Prelude TherapeuticsPRLD
13F holders, Q1 2026 (March 31)At the end of Q1 2026, 55 institutions reported holding Prelude Therapeutics Inc. (PRLD) in their 13F filings, up 7 from Q4 2025. 10 opened new positions and 4 sold out. The largest holders were Orbimed Advisors LLC ($37.3M), Baker Bros. Advisors LP ($34.6M) and Kynam Capital Management, LP ($5.4M). 4 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Prelude Therapeutics Inc.
- CUSIP
- 74065P101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 10 | $4.7M |
| Exits | 4 | $2.9M |
All 13F filers, Q4 2025 → Q1 2026: 3,672,774 shares bought and 1,113,809 shares sold, net +2,558,965 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 55 holders
| Orbimed Advisors LLC | 0.84% | No change | 10,909,256 | $37.3M |
| Baker Bros. Advisors LP | 0.20% | No change | 10,123,824 | $34.6M |
| Kynam Capital Management, LP | 0.35% | Add +101.9% | 1,592,551 | $5.4M |
| Vanguard Capital Management LLC | 0.00% | — | 1,230,406 | $4.2M |
| EcoR1 Capital, LLC | 0.14% | New | 947,049 | $3.2M |
| Two Sigma Investments, LP | 0.00% | Add +17.1% | 923,626 | $3.2M |
| Sphera Funds Management LTD. | 0.33% | Add +354.9% | 558,339 | $1.9M |
| Acadian Asset Management LLC | 0.00% | Reduce -4.5% | 511,519 | $1.7M |
| Millennium Management | 0.00% | Add +153.5% | 382,737 | $1.3M |
| Marshall Wace, LLP | 0.00% | Add +31.0% | 358,906 | $1.2M |
| Morgan Stanley | 0.00% | Reduce -3.8% | 322,161 | $1.1M |
| BlackRock, Inc. | 0.00% | Add +20.9% | 321,886 | $1.1M |
| Geode Capital Management, LLC | 0.00% | Add +10.8% | 302,458 | $1.0M |
| Renaissance Technologies | 0.00% | Add +1.4% | 275,200 | $941K |
| Susquehanna International Group, LLP | 0.00% | Add +97.0% | 267,788 | $916K |
| Goldman Sachs Group Inc. | 0.00% | Add +101.3% | 236,469 | $809K |
| Jane Street Group, LLC | 0.00% | Add +73.8% | 192,963 | $660K |
| Vanguard Fiduciary Trust Co. | 0.00% | — | 157,380 | $538K |
| ADAR1 Capital Management, LLC | 0.03% | New | 152,825 | $523K |
| State Street Corp. | 0.00% | Add +8.6% | 138,231 | $473K |
| Citadel Advisors | 0.00% | New | 124,378 | $425K |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | Add +136.7% | 109,085 | $373K |
| UBS Group AG | 0.00% | Add +3373.6% | 64,505 | $221K |
| HRT Financial LP | 0.00% | New | 58,699 | $200K |
| XTX Topco Ltd | 0.00% | Add +14.0% | 57,190 | $196K |
| Bank of America Corp. | 0.00% | Add +476.3% | 56,525 | $193K |
| Bridgeway Capital Management, LLC | 0.00% | No change | 53,500 | $183K |
| Northern Trust Corp. | 0.00% | No change | 50,120 | $171K |
| Focus Partners Wealth | 0.00% | No change | 50,007 | $171K |
| Dimensional Fund Advisors LP | 0.00% | New | 35,210 | $120K |
| Cerity Partners LLC | 0.00% | Reduce -0.2% | 32,875 | $112K |
| OMERS ADMINISTRATION Corp | 0.00% | Reduce -55.2% | 32,700 | $112K |
| Prudential Financial Inc. | 0.00% | Add +12.2% | 17,420 | $60K |
| Qube Research & Technologies Ltd | 0.00% | Reduce -23.8% | 16,417 | $56K |
| Point72 Asset Management | 0.00% | Reduce -72.4% | 16,329 | $56K |
| HSBC Holdings PLC | 0.00% | No change | 13,652 | $48K |
| Diametric Capital, LP | 0.01% | New | 11,980 | $41K |
| NINE MASTS CAPITAL Ltd | 0.01% | New | 11,699 | $40K |
| Graham Capital Management, L.P. | 0.00% | New | 11,343 | $39K |
| American Century Companies Inc. | 0.00% | New | 10,294 | $35K |
| Barclays PLC | 0.00% | Reduce -0.0% | 8,600 | $29K |
| FMR LLC | 0.00% | Reduce -2.3% | 6,009 | $21K |
| Vanguard Global Advisers, LLC | 0.00% | — | 4,636 | $16K |
| Group One Trading LLC | 0.00% | Add +681.4% | 3,907 | $13K |
| SBI Securities Co., Ltd. | 0.00% | Reduce -3.6% | 2,641 | $9K |
| Royal Bank of Canada | 0.00% | Add +33.8% | 2,331 | $8K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 1,634 | $6K |
| PNC Financial Services Group, Inc. | 0.00% | No change | 1,171 | $4K |
| Caldwell Sutter Capital, Inc. | 0.00% | Reduce -50.0% | 1,000 | $3K |
| Cwm, LLC | 0.00% | Reduce -17.2% | 573 | $2K |
| Fortitude Family Office, LLC | 0.00% | New | 230 | $787 |
| BNP Paribas Financial Markets | 0.00% | No change | 95 | $325 |
| JPMorgan Chase & Co. | 0.00% | No change | 62 | $190 |
| Optiver Holding B.V. | 0.00% | No change | 20 | $68 |
| Citigroup Inc. | 0.00% | Add +400.0% | 5 | $17 |
"% of holder's portfolio" is PRLD's weight in each manager's 13F, not the share of Prelude Therapeutics Inc. the manager owns.