| MLTX Moonlake Immunotherapeutics | 32.08% | 21,751,284 | $1.1B | No change |
| KYMR Kymera Therapeutics Inc. | 7.15% | 5,161,801 | $244.3M | No change |
| RVMD Revolution Medicines Inc. | 4.62% | 3,478,612 | $157.8M | Reduce -41.8% |
| MIRM Mirum Pharmaceuticals Inc. | 3.51% | 3,075,907 | $120.0M | Reduce -29.6% |
| TYRA Tyra Biosciences Inc. | 3.21% | 4,661,194 | $109.6M | No change |
| OLMA Olema Pharmaceuticals Inc. | 3.19% | 9,135,893 | $109.1M | No change |
| GPCR Structure Therapeutics Inc. | 2.87% | 2,238,986 | $98.3M | Reduce -10.0% |
| CGEM Cullinan Therapeutics Inc. | 2.82% | 5,750,683 | $96.3M | No change |
| XOMA Xoma Royalty Corporation | 2.81% | 3,633,743 | $96.2M | No change |
| AXSM Axsome Therapeutics Inc. | 2.75% | 1,046,000 | $94.0M | Add +9.5% |
| PTGX Protagonist Therapeutics Inc. | 2.44% | 1,850,167 | $83.3M | Reduce -44.3% |
| FDMT 4D Molecular Therapeutics Inc. | 2.33% | 7,382,642 | $79.8M | Add +88.2% |
| ACIU Ac Immune SA | 2.16% | 19,522,436 | $73.8M | Add +3.6% |
| GHRS GH Research PLC | 2.04% | 10,400,158 | $69.6M | No change |
| KURA Kura Oncology Inc. | 1.93% | 3,371,761 | $65.9M | Reduce -17.4% |
| THRD Third Harmonic Bio Inc. | 1.73% | 4,365,933 | $59.2M | No change |
| IONS Ionis Pharmaceuticals Inc. | 1.70% | 1,451,879 | $58.2M | Reduce -54.4% |
| ZYME Zymeworks Inc. | 1.69% | 4,607,935 | $57.8M | Reduce -21.5% |
| EPIX Essa Pharma Inc. | 1.55% | 8,748,629 | $53.0M | No change |
| AGIO Agios Pharmaceuticals Inc. | 1.55% | 1,190,107 | $52.9M | No change |
| CELC Celcuity Inc. | 1.51% | 3,466,000 | $51.7M | No change |
| ETNB 89BIO Inc. | 1.47% | 6,811,631 | $50.4M | Reduce -10.0% |
| FHTX Foghorn Therapeutics Inc. | 1.44% | 5,302,000 | $49.4M | No change |
| LKFT Lakefront Biotherapeutic-ADR filed as GALAPAGOS NV | 1.32% | 1,569,422 | $45.2M | No change |
| IDYA Ideaya Biosciences Inc. | 1.31% | 1,409,993 | $44.7M | Add +21.3% |
| ANNX Annexon Inc. | 1.21% | 7,000,000 | $41.4M | No change |
| CGON CG Oncology Inc. | 1.10% | 994,596 | $37.5M | Reduce -58.9% |
| RPTX Repare Therapeutics Inc. | 1.04% | 10,333,600 | $35.5M | No change |
| NAMS Newamsterdam Pharma Co. NV | 0.74% | 1,521,948 | $25.3M | No change |
| XNCR Xencor Inc. | 0.50% | 850,000 | $17.1M | New |
| ELDN Eledon Pharmaceuticals Inc. | 0.46% | 6,293,282 | $15.7M | No change |
| TCRX Tscan Therapeutics Inc. | 0.44% | 2,989,474 | $14.9M | No change |
| ENGN Engene Holdings Inc. | 0.43% | 2,251,037 | $14.9M | No change |
| IMUX Immunic Inc. | 0.43% | 8,902,972 | $14.7M | No change |
| ALLK Allakos LLC | 0.32% | 16,552,417 | $10.8M | No change |
| AVTX Avalo Therapeutics Inc. | 0.27% | 967,000 | $9.1M | New |
| IKENA ONCOLOGY INC | 0.24% | 4,769,164 | $8.3M | No change |
| CDTX Cidara Therapeutics Inc. | 0.22% | 703,065 | $7.6M | Add +104.9% |
| CTMX Cytomx Therapeutics Inc. | 0.18% | 5,228,461 | $6.2M | No change |
| VIGL Vigil Neuroscience Inc. | 0.18% | 1,813,633 | $6.2M | No change |
| VTGN Vistagen Therapeutics Inc. | 0.18% | 2,000,000 | $6.0M | No change |
| VSTM Verastem Inc. | 0.15% | 1,685,219 | $5.0M | No change |
| OVID Ovid Therapeutics Inc. | 0.13% | 3,853,818 | $4.5M | No change |
| PIERIS PHARMACEUTICALS INC | 0.13% | 257,626 | $4.3M | No change |
| VERV Verve Therapeutics Inc. | 0.09% | 650,000 | $3.1M | No change |
| SABS Sab Biotherapeutics Inc. | 0.07% | 917,826 | $2.5M | No change |
| MOLN Molecular Partners AG -ADR | 0.06% | 443,221 | $2.1M | No change |
| ELEV Elevation Oncology Inc. | 0.05% | 2,966,836 | $1.8M | Add +28.3% |
| GLYCOMIMETICS INC | 0.05% | 9,544,262 | $1.6M | No change |
| IVA Inventiva SA - ADR | 0.04% | 686,040 | $1.3M | No change |
| TENX Tenax Therapeutics Inc. | 0.03% | 339,549 | $1.2M | New |
| ENGENE HOLDINGS INC | 0.02% | 945,402 | $804K | No change |
| MTEMQ Molecular Templates Inc. | 0.02% | 522,238 | $734K | No change |
| NLS PHARMACEUTICS LTD | 0.02% | 143,676 | $728K | New |
| FBRX Forte Biosciences Inc. | 0.02% | 119,282 | $668K | No change |