| MLTX Moonlake Immunotherapeutics | 33.31% | 19,751,284 | $932.3M | No change |
| KYMR Kymera Therapeutics Inc. | 8.58% | 5,502,710 | $240.1M | Add +6.6% |
| RVMD Revolution Medicines Inc. | 6.55% | 4,982,384 | $183.3M | No change |
| PTGX Protagonist Therapeutics Inc. | 6.34% | 3,211,041 | $177.5M | Add +24.7% |
| AXSM Axsome Therapeutics Inc. | 6.30% | 1,690,221 | $176.4M | No change |
| MIRM Mirum Pharmaceuticals Inc. | 5.02% | 2,761,333 | $140.5M | Reduce -1.3% |
| GHRS GH Research PLC | 3.84% | 8,827,712 | $107.6M | No change |
| IONS Ionis Pharmaceuticals Inc. | 2.70% | 1,913,385 | $75.6M | No change |
| XOMA Xoma Royalty Corporation | 2.33% | 2,590,303 | $65.3M | Reduce -13.2% |
| ZYME Zymeworks Inc. | 1.93% | 4,308,935 | $54.1M | No change |
| SEPN Septerna Inc. | 1.66% | 4,396,124 | $46.5M | No change |
| CELC Celcuity Inc. | 1.65% | 3,466,000 | $46.3M | No change |
| KURA Kura Oncology Inc. | 1.60% | 7,754,129 | $44.7M | No change |
| CGEM Cullinan Therapeutics Inc. | 1.55% | 5,750,683 | $43.3M | No change |
| ACIU Ac Immune SA | 1.44% | 19,822,436 | $40.2M | No change |
| CDTX Cidara Therapeutics Inc. | 1.37% | 786,392 | $38.3M | Reduce -14.9% |
| TYRA Tyra Biosciences Inc. | 1.35% | 3,944,194 | $37.7M | No change |
| GPCR Structure Therapeutics Inc. | 1.31% | 1,771,417 | $36.7M | No change |
| IMCR Immunocore Holdings PLC-ADR | 1.15% | 1,024,288 | $32.1M | New |
| GLUE Monte Rosa Therapeutics Inc. | 0.91% | 5,660,132 | $25.5M | No change |
| FHTX Foghorn Therapeutics Inc. | 0.89% | 5,302,000 | $24.9M | No change |
| OLMA Olema Pharmaceuticals Inc. | 0.81% | 5,295,893 | $22.6M | No change |
| CBIO Crescent Biopharma Inc. | 0.80% | 1,387,863 | $22.4M | New |
| XNCR Xencor Inc. | 0.77% | 2,740,141 | $21.5M | No change |
| FDMT 4D Molecular Therapeutics Inc. | 0.61% | 4,629,289 | $17.2M | Add +1.5% |
| ELDN Eledon Pharmaceuticals Inc. | 0.61% | 6,293,282 | $17.1M | No change |
| ANNX Annexon Inc. | 0.60% | 7,000,000 | $16.8M | No change |
| PVLA Palvella Therapeutics Inc. | 0.56% | 696,555 | $15.7M | No change |
| EPIX Essa Pharma Inc. | 0.53% | 8,748,629 | $14.9M | No change |
| RPTX Repare Therapeutics Inc. | 0.51% | 10,333,600 | $14.4M | No change |
| VSTM Verastem Inc. | 0.50% | 3,404,425 | $14.1M | Add +62.1% |
| RAPT Rapt Therapeutics Inc. | 0.33% | 1,154,692 | $9.2M | New |
| FBRX Forte Biosciences Inc. | 0.27% | 588,344 | $7.6M | Reduce -1.0% |
| TCRX Tscan Therapeutics Inc. | 0.27% | 5,226,074 | $7.6M | Add +6.9% |
| IKENA ONCOLOGY INC | 0.19% | 4,006,564 | $5.4M | No change |
| IMUX Immunic Inc. | 0.19% | 7,652,972 | $5.3M | Reduce -14.0% |
| MOLN Molecular Partners AG -ADR | 0.19% | 1,353,968 | $5.2M | No change |
| AVTX Avalo Therapeutics Inc. | 0.18% | 1,028,049 | $5.1M | Reduce -0.8% |
| IVA Inventiva SA - ADR | 0.08% | 686,040 | $2.1M | No change |
| TENX Tenax Therapeutics Inc. | 0.07% | 339,549 | $2.0M | No change |
| SABS Sab Biotherapeutics Inc. | 0.06% | 917,826 | $1.6M | No change |
| OVID Ovid Therapeutics Inc. | 0.05% | 3,853,818 | $1.3M | No change |
| ENGENE HOLDINGS INC | 0.02% | 945,402 | $586K | No change |
| NLS PHARMACEUTICS LTD | 0.01% | 143,676 | $417K | No change |