Tyra BiosciencesTYRA
13F holders, Q3 2025 (September 30)116holders −5
8new positions
14sold out
6famous investors
$13.99avg. 13F price*
At the end of Q3 2025, 116 institutions reported holding Tyra Biosciences Inc. (TYRA) in their 13F filings, down 5 from Q2 2025. 8 opened new positions and 14 sold out. The largest holders were Ra Capital Management, L.P. ($170.7M), Alta Partners Management Company, L.P. ($57.1M) and Nextech Invest Ltd. ($56.7M). 6 famous investors held it, including Steve Cohen (0.0% of Point72 Asset Management's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Tyra Biosciences Inc.
- CUSIP
- 90240B106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 8 | $6.8M |
| Exits | 14 | $12.2M |
All 13F filers, Q2 2025 → Q3 2025: 2,317,216 shares bought and 3,396,024 shares sold, net −1,078,808 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 116 holders
| Ra Capital Management, L.P. | 2.10% | No change | 12,198,625 | $170.7M |
| Alta Partners Management Company, L.P. | 95.15% | No change | 4,080,296 | $57.1M |
| Nextech Invest Ltd. | 8.64% | No change | 4,055,861 | $56.7M |
| BVF Inc. | 2.07% | Reduce -7.5% | 3,649,794 | $51.1M |
| Canaan Partners XI LLC | 49.07% | No change | 3,608,109 | $50.5M |
| Commodore Capital LP | 2.31% | Add +8.9% | 3,375,000 | $47.2M |
| TCG Crossover Management, LLC | 1.99% | No change | 2,898,103 | $40.5M |
| Janus Henderson Group PLC | 0.02% | Add +0.7% | 2,874,804 | $40.2M |
| Vestal Point Capital, LP | 1.54% | Reduce -8.7% | 2,425,000 | $33.9M |
| Kynam Capital Management, LP | 2.43% | No change | 2,329,998 | $32.6M |
| BlackRock, Inc. | 0.00% | Reduce -1.3% | 1,869,474 | $26.2M |
| Vanguard Group Inc. | 0.00% | Add +8.4% | 1,520,185 | $21.3M |
| Farallon Capital Management, L.L.C. | 0.09% | No change | 1,143,818 | $16.0M |
| 5AM Venture Management, LLC | 4.81% | No change | 939,298 | $13.1M |
| Balyasny Asset Management L.P. | 0.02% | Add +45.1% | 846,585 | $11.8M |
| Caligan Partners LP | 1.35% | Add +266.9% | 696,825 | $9.7M |
| Marshall Wace, LLP | 0.01% | Add +40.6% | 602,015 | $8.4M |
| Geode Capital Management, LLC | 0.00% | Add +5.3% | 597,454 | $8.4M |
| Sio Capital Management, LLC | 1.82% | Reduce -36.5% | 514,947 | $7.2M |
| State Street Corp. | 0.00% | Add +2.3% | 428,472 | $6.0M |
| Morgan Stanley | 0.00% | Reduce -14.9% | 322,143 | $4.5M |
| Walleye Capital LLC | 0.04% | Reduce -19.6% | 297,808 | $4.2M |
| Point72 Asset Management | 0.01% | Add +25.5% | 282,032 | $3.9M |
| Eversept Partners, LP | 0.29% | New | 272,706 | $3.8M |
| Jacobs Levy Equity Management, Inc. | 0.01% | Reduce -36.4% | 251,562 | $3.5M |
| Northern Trust Corp. | 0.00% | Add +1.6% | 208,486 | $2.9M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +13.2% | 201,587 | $2.8M |
| Two Sigma Investments, LP | 0.00% | Add +88.5% | 199,438 | $2.8M |
| Boothbay Fund Management, LLC | 0.07% | New | 186,670 | $2.6M |
| Renaissance Technologies | 0.00% | Add +25.9% | 170,100 | $2.4M |
| Millennium Management | 0.00% | Reduce -64.7% | 144,016 | $2.0M |
| Bank of America Corp. | 0.00% | Reduce -64.0% | 134,319 | $1.9M |
| BNP Paribas Financial Markets | 0.00% | Add +31.9% | 128,881 | $1.8M |
| AXA Investment Managers S.A. | 0.00% | — | 128,789 | $1.8M |
| Raymond James Financial Inc. | 0.00% | Add +100.0% | 126,374 | $1.8M |
| Two Sigma Advisers, LP | 0.00% | Add +30.1% | 113,200 | $1.6M |
| Citadel Advisors | 0.00% | Reduce -48.5% | 111,293 | $1.6M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -5.2% | 100,150 | $1.4M |
| Ameriprise Financial Inc. | 0.00% | Add +8.1% | 87,107 | $1.2M |
| Investment Counsel Co. of Nevada | 2.42% | No change | 85,020 | $1.2M |
| Wellington Management Group LLP | 0.00% | Reduce -19.6% | 82,871 | $1.2M |
| Oppenheimer & Co. Inc. | 0.01% | Add +11.1% | 82,238 | $1.2M |
| Nuveen, LLC | 0.00% | No change | 80,441 | $1.1M |
| JPMorgan Chase & Co. | 0.00% | Reduce -27.9% | 74,229 | $1.0M |
| HighVista Strategies LLC | 0.23% | Add +163.7% | 65,812 | $921K |
| Jump Financial, LLC | 0.01% | Reduce -12.8% | 62,000 | $867K |
| UBS Group AG | 0.00% | Add +27.8% | 59,144 | $827K |
| Bank of New York Mellon Corp | 0.00% | Add +5.8% | 57,162 | $800K |
| Barclays PLC | 0.00% | Reduce -7.2% | 57,126 | $799K |
| Susquehanna Portfolio Strategies, LLC | 0.01% | No change | 48,644 | $681K |
| Jane Street Group, LLC | 0.00% | Reduce -23.2% | 44,680 | $625K |
| PDT Partners, LLC | 0.04% | No change | 43,310 | $606K |
| Rhumbline Advisers | 0.00% | Reduce -0.1% | 40,636 | $568K |
| Dimensional Fund Advisors LP | 0.00% | Reduce -4.8% | 39,679 | $555K |
| Cubist Systematic Strategies, LLC | 0.01% | Reduce -67.8% | 39,310 | $550K |
| American Century Companies Inc. | 0.00% | Add +33.1% | 38,412 | $537K |
| XTX Topco Ltd | 0.02% | Reduce -2.6% | 33,700 | $471K |
| Alliancebernstein L.P. | 0.00% | Reduce -6.7% | 33,260 | $465K |
| Brevan Howard Capital Management LP | 0.01% | Reduce -15.0% | 31,101 | $435K |
| AlphaQuest LLC | 0.03% | Reduce -58.9% | 30,060 | $421K |
| State of Wisconsin Investment Board | 0.00% | Reduce -61.2% | 29,648 | $415K |
| AQR Capital Management | 0.00% | Reduce -2.2% | 28,069 | $393K |
| Public Employees Retirement System of Ohio | 0.00% | Add +34.8% | 24,962 | $349K |
| Alps Advisors Inc. | 0.00% | Reduce -14.0% | 24,700 | $346K |
| Auour Investments LLC | 0.10% | No change | 21,020 | $294K |
| Victory Capital Management Inc. | 0.00% | Reduce -57.5% | 18,790 | $263K |
| Wells Fargo & Company | 0.00% | Add +19.5% | 18,470 | $258K |
| Trexquant Investment LP | 0.00% | Reduce -64.7% | 15,758 | $220K |
| Invesco Ltd. | 0.00% | New | 15,510 | $217K |
| Deutsche Bank AG | 0.00% | Add +16.4% | 15,483 | $217K |
| MetLife Investment Management, LLC | 0.00% | No change | 14,631 | $205K |
| T. Rowe Price Associates Inc. | 0.00% | Add +6.5% | 12,801 | $180K |
| Russell Investments Group, Ltd. | 0.00% | Add +27.7% | 12,741 | $178K |
| FMR LLC | 0.00% | Add +2.7% | 12,529 | $175K |
| Squarepoint Ops LLC | 0.00% | Reduce -61.1% | 12,214 | $171K |
| Intech Investment Management LLC | 0.00% | Reduce -42.8% | 11,402 | $160K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -14.2% | 11,317 | $158K |
| Virtus Investment Advisers, LLC | 0.04% | Add +21.0% | 11,015 | $154K |
| Tudor Investment Corporation | 0.00% | Reduce -59.0% | 10,761 | $151K |
| Baker Bros. Advisors LP | 0.00% | No change | 10,607 | $148K |
| SG Americas Securities, LLC | 0.00% | New | 9,542 | $133K |
| China Universal Asset Management Co., Ltd. | 0.01% | Reduce -12.5% | 9,342 | $131K |
| New York State Common Retirement Fund | 0.00% | No change | 7,423 | $104K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Add +27.6% | 6,440 | $90K |
| Legal & General Group Plc | 0.00% | No change | 2,192 | $31K |
| Federated Hermes, Inc. | 0.00% | Add +586.3% | 2,155 | $30K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +0.3% | 2,060 | $29K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 1,991 | $28K |
| Citigroup Inc. | 0.00% | Reduce -82.0% | 1,707 | $24K |
| Sterling Capital Management LLC | 0.00% | Add +155.7% | 1,662 | $23K |
| Cwm, LLC | 0.00% | Reduce -0.8% | 1,529 | $21K |
| California State Teachers Retirement System | 0.00% | Add +0.1% | 1,473 | $21K |
| Osaic Holdings, Inc. | 0.00% | Add +18.1% | 1,192 | $16K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -11.5% | 1,147 | $16K |
| Royal Bank of Canada | 0.00% | Reduce -92.9% | 1,156 | $16K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -69.2% | 874 | $12K |
| Versant Capital Management, Inc | 0.00% | No change | 819 | $11K |
| Amalgamated Bank | 0.00% | No change | 701 | $10K |
| STRS Ohio | 0.00% | No change | 700 | $10K |
| Optiver Holding B.V. | 0.00% | New | 368 | $5K |
"% of holder's portfolio" is TYRA's weight in each manager's 13F, not the share of Tyra Biosciences Inc. the manager owns.