Prelude TherapeuticsPRLD
13F holders, Q2 2025 (June 30)At the end of Q2 2025, 50 institutions reported holding Prelude Therapeutics Inc. (PRLD) in their 13F filings, down 8 from Q1 2025. 7 opened new positions and 16 sold out. The largest holders were Orbimed Advisors LLC ($8.8M), Baker Bros. Advisors LP ($8.2M) and Vanguard Group Inc. ($754K). 4 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Cliff Asness (0.0% of AQR Capital Management's portfolio).
- Company
- Prelude Therapeutics Inc.
- CUSIP
- 74065P101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2025 → Q2 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 7 | $437K |
| Exits | 16 | $5.4M |
All 13F filers, Q1 2025 → Q2 2025: 728,871 shares bought and 4,071,734 shares sold, net −3,342,863 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 50 holders
| Orbimed Advisors LLC | 0.22% | No change | 10,909,256 | $8.8M |
| Baker Bros. Advisors LP | 0.08% | No change | 10,123,824 | $8.2M |
| Vanguard Group Inc. | 0.00% | Reduce -7.6% | 932,570 | $754K |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -5.0% | 927,608 | $743K |
| Renaissance Technologies | 0.00% | Reduce -11.4% | 581,800 | $471K |
| Acadian Asset Management LLC | 0.00% | Add +2.1% | 540,565 | $436K |
| BlackRock, Inc. | 0.00% | Reduce -58.7% | 432,559 | $350K |
| Morgan Stanley | 0.00% | Reduce -6.1% | 284,382 | $230K |
| Millennium Management | 0.00% | Add +69.3% | 248,423 | $201K |
| Two Sigma Advisers, LP | 0.00% | Reduce -13.6% | 225,000 | $182K |
| Geode Capital Management, LLC | 0.00% | Reduce -46.3% | 217,568 | $176K |
| Cantor Fitzgerald, L. P. | 0.00% | New | 211,859 | $171K |
| TD Asset Management Inc | 0.00% | No change | 160,652 | $130K |
| Two Sigma Investments, LP | 0.00% | Reduce -15.6% | 154,977 | $125K |
| Goldman Sachs Group Inc. | 0.00% | Reduce -3.9% | 149,178 | $121K |
| UBS Group AG | 0.00% | Add +8.4% | 104,204 | $84K |
| State Street Corp. | 0.00% | Reduce -65.9% | 97,592 | $79K |
| Jane Street Group, LLC | 0.00% | New | 91,753 | $74K |
| Bridgeway Capital Management, LLC | 0.00% | No change | 88,500 | $72K |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -29.1% | 80,845 | $65K |
| Shay Capital LLC | 0.01% | New | 75,000 | $61K |
| Gsa Capital Partners LLP | 0.00% | New | 71,378 | $58K |
| Manufacturers Life Insurance Company, The | 0.00% | No change | 69,252 | $56K |
| Y-Intercept (Hong Kong) Ltd | 0.00% | New | 47,788 | $39K |
| AQR Capital Management | 0.00% | Add +29.1% | 43,647 | $35K |
| XTX Topco Ltd | 0.00% | Add +72.4% | 42,573 | $34K |
| Marshall Wace, LLP | 0.00% | New | 41,747 | $34K |
| Susquehanna International Group, LLP | 0.00% | Reduce -48.7% | 39,977 | $32K |
| Northern Trust Corp. | 0.00% | Reduce -67.4% | 38,127 | $31K |
| Cerity Partners LLC | 0.00% | Add +5.3% | 36,393 | $29K |
| Citadel Advisors | 0.00% | Add +98797.1% | 33,625 | $27K |
| HSBC Holdings PLC | 0.00% | Reduce -15.6% | 17,411 | $14K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +23.6% | 16,799 | $14K |
| Bank of America Corp. | 0.00% | Reduce -26.9% | 11,293 | $9K |
| FMR LLC | 0.00% | Reduce -44.8% | 11,167 | $9K |
| Barclays PLC | 0.00% | Reduce -62.8% | 8,602 | $7K |
| Citigroup Inc. | 0.00% | Reduce -49.3% | 4,718 | $4K |
| Cwm, LLC | 0.00% | Add +20.0% | 4,014 | $3K |
| SBI Securities Co., Ltd. | 0.00% | No change | 2,741 | $2K |
| Royal Bank of Canada | 0.00% | Reduce -15.5% | 2,827 | $2K |
| JPMorgan Chase & Co. | 0.00% | Reduce -91.8% | 1,949 | $2K |
| Nisa Investment Advisors, LLC | 0.00% | Add +308.5% | 1,634 | $1K |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -1.0% | 1,180 | $956 |
| Group One Trading LLC | 0.00% | No change | 500 | $405 |
| Wells Fargo & Company | 0.00% | Reduce -96.3% | 297 | $240 |
| EverSource Wealth Advisors, LLC | 0.00% | Add +1544.4% | 148 | $120 |
| Essential Partners LLC | 0.00% | — | 87 | $70 |
| BNP Paribas Financial Markets | 0.00% | Reduce -99.7% | 52 | $42 |
| IFP Advisors, Inc | 0.00% | New | 34 | $28 |
| True Wealth Design, LLC | 0.00% | Add +30.0% | 13 | $11 |
"% of holder's portfolio" is PRLD's weight in each manager's 13F, not the share of Prelude Therapeutics Inc. the manager owns.