Xenon PharmaceuticalsXENE
13F holders, Q1 2026 (March 31)290holders +45
74new positions
32sold out
8famous investors
$57.90avg. 13F price*
At the end of Q1 2026, 290 institutions reported holding Xenon Pharmaceuticals Inc. (XENE) in their 13F filings, up 45 from Q4 2025. 74 opened new positions and 32 sold out. The largest holders were FMR LLC ($629.1M), Avoro Capital Advisors LLC ($336.0M) and BlackRock, Inc. ($328.0M). 8 famous investors held it, including Stanley Druckenmiller (0.5% of Duquesne Family Office's portfolio), Paul Tudor Jones (0.2% of Tudor Investment Corporation's portfolio) and Ken Griffin (0.1% of Citadel Advisors's portfolio).
- Company
- Xenon Pharmaceuticals Inc.
- CUSIP
- 98420N105
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 74 | $363.1M |
| Exits | 32 | $91.5M |
All 13F filers, Q4 2025 → Q1 2026: 23,174,442 shares bought and 7,003,016 shares sold, net +16,171,426 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 290 holders
| FMR LLC | 0.03% | Add +21.3% | 10,818,491 | $629.1M |
| Avoro Capital Advisors LLC | 3.31% | Add +6.5% | 5,777,777 | $336.0M |
| BlackRock, Inc. | 0.01% | Add +10.6% | 5,640,118 | $328.0M |
| Wellington Management Group LLP | 0.05% | Add +1.4% | 4,829,641 | $280.8M |
| Driehaus Capital Management LLC | 1.92% | Reduce -1.0% | 4,491,653 | $261.2M |
| Polar Capital Holdings Plc | 1.12% | Add +78.7% | 4,405,312 | $256.2M |
| Janus Henderson Group PLC | 0.12% | Add +2.3% | 4,175,982 | $242.9M |
| Capital International Investors | 0.04% | Reduce -21.7% | 2,674,727 | $155.5M |
| Citadel Advisors | 0.11% | Add +100.8% | 2,652,990 | $154.3M |
| JPMorgan Chase & Co. | 0.01% | Add +28.8% | 1,923,610 | $106.9M |
| State Street Corp. | 0.00% | Add +15.3% | 1,720,533 | $100.0M |
| Affinity Asset Advisors, LLC | 5.83% | Add +34.0% | 1,675,000 | $97.4M |
| Deerfield Management Company, L.P. | 1.31% | Add +198.1% | 1,615,696 | $94.0M |
| Holocene Advisors, LP | 0.21% | Add +18.4% | 1,518,686 | $88.3M |
| Westfield Capital Management Co. LP | 0.34% | Add +14.2% | 1,401,483 | $81.5M |
| Caligan Partners LP | 5.73% | Add +153.4% | 1,393,027 | $81.0M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.09% | Add +26.6% | 1,342,028 | $78.0M |
| Braidwell LP | 2.96% | Reduce -26.7% | 1,338,452 | $77.8M |
| T. Rowe Price Associates Inc. | 0.01% | Add +54.2% | 1,329,591 | $77.3M |
| Jennison Associates LLC | 0.05% | Add +2.1% | 1,318,814 | $76.7M |
| Siren, L.L.C. | 2.13% | Add +62.2% | 1,318,564 | $76.7M |
| Alyeska Investment Group, L.P. | 0.21% | New | 1,299,469 | $75.6M |
| Franklin Resources Inc. | 0.02% | Add +68.9% | 1,280,577 | $74.5M |
| Geode Capital Management, LLC | 0.00% | Add +14.7% | 1,092,932 | $63.5M |
| Alliancebernstein L.P. | 0.02% | Reduce -11.9% | 1,403,297 | $62.9M |
| Orbimed Advisors LLC | 1.39% | Add +137.0% | 1,059,971 | $61.6M |
| Federated Hermes, Inc. | 0.09% | Add +44.6% | 972,237 | $56.5M |
| T. Rowe Price Investment Management, Inc. | 0.04% | Add +73.8% | 951,955 | $55.4M |
| Capital World Investors | 0.01% | Add +28.1% | 840,072 | $48.9M |
| Commodore Capital LP | 2.78% | Reduce -54.2% | 825,000 | $48.0M |
| First Turn Management, LLC | 5.11% | Reduce -1.6% | 786,844 | $45.8M |
| Goldman Sachs Group Inc. | 0.01% | Add +10.6% | 769,875 | $44.8M |
| Rock Springs Capital Management LP | 2.62% | Reduce -3.1% | 763,020 | $44.4M |
| Fiera Capital Corp | 0.14% | Add +3.4% | 709,529 | $41.3M |
| American Century Companies Inc. | 0.02% | Reduce -0.2% | 679,314 | $39.5M |
| Pictet Asset Management Holding SA | 0.04% | Add +8.6% | 679,709 | $39.2M |
| Vestal Point Capital, LP | 1.04% | Add +6.7% | 639,900 | $37.2M |
| Aberdeen Group plc | 0.06% | Reduce -18.7% | 609,929 | $35.5M |
| Two Sigma Investments, LP | 0.03% | Add +38.8% | 606,085 | $35.2M |
| MPM Bioimpact LLC | 2.64% | Add +21.2% | 588,706 | $34.2M |
| Loomis Sayles & Co. L P | 0.04% | Reduce -7.7% | 564,897 | $32.8M |
| Vanguard Portfolio Management LLC | 0.00% | — | 543,062 | $31.6M |
| Northern Trust Corp. | 0.00% | Add +20.3% | 527,783 | $30.7M |
| Parkman Healthcare Partners LLC | 3.00% | Add +222.4% | 497,035 | $28.9M |
| Tudor Investment Corporation | 0.16% | Add +95.1% | 495,591 | $28.8M |
| Octagon Capital Advisors LP | 3.15% | New | 490,000 | $28.5M |
| Novo Holdings A/S | 2.29% | New | 485,438 | $28.2M |
| Candriam S.C.A. | 0.14% | Add +14.2% | 476,494 | $27.7M |
| Morgan Stanley | 0.00% | Add +61.0% | 473,759 | $27.5M |
| Adage Capital Partners Gp, L.L.C. | 0.04% | Reduce -31.4% | 470,000 | $27.3M |
| Logos Global Management LP | 1.35% | New | 450,000 | $26.2M |
| Trails Edge Capital Partners, LP | 6.02% | Reduce -26.3% | 440,000 | $25.6M |
| Bank of New York Mellon Corp | 0.00% | Add +2.3% | 396,138 | $23.0M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +158868.6% | 375,166 | $21.8M |
| Baker Bros. Advisors LP | 0.12% | No change | 370,208 | $21.5M |
| TimesSquare Capital Management, LLC | 0.35% | Reduce -32.6% | 359,293 | $20.9M |
| Schonfeld Strategic Advisors LLC | 0.15% | New | 324,722 | $18.9M |
| Sofinnova Investments, Inc. | 0.89% | Add +409.5% | 305,216 | $17.7M |
| Renaissance Technologies | 0.03% | New | 300,500 | $17.5M |
| Soleus Capital Management, L.P. | 0.69% | New | 292,000 | $17.0M |
| Boothbay Fund Management, LLC | 0.38% | Add +657.9% | 270,412 | $15.7M |
| Bank of America Corp. | 0.00% | Add +19.8% | 265,267 | $15.4M |
| Algert Global LLC | 0.23% | Add +114.5% | 264,200 | $15.4M |
| Redmile Group, LLC | 1.01% | Add +96.2% | 262,674 | $15.3M |
| State of Wisconsin Investment Board | 0.03% | Add +23.8% | 254,483 | $14.8M |
| DAFNA Capital Management LLC | 3.36% | Reduce -12.9% | 250,772 | $14.6M |
| Nuveen, LLC | 0.00% | Add +15.6% | 250,036 | $14.5M |
| Nan Fung Trinity (hk) Ltd. | 1.58% | Add +9.2% | 247,765 | $14.4M |
| Nicholas Investment Partners, LP | 1.18% | Add +1.7% | 247,101 | $14.4M |
| Allspring Global Investments Holdings, LLC | 0.02% | New | 246,306 | $14.0M |
| Duquesne Family Office | 0.47% | New | 238,600 | $13.9M |
| Barclays PLC | 0.01% | Reduce -60.4% | 238,209 | $13.9M |
| Balyasny Asset Management L.P. | 0.03% | Add +177.3% | 233,905 | $13.6M |
| ADAR1 Capital Management, LLC | 0.81% | Add +12.2% | 228,899 | $13.3M |
| Patient Square Capital LP | 2.34% | Add +66.3% | 227,000 | $13.2M |
| Millennium Management | 0.01% | Reduce -68.2% | 201,785 | $11.7M |
| Integral Health Asset Management, LLC | 0.62% | New | 200,000 | $11.6M |
| Silverarc Capital Management, LLC | 1.36% | New | 197,759 | $11.5M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +0.0% | 189,080 | $11.0M |
| New York State Common Retirement Fund | 0.02% | Add +1.0% | 188,505 | $11.0M |
| NEXTBio Capital Management LP | 4.95% | Reduce -0.3% | 183,225 | $10.7M |
| DNB Asset Management AS | 0.04% | Reduce -33.6% | 181,085 | $10.5M |
| Susquehanna International Group, LLP | 0.01% | Add +2029.3% | 177,137 | $10.3M |
| ExodusPoint Capital Management, LP | 0.10% | New | 173,425 | $10.1M |
| Deutsche Bank AG | 0.00% | Reduce -14.5% | 162,682 | $9.5M |
| Foresite Capital Management IV, LLC | 3.92% | No change | 160,000 | $9.3M |
| Swiss National Bank | 0.01% | Add +38.3% | 157,700 | $9.2M |
| Jump Financial, LLC | 0.15% | Add +402.7% | 155,776 | $9.1M |
| Woodline Partners LP | 0.03% | New | 150,302 | $8.7M |
| Peregrine Capital Management LLC | 0.31% | Reduce -18.1% | 143,136 | $8.3M |
| Stempoint Capital LP | 1.57% | Reduce -59.6% | 140,755 | $8.2M |
| Neuberger Berman Group LLC | 0.01% | Reduce -27.0% | 130,438 | $7.6M |
| Eversept Partners, LP | 0.50% | Reduce -44.0% | 129,574 | $7.5M |
| Russell Investments Group, Ltd. | 0.01% | Add +50.1% | 129,399 | $7.5M |
| KBC Group NV | 0.02% | Add +4540.6% | 129,010 | $7.5M |
| Sphera Funds Management LTD. | 1.27% | New | 127,000 | $7.4M |
| HSBC Holdings PLC | 0.00% | New | 121,558 | $7.1M |
| Wells Fargo & Company | 0.00% | Reduce -24.1% | 115,652 | $6.7M |
| Mutual of America Capital Management LLC | 0.08% | Reduce -0.4% | 115,594 | $6.7M |
| Sei Investments Co. | 0.01% | Add +160.8% | 114,381 | $6.7M |
"% of holder's portfolio" is XENE's weight in each manager's 13F, not the share of Xenon Pharmaceuticals Inc. the manager owns.