Tyra BiosciencesTYRA
13F holders, Q1 2026 (March 31)164holders +31
40new positions
12sold out
6famous investors
$38.29avg. 13F price*
At the end of Q1 2026, 164 institutions reported holding Tyra Biosciences Inc. (TYRA) in their 13F filings, up 31 from Q4 2025. 40 opened new positions and 12 sold out. The largest holders were Ra Capital Management, L.P. ($467.2M), FMR LLC ($296.7M) and Nextech Invest Ltd. ($155.3M). 6 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio) and Steve Cohen (0.0% of Point72 Asset Management's portfolio).
- Company
- Tyra Biosciences Inc.
- CUSIP
- 90240B106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 40 | $191.6M |
| Exits | 12 | $75.7M |
All 13F filers, Q4 2025 → Q1 2026: 20,515,882 shares bought and 11,329,750 shares sold, net +9,186,132 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 164 holders
| Ra Capital Management, L.P. | 4.95% | No change | 12,198,625 | $467.2M |
| FMR LLC | 0.02% | Add +61570.4% | 7,747,648 | $296.7M |
| Nextech Invest Ltd. | 10.93% | No change | 4,055,861 | $155.3M |
| Janus Henderson Group PLC | 0.07% | Add +32.5% | 3,890,589 | $148.9M |
| Alta Partners Management Company, L.P. | 96.97% | No change | 3,823,425 | $146.4M |
| Farallon Capital Management, L.L.C. | 0.82% | Add +73.3% | 3,580,818 | $137.1M |
| TCG Crossover Management, LLC | 3.56% | Add +12.1% | 3,248,980 | $124.4M |
| Commodore Capital LP | 5.48% | Reduce -26.7% | 2,475,000 | $94.8M |
| BlackRock, Inc. | 0.00% | Add +6.3% | 2,217,929 | $84.9M |
| Paradigm Biocapital Advisors LP | 1.61% | New | 2,054,991 | $78.7M |
| BVF Inc. | 2.41% | Reduce -7.1% | 1,976,196 | $75.7M |
| Caligan Partners LP | 3.46% | Add +35.2% | 1,276,968 | $48.9M |
| State Street Corp. | 0.00% | Add +62.3% | 1,216,078 | $46.6M |
| Vanguard Capital Management LLC | 0.00% | — | 1,125,970 | $43.1M |
| 5AM Venture Management, LLC | 10.94% | No change | 1,029,298 | $39.4M |
| T. Rowe Price Associates Inc. | 0.00% | Add +6732.5% | 986,061 | $37.8M |
| Logos Global Management LP | 1.68% | Add +304.8% | 850,000 | $32.6M |
| Barclays PLC | 0.01% | Add +992.1% | 833,399 | $31.9M |
| Canaan Partners XI LLC | 37.76% | Reduce -77.8% | 750,000 | $28.7M |
| Geode Capital Management, LLC | 0.00% | Add +0.1% | 658,482 | $25.2M |
| Jennison Associates LLC | 0.02% | New | 632,432 | $24.2M |
| Sio Capital Management, LLC | 3.34% | Add +15.1% | 605,439 | $23.2M |
| Goldman Sachs Group Inc. | 0.00% | Add +201.7% | 550,334 | $21.1M |
| Deerfield Management Company, L.P. | 0.29% | New | 549,000 | $21.0M |
| Balyasny Asset Management L.P. | 0.03% | Reduce -57.0% | 351,479 | $13.5M |
| Elmind Capital, LP | 3.81% | No change | 350,000 | $13.4M |
| Woodline Partners LP | 0.04% | New | 301,040 | $11.5M |
| Boothbay Fund Management, LLC | 0.25% | Add +23.6% | 273,274 | $10.5M |
| Affinity Asset Advisors, LLC | 0.59% | New | 257,512 | $9.9M |
| Vanguard Portfolio Management LLC | 0.00% | — | 247,270 | $9.5M |
| Raymond James Financial Inc. | 0.00% | Add +45.3% | 247,098 | $9.5M |
| Millennium Management | 0.01% | Add +93.7% | 221,581 | $8.5M |
| Northern Trust Corp. | 0.00% | Add +8.7% | 218,508 | $8.4M |
| Bank of America Corp. | 0.00% | Add +448.0% | 209,922 | $8.0M |
| Sofinnova Investments, Inc. | 0.39% | New | 204,015 | $7.8M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -0.2% | 199,111 | $7.6M |
| Marshall Wace, LLP | 0.01% | Reduce -72.2% | 197,748 | $7.6M |
| Seven Fleet Capital Management LP | 2.35% | Add +146.0% | 195,685 | $7.5M |
| Stempoint Capital LP | 1.42% | New | 193,177 | $7.4M |
| BNP Paribas Financial Markets | 0.00% | Add +58.0% | 190,039 | $7.3M |
| Algert Global LLC | 0.11% | Add +301.1% | 188,010 | $7.2M |
| Jacobs Levy Equity Management, Inc. | 0.03% | Add +25.0% | 162,204 | $6.2M |
| Vanguard Fiduciary Trust Co. | 0.00% | — | 157,791 | $6.0M |
| Trexquant Investment LP | 0.04% | New | 147,317 | $5.6M |
| Ameriprise Financial Inc. | 0.00% | Add +165.3% | 144,900 | $5.5M |
| HighVista Strategies LLC | 1.39% | Add +274.2% | 131,304 | $5.0M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.01% | Reduce -0.7% | 128,860 | $4.9M |
| Morgan Stanley | 0.00% | Add +1.3% | 120,485 | $4.6M |
| Invesco Ltd. | 0.00% | Reduce -15.8% | 109,052 | $4.2M |
| Two Sigma Investments, LP | 0.00% | Reduce -5.0% | 101,618 | $3.9M |
| Dimensional Fund Advisors LP | 0.00% | Reduce -4.0% | 91,826 | $3.5M |
| Oppenheimer & Co. Inc. | 0.04% | Reduce -0.6% | 84,192 | $3.2M |
| XTX Topco Ltd | 0.06% | Add +175.8% | 83,896 | $3.2M |
| Schonfeld Strategic Advisors LLC | 0.03% | New | 79,592 | $3.0M |
| Cinctive Capital Management LP | 0.20% | New | 78,018 | $3.0M |
| Wellington Management Group LLP | 0.00% | Reduce -26.0% | 77,169 | $3.0M |
| Kalehua Capital Management LLC | 2.02% | No change | 74,465 | $2.9M |
| Ensign Peak Advisors, Inc | 0.01% | New | 74,064 | $2.8M |
| Bank of New York Mellon Corp | 0.00% | Add +18.6% | 72,213 | $2.8M |
| Russell Investments Group, Ltd. | 0.00% | Add +441.9% | 70,422 | $2.7M |
| Catalio Capital Management, LP | 0.54% | New | 67,285 | $2.6M |
| UBS Group AG | 0.00% | Add +4.6% | 61,561 | $2.4M |
| JPMorgan Chase & Co. | 0.00% | Reduce -6.2% | 66,789 | $2.3M |
| Vestal Point Capital, LP | 0.06% | Reduce -97.8% | 54,000 | $2.1M |
| Nuveen, LLC | 0.00% | Add +7.4% | 50,840 | $1.9M |
| TD Asset Management Inc | 0.00% | New | 50,000 | $1.9M |
| American Century Companies Inc. | 0.00% | Add +3.7% | 47,929 | $1.8M |
| Arkadios Wealth Advisors | 0.03% | New | 47,567 | $1.8M |
| Susquehanna Portfolio Strategies, LLC | 0.03% | Reduce -3.3% | 47,025 | $1.8M |
| Alps Advisors Inc. | 0.01% | Add +0.1% | 43,856 | $1.7M |
| PDT Partners, LLC | 0.10% | No change | 42,284 | $1.6M |
| Jump Financial, LLC | 0.03% | New | 41,375 | $1.6M |
| Manufacturers Life Insurance Company, The | 0.00% | Add +381.3% | 40,224 | $1.5M |
| Rhumbline Advisers | 0.00% | Add +2.2% | 39,660 | $1.5M |
| Point72 Asset Management | 0.00% | Reduce -95.6% | 38,850 | $1.5M |
| Voya Investment Management LLC | 0.00% | Add +28.3% | 38,358 | $1.5M |
| Brevan Howard Capital Management LP | 0.02% | New | 38,606 | $1.5M |
| Rafferty Asset Management, LLC | 0.01% | Add +125.5% | 34,856 | $1.3M |
| State of Wisconsin Investment Board | 0.00% | Reduce -14.8% | 33,258 | $1.3M |
| AQR Capital Management | 0.00% | Add +2.8% | 29,423 | $1.1M |
| Fisher Asset Management | 0.00% | No change | 28,800 | $1.1M |
| Eversept Partners, LP | 0.07% | Reduce -90.3% | 27,055 | $1.0M |
| Swiss National Bank | 0.00% | New | 26,400 | $1.0M |
| Creative Planning | 0.00% | Add +22.2% | 23,948 | $917K |
| Alliancebernstein L.P. | 0.00% | No change | 31,990 | $841K |
| Auour Investments LLC | 0.25% | No change | 21,020 | $805K |
| Public Employees Retirement System of Ohio | 0.00% | Add +10.7% | 20,522 | $786K |
| Deutsche Bank AG | 0.00% | Add +25.1% | 20,495 | $785K |
| Squarepoint Ops LLC | 0.00% | Reduce -62.3% | 20,494 | $785K |
| Walleye Capital LLC | 0.00% | New | 18,715 | $717K |
| Quadrature Capital Ltd | 0.01% | New | 18,203 | $697K |
| STRS Ohio | 0.00% | Add +2485.7% | 18,100 | $693K |
| Tudor Investment Corporation | 0.00% | New | 16,284 | $624K |
| PSP Research LLC | 0.43% | Reduce -26.8% | 16,000 | $613K |
| Profund Advisors LLC | 0.02% | New | 15,656 | $600K |
| Susquehanna International Group, LLP | 0.00% | Reduce -71.8% | 15,543 | $595K |
| Vanguard Global Advisers, LLC | 0.00% | — | 15,480 | $593K |
| Citadel Advisors | 0.00% | New | 15,396 | $590K |
| Victory Capital Management Inc. | 0.00% | Reduce -18.9% | 15,230 | $583K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +13.3% | 14,626 | $551K |
"% of holder's portfolio" is TYRA's weight in each manager's 13F, not the share of Tyra Biosciences Inc. the manager owns.