Xenon PharmaceuticalsXENE
13F holders, Q4 2025 (December 31)245holders +26
43new positions
21sold out
5famous investors
$44.81avg. 13F price*
At the end of Q4 2025, 245 institutions reported holding Xenon Pharmaceuticals Inc. (XENE) in their 13F filings, up 26 from Q3 2025. 43 opened new positions and 21 sold out. The largest holders were FMR LLC ($399.8M), Avoro Capital Advisors LLC ($243.1M) and BlackRock, Inc. ($228.6M). 5 famous investors held it, including Paul Tudor Jones (0.1% of Tudor Investment Corporation's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Xenon Pharmaceuticals Inc.
- CUSIP
- 98420N105
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 43 | $89.0M |
| Exits | 21 | $56.4M |
All 13F filers, Q3 2025 → Q4 2025: 9,128,996 shares bought and 9,774,866 shares sold, net −645,870 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 245 holders
| FMR LLC | 0.02% | Add +0.0% | 8,920,250 | $399.8M |
| Avoro Capital Advisors LLC | 2.39% | Add +0.5% | 5,424,444 | $243.1M |
| BlackRock, Inc. | 0.00% | Add +6.9% | 5,100,284 | $228.6M |
| Wellington Management Group LLP | 0.04% | Add +32.0% | 4,764,779 | $213.6M |
| Driehaus Capital Management LLC | 1.38% | Add +8.9% | 4,538,691 | $203.4M |
| Janus Henderson Group PLC | 0.08% | Add +3.5% | 4,084,034 | $183.1M |
| Capital International Investors | 0.02% | Add +7.3% | 3,414,959 | $153.1M |
| Polar Capital Holdings Plc | 0.51% | Reduce -3.2% | 2,465,694 | $110.5M |
| Braidwell LP | 3.13% | Reduce -49.4% | 1,825,076 | $81.8M |
| Commodore Capital LP | 5.37% | Reduce -33.3% | 1,800,000 | $80.7M |
| Alliancebernstein L.P. | 0.02% | Reduce -3.7% | 1,593,814 | $71.4M |
| JPMorgan Chase & Co. | 0.00% | Add +6.8% | 1,494,032 | $67.0M |
| State Street Corp. | 0.00% | Add +1.8% | 1,492,550 | $66.9M |
| Citadel Advisors | 0.04% | Add +37.8% | 1,321,213 | $59.2M |
| Jennison Associates LLC | 0.03% | Add +13.8% | 1,292,055 | $57.9M |
| Holocene Advisors, LP | 0.12% | Reduce -35.1% | 1,282,081 | $57.5M |
| Affinity Asset Advisors, LLC | 4.15% | Reduce -10.7% | 1,250,000 | $56.0M |
| Westfield Capital Management Co. LP | 0.23% | Add +1.7% | 1,226,771 | $55.0M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.05% | Add +58.2% | 1,060,221 | $47.5M |
| Geode Capital Management, LLC | 0.00% | Reduce -2.5% | 952,679 | $42.7M |
| T. Rowe Price Associates Inc. | 0.00% | Add +1968.3% | 862,300 | $38.6M |
| Siren, L.L.C. | 1.09% | No change | 812,761 | $36.4M |
| First Turn Management, LLC | 4.10% | No change | 799,743 | $35.8M |
| Rock Springs Capital Management LP | 1.82% | Reduce -7.5% | 787,788 | $35.3M |
| Franklin Resources Inc. | 0.01% | Add +8.9% | 758,059 | $34.0M |
| Aberdeen Group plc | 0.05% | Add +29.6% | 750,291 | $33.6M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -3.4% | 696,047 | $31.2M |
| Fiera Capital Corp | 0.10% | Add +31.9% | 686,056 | $30.7M |
| Adage Capital Partners Gp, L.L.C. | 0.05% | Reduce -18.0% | 685,100 | $30.7M |
| American Century Companies Inc. | 0.02% | Add +3.2% | 680,473 | $30.5M |
| Federated Hermes, Inc. | 0.05% | Add +189.1% | 672,237 | $30.1M |
| Vanguard Group Inc. | 0.00% | Reduce -21.9% | 664,641 | $29.8M |
| Capital World Investors | 0.00% | No change | 655,737 | $29.4M |
| Millennium Management | 0.02% | Reduce -54.1% | 635,056 | $28.5M |
| Pictet Asset Management Holding SA | 0.03% | Reduce -50.4% | 625,985 | $28.0M |
| Loomis Sayles & Co. L P | 0.03% | Reduce -4.5% | 612,032 | $27.4M |
| Barclays PLC | 0.01% | Add +439.9% | 600,964 | $26.9M |
| Vestal Point Capital, LP | 0.99% | Reduce -45.5% | 600,000 | $26.9M |
| Trails Edge Capital Partners, LP | 6.61% | — | 597,092 | $26.8M |
| Caligan Partners LP | 2.26% | Add +23.6% | 549,665 | $24.6M |
| T. Rowe Price Investment Management, Inc. | 0.02% | Reduce -8.6% | 547,613 | $24.5M |
| Deerfield Management Company, L.P. | 0.36% | No change | 542,020 | $24.3M |
| TimesSquare Capital Management, LLC | 0.36% | Reduce -4.3% | 532,740 | $23.9M |
| MPM Bioimpact LLC | 2.49% | Reduce -3.5% | 485,620 | $21.8M |
| Dimensional Fund Advisors LP | 0.00% | Reduce -0.4% | 452,147 | $20.3M |
| Orbimed Advisors LLC | 0.41% | Add +6.6% | 447,200 | $20.0M |
| Northern Trust Corp. | 0.00% | Reduce -11.9% | 438,714 | $19.7M |
| Two Sigma Investments, LP | 0.03% | New | 436,743 | $19.6M |
| Candriam S.C.A. | 0.09% | Add +5.2% | 417,402 | $18.7M |
| Bank of New York Mellon Corp | 0.00% | Reduce -7.5% | 387,158 | $17.4M |
| Baker Bros. Advisors LP | 0.10% | No change | 370,208 | $16.6M |
| Deep Track Capital, LP | 0.37% | Reduce -69.5% | 366,435 | $16.4M |
| Stempoint Capital LP | 2.68% | Add +81.3% | 348,605 | $15.6M |
| Morgan Stanley | 0.00% | Reduce -19.7% | 294,332 | $13.2M |
| DAFNA Capital Management LLC | 3.04% | No change | 287,939 | $12.9M |
| DNB Asset Management AS | 0.04% | Add +9.5% | 272,831 | $12.2M |
| Two Sigma Advisers, LP | 0.02% | Add +1332.7% | 259,320 | $11.6M |
| Tudor Investment Corporation | 0.06% | Add +230.6% | 254,002 | $11.4M |
| Nicholas Investment Partners, LP | 0.90% | Add +104.0% | 242,989 | $10.9M |
| Iron Triangle Partners LP | 1.20% | New | 233,688 | $10.5M |
| Eversept Partners, LP | 0.58% | New | 231,380 | $10.4M |
| Nan Fung Trinity (hk) Ltd. | 0.81% | Add +43.1% | 226,965 | $10.2M |
| Bank of America Corp. | 0.00% | Add +11.2% | 221,368 | $9.9M |
| Nuveen, LLC | 0.00% | Reduce -3.6% | 216,238 | $9.7M |
| State of Wisconsin Investment Board | 0.02% | Reduce -1.4% | 205,569 | $9.2M |
| ADAR1 Capital Management, LLC | 0.68% | Add +7.9% | 203,969 | $9.1M |
| Perceptive Advisors LLC | 0.17% | No change | 200,791 | $9.0M |
| Deutsche Bank AG | 0.00% | Add +68.4% | 190,233 | $8.5M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +0.2% | 189,059 | $8.5M |
| New York State Common Retirement Fund | 0.01% | Add +8.7% | 186,705 | $8.4M |
| NEXTBio Capital Management LP | 4.83% | — | 183,704 | $8.2M |
| Neuberger Berman Group LLC | 0.01% | Add +3.7% | 178,747 | $8.0M |
| Peregrine Capital Management LLC | 0.24% | New | 174,851 | $7.8M |
| Jain Global LLC | 0.08% | Reduce -31.1% | 173,882 | $7.8M |
| Marshall Wace, LLP | 0.01% | Reduce -73.4% | 162,551 | $7.3M |
| Foresite Capital Management IV, LLC | 3.12% | No change | 160,000 | $7.2M |
| Parkman Healthcare Partners LLC | 0.66% | Reduce -12.5% | 154,184 | $6.9M |
| Wells Fargo & Company | 0.00% | Add +32.2% | 152,297 | $6.8M |
| Moore Capital Management, LP | 0.13% | No change | 140,000 | $6.3M |
| Rhenman & Partners Asset Management AB | 0.58% | Add +71.6% | 139,000 | $6.2M |
| Patient Square Capital LP | 1.31% | New | 136,500 | $6.1M |
| Redmile Group, LLC | 0.44% | New | 133,882 | $6.0M |
| Algert Global LLC | 0.09% | Add +127.1% | 123,189 | $5.5M |
| Assenagon Asset Management S.A. | 0.01% | New | 119,186 | $5.3M |
| Mutual of America Capital Management LLC | 0.05% | Add +22.3% | 116,088 | $5.2M |
| Man Group plc | 0.01% | Add +396.7% | 114,826 | $5.1M |
| Swiss National Bank | 0.00% | Reduce -9.8% | 114,000 | $5.1M |
| Ameriprise Financial Inc. | 0.00% | Add +12.3% | 109,544 | $4.9M |
| Squadron Capital Management LLC | 2.11% | — | 105,551 | $4.7M |
| Palo Alto Investors LP | 0.60% | New | 96,519 | $4.3M |
| Verition Fund Management LLC | 0.02% | Add +64.2% | 93,756 | $4.2M |
| BNP Paribas Financial Markets | 0.00% | Reduce -41.3% | 93,462 | $4.2M |
| Granahan Investment Management, LLC | 0.18% | Add +6.1% | 92,778 | $4.2M |
| Atika Capital Management LLC | 0.58% | Add +143.4% | 92,506 | $4.1M |
| Rhumbline Advisers | 0.00% | Reduce -15.6% | 90,143 | $4.0M |
| Royal Bank of Canada | 0.00% | Reduce -25.5% | 89,757 | $4.0M |
| Russell Investments Group, Ltd. | 0.00% | Add +23.4% | 86,220 | $3.9M |
| Balyasny Asset Management L.P. | 0.01% | Reduce -73.8% | 84,360 | $3.8M |
| Raymond James Financial Inc. | 0.00% | Add +19.1% | 83,255 | $3.7M |
| Schroder Investment Management Group | 0.00% | No change | 81,156 | $3.6M |
"% of holder's portfolio" is XENE's weight in each manager's 13F, not the share of Xenon Pharmaceuticals Inc. the manager owns.