| MLTX Moonlake Immunotherapeutics | 36.25% | 19,751,284 | $1.1B | Reduce -9.2% |
| KYMR Kymera Therapeutics Inc. | 7.04% | 5,161,801 | $207.7M | No change |
| RVMD Revolution Medicines Inc. | 6.20% | 4,181,179 | $182.9M | Add +20.2% |
| AXSM Axsome Therapeutics Inc. | 3.98% | 1,388,064 | $117.4M | Add +32.7% |
| MIRM Mirum Pharmaceuticals Inc. | 3.92% | 2,796,513 | $115.6M | Reduce -9.1% |
| XOMA Xoma Royalty Corporation | 3.24% | 3,633,743 | $95.5M | No change |
| PTGX Protagonist Therapeutics Inc. | 2.49% | 1,900,015 | $73.3M | Add +2.7% |
| GHRS GH Research PLC | 2.47% | 10,400,158 | $72.8M | No change |
| CGEM Cullinan Therapeutics Inc. | 2.37% | 5,750,683 | $70.0M | No change |
| ZYME Zymeworks Inc. | 2.14% | 4,308,935 | $63.1M | Reduce -6.5% |
| SEPN Septerna Inc. | 1.90% | 2,452,024 | $56.2M | New |
| TYRA Tyra Biosciences Inc. | 1.86% | 3,944,194 | $54.8M | Reduce -15.4% |
| ACIU Ac Immune SA | 1.79% | 19,522,436 | $52.7M | No change |
| XNCR Xencor Inc. | 1.78% | 2,288,760 | $52.6M | Add +169.3% |
| GPCR Structure Therapeutics Inc. | 1.63% | 1,771,417 | $48.0M | Reduce -20.9% |
| CELC Celcuity Inc. | 1.54% | 3,466,000 | $45.4M | No change |
| LKFT Lakefront Biotherapeutic-ADR filed as GALAPAGOS NV | 1.46% | 1,569,422 | $43.2M | No change |
| VERV Verve Therapeutics Inc. | 1.32% | 6,904,050 | $38.9M | Add +962.2% |
| ANNX Annexon Inc. | 1.22% | 7,000,000 | $35.9M | No change |
| AGIO Agios Pharmaceuticals Inc. | 1.20% | 1,073,755 | $35.3M | Reduce -9.8% |
| ETNB 89BIO Inc. | 1.15% | 4,333,885 | $33.9M | Reduce -36.4% |
| OLMA Olema Pharmaceuticals Inc. | 1.13% | 5,715,893 | $33.3M | Reduce -37.4% |
| CDTX Cidara Therapeutics Inc. | 1.00% | 1,092,796 | $29.4M | Add +55.4% |
| ELDN Eledon Pharmaceuticals Inc. | 0.88% | 6,293,282 | $25.9M | No change |
| FHTX Foghorn Therapeutics Inc. | 0.85% | 5,302,000 | $25.0M | No change |
| THRD Third Harmonic Bio Inc. | 0.83% | 2,372,933 | $24.4M | Reduce -45.6% |
| KURA Kura Oncology Inc. | 0.76% | 2,567,469 | $22.4M | Reduce -23.9% |
| ALLK Allakos LLC | 0.68% | 16,552,417 | $20.0M | No change |
| GLUE Monte Rosa Therapeutics Inc. | 0.65% | 2,764,471 | $19.2M | New |
| ITOS Iteos Therapeutics Inc. | 0.61% | 2,325,000 | $17.9M | New |
| EPIX Essa Pharma Inc. | 0.53% | 8,748,629 | $15.7M | No change |
| FDMT 4D Molecular Therapeutics Inc. | 0.50% | 2,670,642 | $14.9M | Reduce -63.8% |
| RAPT THERAPEUTICS INC | 0.49% | 9,237,556 | $14.6M | New |
| ENGN Engene Holdings Inc. | 0.47% | 2,106,037 | $14.0M | Reduce -6.4% |
| RPTX Repare Therapeutics Inc. | 0.46% | 10,333,600 | $13.5M | No change |
| FBRX Forte Biosciences Inc. | 0.46% | 594,282 | $13.5M | Add +398.2% |
| VSTM Verastem Inc. | 0.37% | 2,100,468 | $10.9M | Add +24.6% |
| TCRX Tscan Therapeutics Inc. | 0.31% | 2,989,474 | $9.1M | No change |
| IMUX Immunic Inc. | 0.30% | 8,902,972 | $8.9M | No change |
| PVLA Palvella Therapeutics Inc. | 0.28% | 696,555 | $8.4M | New |
| AVTX Avalo Therapeutics Inc. | 0.26% | 1,036,679 | $7.7M | Add +7.2% |
| IKENA ONCOLOGY INC | 0.22% | 4,006,564 | $6.6M | Reduce -16.0% |
| MOLN Molecular Partners AG -ADR | 0.22% | 1,353,968 | $6.5M | Add +205.5% |
| CTMX Cytomx Therapeutics Inc. | 0.18% | 5,228,461 | $5.4M | No change |
| OVID Ovid Therapeutics Inc. | 0.12% | 3,853,818 | $3.6M | No change |
| SABS Sab Biotherapeutics Inc. | 0.12% | 917,826 | $3.5M | No change |
| VIGL Vigil Neuroscience Inc. | 0.10% | 1,813,633 | $3.1M | No change |
| GLYCOMIMETICS INC | 0.08% | 9,544,262 | $2.4M | No change |
| TENX Tenax Therapeutics Inc. | 0.07% | 339,549 | $2.1M | No change |
| ELEV Elevation Oncology Inc. | 0.06% | 2,966,836 | $1.7M | No change |
| IVA Inventiva SA - ADR | 0.05% | 686,040 | $1.5M | No change |
| ENGENE HOLDINGS INC | 0.03% | 945,402 | $804K | No change |
| NLS PHARMACEUTICS LTD | 0.01% | 143,676 | $303K | No change |