Spyre TherapeuticsSYRE
13F holders, Q2 2026 (June 30)265holders +67
88new positions
20sold out
5famous investors
$88.89avg. 13F price*
At the end of Q2 2026, 265 institutions reported holding Spyre Therapeutics Inc. (SYRE) in their 13F filings, up 67 from Q1 2026. 88 opened new positions and 20 sold out. The largest holders were FMR LLC ($1.2B), BlackRock, Inc. ($577.7M) and Perceptive Advisors LLC ($383.5M). 5 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Spyre Therapeutics Inc.
- CUSIP
- 00773J202
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2026 → Q2 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 88 | $552.2M |
| Exits | 20 | $390.1M |
All 13F filers, Q1 2026 → Q2 2026: 24,436,048 shares bought and 11,830,012 shares sold, net +12,606,036 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 265 holders
| FMR LLC | 0.05% | Add +10.6% | 13,026,187 | $1.2B |
| BlackRock, Inc. | 0.01% | Add +17.9% | 6,506,605 | $577.7M |
| Perceptive Advisors LLC | 5.97% | Add +14.2% | 4,319,496 | $383.5M |
| RTW Investments, LP | 3.22% | Add +1.9% | 4,251,996 | $377.5M |
| Paradigm Biocapital Advisors LP | 6.38% | Add +96.2% | 3,840,778 | $341.0M |
| Vanguard Capital Management LLC | 0.01% | Add +12.8% | 3,448,681 | $306.2M |
| State Street Corp. | 0.01% | Add +17.3% | 3,057,416 | $271.4M |
| Venrock Adviser, LLC | 8.04% | Reduce -19.0% | 2,985,448 | $265.0M |
| T. Rowe Price Associates Inc. | 0.03% | Add +85.2% | 2,960,855 | $262.9M |
| Driehaus Capital Management LLC | 1.44% | Add +0.3% | 2,799,166 | $248.5M |
| Geode Capital Management, LLC | 0.01% | Add +48.9% | 2,562,265 | $239.3M |
| Vanguard Portfolio Management LLC | 0.01% | Add +298.2% | 2,330,098 | $206.9M |
| Capital World Investors | 0.02% | Add +247.4% | 2,315,553 | $205.6M |
| Jupiter Topco LLC | 0.08% | — | 2,206,936 | $195.9M |
| TCG Crossover Management, LLC | 4.06% | No change | 1,900,582 | $168.7M |
| Tang Capital Management LLC | 7.67% | No change | 1,892,200 | $168.0M |
| Bank of America Corp. | 0.01% | Add +44.8% | 1,777,854 | $157.8M |
| Adage Capital Partners Gp, L.L.C. | 0.21% | New | 1,722,300 | $152.9M |
| Wellington Management Group LLP | 0.02% | Reduce -13.3% | 1,581,505 | $140.4M |
| Goldman Sachs Group Inc. | 0.01% | Add +447.6% | 1,478,059 | $131.2M |
| Franklin Resources Inc. | 0.03% | Add +66.8% | 1,472,943 | $130.8M |
| Remedium Capital Partners, LLC | 28.78% | Add +0.6% | 1,464,169 | $130.0M |
| Affinity Asset Advisors, LLC | 5.65% | No change | 1,279,134 | $113.6M |
| JPMorgan Chase & Co. | 0.01% | Add +11.6% | 1,093,026 | $98.9M |
| Holocene Advisors, LP | 0.21% | New | 1,015,170 | $90.1M |
| Marshall Wace, LLP | 0.07% | Add +612.1% | 991,693 | $88.0M |
| Polar Capital Holdings Plc | 0.25% | Add +24.6% | 988,009 | $87.7M |
| Siren, L.L.C. | 1.75% | Add +18.3% | 968,598 | $86.0M |
| Capital International Investors | 0.02% | Reduce -45.3% | 955,196 | $84.8M |
| Braidwell LP | 3.00% | Reduce -5.7% | 879,467 | $78.1M |
| Commodore Capital LP | 4.48% | Reduce -55.7% | 846,786 | $75.2M |
| UBS Group AG | 0.01% | Add +25.6% | 843,071 | $74.8M |
| Northern Trust Corp. | 0.01% | Add +16.5% | 674,529 | $59.9M |
| Charles Schwab Investment Management Inc. | 0.01% | Add +16.1% | 652,958 | $58.0M |
| Pictet Asset Management Holding SA | 0.05% | Add +27.8% | 628,138 | $55.8M |
| Emerald Advisers, LLC | 1.19% | Reduce -7.5% | 567,430 | $50.4M |
| Victory Capital Management Inc. | 0.03% | Add +89.6% | 553,980 | $49.2M |
| Vanguard Fiduciary Trust Co. | 0.01% | Add +18.7% | 551,389 | $49.0M |
| Candriam S.C.A. | 0.22% | Reduce -10.5% | 546,312 | $48.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.01% | Add +151.8% | 522,071 | $46.3M |
| Morgan Stanley | 0.00% | Add +102.6% | 499,963 | $44.4M |
| Voya Investment Management LLC | 0.04% | Add +699.9% | 431,694 | $38.3M |
| Emerald Mutual Fund Advisers Trust | 1.25% | Reduce -1.7% | 401,271 | $35.6M |
| Samlyn Capital, LLC | 0.59% | Add +0.9% | 400,075 | $35.5M |
| Ameriprise Financial Inc. | 0.01% | Add +123.7% | 356,082 | $31.6M |
| Integral Health Asset Management, LLC | 1.18% | New | 325,000 | $28.9M |
| Woodline Partners LP | 0.08% | Add +15.1% | 306,049 | $27.2M |
| Jennison Associates LLC | 0.02% | New | 303,180 | $26.9M |
| ADAR1 Capital Management, LLC | 1.19% | Reduce -16.1% | 283,982 | $25.2M |
| BNP Paribas Financial Markets | 0.01% | Add +1295.2% | 259,923 | $23.1M |
| Bank of New York Mellon Corp | 0.00% | Add +28.1% | 245,193 | $21.8M |
| Bellevue Group AG | 0.43% | New | 229,931 | $20.4M |
| Cormorant Asset Management, LP | 1.02% | New | 225,000 | $20.0M |
| Seven Grand Managers, LLC | 0.81% | Add +125.0% | 225,000 | $20.0M |
| Eventide Asset Management, LLC | 0.24% | New | 201,616 | $17.9M |
| Millennium Management | 0.01% | Add +34.1% | 196,712 | $17.5M |
| Orbimed Advisors LLC | 0.31% | New | 186,145 | $16.5M |
| Frontier Capital Management Co. LLC | 0.15% | New | 182,931 | $16.2M |
| Nuveen, LLC | 0.00% | Add +17.7% | 181,105 | $16.1M |
| Neuberger Berman Group LLC | 0.01% | New | 180,884 | $16.1M |
| Deutsche Bank AG | 0.00% | Add +35.0% | 174,459 | $15.5M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.02% | Add +1.5% | 172,923 | $15.4M |
| Balyasny Asset Management L.P. | 0.02% | Add +165.1% | 147,042 | $13.1M |
| Soleus Capital Management, L.P. | 0.45% | New | 147,000 | $13.1M |
| Squarepoint Ops LLC | 0.02% | New | 139,605 | $12.4M |
| Armistice Capital, LLC | 0.34% | Add +13.8% | 137,588 | $12.2M |
| Russell Investments Group, Ltd. | 0.01% | Add +1256.9% | 134,757 | $12.0M |
| Ensign Peak Advisors, Inc | 0.02% | Reduce -14.8% | 126,620 | $11.2M |
| Invesco Ltd. | 0.00% | Reduce -8.9% | 120,541 | $10.7M |
| Blackstone Inc. | 0.04% | Reduce -59.0% | 120,177 | $10.7M |
| Rhenman & Partners Asset Management AB | 1.00% | New | 119,300 | $10.6M |
| TD Asset Management Inc | 0.01% | Reduce -15.6% | 115,990 | $10.3M |
| Swiss National Bank | 0.01% | Add +16.6% | 112,500 | $10.0M |
| Stempoint Capital LP | 1.64% | Reduce -36.2% | 106,926 | $9.5M |
| Manufacturers Life Insurance Company, The | 0.01% | Reduce -7.4% | 104,516 | $9.3M |
| Citadel Advisors | 0.01% | Reduce -4.7% | 103,100 | $9.2M |
| Boxer Capital Management, LLC | 0.67% | New | 100,000 | $8.9M |
| Rhumbline Advisers | 0.01% | Add +11.3% | 94,763 | $8.4M |
| Barclays PLC | 0.00% | Add +105.5% | 94,069 | $8.4M |
| F/m Investments LLC | 0.42% | Reduce -6.9% | 92,618 | $8.2M |
| Prudential Financial Inc. | 0.01% | Add +46.7% | 87,370 | $7.8M |
| Federated Hermes, Inc. | 0.01% | New | 85,950 | $7.6M |
| Granahan Investment Management, LLC | 0.26% | New | 82,991 | $7.4M |
| Citigroup Inc. | 0.00% | Add +587.9% | 82,593 | $7.3M |
| Wells Fargo & Company | 0.00% | Add +148.4% | 82,506 | $7.3M |
| HighVista Strategies LLC | 1.57% | Reduce -46.8% | 77,807 | $6.9M |
| Mercer Global Advisors Inc. | 0.01% | Add +0.1% | 71,145 | $6.3M |
| B Group, Inc. | 3.53% | Reduce -30.0% | 70,000 | $6.2M |
| Trexquant Investment LP | 0.04% | New | 67,007 | $5.9M |
| California State Teachers Retirement System | 0.01% | Add +9.2% | 64,687 | $5.7M |
| Informed Momentum Co LLC | 0.48% | New | 60,393 | $5.4M |
| Silverarc Capital Management, LLC | 0.59% | Reduce -67.9% | 59,959 | $5.3M |
| Principal Financial Group Inc. | 0.00% | Add +1289.8% | 59,747 | $5.3M |
| Hudson Bay Capital Management LP | 0.03% | New | 58,387 | $5.2M |
| Atle Fund Management AB | 1.36% | Reduce -9.1% | 57,030 | $5.1M |
| Raymond James Financial Inc. | 0.00% | Add +171.5% | 53,627 | $4.8M |
| Susquehanna Portfolio Strategies, LLC | 0.08% | No change | 53,101 | $4.7M |
| Alliancebernstein L.P. | 0.00% | Add +30.5% | 92,540 | $4.7M |
| Royce & Associates LP | 0.04% | New | 51,789 | $4.6M |
| XTX Topco Ltd | 0.06% | Add +106.6% | 50,483 | $4.5M |
| Monashee Investment Management LLC | 10.71% | New | 50,000 | $4.4M |
| Legal & General Group Plc | 0.00% | Add +9.7% | 49,141 | $4.4M |
| Cinctive Capital Management LP | 0.17% | Add +78.6% | 48,978 | $4.3M |
| Dimensional Fund Advisors LP | 0.00% | Add +0.0% | 47,698 | $4.2M |
| Rockefeller Capital Management L.P. | 0.01% | Reduce -25.8% | 47,466 | $4.2M |
| PFM Health Sciences, LP | 0.36% | New | 46,217 | $4.1M |
| Schroder Investment Management Group | 0.00% | Reduce -30.0% | 44,586 | $4.0M |
| State of Wisconsin Investment Board | 0.01% | Add +69.8% | 45,030 | $4.0M |
| MetLife Investment Management, LLC | 0.02% | Add +12.8% | 43,316 | $3.8M |
| Nomura Asset Management International Inc. | 0.01% | New | 43,071 | $3.8M |
| Moody Aldrich Partners LLC | 0.68% | New | 42,458 | $3.8M |
| Rock Springs Capital Management LP | 0.18% | New | 42,254 | $3.8M |
| Maven Securities LTD | 0.25% | New | 40,000 | $3.6M |
| Susquehanna International Group, LLP | 0.00% | Add +35.7% | 39,311 | $3.5M |
| VANGUARD ASSET MANAGEMENT, Ltd | 0.00% | Add +18.0% | 39,220 | $3.5M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +5.8% | 38,439 | $3.4M |
| Engineers Gate Manager LP | 0.04% | New | 38,474 | $3.4M |
| Rafferty Asset Management, LLC | 0.01% | Reduce -35.4% | 36,767 | $3.3M |
| Caption Management, LLC | 0.12% | New | 36,000 | $3.2M |
| Vanguard Global Advisers, LLC | 0.00% | Add +10.8% | 34,500 | $3.1M |
| Ghisallo Capital Management LLC | 0.07% | New | 30,000 | $2.7M |
| Fred Alger Management, LLC | 0.01% | Reduce -51.5% | 28,834 | $2.6M |
| D. E. Shaw & Co. | 0.00% | New | 26,452 | $2.3M |
| Castleark Management LLC | 0.06% | New | 26,420 | $2.3M |
| New York State Common Retirement Fund | 0.00% | Add +17.5% | 26,165 | $2.3M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +87.3% | 26,143 | $2.3M |
| Handelsbanken Fonder AB | 0.01% | New | 26,000 | $2.3M |
| Teachers Retirement System of the State of Kentucky | 0.02% | No change | 25,799 | $2.3M |
| Creative Planning | 0.00% | Add +66.0% | 25,713 | $2.3M |
| Waverly Advisors, LLC | 0.01% | Reduce -1.8% | 25,512 | $2.3M |
| Aquatic Capital Management LLC | 0.08% | New | 25,222 | $2.2M |
| AQR Capital Management | 0.00% | Add +9.9% | 22,937 | $2.0M |
| Freestone Grove Partners LP | 0.01% | New | 22,777 | $2.0M |
| Police & Firemen's Retirement System of New Jersey | 0.01% | Add +19.6% | 21,968 | $2.0M |
| Profund Advisors LLC | 0.05% | Reduce -25.4% | 19,419 | $1.7M |
| Schonfeld Strategic Advisors LLC | 0.01% | New | 19,089 | $1.7M |
| Ellsworth Advisors, LLC | 0.28% | Reduce -24.6% | 16,553 | $1.7M |
| Osaic Holdings, Inc. | 0.00% | Add +3543.8% | 18,146 | $1.6M |
| State of New Jersey Common Pension Fund D | 0.01% | Add +8.4% | 18,129 | $1.6M |
| State Board of Administration of Florida Retirement System | 0.00% | Add +30.0% | 18,076 | $1.6M |
| Intech Investment Management LLC | 0.01% | Add +7.2% | 17,628 | $1.6M |
| Kennedy Capital Management LLC | 0.03% | Add +2.6% | 17,310 | $1.5M |
| Algert Global LLC | 0.02% | New | 16,460 | $1.5M |
| Fifth Third Bancorp | 0.00% | Add +312660.0% | 15,638 | $1.4M |
| Arizona State Retirement System | 0.01% | Add +15.1% | 15,471 | $1.4M |
| Diadema Partners LP | 0.50% | New | 15,000 | $1.3M |
| Vanguard Investments Australia, Ltd. | 0.00% | Add +15.1% | 14,752 | $1.3M |
| Neo Ivy Capital Management | 0.30% | Add +2333.3% | 14,551 | $1.3M |
| Allianz Asset Management GmbH | 0.00% | New | 14,100 | $1.3M |
| Sei Investments Co. | 0.00% | Add +55.3% | 13,941 | $1.2M |
| China Universal Asset Management Co., Ltd. | 0.07% | Reduce -0.8% | 13,821 | $1.2M |
| Brown Advisory Inc. | 0.00% | Add +9.3% | 13,550 | $1.2M |
| Seven Fleet Capital Management LP | 0.19% | Reduce -32.5% | 13,300 | $1.2M |
| KLP Kapitalforvaltning As | 0.00% | Add +17.4% | 12,800 | $1.1M |
| Two Sigma Investments, LP | 0.00% | New | 12,771 | $1.1M |
| SG Americas Securities, LLC | 0.00% | Reduce -5.0% | 12,727 | $1.1M |
| ProShare Advisors LLC | 0.00% | Reduce -6.7% | 12,599 | $1.1M |
| Atom Investors LP | 0.10% | New | 12,457 | $1.1M |
| Global Endowment Management, LP | 0.11% | Reduce -33.3% | 12,123 | $1.1M |
| STRS Ohio | 0.00% | Add +155.6% | 11,500 | $1.0M |
| Calamos Advisors LLC | 0.01% | New | 11,323 | $1.0M |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.01% | Reduce -59.2% | 11,250 | $999K |
| Diametric Capital, LP | 0.09% | New | 10,000 | $888K |
| Glenmede Trust Co. NA | 0.00% | New | 9,966 | $885K |
| First Trust Advisors LP | 0.00% | Reduce -94.5% | 9,779 | $868K |
| Quantbot Technologies LP | 0.03% | Add +9995.5% | 8,884 | $789K |
| Persistent Asset Partners Ltd | 0.25% | Add +82.4% | 8,760 | $778K |
| Brevan Howard Capital Management LP | 0.01% | New | 8,288 | $736K |
| Man Group plc | 0.00% | Reduce -19.2% | 7,714 | $685K |
| Envestnet Asset Management Inc. | 0.00% | New | 7,666 | $681K |
| Xponance LLC | 0.00% | Add +13.1% | 7,291 | $647K |
| Ameritas Investment Partners, Inc. | 0.02% | Add +20.9% | 6,760 | $600K |
| State of Wyoming | 0.06% | New | 6,690 | $594K |
| AlphaCentric Advisors LLC | 0.50% | Add +0.5% | 6,670 | $592K |
| Teacher Retirement System of Texas | 0.00% | Add +4.4% | 6,554 | $582K |
| Boothbay Fund Management, LLC | 0.01% | Reduce -96.7% | 6,453 | $573K |
| Harvest Investment Services, LLC | 0.09% | New | 6,432 | $571K |
| Fieldview Capital Management, LLC | 0.16% | New | 6,392 | $567K |
| Allspring Global Investments Holdings, LLC | 0.00% | New | 6,090 | $541K |
| Quantinno Capital Management LP | 0.00% | Add +31.9% | 6,015 | $534K |
| High Net Worth Advisory Group LLC | 0.11% | No change | 6,000 | $533K |
| OMERS ADMINISTRATION Corp | 0.00% | New | 5,200 | $462K |
| Dark Forest Capital Management LP | 0.03% | New | 5,192 | $461K |
| E Fund Management Co., Ltd. | 0.01% | Reduce -27.6% | 5,184 | $460K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Add +16.4% | 5,118 | $454K |
| Captrust Financial Advisors | 0.00% | New | 5,023 | $446K |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | New | 4,801 | $426K |
| Martingale Asset Management L P | 0.01% | Reduce -51.3% | 4,425 | $393K |
| Virtu Financial LLC | 0.01% | Reduce -46.2% | 4,351 | $386K |
| CIBC Bancorp USA Inc. | 0.00% | New | 4,122 | $366K |
| Virtus Investment Advisers, LLC | 0.08% | Reduce -50.1% | 4,050 | $360K |
| PSP Research LLC | 0.19% | Reduce -22.5% | 4,000 | $355K |
| Artia Global Partners LP | 0.07% | New | 4,000 | $355K |
| Wexford Capital LP | 0.05% | New | 4,000 | $355K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Reduce -5.2% | 3,884 | $345K |
| Landscape Capital Management, L.L.C. | 0.02% | Reduce -25.5% | 3,875 | $344K |
| Jump Financial, LLC | 0.00% | New | 3,813 | $339K |
| Swiss Life Asset Management Ltd | 0.00% | New | 3,601 | $320K |
| Bridgefront Capital, LLC | 0.08% | Reduce -58.7% | 3,577 | $318K |
| Stifel Financial Corp. | 0.00% | New | 3,011 | $267K |
| Two Sigma Securities, LLC | 0.02% | Reduce -56.2% | 3,003 | $267K |
| Tower Research Capital LLC (TRC) | 0.01% | Reduce -65.9% | 3,001 | $266K |
| Jane Street Group, LLC | 0.00% | New | 2,909 | $258K |
| VARCOV Co. | 0.10% | New | 2,895 | $257K |
| Aster Capital Management (DIFC) Ltd | 0.05% | New | 2,865 | $254K |
| Amundi | 0.00% | New | 2,793 | $248K |
| Empowered Funds, LLC | 0.00% | New | 2,731 | $242K |
| DNB Asset Management AS | 0.00% | New | 2,661 | $236K |
| Tudor Investment Corporation | 0.00% | Reduce -68.4% | 2,645 | $235K |
| Orion Porfolio Solutions, LLC | 0.00% | New | 2,577 | $229K |
| CIBC Asset Management Inc | 0.00% | New | 2,429 | $216K |
| Nisa Investment Advisors, LLC | 0.00% | Add +22.5% | 2,347 | $208K |
| Royal Bank of Canada | 0.00% | Reduce -28.1% | 2,338 | $208K |
| Los Angeles Capital Management LLC | 0.00% | Reduce -60.6% | 2,310 | $205K |
| Bayforest Capital Ltd | 0.19% | New | 2,305 | $205K |
| Acadian Asset Management LLC | 0.00% | New | 2,296 | $203K |
| CFC Planning Co LLC | 0.12% | New | 2,277 | $202K |
| Fulcrum Asset Management LLP | 0.02% | New | 2,114 | $191K |
| ABS Investment Management LLC | 0.12% | — | 89 | $186K |
| Nykredit A/S | 0.00% | — | 1,953 | $173K |
| Mitsubishi UFJ Trust & Banking Corp | 0.00% | New | 1,844 | $164K |
| KBC Group NV | 0.00% | Add +30.9% | 1,796 | $159K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -4.5% | 1,664 | $148K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 1,589 | $141K |
| US Bancorp \de | 0.00% | Add +1453.6% | 1,507 | $134K |
| Farther Finance Advisors, LLC | 0.00% | Add +1425.7% | 1,129 | $100K |
| PNC Financial Services Group, Inc. | 0.00% | Add +643.1% | 914 | $81K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.00% | Add +1.0% | 897 | $80K |
| Union Bancaire Privee, UBP SA | 0.00% | Reduce -77.3% | 880 | $79K |
| Kemnay Advisory Services Inc. | 0.01% | Add +29.1% | 741 | $66K |
| Parallel Advisors, LLC | 0.00% | Add +2150.0% | 720 | $64K |
| GAMMA Investing LLC | 0.00% | Add +26.8% | 663 | $59K |
| Pacer Advisors, Inc. | 0.00% | New | 614 | $55K |
| Optiver Holding B.V. | 0.00% | Add +38.9% | 400 | $36K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +336.7% | 345 | $31K |
| Simplex Trading, LLC | 0.00% | New | 278 | $25K |
| Toronto Dominion Bank | 0.00% | New | 270 | $24K |
| Sterling Capital Management LLC | 0.00% | Reduce -75.1% | 262 | $23K |
| Allworth Financial LP | 0.00% | Add +93.2% | 226 | $20K |
| Axiom Investment Management LLC | 0.01% | New | 200 | $18K |
| Arax Advisory Partners | 0.00% | Add +838.9% | 169 | $15K |
| J.Safra Asset Management Corp | 0.00% | New | 167 | $15K |
| IFG Advisory, LLC | 0.00% | New | 161 | $14K |
| Smartleaf Asset Management LLC | 0.00% | No change | 157 | $14K |
| National Bank of Canada | 0.00% | New | 124 | $11K |
| Jones Financial Companies LLLP | 0.00% | New | 103 | $9K |
| Rothschild Investment LLC | 0.00% | No change | 99 | $9K |
| Larson Financial Group LLC | 0.00% | Add +75.0% | 63 | $6K |
| Signaturefd, LLC | 0.00% | Reduce -15.7% | 59 | $5K |
| Parkside Financial Bank & Trust | 0.00% | Add +28.6% | 45 | $4K |
| Meeder Asset Management Inc. | 0.00% | New | 30 | $3K |
| IFP Advisors, Inc | 0.00% | No change | 24 | $2K |
| Bare Financial Services, Inc | 0.00% | No change | 16 | $1K |
| Covestor Ltd | 0.00% | Add +225.0% | 13 | $1K |
| Ares Financial Consulting, LLC | 0.00% | New | 11 | $977 |
| Physician Wealth Advisors, Inc. | 0.00% | New | 5 | $444 |
| SBI Securities Co., Ltd. | 0.00% | No change | 5 | $444 |
| Stone House Investment Management, LLC | 0.00% | New | 4 | $355 |
| Hughes Financial Services, LLC | 0.00% | New | 4 | $355 |
| Keating Financial Advisory Services, Inc. | 0.00% | No change | 4 | $355 |
| Silver Grove Financial Group, Inc. | 0.00% | New | 3 | $266 |
| Essential Partners LLC | 0.00% | No change | 2 | $178 |
| Caitong International Asset Management Co., Ltd | 0.00% | Reduce -99.3% | 2 | $178 |
| Quarry LP | 0.00% | New | 2 | $178 |
| Zions Bancorporation, National Association | 0.00% | New | 1 | $89 |
"% of holder's portfolio" is SYRE's weight in each manager's 13F, not the share of Spyre Therapeutics Inc. the manager owns.