Orbimed Advisors LLC

In its 13F for Q1 2024 (holdings as of March 31, 2024, filed May 15, 2024), Orbimed Advisors LLC reported 112 stock positions worth $5.4 billion. Its top holding was Sinovac Biotech (SVA) at 6.2% of the portfolio, followed by Eli Lilly (LLY, 5.2%) and Edgewise Therapeutics (EWTX, 5.0%). Compared with Q4 2023, it opened 20 new positions, sold out of 17, added to 22 and reduced 29. The biggest buy was Janux Therapeutics (JANX, shares +29%) and the biggest sale an exit from Rayzebio (RYZB).

Most Recent 13F
Q2 2026
Location
New York, NY
CIK
0001055951
Portfolio Value
$5.4B (Q1 2024)
SEC Filing
0001172661-24-002506 ↗ filed May 15, 2024

Holdings Value

0$2.0B$4.0B$6.0B Q1 2024: $5.4B $5.4B Q1 2024 Q2 2024: $5.0B Q2 2024 Q3 2024: $5.5B Q3 2024 Q4 2024: $4.8B Q4 2024 Q1 2025: $4.2B Q1 2025 Q2 2025: $4.0B Q2 2025 Q3 2025: $4.2B Q3 2025 Q4 2025: $4.9B Q4 2025 Q1 2026: $4.4B Q1 2026 Q2 2026: $5.3B Q2 2026

Holdings 112 stocks · $5.4B
SVA Sinovac Biotech Ltd. 6.24% 2,718,735 $340.0M No change
LLY Eli Lilly & Co. 5.15% 360,800 $280.7M Reduce -1.3%
EWTX Edgewise Therapeutics Inc. 5.03% 15,021,721 $274.0M Add +3.1%
BSX Boston Scientific Corp. 4.12% 3,273,000 $224.2M Reduce -1.0%
ISRG Intuitive Surgical Inc. 3.61% 493,100 $196.8M Reduce -1.2%
BIIB Biogen Inc. 3.57% 900,900 $194.3M Add +8.9%
MRK Merck & Co. Inc. 3.19% 1,316,000 $173.6M Add +24.7%
JANX Janux Therapeutics Inc. 2.96% 4,275,553 $161.0M Add +28.9%
ELVN Enliven Therapeutics Inc. 2.91% 8,998,338 $158.3M No change
THC Tenet Healthcare Corp. 2.26% 1,173,300 $123.3M Reduce -4.2%
BMRN Biomarin Pharmaceutical Inc. 2.05% 1,278,500 $111.7M Reduce -18.6%
ALPN Alpine Immune Sciences Inc. 1.95% 2,680,496 $106.3M Add +5.7%
IRON Disc Medicine Inc. 1.95% 1,702,237 $106.0M No change
SYK Stryker Corp. 1.77% 269,000 $96.3M No change
SPRY Ars Pharmaceuticals Inc. 1.73% 9,240,887 $94.4M No change
SRPT Sarepta Therapeutics Inc. 1.66% 697,500 $90.3M No change
IONS Ionis Pharmaceuticals Inc. 1.60% 2,013,033 $87.3M Reduce -2.5%
ELV Elevance Health Inc. 1.60% 168,100 $87.2M Add +18.8%
XTNT Xtant Medical Holdings Inc. 1.57% 73,114,592 $85.5M No change
EVH Evolent Health Inc. Class A 1.57% 2,605,615 $85.4M Reduce -5.1%
SWTX Springworks Therapeutics Inc. 1.54% 1,707,331 $84.0M Reduce -47.0%
KROS Keros Therapeutics Inc. 1.54% 1,268,734 $84.0M No change
NTRA Natera Inc. 1.51% 899,431 $82.3M Reduce -5.8%
TMO Thermo Fisher Scientific Inc. 1.41% 132,000 $76.7M Reduce -8.2%
APLS Apellis Pharmaceuticals Inc. 1.40% 1,297,800 $76.3M Add +40.7%
PCVX Vaxcyte Inc. 1.34% 1,066,131 $72.8M Reduce -7.5%
CRNX Crinetics Pharmaceuticals Inc. 1.19% 1,385,000 $64.8M Reduce -16.9%
SRRK Scholar Rock Holding Corp. 1.17% 3,574,632 $63.5M Reduce -15.8%
ARGX Argenx SE - ADR 1.10% 151,600 $59.7M Add +79.2%
ICLR Icon PLC 1.07% 174,100 $58.5M Add +31.7%
NBIX Neurocrine Biosciences Inc. 1.07% 423,100 $58.4M Reduce -18.5%
VRNA Verona Pharma Ltd. 1.00% 3,398,067 $54.7M Reduce -10.1%
THRD Third Harmonic Bio Inc. 1.00% 5,779,071 $54.6M No change
AVBP Arrivent Biopharma Inc. 0.99% 3,027,328 $54.1M New
NPCE Neuropace Inc. 0.97% 4,003,967 $52.9M No change
SIBN Si-Bone Inc. 0.95% 3,174,521 $52.0M Add +38.5%
PRLD Prelude Therapeutics Inc. 0.95% 10,909,256 $51.7M No change
VRTX Vertex Pharmaceuticals Inc. 0.94% 122,700 $51.3M Reduce -30.0%
TERN Terns Pharmaceuticals Inc. 0.92% 7,619,135 $50.0M No change
CYTK Cytokinetics Inc. 0.88% 682,700 $47.9M New
APGE Apogee Therapeutics Inc. 0.88% 718,901 $47.8M Reduce -43.7%
CMPX Compass Therapeutics Inc. 0.81% 22,362,850 $44.3M No change
GERN Geron Corp. 0.78% 12,893,611 $42.5M Add +2558.5%
SNDX Syndax Pharmaceuticals Inc. 0.76% 1,749,000 $41.6M No change
QTTB Q32 Bio Inc. 0.70% 2,252,987 $38.4M New
ESPR Esperion Therapeutics Inc. 0.67% 13,708,731 $36.7M New
0 0.66% 12,048,773 $36.0M No change
UNH Unitedhealth Group Inc. 0.64% 70,000 $34.6M No change
RYTM Rhythm Pharmaceuticals Inc. 0.56% 704,842 $30.5M Add +31.3%
ALXO Alx Oncology Holdings Inc. 0.56% 2,717,970 $30.3M Reduce -12.2%
VERA Vera Therapeutics Inc. 0.54% 675,872 $29.1M Reduce -55.5%
PRAX Praxis Precision Medicines I 0.52% 460,512 $28.1M New
HRTX Heron Therapeutics Inc. 0.51% 10,111,550 $28.0M Add +70.6%
SCPH Scpharmaceuticals Inc. 0.51% 5,559,528 $27.9M No change
SLRN Acelyrin Inc. 0.50% 4,001,711 $27.0M No change
ACET Adicet Bio Inc. 0.49% 11,447,140 $26.9M Add +37.5%
MLYS Mineralys Therapeutics Inc. 0.48% 2,021,424 $26.1M New
RNAM Avidity Biosciences Inc. 0.47% 994,100 $25.4M New
XENE Xenon Pharmaceuticals Inc. 0.43% 550,000 $23.7M No change
REGN Regeneron Pharmaceuticals 0.40% 22,800 $21.9M Add +68.9%
KNTE Kinnate Biopharma Inc. 0.39% 8,009,729 $21.3M No change
ARWR Arrowhead Pharmaceuticals Inc. 0.39% 739,651 $21.2M Add +131.4%
NMRA Neumora Therapeutics Inc. 0.38% 1,500,000 $20.6M No change
DYN Dyne Therapeutics Inc. 0.37% 708,400 $20.1M New
MORF Morphic Holding Inc. 0.36% 558,500 $19.7M Add +104.3%
DXCM Dexcom Inc. 0.36% 140,300 $19.5M Add +91.7%
ABCL Abcellera Biologics Inc. 0.35% 4,180,768 $18.9M No change
IMTX Immatics NV 0.34% 1,769,708 $18.6M Add +14.7%
VSTM Verastem Inc. 0.33% 1,529,115 $18.0M No change
AMGN Amgen Inc. 0.33% 63,400 $18.0M Reduce -50.2%
AEROVATE THERAPEUTICS INC 0.31% 565,374 $16.7M Reduce -25.3%
TELA Tela Bio Inc. 0.30% 2,835,542 $16.1M No change
RPTX Repare Therapeutics Inc. 0.29% 3,322,488 $15.6M No change
PASG Passage Bio Inc. 0.25% 10,124,576 $13.7M No change
TYRA Tyra Biosciences Inc. 0.23% 768,638 $12.6M New
CRVS Corvus Pharmaceuticals Inc. 0.23% 6,943,654 $12.4M No change
IVVD Invivyd Inc. 0.22% 2,690,300 $11.9M Reduce -34.8%
PMVP PMV Pharmaceuticals Inc. 0.20% 6,475,291 $11.0M No change
VTYX Ventyx Biosciences Inc. 0.19% 1,870,456 $10.3M New
FATE Fate Therapeutics Inc. 0.18% 1,355,352 $9.9M Add +156.7%
XFOR X4 Pharmaceuticals Inc. 0.18% 7,133,515 $9.9M No change
EXAS Exact Sciences Corp. 0.18% 140,400 $9.7M New
CGEM Cullinan Therapeutics Inc. 0.16% 517,606 $8.8M Reduce -5.0%
NKTX Nkarta Inc. 0.16% 800,000 $8.6M New
LXRX Lexicon Pharmaceuticals Inc. 0.16% 3,542,000 $8.5M New
TXG 10X Genomics Inc. Class A 0.16% 225,200 $8.5M Add +465.8%
TSBX Turnstone Biologics Corp. 0.15% 3,099,265 $8.1M No change
CATX Perspective Therapeutics Inc. 0.14% 6,505,800 $7.7M New
CTMX Cytomx Therapeutics Inc. 0.14% 3,544,578 $7.7M New
FOLD Amicus Therapeutics Inc. 0.12% 570,300 $6.7M Reduce -29.2%
KRYS Krystal Biotech Inc. 0.12% 37,166 $6.6M Reduce -64.2%
VIR Vir Biotechnology Inc. 0.12% 640,000 $6.5M Add +533.7%
APLM Apollomics Inc. 0.12% 8,565,456 $6.4M No change
NSPR Inspiremd Inc. 0.09% 2,133,405 $5.1M No change
IKENA ONCOLOGY INC 0.09% 3,539,358 $5.0M No change
ELEV Elevation Oncology Inc. 0.09% 941,275 $4.8M Reduce -37.3%
PGNY Progyny Inc. 0.08% 113,300 $4.3M New
ORIC Oric Pharmaceuticals Inc. 0.07% 287,100 $3.9M Reduce -45.1%
MIST Milestone Pharmaceuticals Inc. 0.07% 2,000,000 $3.6M New
NXTC Nextcure Inc. 0.05% 1,141,200 $2.5M Reduce -57.9%
BOLT Bolt Biotherapeutics Inc. 0.04% 1,541,000 $2.2M No change
BIOMX INC 0.04% 4,517,589 $2.0M No change
CMMB Chemomab Therapeutics Ltd. 0.03% 2,241,274 $1.7M No change
KEZAR LIFE SCIENCES INC 0.03% 1,927,000 $1.7M No change
VIGL Vigil Neuroscience Inc. 0.03% 448,891 $1.5M No change
DVAX Dynavax Technologies Corp. 0.03% 113,500 $1.4M New
CALC Calcimedica Inc. 0.02% 297,380 $1.2M No change
LAKESHORE BIOPHARMA CO LTD filed as YS BIOPHARMA CO LTD 0.02% 1,534,430 $1.1M Reduce -52.6%
AFIB Acutus Medical Inc. 0.01% 2,648,386 $498K No change
LYEL Lyell Immunopharma Inc. 0.01% 199,500 $445K New
SINGULAR GENOMICS SYSTEMS IN 0.01% 540,697 $278K No change
XERS Xeris Biopharma Holdings Inc. 0.00% 80,420 $178K New

Options reported separately and not counted above: APLS calls ($8.8M), SIBN calls ($4.1M).

Portfolio Sells Q4 2023 → Q1 2024
RYZB Rayzebio Inc. Sold out 0.00% −2.95
GRCL Gracell Biotechnologies-ADR Sold out 0.00% −1.87
UTHR United Therapeutics Corp. Sold out 0.00% −1.70
THRX Theseus Pharmaceuticals Inc. Sold out 0.00% −1.44
RCM R1 RCM Inc. Sold out 0.00% −1.02
HUM Humana Inc. Sold out 0.00% −1.01
BMRN Biomarin Pharmaceutical Inc. Reduce -18.6% 2.05% −0.98
SWTX Springworks Therapeutics Inc. Reduce -47.0% 1.54% −0.81
IOVA Iovance Biotherapeutics Inc. Sold out 0.00% −0.77
FUSN Fusion Pharmaceuticals Inc. Sold out 0.00% −0.60
VRNA Verona Pharma Ltd. Reduce -10.1% 1.00% −0.50
IONS Ionis Pharmaceuticals Inc. Reduce -2.5% 1.60% −0.49
VRTX Vertex Pharmaceuticals Inc. Reduce -30.0% 0.94% −0.49
SRRK Scholar Rock Holding Corp. Reduce -15.8% 1.17% −0.43
AMGN Amgen Inc. Reduce -50.2% 0.33% −0.40
ALXO Alx Oncology Holdings Inc. Reduce -12.2% 0.56% −0.37
ALNY Alnylam Pharmaceuticals Inc. Sold out 0.00% −0.30
NBIX Neurocrine Biosciences Inc. Reduce -18.5% 1.07% −0.30
EVH Evolent Health Inc. Class A Reduce -5.1% 1.57% −0.25
QURE Uniqure NV Sold out 0.00% −0.18
GILD Gilead Sciences Inc. Sold out 0.00% −0.16
RAPT THERAPEUTICS INC Sold out 0.00% −0.14
KRYS Krystal Biotech Inc. Reduce -64.2% 0.12% −0.14
TMO Thermo Fisher Scientific Inc. Reduce -8.2% 1.41% −0.12
PCVX Vaxcyte Inc. Reduce -7.5% 1.34% −0.11
IVVD Invivyd Inc. Reduce -34.8% 0.22% −0.11
FOLD Amicus Therapeutics Inc. Reduce -29.2% 0.12% −0.11
ILMN Illumina Inc. Sold out 0.00% −0.08
AMAM New Ambrx Biopharma Inc. Sold out 0.00% −0.08
CLDX Celldex Therapeutics Inc. Sold out 0.00% −0.05
RCUS Arcus Biosciences Inc. Sold out 0.00% −0.04
AEROVATE THERAPEUTICS INC Reduce -25.3% 0.31% −0.04
ORIC Oric Pharmaceuticals Inc. Reduce -45.1% 0.07% −0.02
AGIO Agios Pharmaceuticals Inc. Sold out 0.00% −0.02
NXTC Nextcure Inc. Reduce -57.9% 0.05% −0.02
LAKESHORE BIOPHARMA CO LTD Reduce -52.6% 0.02% −0.01
CRNX Crinetics Pharmaceuticals Inc. Reduce -16.9% 1.19% +0.00
CGEM Cullinan Therapeutics Inc. Reduce -5.0% 0.16% +0.05
VERA Vera Therapeutics Inc. Reduce -55.5% 0.54% +0.07
ELEV Elevation Oncology Inc. Reduce -37.3% 0.09% +0.07
APGE Apogee Therapeutics Inc. Reduce -43.7% 0.88% +0.16
ISRG Intuitive Surgical Inc. Reduce -1.2% 3.61% +0.24
BSX Boston Scientific Corp. Reduce -1.0% 4.12% +0.29
NTRA Natera Inc. Reduce -5.8% 1.51% +0.31
THC Tenet Healthcare Corp. Reduce -4.2% 2.26% +0.41
LLY Eli Lilly & Co. Reduce -1.3% 5.15% +0.89

Portfolio Buys Q4 2023 → Q1 2024
JANX Janux Therapeutics Inc. Add +28.9% 2.96% +2.24
EWTX Edgewise Therapeutics Inc. Add +3.1% 5.03% +1.84
AVBP Arrivent Biopharma Inc. New 0.99% +0.99
ALPN Alpine Immune Sciences Inc. Add +5.7% 1.95% +0.98
MRK Merck & Co. Inc. Add +24.7% 3.19% +0.88
CYTK Cytokinetics Inc. New 0.88% +0.88
GERN Geron Corp. Add +2558.5% 0.78% +0.76
QTTB Q32 Bio Inc. New 0.70% +0.70
ESPR Esperion Therapeutics Inc. New 0.67% +0.67
PRAX Praxis Precision Medicines I New 0.52% +0.52
MLYS Mineralys Therapeutics Inc. New 0.48% +0.48
RNAM Avidity Biosciences Inc. New 0.47% +0.47
ARGX Argenx SE - ADR Add +79.2% 1.10% +0.45
DYN Dyne Therapeutics Inc. New 0.37% +0.37
ICLR Icon PLC Add +31.7% 1.07% +0.32
HRTX Heron Therapeutics Inc. Add +70.6% 0.51% +0.31
APLS Apellis Pharmaceuticals Inc. Add +40.7% 1.40% +0.29
ELV Elevance Health Inc. Add +18.8% 1.60% +0.26
TYRA Tyra Biosciences Inc. New 0.23% +0.23
MORF Morphic Holding Inc. Add +104.3% 0.36% +0.20
ARWR Arrowhead Pharmaceuticals Inc. Add +131.4% 0.39% +0.19
VTYX Ventyx Biosciences Inc. New 0.19% +0.19
ACET Adicet Bio Inc. Add +37.5% 0.49% +0.18
EXAS Exact Sciences Corp. New 0.18% +0.18
DXCM Dexcom Inc. Add +91.7% 0.36% +0.18
REGN Regeneron Pharmaceuticals Add +68.9% 0.40% +0.17
NKTX Nkarta Inc. New 0.16% +0.16
LXRX Lexicon Pharmaceuticals Inc. New 0.16% +0.16
FATE Fate Therapeutics Inc. Add +156.7% 0.18% +0.14
CATX Perspective Therapeutics Inc. New 0.14% +0.14
CTMX Cytomx Therapeutics Inc. New 0.14% +0.14
TXG 10X Genomics Inc. Class A Add +465.8% 0.16% +0.11
VIR Vir Biotechnology Inc. Add +533.7% 0.12% +0.10
PGNY Progyny Inc. New 0.08% +0.08
RYTM Rhythm Pharmaceuticals Inc. Add +31.3% 0.56% +0.07
MIST Milestone Pharmaceuticals Inc. New 0.07% +0.07
DVAX Dynavax Technologies Corp. New 0.03% +0.03
IMTX Immatics NV Add +14.7% 0.34% +0.02
LYEL Lyell Immunopharma Inc. New 0.01% +0.01
XERS Xeris Biopharma Holdings Inc. New 0.00% +0.00
SIBN Si-Bone Inc. Add +38.5% 0.95% −0.01
BIIB Biogen Inc. Add +8.9% 3.57% −0.72

Options Activity Q4 2023 → Q1 2024
PFE Pfizer Inc. call Sold out 500,000 $14.4Mbefore exit
APLS Apellis Pharmaceuticals Inc. call New 150,000 $8.8M
SIBN Si-Bone Inc. call New 250,000 $4.1M

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 117$5.3BEWTX, ELVN, LLY, MBX, SVA
Q1 2026 105$4.4BEWTX, ELVN, LLY, SVA, BSX
Q4 2025 104$4.9BEWTX, LLY, BSX, SVA, EW
Q3 2025 98$4.2BEWTX, BSX, LLY, SVA, ELVN
Q2 2025 97$4.0BSVA, BSX, LLY, EWTX, ELVN
Q1 2025 106$4.2BSVA, EWTX, BSX, LLY, ELVN
Q4 2024 111$4.8BEWTX, SVA, BSX, LLY, ISRG
Q3 2024 109$5.5BEWTX, SVA, LLY, BSX, ISRG
Q2 2024 108$5.0BSVA, LLY, EWTX, BSX, ISRG
Q1 2024 112$5.4BSVA, LLY, EWTX, BSX, ISRG