Prime MedicinePRME
13F holders, Q4 2025 (December 31)183holders +16
41new positions
26sold out
7famous investors
$3.47avg. 13F price*
At the end of Q4 2025, 183 institutions reported holding Prime Medicine Inc. (PRME) in their 13F filings, up 16 from Q3 2025. 41 opened new positions and 26 sold out. The largest holders were Alphabet Inc. ($57.5M), BlackRock, Inc. ($28.7M) and Vanguard Group Inc. ($22.4M). 7 famous investors held it, including Cathie Wood (0.1% of ARK Investment Management's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Prime Medicine Inc.
- CUSIP
- 74168J101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 41 | $11.1M |
| Exits | 26 | $41.4M |
All 13F filers, Q3 2025 → Q4 2025: 24,331,317 shares bought and 19,703,585 shares sold, net +4,627,732 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 183 holders
| Alphabet Inc. | 2.23% | No change | 16,562,498 | $57.5M |
| BlackRock, Inc. | 0.00% | Add +46.3% | 8,268,843 | $28.7M |
| Vanguard Group Inc. | 0.00% | Add +31.4% | 6,467,872 | $22.4M |
| T. Rowe Price Investment Management, Inc. | 0.01% | Reduce -35.0% | 5,995,183 | $20.8M |
| ARK Investment Management | 0.12% | Reduce -2.0% | 5,368,526 | $18.6M |
| State Street Corp. | 0.00% | Add +293.0% | 5,095,510 | $17.7M |
| Sumitomo Mitsui Trust Group, Inc. | 0.01% | Reduce -10.6% | 3,245,506 | $11.3M |
| Amova Asset Management Americas, Inc. | 0.13% | Reduce -10.6% | 3,245,506 | $11.2M |
| Casdin Capital, LLC | 0.68% | No change | 3,167,175 | $11.0M |
| Balyasny Asset Management L.P. | 0.02% | Add +6426.4% | 3,124,362 | $10.8M |
| Woodline Partners LP | 0.04% | Add +0.0% | 3,002,844 | $10.4M |
| Geode Capital Management, LLC | 0.00% | Add +48.8% | 2,628,429 | $9.1M |
| UBS Group AG | 0.00% | Add +700.8% | 2,440,583 | $8.5M |
| FMR LLC | 0.00% | Reduce -22.6% | 2,176,646 | $7.6M |
| MWG Caph Ltd | 8.59% | — | 1,792,210 | $6.2M |
| Goldman Sachs Group Inc. | 0.00% | Add +327.5% | 1,755,768 | $6.1M |
| Two Sigma Investments, LP | 0.01% | Add +264.0% | 1,629,324 | $5.7M |
| D. E. Shaw & Co. | 0.00% | Reduce -30.0% | 1,551,369 | $5.4M |
| Farallon Capital Management, L.L.C. | 0.02% | Reduce -73.9% | 1,240,843 | $4.3M |
| Susquehanna International Group, LLP | 0.01% | Add +101.3% | 1,176,727 | $4.1M |
| Morgan Stanley | 0.00% | Add +60.0% | 1,169,898 | $4.1M |
| Renaissance Technologies | 0.01% | Add +1.3% | 1,149,159 | $4.0M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +63.5% | 936,815 | $3.3M |
| Northern Trust Corp. | 0.00% | Add +38.5% | 842,153 | $2.9M |
| Greenwich Wealth Management LLC | 0.11% | Add +2.8% | 740,001 | $2.6M |
| HRT Financial LP | 0.01% | Add +195.9% | 655,351 | $2.3M |
| Bank of America Corp. | 0.00% | Add +484.6% | 648,012 | $2.2M |
| Point72 Asset Management | 0.00% | New | 551,030 | $1.9M |
| Moore Capital Management, LP | 0.04% | No change | 500,000 | $1.7M |
| JPMorgan Chase & Co. | 0.00% | Add +904.2% | 435,710 | $1.5M |
| AQR Capital Management | 0.00% | Add +0.4% | 415,821 | $1.4M |
| HighTower Advisors, LLC | 0.00% | Add +19.9% | 400,110 | $1.4M |
| Two Sigma Advisers, LP | 0.00% | New | 383,500 | $1.3M |
| Barclays PLC | 0.00% | Add +213.9% | 363,826 | $1.3M |
| Bollard Group LLC | 0.03% | No change | 361,136 | $1.3M |
| Wells Fargo & Company | 0.00% | Add +49.5% | 294,496 | $1.0M |
| Verition Fund Management LLC | 0.01% | New | 290,983 | $1.0M |
| Nuveen, LLC | 0.00% | Add +11.4% | 251,636 | $873K |
| Wellington Management Group LLP | 0.00% | Add +20.9% | 248,227 | $861K |
| Bank of New York Mellon Corp | 0.00% | Add +24.8% | 246,770 | $856K |
| Chelsea Counsel Co. | 0.34% | Add +9.0% | 227,000 | $788K |
| Dark Forest Capital Management LP | 0.04% | New | 225,859 | $784K |
| Squarepoint Ops LLC | 0.00% | Add +450.6% | 218,042 | $757K |
| Green Alpha Advisors, LLC | 0.61% | Add +0.3% | 190,883 | $662K |
| Rafferty Asset Management, LLC | 0.00% | New | 187,711 | $651K |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 0.04% | Add +47.8% | 178,519 | $619K |
| Jump Financial, LLC | 0.01% | New | 171,931 | $597K |
| Swiss National Bank | 0.00% | New | 170,100 | $590K |
| Deutsche Bank AG | 0.00% | Add +11.4% | 147,943 | $513K |
| Bridgeway Capital Management, LLC | 0.01% | Reduce -18.2% | 134,800 | $468K |
| Keystone Financial Group | 0.03% | Add +83.0% | 129,665 | $450K |
| Rockefeller Capital Management L.P. | 0.00% | Add +10557.7% | 121,391 | $421K |
| Steward Partners Investment Advisory, LLC | 0.00% | Reduce -6.3% | 118,406 | $411K |
| FIL Ltd | 0.00% | Reduce -0.6% | 115,602 | $401K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -4.5% | 115,060 | $399K |
| Graham Capital Management, L.P. | 0.02% | New | 114,680 | $398K |
| Citadel Advisors | 0.00% | Reduce -87.5% | 112,870 | $392K |
| Alliancebernstein L.P. | 0.00% | No change | 108,690 | $377K |
| Rhumbline Advisers | 0.00% | Reduce -1.3% | 108,409 | $376K |
| T. Rowe Price Associates Inc. | 0.00% | Add +40.3% | 104,553 | $363K |
| Group One Trading LLC | 0.01% | New | 103,213 | $358K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | New | 99,100 | $344K |
| Virtu Financial LLC | 0.01% | Add +701.2% | 94,778 | $329K |
| Qube Research & Technologies Ltd | 0.00% | New | 94,670 | $329K |
| TD Asset Management Inc | 0.00% | Reduce -48.0% | 94,148 | $327K |
| California State Teachers Retirement System | 0.00% | Add +2279.0% | 86,929 | $302K |
| Palumbo Wealth Management LLC | 0.07% | Reduce -7.6% | 85,539 | $297K |
| Dimensional Fund Advisors LP | 0.00% | New | 84,054 | $292K |
| Legal & General Group Plc | 0.00% | Add +1096.1% | 80,749 | $280K |
| XTX Topco Ltd | 0.01% | Add +51.2% | 72,935 | $253K |
| Profund Advisors LLC | 0.01% | New | 69,605 | $242K |
| Virtus Investment Advisers, LLC | 0.06% | New | 64,886 | $225K |
| Janus Henderson Group PLC | 0.00% | New | 60,900 | $210K |
| Engineers Gate Manager LP | 0.00% | Add +8.8% | 60,490 | $210K |
| &partners | 0.00% | Add +409.4% | 60,352 | $209K |
| MetLife Investment Management, LLC | 0.00% | Add +33.9% | 57,570 | $200K |
| Invesco Ltd. | 0.00% | Reduce -92.5% | 56,779 | $197K |
| Brevan Howard Capital Management LP | 0.00% | Reduce -9.9% | 56,088 | $195K |
| Ameriprise Financial Inc. | 0.00% | Reduce -12.2% | 54,082 | $188K |
| Quadrature Capital Ltd | 0.00% | Add +419.2% | 52,866 | $183K |
| Millennium Management | 0.00% | Reduce -96.4% | 51,335 | $178K |
| Citigroup Inc. | 0.00% | Add +894.5% | 51,229 | $178K |
| Tidal Investments LLC | 0.00% | New | 50,244 | $174K |
| Walleye Capital LLC | 0.00% | New | 46,139 | $160K |
| Mutual Advisors, LLC | 0.00% | No change | 45,200 | $157K |
| Elevate Capital Advisors, LLC | 0.10% | New | 42,666 | $148K |
| IvyRock Asset Management (HK) Ltd | 0.08% | No change | 41,800 | $145K |
| Jones Financial Companies LLLP | 0.00% | Add +322.0% | 40,403 | $140K |
| Corient Private Wealth LP | 0.00% | No change | 38,777 | $135K |
| Caitong International Asset Management Co., Ltd | 0.03% | New | 38,696 | $134K |
| Gsa Capital Partners LLP | 0.01% | New | 38,510 | $134K |
| Ieq Capital, LLC | 0.00% | Add +1.3% | 37,136 | $129K |
| Mariner, LLC | 0.00% | Add +99.2% | 36,290 | $126K |
| Polymer Capital Management (US) LLC | 0.02% | Add +73.1% | 35,981 | $125K |
| Intech Investment Management LLC | 0.00% | Add +50.8% | 35,036 | $122K |
| CENTRAL TRUST Co | 0.00% | New | 34,995 | $121K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -45.5% | 34,399 | $119K |
| Axq Capital, LP | 0.03% | Reduce -25.5% | 33,405 | $116K |
| LPL Financial LLC | 0.00% | Add +6.1% | 32,924 | $114K |
| Envestnet Asset Management Inc. | 0.00% | New | 32,576 | $113K |
| Crestwood Advisors Group, LLC | 0.00% | Add +0.9% | 31,973 | $111K |
| Manufacturers Life Insurance Company, The | 0.00% | Add +16.5% | 31,602 | $110K |
| SG Americas Securities, LLC | 0.00% | New | 30,954 | $107K |
| China Universal Asset Management Co., Ltd. | 0.01% | Reduce -4.0% | 29,414 | $102K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Reduce -2.5% | 26,098 | $97K |
| Raymond James Financial Inc. | 0.00% | Reduce -15.0% | 27,044 | $94K |
| Transcend Capital Advisors, LLC | 0.01% | New | 26,500 | $92K |
| ProShare Advisors LLC | 0.00% | Add +37.0% | 26,158 | $91K |
| Cwm, LLC | 0.00% | Add +0.3% | 25,427 | $88K |
| Abacus Planning Group, Inc. | 0.01% | No change | 25,188 | $87K |
| Nomura Holdings Inc. | 0.00% | Reduce -0.5% | 24,789 | $86K |
| Arizona State Retirement System | 0.00% | New | 24,085 | $84K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Reduce -1.4% | 23,651 | $82K |
| Voloridge Investment Management, LLC | 0.00% | Reduce -86.4% | 23,121 | $80K |
| Thompson Davis & Co., Inc. | 0.05% | Reduce -17.5% | 22,740 | $79K |
| Scientech Research LLC | 0.05% | New | 22,393 | $78K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 21,166 | $73K |
| Shelton Wealth Management, LLC | 0.03% | Add +15.8% | 20,066 | $70K |
| KLP Kapitalforvaltning As | 0.00% | New | 18,500 | $64K |
| Creative Planning | 0.00% | Reduce -22.5% | 17,892 | $62K |
| Voya Investment Management LLC | 0.00% | Add +36.1% | 17,491 | $61K |
| Clarius Group, LLC | 0.00% | No change | 16,080 | $56K |
| Levin Capital Strategies, L.P. | 0.00% | No change | 15,000 | $52K |
| Kingsview Wealth Management, LLC | 0.00% | Reduce -39.4% | 15,000 | $52K |
| Martingale Asset Management L P | 0.00% | New | 14,808 | $51K |
| Sanctuary Advisors, LLC | 0.00% | Add +2.4% | 14,659 | $51K |
| Prime Capital Investment Advisors, LLC | 0.00% | Reduce -2.3% | 14,055 | $49K |
| Sterling Investment Advisors, Ltd. | 0.01% | Add +34.0% | 13,400 | $46K |
| JTC Employer Solutions Trustee Ltd | 0.00% | No change | 13,249 | $46K |
| Oppenheimer & Co. Inc. | 0.00% | New | 12,433 | $43K |
| Teacher Retirement System of Texas | 0.00% | New | 12,235 | $42K |
| Federation des caisses Desjardins du Quebec | 0.00% | Reduce -24.5% | 12,000 | $42K |
| Integrity Advisory Solutions, LLC | 0.01% | New | 11,689 | $41K |
| Callan Family Office, LLC | 0.00% | New | 11,292 | $39K |
| Neuberger Berman Group LLC | 0.00% | New | 10,915 | $38K |
| Lazard Asset Management LLC | 0.00% | New | 10,844 | $38K |
| Victory Capital Management Inc. | 0.00% | Add +6.0% | 10,801 | $37K |
| Rhodes Investment Advisors Inc. | 0.03% | — | 10,750 | $37K |
| Prelude Capital Management, LLC | 0.00% | Reduce -54.6% | 10,200 | $35K |
| Glen Eagle Advisors, LLC | 0.00% | New | 10,000 | $35K |
| Forum Financial Management, LP | 0.00% | New | 10,000 | $35K |
| BNP Paribas Financial Markets | 0.00% | Reduce -50.0% | 9,823 | $34K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | New | 8,814 | $31K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +29.8% | 8,772 | $30K |
| New York State Common Retirement Fund | 0.00% | No change | 8,434 | $29K |
| Osaic Holdings, Inc. | 0.00% | Add +21.3% | 8,428 | $29K |
| Russell Investments Group, Ltd. | 0.00% | No change | 6,827 | $24K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 5,901 | $20K |
| Sterling Capital Management LLC | 0.00% | Add +10.4% | 5,736 | $20K |
| Lanark Financial, Inc. | 0.00% | Reduce -33.3% | 5,000 | $17K |
| Signaturefd, LLC | 0.00% | No change | 5,000 | $17K |
| Royal Bank of Canada | 0.00% | Add +165.3% | 4,889 | $17K |
| Nisa Investment Advisors, LLC | 0.00% | Reduce -92.5% | 4,546 | $16K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -5.7% | 3,547 | $12K |
| Financial Connections Group, Inc. | 0.00% | No change | 3,712 | $12K |
| Amalgamated Bank | 0.00% | Add +59.7% | 3,126 | $11K |
| Allworth Financial LP | 0.00% | Add +209.6% | 3,115 | $11K |
| MTM Investment Management, LLC | 0.00% | New | 3,090 | $11K |
| EverSource Wealth Advisors, LLC | 0.00% | No change | 1,762 | $6K |
| Scarborough Advisors, LLC | 0.00% | Add +148.9% | 1,257 | $4K |
| Corsicana & Co. | 0.00% | No change | 1,000 | $3K |
| NewEdge Advisors, LLC | 0.00% | No change | 1,000 | $3K |
| Leonteq Securities AG | 0.00% | No change | 915 | $3K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -79.3% | 807 | $3K |
| Fairman Group, LLC | 0.00% | No change | 500 | $2K |
| Rothschild Investment LLC | 0.00% | No change | 345 | $1K |
| PNC Financial Services Group, Inc. | 0.00% | No change | 319 | $1K |
| SBI Securities Co., Ltd. | 0.00% | Reduce -69.7% | 303 | $1K |
| Fortitude Family Office, LLC | 0.00% | No change | 296 | $1K |
| Daiwa Securities Group Inc. | 0.00% | No change | 398 | $1K |
| Basecamp Wealth Advisors LLC | 0.00% | — | 287 | $996 |
| Parkside Financial Bank & Trust | 0.00% | No change | 285 | $989 |
| MAI Capital Management | 0.00% | No change | 274 | $951 |
| CIBC Private Wealth Group LLC | 0.00% | New | 267 | $926 |
| Essential Partners LLC | 0.00% | Add +5.2% | 221 | $767 |
| Optiver Holding B.V. | 0.00% | Reduce -82.2% | 160 | $555 |
| Global Retirement Partners, LLC | 0.00% | New | 146 | $507 |
| True Wealth Design, LLC | 0.00% | No change | 115 | $400 |
| GAMMA Investing LLC | 0.00% | New | 111 | $385 |
| Sunbelt Securities, Inc. | 0.00% | No change | 80 | $278 |
| Farther Finance Advisors, LLC | 0.00% | No change | 71 | $246 |
| IFP Advisors, Inc | 0.00% | Add +11.1% | 10 | $35 |
| Covestor Ltd | 0.00% | No change | 31 | $0 |
"% of holder's portfolio" is PRME's weight in each manager's 13F, not the share of Prime Medicine Inc. the manager owns.