Diadema Partners LP
In its 13F for Q3 2025 (holdings as of September 30, 2025, filed November 14, 2025), Diadema Partners LP reported 59 stock positions worth $143.6 million. Its top holding was Regeneron Pharmaceuticals (REGN) at 11.8% of the portfolio, followed by Soleno Therapeutics (SLNO, 8.4%) and Biomarin Pharmaceutical (BMRN, 8.0%). Compared with Q2 2025, it opened 33 new positions, sold out of 20, added to 6 and reduced 16. The biggest buy was Regeneron Pharmaceuticals (REGN, shares +438%) and the biggest sale an exit from Amgen (AMGN).
- Most Recent 13F
- Q2 2026
- Location
- MORRISTOWN, NJ
- CIK
- 0002026172
- Portfolio Value
- $143.6M (Q3 2025)
- SEC Filing
- 0001892688-25-000193 ↗ filed Nov 14, 2025
Holdings Value
Holdings 59 stocks · $143.6M
| REGN Regeneron Pharmaceuticals | 11.81% | 30,160 | $17.0M | Add +437.9% |
| SLNO Soleno Therapeutics Inc. | 8.35% | 177,330 | $12.0M | Reduce -37.6% |
| BMRN Biomarin Pharmaceutical Inc. | 8.03% | 212,877 | $11.5M | Add +10.4% |
| PCVX Vaxcyte Inc. | 5.48% | 218,285 | $7.9M | Add +10.1% |
| INDV Indivior Ltd. | 4.27% | 254,252 | $6.1M | New |
| BMY Bristol-Myers Squibb Co. | 4.08% | 130,000 | $5.9M | New |
| ASND Ascendis Pharma A/S | 3.82% | 27,572 | $5.5M | New |
| NBIX Neurocrine Biosciences Inc. | 3.69% | 37,754 | $5.3M | Reduce -59.9% |
| VKTX Viking Therapeutics Inc. | 3.55% | 193,689 | $5.1M | Reduce -1.9% |
| ALNY Alnylam Pharmaceuticals Inc. | 3.18% | 10,000 | $4.6M | New |
| IMCR Immunocore Holdings PLC-ADR | 3.15% | 124,384 | $4.5M | Add +19.2% |
| NKTR Nektar Therapeutics | 2.97% | 75,000 | $4.3M | New |
| ABVX Abivax SA-ADR | 2.45% | 41,620 | $3.5M | New |
| PTGX Protagonist Therapeutics Inc. | 2.37% | 51,185 | $3.4M | Reduce -32.8% |
| JAZZ Jazz Pharmaceuticals PLC | 2.12% | 23,140 | $3.0M | Reduce -77.8% |
| ANIP Ani Pharmaceuticals Inc. | 2.00% | 31,400 | $2.9M | New |
| RVMD Revolution Medicines Inc. | 1.92% | 59,079 | $2.8M | Reduce -25.3% |
| APGE Apogee Therapeutics Inc. | 1.78% | 64,250 | $2.6M | Add +507.7% |
| TERN Terns Pharmaceuticals Inc. | 1.69% | 323,159 | $2.4M | Add +24.4% |
| ARDX Ardelyx Inc. | 1.54% | 400,000 | $2.2M | New |
| TGTX TG Therapeutics Inc. | 1.53% | 60,748 | $2.2M | Reduce -83.7% |
| ALKS Alkermes PLC | 1.51% | 72,079 | $2.2M | New |
| ROIV Roivant Sciences Ltd. | 1.26% | 120,000 | $1.8M | New |
| URGN Urogen Pharma Ltd. | 1.25% | 90,000 | $1.8M | Reduce -40.0% |
| PCRX Pacira Biosciences Inc. | 1.06% | 58,926 | $1.5M | No change |
| COGT Cogent Biosciences Inc. | 0.98% | 97,813 | $1.4M | Reduce -75.1% |
| NVO Novo-Nordisk A/S-Spons ADR | 0.97% | 25,000 | $1.4M | New |
| HRMY Harmony Biosciences Holdings | 0.96% | 50,000 | $1.4M | New |
| AMLX Amylyx Pharmaceuticals Inc. | 0.95% | 100,000 | $1.4M | New |
| RNAM Avidity Biosciences Inc. | 0.91% | 30,000 | $1.3M | New |
| MIND MEDICINE MINDMED INC | 0.87% | 105,891 | $1.2M | Reduce -33.2% |
| VTGN Vistagen Therapeutics Inc. | 0.86% | 349,789 | $1.2M | Reduce -13.4% |
| MNKD Mannkind Corp. | 0.79% | 212,475 | $1.1M | New |
| SUPN Supernus Pharmaceuticals Inc. | 0.74% | 22,348 | $1.1M | New |
| CPRX Catalyst Pharmaceuticals Inc. | 0.69% | 50,000 | $985K | New |
| REVIVA PHARMACEUTCLS HLDGS I | 0.64% | 2,506,921 | $924K | Reduce -8.3% |
| ARCT Arcturus Therapeutics Holdin | 0.63% | 48,811 | $900K | New |
| TRVI Trevi Therapeutics Inc. | 0.55% | 85,830 | $785K | Reduce -53.8% |
| XERS Xeris Biopharma Holdings Inc. | 0.42% | 74,753 | $608K | New |
| CTMX Cytomx Therapeutics Inc. | 0.41% | 185,286 | $591K | New |
| MRNA Moderna Inc. | 0.36% | 20,000 | $517K | New |
| AYTU Aytu Biopharma Inc. | 0.36% | 272,670 | $513K | New |
| TNYA Tenaya Therapeutics Inc. | 0.36% | 315,519 | $511K | New |
| EQ Equillium Inc. | 0.30% | 300,000 | $429K | New |
| ALEC Alector Inc. | 0.28% | 136,023 | $403K | Reduce -48.9% |
| PRQR Proqr Therapeutics NV | 0.23% | 157,694 | $336K | No change |
| PYXS Pyxis Oncology Inc. | 0.23% | 150,000 | $333K | New |
| PTHS Pelthos Therapeutics Inc. | 0.20% | 10,498 | $294K | New |
| RARE Ultragenyx Pharmaceutical Inc. | 0.19% | 9,189 | $276K | Reduce -83.0% |
| CLYM Climb Bio Inc. | 0.19% | 136,488 | $274K | Reduce -80.6% |
| NEUP Neuphoria Therapeutics Inc. | 0.18% | 21,452 | $253K | New |
| FHTX Foghorn Therapeutics Inc. | 0.17% | 50,000 | $245K | New |
| OVID Ovid Therapeutics Inc. | 0.17% | 187,739 | $244K | New |
| RLAY Relay Therapeutics Inc. | 0.16% | 43,616 | $228K | No change |
| VTYX Ventyx Biosciences Inc. | 0.15% | 71,204 | $221K | New |
| PRTCY Puretech Health PLC - ADR | 0.09% | 7,324 | $135K | No change |
| ANAB Anaptysbio Inc. | 0.07% | 3,295 | $101K | New |
| TVRD Tvardi Therapeutics Inc. | 0.06% | 2,185 | $85K | New |
| PMVP PMV Pharmaceuticals Inc. | 0.01% | 11,300 | $16K | New |
Options reported separately and not counted above: QURE puts ($17.5M), SPY puts ($13.3M), JAZZ calls ($13.2M), VKTX calls ($10.6M), AGIO calls ($8.9M), RNAM calls ($8.7M), INCY calls ($8.5M), NTLA calls ($8.1M), BMY calls ($8.1M), LLY puts ($7.6M), CRSP calls ($7.3M), BBIO calls ($6.8M), and 59 more.
Portfolio Sells Q2 2025 → Q3 2025
| AMGN Amgen Inc. | Sold out | 0.00% | −9.04 |
| LLY Eli Lilly & Co. | Sold out | 0.00% | −7.18 |
| TGTX TG Therapeutics Inc. | Reduce -83.7% | 1.53% | −6.78 |
| SLNO Soleno Therapeutics Inc. | Reduce -37.6% | 8.35% | −6.45 |
| JAZZ Jazz Pharmaceuticals PLC | Reduce -77.8% | 2.12% | −4.77 |
| NBIX Neurocrine Biosciences Inc. | Reduce -59.9% | 3.69% | −3.66 |
| VRTX Vertex Pharmaceuticals Inc. | Sold out | 0.00% | −2.77 |
| GILD Gilead Sciences Inc. | Sold out | 0.00% | −2.07 |
| ARGX Argenx SE - ADR | Sold out | 0.00% | −2.05 |
| SRRK Scholar Rock Holding Corp. | Sold out | 0.00% | −1.39 |
| ITOS Iteos Therapeutics Inc. | Sold out | 0.00% | −1.28 |
| VRDN Viridian Therapeutics Inc. | Sold out | 0.00% | −1.06 |
| RARE Ultragenyx Pharmaceutical Inc. | Reduce -83.0% | 0.19% | −1.03 |
| MRK Merck & Co. Inc. | Sold out | 0.00% | −0.98 |
| COGT Cogent Biosciences Inc. | Reduce -75.1% | 0.98% | −0.77 |
| OLMA Olema Pharmaceuticals Inc. | Sold out | 0.00% | −0.67 |
| ETNB 89BIO Inc. | Sold out | 0.00% | −0.60 |
| SCPH Scpharmaceuticals Inc. | Sold out | 0.00% | −0.52 |
| ARVN Arvinas Inc. | Sold out | 0.00% | −0.44 |
| CLYM Climb Bio Inc. | Reduce -80.6% | 0.19% | −0.35 |
| PTGX Protagonist Therapeutics Inc. | Reduce -32.8% | 2.37% | −0.25 |
| PHAT Phathom Pharmaceuticals Inc. | Sold out | 0.00% | −0.24 |
| NUVL Nuvalent Inc. Class A | Sold out | 0.00% | −0.24 |
| REPL Replimune Group Inc. | Sold out | 0.00% | −0.19 |
| ELDN Eledon Pharmaceuticals Inc. | Sold out | 0.00% | −0.11 |
| TRVI Trevi Therapeutics Inc. | Reduce -53.8% | 0.55% | −0.08 |
| ELEV Elevation Oncology Inc. | Sold out | 0.00% | −0.08 |
| URGN Urogen Pharma Ltd. | Reduce -40.0% | 1.25% | −0.03 |
| SMMT Summit Therapeutics Inc. | Sold out | 0.00% | −0.01 |
| ZLAB Zai Lab Ltd.-ADR | Sold out | 0.00% | −0.01 |
| REVIVA PHARMACEUTCLS HLDGS I | Reduce -8.3% | 0.64% | −0.00 |
| ALEC Alector Inc. | Reduce -48.9% | 0.28% | +0.05 |
| RVMD Revolution Medicines Inc. | Reduce -25.3% | 1.92% | +0.11 |
| MIND MEDICINE MINDMED INC | Reduce -33.2% | 0.87% | +0.23 |
| VKTX Viking Therapeutics Inc. | Reduce -1.9% | 3.55% | +0.29 |
| VTGN Vistagen Therapeutics Inc. | Reduce -13.4% | 0.86% | +0.36 |
Portfolio Buys Q2 2025 → Q3 2025
| REGN Regeneron Pharmaceuticals | Add +437.9% | 11.81% | +9.98 |
| INDV Indivior Ltd. | New | 4.27% | +4.27 |
| BMY Bristol-Myers Squibb Co. | New | 4.08% | +4.08 |
| ASND Ascendis Pharma A/S | New | 3.82% | +3.82 |
| ALNY Alnylam Pharmaceuticals Inc. | New | 3.18% | +3.18 |
| NKTR Nektar Therapeutics | New | 2.97% | +2.97 |
| ABVX Abivax SA-ADR | New | 2.45% | +2.45 |
| ANIP Ani Pharmaceuticals Inc. | New | 2.00% | +2.00 |
| ARDX Ardelyx Inc. | New | 1.54% | +1.54 |
| ALKS Alkermes PLC | New | 1.51% | +1.51 |
| APGE Apogee Therapeutics Inc. | Add +507.7% | 1.78% | +1.49 |
| PCVX Vaxcyte Inc. | Add +10.1% | 5.48% | +1.47 |
| BMRN Biomarin Pharmaceutical Inc. | Add +10.4% | 8.03% | +1.44 |
| ROIV Roivant Sciences Ltd. | New | 1.26% | +1.26 |
| IMCR Immunocore Holdings PLC-ADR | Add +19.2% | 3.15% | +1.11 |
| TERN Terns Pharmaceuticals Inc. | Add +24.4% | 1.69% | +1.09 |
| NVO Novo-Nordisk A/S-Spons ADR | New | 0.97% | +0.97 |
| HRMY Harmony Biosciences Holdings | New | 0.96% | +0.96 |
| AMLX Amylyx Pharmaceuticals Inc. | New | 0.95% | +0.95 |
| RNAM Avidity Biosciences Inc. | New | 0.91% | +0.91 |
| MNKD Mannkind Corp. | New | 0.79% | +0.79 |
| SUPN Supernus Pharmaceuticals Inc. | New | 0.74% | +0.74 |
| CPRX Catalyst Pharmaceuticals Inc. | New | 0.69% | +0.69 |
| ARCT Arcturus Therapeutics Holdin | New | 0.63% | +0.63 |
| XERS Xeris Biopharma Holdings Inc. | New | 0.42% | +0.42 |
| CTMX Cytomx Therapeutics Inc. | New | 0.41% | +0.41 |
| MRNA Moderna Inc. | New | 0.36% | +0.36 |
| AYTU Aytu Biopharma Inc. | New | 0.36% | +0.36 |
| TNYA Tenaya Therapeutics Inc. | New | 0.36% | +0.36 |
| EQ Equillium Inc. | New | 0.30% | +0.30 |
| PYXS Pyxis Oncology Inc. | New | 0.23% | +0.23 |
| PTHS Pelthos Therapeutics Inc. | New | 0.20% | +0.20 |
| NEUP Neuphoria Therapeutics Inc. | New | 0.18% | +0.18 |
| FHTX Foghorn Therapeutics Inc. | New | 0.17% | +0.17 |
| OVID Ovid Therapeutics Inc. | New | 0.17% | +0.17 |
| VTYX Ventyx Biosciences Inc. | New | 0.15% | +0.15 |
| ANAB Anaptysbio Inc. | New | 0.07% | +0.07 |
| TVRD Tvardi Therapeutics Inc. | New | 0.06% | +0.06 |
| PMVP PMV Pharmaceuticals Inc. | New | 0.01% | +0.01 |
Options Activity Q2 2025 → Q3 2025
| QURE Uniqure NV | put | New | 300,000 | $17.5M |
| AMGN Amgen Inc. | put | Sold out | 62,100 | $17.3Mbefore exit |
| SPY SS SPDR S&P 500 ETF Trust-US | put | New | 20,000 | $13.3M |
| JAZZ Jazz Pharmaceuticals PLC | call | Add +100.0% | 100,000 | $13.2M |
| VKTX Viking Therapeutics Inc. | call | New | 405,100 | $10.6M |
| AGIO Agios Pharmaceuticals Inc. | call | Add +81.9% | 222,100 | $8.9M |
| RNAM Avidity Biosciences Inc. | call | New | 200,100 | $8.7M |
| INCY Incyte Corp. | call | New | 100,000 | $8.5M |
| XBI SS SPDR S&P Biotech ETF | call | Sold out | 100,000 | $8.3Mbefore exit |
| NTLA Intellia Therapeutics Inc. | call | New | 470,200 | $8.1M |
| BMY Bristol-Myers Squibb Co. | call | New | 180,000 | $8.1M |
| LLY Eli Lilly & Co. | call | Sold out | 10,000 | $7.8Mbefore exit |
| LLY Eli Lilly & Co. | put | Reduce -51.7% | 10,000 | $7.6M |
| RVMD Revolution Medicines Inc. | call | Sold out | 200,000 | $7.4Mbefore exit |
| NVO Novo-Nordisk A/S-Spons ADR | call | Sold out | 100,000 | $6.9Mbefore exit |
| SLNO Soleno Therapeutics Inc. | put | New | 100,000 | $6.8M |
| JAZZ Jazz Pharmaceuticals PLC | put | New | 50,000 | $6.6M |
| IONS Ionis Pharmaceuticals Inc. | call | New | 100,000 | $6.5M |
| MNKD Mannkind Corp. | call | Add +99.9% | 1,039,500 | $5.6M |
| NVO Novo-Nordisk A/S-Spons ADR | put | New | 100,000 | $5.5M |
| PRAX Praxis Precision Medicines I | put | New | 100,000 | $5.3M |
| APGE Apogee Therapeutics Inc. | call | Reduce -18.5% | 127,400 | $5.1M |
| SPRY Ars Pharmaceuticals Inc. | call | Sold out | 280,700 | $4.9Mbefore exit |
| PFE Pfizer Inc. | call | Sold out | 200,000 | $4.8Mbefore exit |
| ROIV Roivant Sciences Ltd. | put | New | 300,000 | $4.5M |
| RARE Ultragenyx Pharmaceutical Inc. | call | Reduce -30.9% | 150,000 | $4.5M |
| HRMY Harmony Biosciences Holdings | call | New | 150,000 | $4.1M |
| UPB Upstream Bio Inc. | call | New | 200,000 | $3.8M |
| SRRK Scholar Rock Holding Corp. | call | New | 100,000 | $3.7M |
| SLNO Soleno Therapeutics Inc. | call | New | 50,000 | $3.4M |
| ZYME Zymeworks Inc. | call | Add +9.6% | 196,500 | $3.4M |
| MREO Mereo Biopharma Group PL-ADR | call | Add +15.4% | 1,520,200 | $3.1M |
| COGT Cogent Biosciences Inc. | call | Add +2798.6% | 200,000 | $2.9M |
| ARCT Arcturus Therapeutics Holdin | put | New | 150,900 | $2.8M |
| SCPH Scpharmaceuticals Inc. | call | Reduce -5.0% | 462,000 | $2.6M |
| REPL Replimune Group Inc. | call | New | 612,300 | $2.6M |
| ABUS Arbutus Biopharma Corp. | call | New | 516,300 | $2.3M |
| CORT Corcept Therapeutics Inc. | put | Reduce -73.5% | 26,500 | $2.2M |
| CAPR Capricor Therapeutics Inc. | call | New | 300,000 | $2.2M |
| MLTX Moonlake Immunotherapeutics | put | Sold out | 41,300 | $1.9Mbefore exit |
| ACAD Acadia Pharmaceuticals Inc. | call | Add +0.1% | 89,000 | $1.9M |
| MBX MBX Biosciences Inc. | call | New | 100,000 | $1.8M |
| ALT Altimmune Inc. | call | Reduce -63.3% | 463,000 | $1.7M |
| TERN Terns Pharmaceuticals Inc. | call | Add +40.0% | 225,200 | $1.7M |
| TECX Tectonic Therapeutic Inc. | call | New | 100,000 | $1.6M |
| REVIVA PHARMACEUTCLS HLDGS I | call | Sold out | 4,000,000 | $1.5Mbefore exit |
| NVAX Novavax Inc. | call | New | 173,500 | $1.5M |
| QURE Uniqure NV | call | Sold out | 104,100 | $1.5Mbefore exit |
| COGT Cogent Biosciences Inc. | put | Sold out | 201,400 | $1.4Mbefore exit |
| BHVN Biohaven Ltd. | call | Sold out | 100,000 | $1.4Mbefore exit |
Showing the first 50 of 77.
Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 77 | $264.6M | UTHR, RVMD, ABVX, COGT, BMRN |
| Q1 2026 | 86 | $242.2M | BRIDGEBIO PHARMA INC (BBIO 1.75 03/01/31), VKTX, UTHR, JNJ, COGT |
| Q4 2025 | 73 | $167.9M | TERN, JNJ, VKTX, ABVX, BMRN |
| Q3 2025 | 59 | $143.6M | REGN, SLNO, BMRN, PCVX, INDV |
| Q2 2025 | 46 | $160.8M | SLNO, AMGN, TGTX, NBIX, LLY |
| Q1 2025 | 43 | $125.1M | REGN, LLY, JAZZ, TGTX, ARGX |
| Q4 2024 | 54 | $88.7M | BMY, ABBV, TEVA, BPMC, RYTM |