Milestone PharmaceuticalsMIST
13F holders, Q4 2025 (December 31)80holders +19
27new positions
9sold out
4famous investors
$2.02avg. 13F price*
At the end of Q4 2025, 80 institutions reported holding Milestone Pharmaceuticals Inc. (MIST) in their 13F filings, up 19 from Q3 2025. 27 opened new positions and 9 sold out. The largest holders were Pavaki Capital Management LLC ($17.2M), Propel Bio Management, LLC ($8.3M) and Adage Capital Partners Gp, L.L.C. ($5.7M). 4 famous investors held it, including Steve Cohen (0.0% of Point72 Asset Management's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Milestone Pharmaceuticals Inc.
- CUSIP
- 59935V107
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 27 | $5.6M |
| Exits | 9 | $11.0M |
All 13F filers, Q3 2025 → Q4 2025: 7,107,858 shares bought and 14,520,319 shares sold, net −7,412,461 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 80 holders
| Pavaki Capital Management LLC | 11.99% | — | 8,498,915 | $17.2M |
| Propel Bio Management, LLC | 7.10% | Reduce -19.6% | 4,118,321 | $8.3M |
| Adage Capital Partners Gp, L.L.C. | 0.01% | Reduce -59.7% | 2,810,037 | $5.7M |
| RTW Investments, LP | 0.05% | No change | 2,506,102 | $5.1M |
| Marshall Wace, LLP | 0.00% | Add +289.8% | 1,656,821 | $3.3M |
| Two Sigma Investments, LP | 0.00% | Add +127.2% | 1,514,461 | $3.1M |
| Simplify Asset Management Inc. | 0.05% | Reduce -46.8% | 1,506,405 | $3.0M |
| Jane Street Group, LLC | 0.00% | Add +167.6% | 1,093,230 | $2.2M |
| Pathstone Holdings, LLC | 0.01% | Add +1.7% | 1,017,040 | $2.1M |
| Morgan Stanley | 0.00% | Reduce -73.7% | 781,875 | $1.6M |
| Lion Point Capital, LP | 7.89% | Add +14.7% | 755,000 | $1.5M |
| Toronto Dominion Bank | 0.00% | No change | 750,000 | $1.5M |
| Boxer Capital Management, LLC | 0.29% | No change | 666,666 | $1.3M |
| Stonepine Capital Management, LLC | 1.06% | New | 662,666 | $1.3M |
| Susquehanna International Group, LLP | 0.00% | Add +150.5% | 643,300 | $1.3M |
| Two Sigma Advisers, LP | 0.00% | Add +164.7% | 619,592 | $1.3M |
| UBS Group AG | 0.00% | Add +23.7% | 491,868 | $994K |
| Point72 Asset Management | 0.00% | New | 482,355 | $974K |
| Millennium Management | 0.00% | Add +0.3% | 402,635 | $813K |
| Citadel Advisors | 0.00% | Reduce -31.0% | 353,232 | $714K |
| Guardian Wealth Advisors, LLC / NC | 0.03% | Add +25.2% | 263,200 | $532K |
| Aptus Capital Advisors, LLC | 0.00% | Add +25.2% | 263,200 | $532K |
| Squarepoint Ops LLC | 0.00% | New | 249,344 | $504K |
| Gsa Capital Partners LLP | 0.04% | Add +199.9% | 236,138 | $477K |
| Nomura Holdings Inc. | 0.00% | New | 225,000 | $455K |
| BNP Paribas Financial Markets | 0.00% | New | 221,951 | $448K |
| Group One Trading LLC | 0.01% | Add +2678.4% | 195,099 | $394K |
| Acadian Asset Management LLC | 0.00% | New | 176,200 | $353K |
| XTX Topco Ltd | 0.01% | Reduce -8.2% | 171,960 | $347K |
| LPL Financial LLC | 0.00% | Add +49.5% | 142,463 | $288K |
| Graham Capital Management, L.P. | 0.01% | New | 133,620 | $270K |
| Valeo Financial Advisors, LLC | 0.01% | No change | 130,699 | $264K |
| ADAR1 Capital Management, LLC | 0.02% | New | 100,100 | $202K |
| Tru Independence Asset Management 2, LLC | 0.13% | New | 100,000 | $202K |
| SG Americas Securities, LLC | 0.00% | New | 97,375 | $197K |
| Cascades Capital Asset Management, LLC | 0.07% | Add +0.2% | 77,510 | $157K |
| Geode Capital Management, LLC | 0.00% | No change | 74,022 | $150K |
| Engineers Gate Manager LP | 0.00% | New | 59,053 | $119K |
| October Effect Ltd | 0.12% | New | 52,100 | $105K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | Add +271.2% | 47,140 | $95K |
| Northern Trust Corp. | 0.00% | No change | 39,258 | $79K |
| Focus Partners Wealth | 0.00% | No change | 36,000 | $73K |
| Qube Research & Technologies Ltd | 0.00% | New | 34,596 | $70K |
| Citigroup Inc. | 0.00% | Add +333.4% | 33,858 | $68K |
| Scientech Research LLC | 0.04% | New | 30,124 | $61K |
| Federation des caisses Desjardins du Quebec | 0.00% | No change | 29,781 | $60K |
| Bay Rivers Group | 0.02% | Add +72.9% | 28,861 | $58K |
| Raymond James Financial Inc. | 0.00% | No change | 26,600 | $54K |
| Safeguard Investment Advisory Group, LLC | 0.01% | No change | 25,044 | $51K |
| Mariner, LLC | 0.00% | No change | 25,000 | $51K |
| Creative Planning | 0.00% | No change | 23,410 | $47K |
| Invesco Ltd. | 0.00% | New | 21,893 | $44K |
| State Street Corp. | 0.00% | Reduce -1.6% | 21,875 | $44K |
| Cetera Investment Advisers | 0.00% | New | 20,722 | $42K |
| Stephenson & Company, Inc. | 0.02% | No change | 20,000 | $40K |
| Journey Strategic Wealth LLC | 0.00% | Add +100.0% | 20,000 | $40K |
| Quantbot Technologies LP | 0.00% | New | 18,990 | $38K |
| National Bank of Canada | 0.00% | No change | 18,700 | $38K |
| Bayesian Capital Management, LP | 0.08% | New | 17,215 | $35K |
| Jones Financial Companies LLLP | 0.00% | Add +45.5% | 16,000 | $32K |
| SJS Investment Consulting Inc. | 0.00% | New | 15,000 | $30K |
| Beta Wealth Group, Inc. | 0.01% | No change | 14,127 | $29K |
| Eaton Financial Holdings Company, LLC | 0.01% | New | 12,750 | $26K |
| Strategic Family Wealth Counselors, L.L.C. | 0.01% | New | 12,675 | $25K |
| Bronte Capital Management Pty Ltd. | 0.00% | New | 10,414 | $21K |
| Taylor Financial Group, Inc. | 0.01% | No change | 10,000 | $20K |
| Integral Investment Advisors, Inc. | 0.01% | New | 10,000 | $20K |
| Secure Asset Management, LLC | 0.00% | No change | 10,000 | $20K |
| Ancora Advisors LLC | 0.00% | No change | 10,000 | $20K |
| AQR Capital Management | 0.00% | No change | 10,000 | $20K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 8,980 | $18K |
| Royal Bank of Canada | 0.00% | Reduce -95.3% | 6,698 | $13K |
| US Bancorp \de | 0.00% | No change | 3,200 | $6K |
| Rockefeller Capital Management L.P. | 0.00% | New | 1,700 | $3K |
| Arax Advisory Partners | 0.00% | Add +47.7% | 1,591 | $3K |
| Bank of America Corp. | 0.00% | Reduce -94.8% | 841 | $2K |
| Medallion Wealth Advisors, LLC | 0.00% | New | 340 | $687 |
| Rialto Wealth Management, LLC | 0.00% | New | 300 | $606 |
| Key Capital Management, INC | 0.00% | — | 212 | $428 |
| SBI Securities Co., Ltd. | 0.00% | No change | 6 | $12 |
"% of holder's portfolio" is MIST's weight in each manager's 13F, not the share of Milestone Pharmaceuticals Inc. the manager owns.