Prelude TherapeuticsPRLD
13F holders, Q4 2025 (December 31)At the end of Q4 2025, 48 institutions reported holding Prelude Therapeutics Inc. (PRLD) in their 13F filings, up 1 from Q3 2025. 10 opened new positions and 9 sold out. The largest holders were Orbimed Advisors LLC ($31.6M), Baker Bros. Advisors LP ($29.4M) and Vanguard Group Inc. ($4.1M). 3 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Steve Cohen (0.0% of Point72 Asset Management's portfolio).
- Company
- Prelude Therapeutics Inc.
- CUSIP
- 74065P101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 10 | $4.6M |
| Exits | 9 | $301K |
All 13F filers, Q3 2025 → Q4 2025: 2,947,404 shares bought and 1,637,225 shares sold, net +1,310,179 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 48 holders
| Orbimed Advisors LLC | 0.65% | No change | 10,909,256 | $31.6M |
| Baker Bros. Advisors LP | 0.17% | No change | 10,123,824 | $29.4M |
| Vanguard Group Inc. | 0.00% | Add +42.4% | 1,413,986 | $4.1M |
| Kynam Capital Management, LP | 0.15% | New | 788,867 | $2.3M |
| Two Sigma Investments, LP | 0.00% | Add +418.1% | 788,695 | $2.3M |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -13.7% | 755,956 | $2.2M |
| Acadian Asset Management LLC | 0.00% | Reduce -0.9% | 535,703 | $1.6M |
| Morgan Stanley | 0.00% | Add +17.8% | 334,916 | $971K |
| Marshall Wace, LLP | 0.00% | New | 273,883 | $794K |
| Geode Capital Management, LLC | 0.00% | Add +25.4% | 272,886 | $792K |
| Renaissance Technologies | 0.00% | Reduce -50.1% | 271,300 | $787K |
| BlackRock, Inc. | 0.00% | Add +0.5% | 266,280 | $772K |
| Two Sigma Advisers, LP | 0.00% | Add +6.6% | 237,300 | $688K |
| TD Asset Management Inc | 0.00% | No change | 160,652 | $466K |
| Millennium Management | 0.00% | Reduce -86.8% | 150,997 | $438K |
| Susquehanna International Group, LLP | 0.00% | New | 135,909 | $394K |
| State Street Corp. | 0.00% | Add +30.4% | 127,292 | $369K |
| Sphera Funds Management LTD. | 0.07% | New | 122,752 | $356K |
| Goldman Sachs Group Inc. | 0.00% | Add +48.1% | 117,477 | $341K |
| Jane Street Group, LLC | 0.00% | Add +218.9% | 111,040 | $322K |
| OMERS ADMINISTRATION Corp | 0.00% | New | 73,000 | $212K |
| Manufacturers Life Insurance Company, The | 0.00% | Add +1.9% | 70,546 | $200K |
| Point72 Asset Management | 0.00% | New | 59,168 | $172K |
| Bridgeway Capital Management, LLC | 0.00% | No change | 53,500 | $155K |
| XTX Topco Ltd | 0.00% | Add +222.0% | 50,159 | $145K |
| Northern Trust Corp. | 0.00% | Add +37.6% | 50,120 | $145K |
| Focus Partners Wealth | 0.00% | New | 50,007 | $145K |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | New | 46,090 | $134K |
| Cerity Partners LLC | 0.00% | Reduce -4.0% | 32,953 | $96K |
| Qube Research & Technologies Ltd | 0.00% | New | 21,551 | $62K |
| Prudential Financial Inc. | 0.00% | Reduce -39.9% | 15,520 | $45K |
| HSBC Holdings PLC | 0.00% | Reduce -0.7% | 13,652 | $39K |
| Bank of America Corp. | 0.00% | Add +10.8% | 9,808 | $28K |
| Barclays PLC | 0.00% | Reduce -1.3% | 8,602 | $25K |
| FMR LLC | 0.00% | Reduce -32.4% | 6,152 | $18K |
| SBI Securities Co., Ltd. | 0.00% | No change | 2,741 | $8K |
| Caldwell Sutter Capital, Inc. | 0.00% | New | 2,000 | $6K |
| UBS Group AG | 0.00% | Reduce -55.5% | 1,857 | $5K |
| Royal Bank of Canada | 0.00% | Reduce -77.4% | 1,742 | $5K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 1,634 | $5K |
| PNC Financial Services Group, Inc. | 0.00% | No change | 1,171 | $3K |
| Cwm, LLC | 0.00% | Reduce -43.2% | 692 | $2K |
| Group One Trading LLC | 0.00% | No change | 500 | $1K |
| BNP Paribas Financial Markets | 0.00% | Add +82.7% | 95 | $276 |
| JPMorgan Chase & Co. | 0.00% | Reduce -98.4% | 62 | $180 |
| Optiver Holding B.V. | 0.00% | No change | 20 | $58 |
| Citigroup Inc. | 0.00% | Reduce -100.0% | 1 | $3 |
| IFP Advisors, Inc | 0.00% | Reduce -94.4% | 1 | $3 |
"% of holder's portfolio" is PRLD's weight in each manager's 13F, not the share of Prelude Therapeutics Inc. the manager owns.