00% | Reduce -77.1% | 1,551 | $2K |
| Cassaday & Co Wealth Management LLC | 0.00% | New | 1,000 | $2K |
| Fortitude Family Office, LLC | 0.00% | No change | 706 | $1K |
| Basecamp Wealth Advisors LLC | 0.00% | No change | 691 | $1K |
| Osaic Holdings, Inc. | 0.00% | Add +3.3% | 663 | $1K |
| Northwestern Mutual Wealth Management Co. | 0.00% | Add +0.6% | 503 | $785 |
| Steward Partners Investment Advisory, LLC | 0.00% | No change | 500 | $780 |
| Jones Financial Companies LLLP | 0.00% | Reduce -67.8% | 356 | $587 |
| Caitong International Asset Management Co., Ltd | 0.00% | Add +140.1% | 353 | $551 |
| Rockefeller Capital Management L.P. | 0.00% | No change | 335 | $523 |
| Farther Finance Advisors, LLC | 0.00% | Reduce -90.7% | 255 | $418 |
| Parallel Advisors, LLC | 0.00% | New | 247 | $385 |
| Syntax Research, Inc. | 0.00% | No change | 142 | $222 |
| Larson Financial Group LLC | 0.00% | No change | 100 | $156 |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -69.6% | 48 | $75 |
| Arax Advisory Partners | 0.00% | No change | 41 | $64 |
| HM Payson & Co. | 0.00% | New | 37 | $58 |
| True Wealth Design, LLC | 0.00% | Reduce -95.9% | 2 | $4 |
| Covestor Ltd | 0.00% | No change | 81 | $0 |
"% of holder's portfolio" is LXRX's weight in each manager's 13F, not the share of Lexicon Pharmaceuticals Inc. the manager owns.