| MLTX Moonlake Immunotherapeutics | 31.45% | 19,751,284 | $771.7M | No change |
| AXSM Axsome Therapeutics Inc. | 8.03% | 1,690,221 | $197.1M | Add +21.8% |
| RVMD Revolution Medicines Inc. | 7.18% | 4,982,384 | $176.2M | Add +19.2% |
| KYMR Kymera Therapeutics Inc. | 5.76% | 5,161,801 | $141.3M | No change |
| MIRM Mirum Pharmaceuticals Inc. | 5.13% | 2,796,513 | $126.0M | No change |
| PTGX Protagonist Therapeutics Inc. | 5.08% | 2,575,015 | $124.5M | Add +35.5% |
| GHRS GH Research PLC | 3.97% | 8,827,712 | $97.4M | Reduce -15.1% |
| XOMA Xoma Royalty Corporation | 2.42% | 2,983,026 | $59.5M | Reduce -17.9% |
| IONS Ionis Pharmaceuticals Inc. | 2.35% | 1,913,385 | $57.7M | New |
| ZYME Zymeworks Inc. | 2.09% | 4,308,935 | $51.3M | No change |
| KURA Kura Oncology Inc. | 2.09% | 7,754,129 | $51.2M | Add +202.0% |
| CGEM Cullinan Therapeutics Inc. | 1.77% | 5,750,683 | $43.5M | No change |
| ACIU Ac Immune SA | 1.51% | 19,822,436 | $37.1M | Add +1.5% |
| TYRA Tyra Biosciences Inc. | 1.50% | 3,944,194 | $36.7M | No change |
| LKFT Lakefront Biotherapeutic-ADR filed as GALAPAGOS NV | 1.49% | 1,454,422 | $36.5M | Reduce -7.3% |
| CELC Celcuity Inc. | 1.43% | 3,466,000 | $35.0M | No change |
| VERV Verve Therapeutics Inc. | 1.29% | 6,904,050 | $31.6M | No change |
| GPCR Structure Therapeutics Inc. | 1.25% | 1,771,417 | $30.7M | No change |
| XNCR Xencor Inc. | 1.19% | 2,740,141 | $29.2M | Add +19.7% |
| GLUE Monte Rosa Therapeutics Inc. | 1.07% | 5,660,132 | $26.3M | Add +104.8% |
| SEPN Septerna Inc. | 1.04% | 4,396,124 | $25.5M | Add +79.3% |
| ELDN Eledon Pharmaceuticals Inc. | 0.87% | 6,293,282 | $21.3M | No change |
| CDTX Cidara Therapeutics Inc. | 0.81% | 924,642 | $19.9M | Reduce -15.4% |
| OLMA Olema Pharmaceuticals Inc. | 0.81% | 5,295,893 | $19.9M | Reduce -7.3% |
| PVLA Palvella Therapeutics Inc. | 0.79% | 696,555 | $19.5M | No change |
| FHTX Foghorn Therapeutics Inc. | 0.79% | 5,302,000 | $19.4M | No change |
| ITOS Iteos Therapeutics Inc. | 0.75% | 3,075,000 | $18.4M | Add +32.3% |
| FDMT 4D Molecular Therapeutics Inc. | 0.60% | 4,561,289 | $14.7M | Add +70.8% |
| EPIX Essa Pharma Inc. | 0.56% | 8,748,629 | $13.8M | No change |
| ANNX Annexon Inc. | 0.55% | 7,000,000 | $13.5M | No change |
| VSTM Verastem Inc. | 0.52% | 2,100,468 | $12.7M | No change |
| RAPT THERAPEUTICS INC | 0.46% | 9,237,556 | $11.3M | No change |
| RPTX Repare Therapeutics Inc. | 0.42% | 10,333,600 | $10.2M | No change |
| IMUX Immunic Inc. | 0.40% | 8,902,972 | $9.7M | No change |
| AVTX Avalo Therapeutics Inc. | 0.34% | 1,036,679 | $8.3M | No change |
| THRD Third Harmonic Bio Inc. | 0.34% | 2,372,933 | $8.2M | No change |
| VIGL Vigil Neuroscience Inc. | 0.29% | 4,013,633 | $7.1M | Add +121.3% |
| TCRX Tscan Therapeutics Inc. | 0.28% | 4,889,474 | $6.7M | Add +63.6% |
| MOLN Molecular Partners AG -ADR | 0.22% | 1,353,968 | $5.5M | No change |
| IKENA ONCOLOGY INC | 0.21% | 4,006,564 | $5.1M | No change |
| FBRX Forte Biosciences Inc. | 0.19% | 594,282 | $4.6M | No change |
| ALLK Allakos LLC | 0.15% | 16,552,417 | $3.8M | No change |
| CTMX Cytomx Therapeutics Inc. | 0.14% | 5,228,461 | $3.3M | No change |
| TENX Tenax Therapeutics Inc. | 0.09% | 339,549 | $2.2M | No change |
| IVA Inventiva SA - ADR | 0.08% | 686,040 | $2.1M | No change |
| GLYCOMIMETICS INC | 0.08% | 9,544,262 | $2.0M | No change |
| SABS Sab Biotherapeutics Inc. | 0.05% | 917,826 | $1.2M | No change |
| NAMS Newamsterdam Pharma Co. NV | 0.05% | 59,065 | $1.2M | New |
| OVID Ovid Therapeutics Inc. | 0.05% | 3,853,818 | $1.2M | No change |
| ENGENE HOLDINGS INC | 0.02% | 945,402 | $605K | No change |
| NLS PHARMACEUTICS LTD | 0.01% | 143,676 | $221K | No change |