| KYMR Kymera Therapeutics Inc. | 12.63% | 5,502,710 | $311.5M | No change |
| RVMD Revolution Medicines Inc. | 7.52% | 3,974,913 | $185.6M | Reduce -20.2% |
| PTGX Protagonist Therapeutics Inc. | 6.90% | 2,560,916 | $170.1M | Reduce -20.3% |
| MLTX Moonlake Immunotherapeutics | 5.74% | 19,751,284 | $141.6M | No change |
| CDTX Cidara Therapeutics Inc. | 5.49% | 1,414,165 | $135.4M | Add +79.8% |
| GHRS GH Research PLC | 5.12% | 8,827,712 | $126.2M | No change |
| MIRM Mirum Pharmaceuticals Inc. | 4.44% | 1,495,290 | $109.6M | Reduce -45.9% |
| XOMA Xoma Royalty Corporation | 4.05% | 2,590,303 | $99.8M | No change |
| GPCR Structure Therapeutics Inc. | 3.64% | 3,203,917 | $89.7M | Add +80.9% |
| KURA Kura Oncology Inc. | 3.09% | 8,617,162 | $76.3M | Add +11.1% |
| SEPN Septerna Inc. | 3.06% | 4,015,790 | $75.5M | Reduce -8.7% |
| PVLA Palvella Therapeutics Inc. | 2.95% | 1,161,249 | $72.8M | Add +66.7% |
| NKTR Nektar Therapeutics | 2.94% | 1,276,595 | $72.6M | New |
| ZYME Zymeworks Inc. | 2.73% | 3,938,641 | $67.3M | Reduce -8.6% |
| AXSM Axsome Therapeutics Inc. | 2.40% | 486,757 | $59.1M | Reduce -71.2% |
| ACIU Ac Immune SA | 2.32% | 19,822,436 | $57.3M | No change |
| IMCR Immunocore Holdings PLC-ADR | 2.32% | 1,574,288 | $57.2M | Add +53.7% |
| OLMA Olema Pharmaceuticals Inc. | 2.10% | 5,295,893 | $51.8M | No change |
| TYRA Tyra Biosciences Inc. | 2.07% | 3,649,794 | $51.1M | Reduce -7.5% |
| ABVX Abivax SA-ADR | 1.92% | 558,031 | $47.4M | New |
| GLUE Monte Rosa Therapeutics Inc. | 1.70% | 5,660,132 | $41.9M | No change |
| FDMT 4D Molecular Therapeutics Inc. | 1.63% | 4,629,289 | $40.2M | No change |
| STOK Stoke Therapeutics Inc. | 1.58% | 1,657,096 | $38.9M | New |
| CGEM Cullinan Therapeutics Inc. | 1.38% | 5,750,683 | $34.1M | No change |
| CELC Celcuity Inc. | 1.32% | 658,421 | $32.5M | Reduce -81.0% |
| XNCR Xencor Inc. | 1.30% | 2,740,141 | $32.1M | No change |
| FHTX Foghorn Therapeutics Inc. | 1.05% | 5,302,000 | $25.9M | No change |
| ANNX Annexon Inc. | 0.87% | 7,000,000 | $21.4M | No change |
| RPTX Repare Therapeutics Inc. | 0.74% | 10,333,600 | $18.2M | No change |
| AVTX Avalo Therapeutics Inc. | 0.70% | 1,355,256 | $17.2M | Add +31.8% |
| CMPX Compass Therapeutics Inc. | 0.67% | 4,750,000 | $16.6M | New |
| CBIO Crescent Biopharma Inc. | 0.67% | 1,387,863 | $16.5M | No change |
| ELDN Eledon Pharmaceuticals Inc. | 0.66% | 6,293,282 | $16.3M | No change |
| TCRX Tscan Therapeutics Inc. | 0.39% | 5,226,074 | $9.5M | No change |
| PEPG Pepgen Inc. | 0.36% | 1,915,000 | $8.8M | New |
| XFOR X4 Pharmaceuticals Inc. | 0.31% | 2,233,742 | $7.6M | New |
| IMUX Immunic Inc. | 0.27% | 7,652,972 | $6.7M | No change |
| IMA Imagenebio Inc. | 0.27% | 802,102 | $6.5M | New |
| MOLN Molecular Partners AG -ADR | 0.20% | 1,353,968 | $5.0M | No change |
| IVA Inventiva SA - ADR | 0.16% | 686,040 | $4.0M | No change |
| TENX Tenax Therapeutics Inc. | 0.10% | 339,549 | $2.6M | No change |
| EPIX Essa Pharma Inc. | 0.09% | 11,668,473 | $2.2M | Add +33.4% |
| SABS Sab Biotherapeutics Inc. | 0.08% | 932,697 | $1.9M | Add +1.6% |
| FBRX Forte Biosciences Inc. | 0.04% | 65,350 | $980K | Reduce -88.9% |
| ENGENE HOLDINGS INC | 0.03% | 945,402 | $681K | No change |
| NLS PHARMACEUTICS LTD | 0.01% | 143,676 | $263K | No change |