ADAR1 Capital Management, LLC

In its 13F for Q3 2025 (holdings as of September 30, 2025, filed November 14, 2025), ADAR1 Capital Management, LLC reported 196 stock positions worth $1.0 billion. Its top holding was Abivax SA-ADR (ABVX) at 11.4% of the portfolio, followed by Keros Therapeutics (KROS, 8.5%) and Protagonist Therapeutics (PTGX, 6.6%). Compared with Q2 2025, it opened 47 new positions, sold out of 43, added to 67 and reduced 50. The biggest buy was Immunovant (IMVT, shares +319%) and the biggest sale Prothena (PRTA, shares −56%).

Most Recent 13F
Q2 2026
Location
AUSTIN, TX
CIK
0001940272
Portfolio Value
$1.0B (Q3 2025)
SEC Filing
0001940272-25-000008 ↗ filed Nov 14, 2025

Holdings Value

0$500.0M$1.0B$1.5B$2.0B$2.5B Q1 2024: $366.2M Q1 2024 Q2 2024: $496.6M Q2 2024 Q3 2024: $596.5M Q3 2024 Q4 2024: $469.3M Q4 2024 Q1 2025: $505.1M Q1 2025 Q2 2025: $609.1M Q2 2025 Q3 2025: $1.0B $1.0B Q3 2025 Q4 2025: $1.3B Q4 2025 Q1 2026: $1.6B Q1 2026 Q2 2026: $2.1B Q2 2026

Holdings 196 stocks · $1.0B

ABVX Abivax SA-ADR 11.44% 1,350,826 $114.7M Reduce -56.0%
KROS Keros Therapeutics Inc. 8.50% 5,389,264 $85.3M No change
PTGX Protagonist Therapeutics Inc. 6.55% 989,182 $65.7M Add +4.3%
ROIV Roivant Sciences Ltd. 5.05% 3,347,501 $50.6M Add +72.5%
BOXX Alpha Architect 1-3 MNTH Box 3.83% 337,125 $38.4M No change
SPY SS SPDR S&P 500 ETF Trust-US 3.63% 54,684 $36.4M Add +141.1%
IMVT Immunovant Inc. 3.60% 2,241,753 $36.1M Add +319.0%
ETNB 89BIO Inc. 3.10% 2,113,153 $31.1M Add +141.2%
ZLAB Zai Lab Ltd.-ADR 2.94% 868,780 $29.4M Add +2.2%
CYTK Cytokinetics Inc. 2.84% 518,921 $28.5M Reduce -10.9%
SEPN Septerna Inc. 2.21% 1,176,491 $22.1M Add +38.9%
PRTA Prothena Corp. PLC 1.43% 1,469,098 $14.3M Reduce -56.5%
BBIO Bridgebio Pharma Inc. 1.42% 273,414 $14.2M Add +5.3%
ABUS Arbutus Biopharma Corp. 1.31% 2,903,226 $13.2M Add +2.7%
RAPT Rapt Therapeutics Inc. 1.31% 507,771 $13.1M Reduce -35.2%
CTMX Cytomx Therapeutics Inc. 1.29% 4,045,414 $12.9M Add +31.3%
BIL SS SPDR BB 1-3M T-Bill ETF 1.24% 135,585 $12.4M No change
AMLX Amylyx Pharmaceuticals Inc. 1.17% 866,202 $11.8M Reduce -28.1%
BIOA Bioage Labs Inc. 1.10% 1,880,073 $11.1M Reduce -3.0%
MNPR Monopar Therapeutics Inc. 1.06% 129,999 $10.6M Add +28.8%
CRNX Crinetics Pharmaceuticals Inc. 1.03% 248,368 $10.3M Add +367.5%
LXEO Lexeo Therapeutics Inc. 1.01% 1,531,953 $10.2M Add +955.7%
CGON CG Oncology Inc. 1.00% 248,917 $10.0M Reduce -52.4%
TSHA Taysha Gene Therapies Inc. 0.92% 2,835,680 $9.3M Reduce -5.8%
REGN Regeneron Pharmaceuticals 0.88% 15,700 $8.8M Add +367.1%
IONS Ionis Pharmaceuticals Inc. 0.87% 133,818 $8.8M Reduce -9.9%
JANX Janux Therapeutics Inc. 0.86% 351,032 $8.6M Add +465.4%
IKT Inhibikase Therapeutics Inc. 0.85% 5,247,603 $8.5M Add +2.5%
IVVD Invivyd Inc. 0.81% 7,370,987 $8.1M New
MTSR Metsera Inc. 0.80% 152,521 $8.0M New
EQ Equillium Inc. 0.79% 5,559,988 $8.0M New
FRNM Freenome Inc. filed as PERCEPTIVE CAP SOLUTIONS COR 0.79% 750,000 $7.9M No change
QURE Uniqure NV 0.78% 133,316 $7.8M New
PCVX Vaxcyte Inc. 0.77% 213,064 $7.7M Add +117.3%
RZLT Rezolute Inc. 0.77% 815,975 $7.7M Reduce -17.5%
XENE Xenon Pharmaceuticals Inc. 0.76% 189,098 $7.6M Reduce -27.1%
ASND Ascendis Pharma A/S 0.72% 36,345 $7.2M Add +2492.4%
SVRA Savara Inc. 0.71% 1,988,288 $7.1M Reduce -44.8%
SRPT Sarepta Therapeutics Inc. 0.67% 349,807 $6.7M Add +66.3%
RVMD Revolution Medicines Inc. 0.65% 139,136 $6.5M Add +3.7%
AAM Aa Mission Acquisition Cor-A 0.61% 578,359 $6.1M No change
BBOT Bridgebio Oncology Therapeut 0.58% 501,228 $5.8M New
VRNA Verona Pharma Ltd. 0.55% 51,450 $5.5M Add +80.8%
OACCU Oaktree Acquisition III Life 0.55% 516,482 $5.5M No change
TEVA Teva Pharmaceutical-SP ADR 0.54% 267,816 $5.4M Reduce -22.6%
RYTM Rhythm Pharmaceuticals Inc. 0.50% 49,571 $5.0M Add +9.2%
ATAIBECKLEY INC filed as ATAI LIFE SCIENCES NV 0.48% 913,242 $4.8M New
UTHR United Therapeutics Corp. 0.47% 11,200 $4.7M New
VKTX Viking Therapeutics Inc. 0.46% 175,919 $4.6M Add +159.4%
REPL Replimune Group Inc. 0.41% 978,894 $4.1M Add +9312.4%
NKTR Nektar Therapeutics 0.41% 72,007 $4.1M Add +355.9%
ESTA Establishment Labs Holdings 0.37% 90,688 $3.7M Add +262.8%
SNY Sanofi-ADR 0.35% 74,212 $3.5M Add +642.1%
KRYS Krystal Biotech Inc. 0.33% 18,523 $3.3M New
NAMS Newamsterdam Pharma Co. NV 0.32% 114,359 $3.3M Add +1.8%
FULC Fulcrum Therapeutics Inc. 0.31% 341,612 $3.1M Add +540.3%
MRUS Merus NV 0.31% 33,313 $3.1M Add +81.9%
MLYS Mineralys Therapeutics Inc. 0.30% 78,238 $3.0M Reduce -74.1%
KNSA Kiniksa Pharmaceuticals Inte 0.29% 75,187 $2.9M Add +33.0%
CLDX Celldex Therapeutics Inc. 0.28% 109,442 $2.8M Add +90.5%
ZURA Zura Bio Ltd. 0.28% 652,154 $2.8M Reduce -34.6%
VRTX Vertex Pharmaceuticals Inc. 0.27% 7,000 $2.7M New
ACLX Arcellx Inc. 0.26% 31,484 $2.6M Add +125.5%
BIIB Biogen Inc. 0.25% 18,000 $2.5M Add +252.9%
DCTH Delcath Systems Inc. 0.24% 224,385 $2.4M Add +50.2%
RNAM Avidity Biosciences Inc. 0.23% 53,656 $2.3M New
MDGL Madrigal Pharmaceuticals Inc. 0.22% 4,895 $2.2M Add +364.4%
ASPC A Spac III Acquisition Class A 0.22% 215,000 $2.2M No change
MASI Masimo Corp. 0.22% 15,000 $2.2M New
VRDN Viridian Therapeutics Inc. 0.22% 101,704 $2.2M Reduce -40.4%
SMMT Summit Therapeutics Inc. 0.21% 102,969 $2.1M Add +758.1%
CDTX Cidara Therapeutics Inc. 0.21% 21,522 $2.1M No change
RGNX Regenxbio Inc. 0.20% 205,409 $2.0M Reduce -1.2%
KRRO Korro Bio Inc. 0.19% 40,235 $1.9M Reduce -41.5%
RCKT Rocket Pharmaceuticals Inc. 0.19% 575,800 $1.9M Add +108.8%
OABI Omniab Inc. 0.17% 1,090,628 $1.7M Add +234.4%
ARWR Arrowhead Pharmaceuticals Inc. 0.17% 49,800 $1.7M Reduce -9.8%
SLNO Soleno Therapeutics Inc. 0.17% 25,230 $1.7M Add +45.6%
DVAX Dynavax Technologies Corp. 0.17% 170,000 $1.7M No change
ALKS Alkermes PLC 0.17% 56,200 $1.7M Add +24.9%
GLUE Monte Rosa Therapeutics Inc. 0.16% 215,752 $1.6M New
MRK Merck & Co. Inc. 0.16% 18,540 $1.6M Add +163.3%
CCIIU Cohen Circle Acquisition Cor 0.15% 150,000 $1.5M New
ABOS Acumen Pharmaceuticals Inc. 0.15% 891,183 $1.5M Reduce -2.7%
XNCR Xencor Inc. 0.15% 128,865 $1.5M Add +50.1%
AGIO Agios Pharmaceuticals Inc. 0.15% 37,000 $1.5M Add +3.1%
WW WW International Inc.-New filed as WW INTL INC 0.14% 52,450 $1.4M New
ATXS Astria Therapeutics Inc. 0.14% 193,934 $1.4M Reduce -22.3%
CNTA Centessa Pharmaceuticals Ltd. 0.13% 53,666 $1.3M Reduce -81.9%
QUINCE THERAPEUTICS INC 0.13% 775,034 $1.3M Add +442.1%
PFE Pfizer Inc. 0.11% 44,400 $1.1M Add +12.7%
MLTX Moonlake Immunotherapeutics 0.11% 151,495 $1.1M Add +341.5%
GRCE Grace Therapeutics Inc. 0.10% 350,450 $1.0M Add +98.4%
NUVL Nuvalent Inc. Class A 0.10% 11,842 $1.0M No change
BSAAU Best Spac I Acquisition Corp. 0.10% 100,000 $1.0M No change
EA Electronic Arts Inc. 0.10% 4,936 $996K New
BNTX Biontech SE-ADR 0.10% 10,000 $986K New
CTNM Contineum Therapeutics Inc. Class A 0.09% 77,961 $916K Reduce -53.3%
AVR Anteris Technologies Global 0.09% 197,615 $889K Reduce -62.8%
TECX Tectonic Therapeutic Inc. 0.09% 56,007 $879K Reduce -23.8%

Show all 196 holdings

Options reported separately and not counted above: SPY puts ($30.3M), QURE calls ($11.7M), AAM calls ($4.3M), XBI puts ($4.0M), KVACF calls ($863K), URGN calls ($798K), FULC calls ($690K), NVCR calls ($388K), BHVN calls ($375K), DYN calls ($253K), OLMA calls ($245K), REPL calls ($210K), and 6 more.

Other holdings (3): bonds, preferreds, convertibles and warrants · $2.9M (not counted above)
SecurityClassShares / PrincipalValueChange
BRIDGEBIO PHARMA INC (BBIO 2.5 03/15/27) NOTE 2.500% 3/1 · principal 20,000$2.8MReduce -99.0%
BRIDGEBIO PHARMA INC (BBIO 2.25 02/01/29) NOTE 2.250% 2/0 · principal 45,000$44KReduce -99.0%
ASPCR A Spac III Acquisition Corp. RIGHT 01/02/2026 215,000$41KNo change

Total filed on the 13F, all lines: $1.0B.

Portfolio Sells Q2 2025 → Q3 2025

PRTA Prothena Corp. PLC Reduce -56.5% 1.43% −1.93
CGON CG Oncology Inc. Reduce -52.4% 1.00% −1.23
SAGE Sage Therapeutics Inc. Sold out 0.00% −1.08
VERV Verve Therapeutics Inc. Sold out 0.00% −0.86
BBOT Bridgebio Oncology Therapeut Sold out 0.00% −0.77
SHY iShares 1-3 Year Treasury Bo Sold out 0.00% −0.73
SVRA Savara Inc. Reduce -44.8% 0.71% −0.64
ARDX Ardelyx Inc. Sold out 0.00% −0.59
XENE Xenon Pharmaceuticals Inc. Reduce -27.1% 0.76% −0.58
THRD Third Harmonic Bio Inc. Sold out 0.00% −0.56
CNTA Centessa Pharmaceuticals Ltd. Reduce -81.9% 0.13% −0.51
TEVA Teva Pharmaceutical-SP ADR Reduce -22.6% 0.54% −0.41
ALEC Alector Inc. Sold out 0.00% −0.40
MLYS Mineralys Therapeutics Inc. Reduce -74.1% 0.30% −0.38
CRMD Cormedix Inc. Sold out 0.00% −0.35
BPMC Blueprint Medicines Corp. Sold out 0.00% −0.32
CYTK Cytokinetics Inc. Reduce -10.9% 2.84% −0.31
AKRO Akero Therapeutics Inc. Reduce -81.5% 0.03% −0.26
AVR Anteris Technologies Global Reduce -62.8% 0.09% −0.24
ORKA Oruka Therapeutics Inc. Reduce -85.4% 0.04% −0.22
TSHA Taysha Gene Therapies Inc. Reduce -5.8% 0.92% −0.22
BIOA Bioage Labs Inc. Reduce -3.0% 1.10% −0.21
VIR Vir Biotechnology Inc. Sold out 0.00% −0.21
SWTX Springworks Therapeutics Inc. Sold out 0.00% −0.19
VRDN Viridian Therapeutics Inc. Reduce -40.4% 0.22% −0.17
ARGX Argenx SE - ADR Sold out 0.00% −0.16
ALDX Aldeyra Therapeutics Inc. Sold out 0.00% −0.16
SRRK Scholar Rock Holding Corp. Reduce -49.4% 0.07% −0.16
TECX Tectonic Therapeutic Inc. Reduce -23.8% 0.09% −0.15
KVACF Keen Vision Acquisition Corp. Sold out 0.00% −0.14
APGE Apogee Therapeutics Inc. Sold out 0.00% −0.13
TENX Tenax Therapeutics Inc. Reduce -65.7% 0.04% −0.11
SGRY Surgery Partners Inc. Reduce -50.0% 0.04% −0.10
VTGN Vistagen Therapeutics Inc. Reduce -73.1% 0.04% −0.10
KYMR Kymera Therapeutics Inc. Sold out 0.00% −0.10
KALA Kala Bio Inc. Reduce -5.2% 0.02% −0.10
AMLX Amylyx Pharmaceuticals Inc. Reduce -28.1% 1.17% −0.09
IONS Ionis Pharmaceuticals Inc. Reduce -9.9% 0.87% −0.09
ARVN Arvinas Inc. Reduce -35.9% 0.07% −0.09
RGNX Regenxbio Inc. Reduce -1.2% 0.20% −0.08
ATXS Astria Therapeutics Inc. Reduce -22.3% 0.14% −0.08
NETD Nabors Energy Transition C-A Sold out 0.00% −0.07
NTRA Natera Inc. Sold out 0.00% −0.07
KZR Kezar Life Sciences Inc. Reduce -15.2% 0.05% −0.06
PYPD Polypid Ltd. Sold out 0.00% −0.06
STOK Stoke Therapeutics Inc. Sold out 0.00% −0.05
PHAT Phathom Pharmaceuticals Inc. Reduce -32.4% 0.05% −0.05
SPRO Spero Therapeutics Inc. Reduce -19.7% 0.02% −0.05
TARA Protara Therapeutic Inc. Reduce -71.3% 0.02% −0.05
AVTX Avalo Therapeutics Inc. Reduce -69.1% 0.04% −0.04

Portfolio Buys Q2 2025 → Q3 2025

IMVT Immunovant Inc. Add +319.0% 3.60% +2.20
ETNB 89BIO Inc. Add +141.2% 3.10% +1.69
ROIV Roivant Sciences Ltd. Add +72.5% 5.05% +1.46
SPY SS SPDR S&P 500 ETF Trust-US Add +141.1% 3.63% +1.33
LXEO Lexeo Therapeutics Inc. Add +955.7% 1.01% +0.92
IVVD Invivyd Inc. New 0.81% +0.81
MTSR Metsera Inc. New 0.80% +0.80
EQ Equillium Inc. New 0.79% +0.79
CRNX Crinetics Pharmaceuticals Inc. Add +367.5% 1.03% +0.78
QURE Uniqure NV New 0.78% +0.78
SEPN Septerna Inc. Add +38.9% 2.21% +0.74
ASND Ascendis Pharma A/S Add +2492.4% 0.72% +0.68
JANX Janux Therapeutics Inc. Add +465.4% 0.86% +0.62
REGN Regeneron Pharmaceuticals Add +367.1% 0.88% +0.59
BBOT Bridgebio Oncology Therapeut New 0.58% +0.58
ATAIBECKLEY INC New 0.48% +0.48
UTHR United Therapeutics Corp. New 0.47% +0.47
MNPR Monopar Therapeutics Inc. Add +28.8% 1.06% +0.47
REPL Replimune Group Inc. Add +9312.4% 0.41% +0.39
NKTR Nektar Therapeutics Add +355.9% 0.41% +0.34
KRYS Krystal Biotech Inc. New 0.33% +0.33
VRTX Vertex Pharmaceuticals Inc. New 0.27% +0.27
SNY Sanofi-ADR Add +642.1% 0.35% +0.27
FULC Fulcrum Therapeutics Inc. Add +540.3% 0.31% +0.25
PCVX Vaxcyte Inc. Add +117.3% 0.77% +0.24
RNAM Avidity Biosciences Inc. New 0.23% +0.23
MASI Masimo Corp. New 0.22% +0.22
ESTA Establishment Labs Holdings Add +262.8% 0.37% +0.20
MDGL Madrigal Pharmaceuticals Inc. Add +364.4% 0.22% +0.17
SMMT Summit Therapeutics Inc. Add +758.1% 0.21% +0.17
VKTX Viking Therapeutics Inc. Add +159.4% 0.46% +0.17
GLUE Monte Rosa Therapeutics Inc. New 0.16% +0.16
MRUS Merus NV Add +81.9% 0.31% +0.15
CCIIU Cohen Circle Acquisition Cor New 0.15% +0.15
BIIB Biogen Inc. Add +252.9% 0.25% +0.15
WW WW International Inc.-New New 0.14% +0.14
CTMX Cytomx Therapeutics Inc. Add +31.3% 1.29% +0.14
ACLX Arcellx Inc. Add +125.5% 0.26% +0.11
VRNA Verona Pharma Ltd. Add +80.8% 0.55% +0.11
EA Electronic Arts Inc. New 0.10% +0.10
BNTX Biontech SE-ADR New 0.10% +0.10
CLDX Celldex Therapeutics Inc. Add +90.5% 0.28% +0.09
QUINCE THERAPEUTICS INC Add +442.1% 0.13% +0.09
SRPT Sarepta Therapeutics Inc. Add +66.3% 0.67% +0.08
OABI Omniab Inc. Add +234.4% 0.17% +0.08
RCKT Rocket Pharmaceuticals Inc. Add +108.8% 0.19% +0.08
ACRS Aclaris Therapeutics Inc. New 0.07% +0.07
LITS Lite Strategy Inc. New 0.07% +0.07
DAY Dayforce Inc. New 0.07% +0.07
SUPN Supernus Pharmaceuticals Inc. New 0.07% +0.07

Options Activity Q2 2025 → Q3 2025

SPY SS SPDR S&P 500 ETF Trust-US put Add +12.3% 45,500 $30.3M
QURE Uniqure NV call New 200,000 $11.7M
JANX Janux Therapeutics Inc. call Sold out 264,900 $6.1Mbefore exit
AAM Aa Mission Acquisition Cor-A call New 405,089 $4.3M
XBI SS SPDR S&P Biotech ETF put New 40,000 $4.0M
SMMT Summit Therapeutics Inc. call Sold out 100,000 $2.1Mbefore exit
SRPT Sarepta Therapeutics Inc. call Sold out 55,000 $941Kbefore exit
NKTR Nektar Therapeutics put Sold out 35,000 $904Kbefore exit
KVACF Keen Vision Acquisition Corp. call New 75,000 $863K
URGN Urogen Pharma Ltd. call New 40,000 $798K
FULC Fulcrum Therapeutics Inc. call New 75,000 $690K
NVCR Novocure Ltd. call New 30,000 $388K
INMB Inmune Bio Inc. put Sold out 130,200 $301Kbefore exit
OLMA Olema Pharmaceuticals Inc. call New 25,000 $245K
REPL Replimune Group Inc. call New 50,000 $210K
ATYR Atyr Pharma Inc. put Add +345.0% 222,500 $161K
GOSS Gossamer Bio Inc. call New 55,100 $145K
MLTX Moonlake Immunotherapeutics call New 17,000 $122K
IOVA Iovance Biotherapeutics Inc. call New 50,000 $109K
STI Solidion Technology Inc. call New 13,500 $63K
ATYR Atyr Pharma Inc. call New 84,800 $61K

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

Notes & Other Activity Q2 2025 → Q3 2025

BRIDGEBIO PHARMA INC (BBIO 2.5 03/15/27) NOTE 2.500% 3/1 · principal Reduce -99.0% 20,000 $2.8M
AAM.WS Aa Mission Acquisition -30 *W EXP 08/01/203 Sold out 505,099 $50Kbefore exit
BRIDGEBIO PHARMA INC (BBIO 2.25 02/01/29) NOTE 2.250% 2/0 · principal Reduce -99.0% 45,000 $44K
JVSAR Jvspac Acquisition Corp.-RTS RIGHT 11/26/2026 Sold out 24,000 $21Kbefore exit
IROHR Iron Horse Acquisitions Righ RIGHT 99/99/9999 Sold out 12,320 $6Kbefore exit
KVAWF Keen Vision Acquisition C-28 *W EXP 03/15/202 Sold out 75,000 $4Kbefore exit
EMCRF Embrace Change Acq-Rights RIGHT 10/25/2026 Sold out 13,144 $2Kbefore exit
EMCWF Embrace Change Acquisitio-26 *W EXP 10/25/202 Sold out 18,000 $360before exit

Bonds, preferreds, convertibles and warrants; not part of the stock holdings or percentages above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 260$2.1BABVX, PTGX, ROIV, SPY, IMVT
Q1 2026 290$1.6BABVX, PTGX, ROIV, IMVT, SPY
Q4 2025Amended 248$1.3BABVX, PTGX, ROIV, IMVT, RNAM
Q3 2025 196$1.0BABVX, KROS, PTGX, ROIV, BOXX
Q2 2025 192$609.1MKROS, PTGX, BOXX, ZLAB, ABVX
Q1 2025 185$505.1MPTGX, BOXX, ROIV, ZLAB, IMVT
Q4 2024 185$469.3MROIV, PTGX, BOXX, ZLAB, IMVT
Q3 2024 244$596.5MCYTK, PTGX, BBIO, BOXX, ROIV
Q2 2024 231$496.6MPTGX, CYTK, ROIV, BOXX, BBIO
Q1 2024 223$366.2MBOXX, ROIV, ALNY, PTGX, CYTK