Orbimed Advisors LLC
In its 13F for Q4 2024 (holdings as of December 31, 2024, filed February 14, 2025), Orbimed Advisors LLC reported 111 stock positions worth $4.8 billion. Its top holding was Edgewise Therapeutics (EWTX) at 8.3% of the portfolio, followed by Sinovac Biotech (SVA, 6.9%) and Boston Scientific (BSX, 5.9%). Compared with Q3 2024, it opened 19 new positions, sold out of 17, added to 23 and reduced 21. The biggest buy was Neurocrine Biosciences (NBIX, shares +210%) and the biggest sale an exit from Amgen (AMGN).
- Most Recent 13F
- Q2 2026
- Location
- New York, NY
- CIK
- 0001055951
- Portfolio Value
- $4.8B (Q4 2024)
- SEC Filing
- 0001172661-25-001136 ↗ filed Feb 14, 2025
Holdings Value
Holdings 111 stocks · $4.8B
| EWTX Edgewise Therapeutics Inc. | 8.33% | 15,021,721 | $401.1M | No change |
| SVA Sinovac Biotech Ltd. | 6.94% | 2,718,735 | $334.0M | No change |
| BSX Boston Scientific Corp. | 5.86% | 3,160,300 | $282.3M | Reduce -3.4% |
| LLY Eli Lilly & Co. | 5.41% | 337,600 | $260.6M | No change |
| ISRG Intuitive Surgical Inc. | 4.35% | 401,700 | $209.7M | Reduce -7.4% |
| ELVN Enliven Therapeutics Inc. | 3.72% | 7,959,538 | $179.1M | No change |
| NBIX Neurocrine Biosciences Inc. | 2.66% | 938,120 | $128.1M | Add +210.4% |
| SYK Stryker Corp. | 2.57% | 344,400 | $124.0M | No change |
| SRPT Sarepta Therapeutics Inc. | 2.43% | 963,400 | $117.1M | Add +0.9% |
| ARGX Argenx SE - ADR | 2.42% | 189,700 | $116.7M | Reduce -7.2% |
| IRON Disc Medicine Inc. | 2.35% | 1,785,571 | $113.2M | No change |
| THC Tenet Healthcare Corp. | 2.08% | 792,000 | $100.0M | Add +1.3% |
| IONS Ionis Pharmaceuticals Inc. | 2.05% | 2,817,347 | $98.5M | Add +21.2% |
| ALNY Alnylam Pharmaceuticals Inc. | 2.03% | 415,600 | $97.8M | Add +66.0% |
| UPB Upstream Bio Inc. | 1.94% | 5,693,589 | $93.6M | New |
| SPRY Ars Pharmaceuticals Inc. | 1.82% | 8,288,510 | $87.4M | No change |
| EW Edwards Lifesciences Corp. | 1.76% | 1,145,302 | $84.8M | New |
| MRK Merck & Co. Inc. | 1.71% | 829,900 | $82.6M | Reduce -36.9% |
| AVBP Arrivent Biopharma Inc. | 1.67% | 3,027,328 | $80.6M | No change |
| BIIB Biogen Inc. | 1.62% | 509,100 | $77.9M | Reduce -37.4% |
| ITGR Integer Holdings Corp. | 1.58% | 575,000 | $76.2M | No change |
| CYTK Cytokinetics Inc. | 1.55% | 1,584,005 | $74.5M | Add +106.5% |
| MBX MBX Biosciences Inc. | 1.46% | 3,812,215 | $70.3M | No change |
| UNH Unitedhealth Group Inc. | 1.37% | 130,900 | $66.2M | Reduce -26.9% |
| NTRA Natera Inc. | 1.36% | 413,000 | $65.4M | Reduce -39.9% |
| VRTX Vertex Pharmaceuticals Inc. | 1.26% | 151,000 | $60.8M | No change |
| THRD Third Harmonic Bio Inc. | 1.23% | 5,779,071 | $59.5M | No change |
| CRNX Crinetics Pharmaceuticals Inc. | 1.06% | 999,000 | $51.1M | Reduce -4.9% |
| UHS Universal Health Services-B | 1.00% | 269,300 | $48.3M | Add +72.6% |
| SIBN Si-Bone Inc. | 1.00% | 3,442,853 | $48.3M | Add +4.2% |
| SWTX Springworks Therapeutics Inc. | 0.94% | 1,255,031 | $45.3M | Reduce -9.8% |
| TMO Thermo Fisher Scientific Inc. | 0.91% | 84,400 | $43.9M | No change |
| TERN Terns Pharmaceuticals Inc. | 0.87% | 7,562,971 | $41.9M | No change |
| CGON CG Oncology Inc. | 0.85% | 1,431,114 | $41.0M | Add +107.1% |
| JANX Janux Therapeutics Inc. | 0.84% | 758,566 | $40.6M | Reduce -39.7% |
| EXAS Exact Sciences Corp. | 0.79% | 679,816 | $38.2M | No change |
| NPCE Neuropace Inc. | 0.79% | 3,406,335 | $38.1M | No change |
| XENE Xenon Pharmaceuticals Inc. | 0.77% | 947,877 | $37.2M | Add +4.0% |
| CRVS Corvus Pharmaceuticals Inc. | 0.77% | 6,943,654 | $37.1M | No change |
| XBI SS SPDR S&P Biotech ETF | 0.70% | 372,000 | $33.5M | New |
| CMPX Compass Therapeutics Inc. | 0.67% | 22,362,850 | $32.4M | No change |
| XTNT Xtant Medical Holdings Inc. | 0.67% | 73,114,592 | $32.4M | No change |
| RNAM Avidity Biosciences Inc. | 0.67% | 1,112,886 | $32.4M | Add +6.5% |
| VERA Vera Therapeutics Inc. | 0.65% | 742,572 | $31.4M | Add +9.9% |
| DYN Dyne Therapeutics Inc. | 0.60% | 1,227,080 | $28.9M | Add +73.2% |
| CGEM Cullinan Therapeutics Inc. | 0.49% | 1,942,555 | $23.7M | Add +81.5% |
| VIR Vir Biotechnology Inc. | 0.49% | 3,218,617 | $23.6M | Reduce -9.9% |
| GILD Gilead Sciences Inc. | 0.47% | 245,600 | $22.7M | Add +61.9% |
| RYTM Rhythm Pharmaceuticals Inc. | 0.46% | 400,000 | $22.4M | Reduce -8.2% |
| IMTX Immatics NV | 0.46% | 3,087,462 | $22.0M | Add +53.9% |
| FOLD Amicus Therapeutics Inc. | 0.45% | 2,285,400 | $21.5M | Add +300.7% |
| SCPH Scpharmaceuticals Inc. | 0.45% | 6,059,528 | $21.5M | No change |
| RAPT THERAPEUTICS INC | 0.43% | 13,135,260 | $20.8M | New |
| TYRA Tyra Biosciences Inc. | 0.42% | 1,470,086 | $20.4M | Add +91.3% |
| MLYS Mineralys Therapeutics Inc. | 0.41% | 1,611,637 | $19.8M | Reduce -19.5% |
| 0 | 0.37% | 12,048,773 | $17.7M | No change |
| GPCR Structure Therapeutics Inc. | 0.37% | 652,028 | $17.7M | Add +69.9% |
| KROS Keros Therapeutics Inc. | 0.33% | 1,018,734 | $16.1M | No change |
| CCCC C4 Therapeutics Inc. | 0.33% | 4,377,900 | $15.8M | No change |
| MEDP Medpace Holdings Inc. | 0.31% | 44,900 | $14.9M | No change |
| VSTM Verastem Inc. | 0.31% | 2,862,448 | $14.8M | No change |
| PRLD Prelude Therapeutics Inc. | 0.29% | 10,909,256 | $13.9M | No change |
| CRBP Corbus Pharmaceuticals Holdi | 0.29% | 1,172,287 | $13.8M | Add +28.5% |
| FBRX Forte Biosciences Inc. | 0.28% | 600,000 | $13.6M | New |
| ITCI Intra-Cellular Therapies Inc. | 0.28% | 163,000 | $13.6M | New |
| SLRN Acelyrin Inc. | 0.26% | 4,001,711 | $12.6M | No change |
| ABCL Abcellera Biologics Inc. | 0.25% | 4,180,768 | $12.2M | No change |
| ADCT Adc Therapeutics SA | 0.25% | 5,968,451 | $11.9M | Add +31.6% |
| ACET Adicet Bio Inc. | 0.23% | 11,447,140 | $11.0M | No change |
| PMVP PMV Pharmaceuticals Inc. | 0.20% | 6,475,291 | $9.8M | No change |
| NMRA Neumora Therapeutics Inc. | 0.18% | 804,996 | $8.5M | Reduce -46.3% |
| QTTB Q32 Bio Inc. | 0.16% | 2,252,987 | $7.8M | No change |
| GERN Geron Corp. | 0.16% | 2,168,000 | $7.7M | New |
| AVTX Avalo Therapeutics Inc. | 0.15% | 967,000 | $7.2M | No change |
| CRDF Cardiff Oncology Inc. | 0.14% | 1,538,462 | $6.7M | New |
| SRRK Scholar Rock Holding Corp. | 0.14% | 151,800 | $6.6M | Reduce -79.5% |
| INSM Insmed Inc. | 0.14% | 94,559 | $6.5M | New |
| ENGN Engene Holdings Inc. | 0.13% | 920,339 | $6.1M | New |
| IKENA ONCOLOGY INC | 0.12% | 3,539,358 | $5.8M | No change |
| NSPR Inspiremd Inc. | 0.12% | 2,133,405 | $5.6M | No change |
| TRAW Traws Pharma Inc. | 0.11% | 605,531 | $5.4M | No change |
| BIOA Bioage Labs Inc. | 0.11% | 921,959 | $5.3M | Reduce -35.2% |
| XFOR X4 Pharmaceuticals Inc. | 0.11% | 7,133,515 | $5.2M | No change |
| BCAX Bicara Therapeutics Inc. | 0.11% | 298,301 | $5.2M | Add +9.7% |
| MIST Milestone Pharmaceuticals Inc. | 0.10% | 2,000,000 | $4.7M | No change |
| RPTX Repare Therapeutics Inc. | 0.09% | 3,322,488 | $4.4M | No change |
| PASG Passage Bio Inc. | 0.09% | 7,404,869 | $4.2M | Reduce -24.6% |
| KRYS Krystal Biotech Inc. | 0.08% | 23,500 | $3.7M | No change |
| ARDT Ardent Health Inc. | 0.07% | 206,000 | $3.5M | No change |
| CMMB Chemomab Therapeutics Ltd. | 0.07% | 1,741,273 | $3.2M | No change |
| CBLL Ceribell Inc. | 0.06% | 112,500 | $2.9M | New |
| FATE Fate Therapeutics Inc. | 0.06% | 1,680,580 | $2.8M | No change |
| PEPG Pepgen Inc. | 0.05% | 653,016 | $2.5M | Reduce -18.1% |
| TIL Instil Bio Inc. | 0.05% | 116,785 | $2.2M | Add +246.5% |
| NKTX Nkarta Inc. | 0.04% | 821,400 | $2.0M | Reduce -44.5% |
| LYEL Lyell Immunopharma Inc. | 0.04% | 3,103,623 | $2.0M | Reduce -49.0% |
| IMVT Immunovant Inc. | 0.04% | 78,500 | $1.9M | New |
| AKRO Akero Therapeutics Inc. | 0.04% | 66,000 | $1.8M | New |
| TNGX Tango Therapeutics Inc. | 0.04% | 550,000 | $1.7M | New |
| TSBX Turnstone Biologics Corp. | 0.03% | 3,099,265 | $1.5M | No change |
Options reported separately and not counted above: GILD calls ($18.5M), UHS calls ($9.0M), PFE calls ($6.6M), GPCR calls ($4.1M), SIBN calls ($3.5M), THC calls ($3.2M), CCCC calls ($540K).
Portfolio Sells Q3 2024 → Q4 2024
| AMGN Amgen Inc. | Sold out | 0.00% | −1.49 |
| BIIB Biogen Inc. | Reduce -37.4% | 1.62% | −1.27 |
| MRK Merck & Co. Inc. | Reduce -36.9% | 1.71% | −1.02 |
| ELV Elevance Health Inc. | Sold out | 0.00% | −1.01 |
| REGN Regeneron Pharmaceuticals | Sold out | 0.00% | −0.87 |
| EVH Evolent Health Inc. Class A | Sold out | 0.00% | −0.86 |
| PCVX Vaxcyte Inc. | Sold out | 0.00% | −0.81 |
| SNDX Syndax Pharmaceuticals Inc. | Sold out | 0.00% | −0.68 |
| APLS Apellis Pharmaceuticals Inc. | Sold out | 0.00% | −0.67 |
| ICLR Icon PLC | Sold out | 0.00% | −0.65 |
| UNH Unitedhealth Group Inc. | Reduce -26.9% | 1.37% | −0.54 |
| PHAT Phathom Pharmaceuticals Inc. | Sold out | 0.00% | −0.48 |
| BIOA Bioage Labs Inc. | Reduce -35.2% | 0.11% | −0.43 |
| APGE Apogee Therapeutics Inc. | Sold out | 0.00% | −0.41 |
| LXRX Lexicon Pharmaceuticals Inc. | Sold out | 0.00% | −0.32 |
| NTRA Natera Inc. | Reduce -39.9% | 1.36% | −0.24 |
| BNTX Biontech SE-ADR | Sold out | 0.00% | −0.22 |
| ACAD Acadia Pharmaceuticals Inc. | Sold out | 0.00% | −0.22 |
| JANX Janux Therapeutics Inc. | Reduce -39.7% | 0.84% | −0.20 |
| NMRA Neumora Therapeutics Inc. | Reduce -46.3% | 0.18% | −0.19 |
| OSCR Oscar Health Inc. Class A | Sold out | 0.00% | −0.14 |
| LYEL Lyell Immunopharma Inc. | Reduce -49.0% | 0.04% | −0.11 |
| LBPH Longboard Pharmaceuticals Inc. | Sold out | 0.00% | −0.10 |
| TELA Tela Bio Inc. | Sold out | 0.00% | −0.10 |
| NKTX Nkarta Inc. | Reduce -44.5% | 0.04% | −0.08 |
| PEPG Pepgen Inc. | Reduce -18.1% | 0.05% | −0.07 |
| PASG Passage Bio Inc. | Reduce -24.6% | 0.09% | −0.04 |
| MLYS Mineralys Therapeutics Inc. | Reduce -19.5% | 0.41% | −0.03 |
| VIGL Vigil Neuroscience Inc. | Sold out | 0.00% | −0.03 |
| IVVD Invivyd Inc. | Reduce -33.5% | 0.01% | −0.02 |
| VIR Vir Biotechnology Inc. | Reduce -9.9% | 0.49% | +0.00 |
| SRRK Scholar Rock Holding Corp. | Reduce -79.5% | 0.14% | +0.03 |
| RYTM Rhythm Pharmaceuticals Inc. | Reduce -8.2% | 0.46% | +0.05 |
| CRNX Crinetics Pharmaceuticals Inc. | Reduce -4.9% | 1.06% | +0.08 |
| SWTX Springworks Therapeutics Inc. | Reduce -9.8% | 0.94% | +0.13 |
| ARGX Argenx SE - ADR | Reduce -7.2% | 2.42% | +0.39 |
| ISRG Intuitive Surgical Inc. | Reduce -7.4% | 4.35% | +0.45 |
| BSX Boston Scientific Corp. | Reduce -3.4% | 5.86% | +0.84 |
Portfolio Buys Q3 2024 → Q4 2024
| NBIX Neurocrine Biosciences Inc. | Add +210.4% | 2.66% | +2.02 |
| UPB Upstream Bio Inc. | New | 1.94% | +1.94 |
| EW Edwards Lifesciences Corp. | New | 1.76% | +1.76 |
| CYTK Cytokinetics Inc. | Add +106.5% | 1.55% | +0.81 |
| ALNY Alnylam Pharmaceuticals Inc. | Add +66.0% | 2.03% | +0.77 |
| XBI SS SPDR S&P Biotech ETF | New | 0.70% | +0.70 |
| RAPT THERAPEUTICS INC | New | 0.43% | +0.43 |
| CGON CG Oncology Inc. | Add +107.1% | 0.85% | +0.38 |
| UHS Universal Health Services-B | Add +72.6% | 1.00% | +0.35 |
| IONS Ionis Pharmaceuticals Inc. | Add +21.2% | 2.05% | +0.34 |
| FOLD Amicus Therapeutics Inc. | Add +300.7% | 0.45% | +0.34 |
| FBRX Forte Biosciences Inc. | New | 0.28% | +0.28 |
| ITCI Intra-Cellular Therapies Inc. | New | 0.28% | +0.28 |
| SRPT Sarepta Therapeutics Inc. | Add +0.9% | 2.43% | +0.25 |
| GILD Gilead Sciences Inc. | Add +61.9% | 0.47% | +0.24 |
| CGEM Cullinan Therapeutics Inc. | Add +81.5% | 0.49% | +0.16 |
| GERN Geron Corp. | New | 0.16% | +0.16 |
| SIBN Si-Bone Inc. | Add +4.2% | 1.00% | +0.16 |
| CRDF Cardiff Oncology Inc. | New | 0.14% | +0.14 |
| INSM Insmed Inc. | New | 0.14% | +0.14 |
| DYN Dyne Therapeutics Inc. | Add +73.2% | 0.60% | +0.13 |
| ENGN Engene Holdings Inc. | New | 0.13% | +0.13 |
| XENE Xenon Pharmaceuticals Inc. | Add +4.0% | 0.77% | +0.11 |
| VERA Vera Therapeutics Inc. | Add +9.9% | 0.65% | +0.11 |
| TYRA Tyra Biosciences Inc. | Add +91.3% | 0.42% | +0.09 |
| CBLL Ceribell Inc. | New | 0.06% | +0.06 |
| GPCR Structure Therapeutics Inc. | Add +69.9% | 0.37% | +0.06 |
| IMVT Immunovant Inc. | New | 0.04% | +0.04 |
| AKRO Akero Therapeutics Inc. | New | 0.04% | +0.04 |
| IMTX Immatics NV | Add +53.9% | 0.46% | +0.04 |
| TNGX Tango Therapeutics Inc. | New | 0.04% | +0.04 |
| AMLX Amylyx Pharmaceuticals Inc. | New | 0.03% | +0.03 |
| KRRO Korro Bio Inc. | New | 0.03% | +0.03 |
| ANRO Alto Neuroscience Inc. | New | 0.02% | +0.02 |
| AGIO Agios Pharmaceuticals Inc. | New | 0.02% | +0.02 |
| LSBCF Lakeshore Biopharma Co. Ltd. | New | 0.01% | +0.01 |
| TIL Instil Bio Inc. | Add +246.5% | 0.05% | +0.00 |
| ADCT Adc Therapeutics SA | Add +31.6% | 0.25% | −0.01 |
| BCAX Bicara Therapeutics Inc. | Add +9.7% | 0.11% | −0.02 |
| CRBP Corbus Pharmaceuticals Holdi | Add +28.5% | 0.29% | −0.06 |
| RNAM Avidity Biosciences Inc. | Add +6.5% | 0.67% | −0.21 |
| THC Tenet Healthcare Corp. | Add +1.3% | 2.08% | −0.30 |
Options Activity Q3 2024 → Q4 2024
| GILD Gilead Sciences Inc. | call | New | 200,000 | $18.5M |
| UHS Universal Health Services-B | call | New | 50,000 | $9.0M |
| EVH Evolent Health Inc. Class A | call | Sold out | 258,400 | $7.3Mbefore exit |
| MRNA Moderna Inc. | call | Sold out | 100,000 | $6.7Mbefore exit |
| PFE Pfizer Inc. | call | New | 250,000 | $6.6M |
| SRPT Sarepta Therapeutics Inc. | call | Sold out | 50,000 | $6.2Mbefore exit |
| SOLV Solventum Corp. | call | Sold out | 69,300 | $4.8Mbefore exit |
| RNAM Avidity Biosciences Inc. | call | Sold out | 100,000 | $4.6Mbefore exit |
| GPCR Structure Therapeutics Inc. | call | New | 150,000 | $4.1M |
| THC Tenet Healthcare Corp. | call | New | 25,000 | $3.2M |
| FLNA Filana Therapeutics Inc. | put | Sold out | 95,000 | $2.8Mbefore exit |
| GERN Geron Corp. | call | Sold out | 400,000 | $1.8Mbefore exit |
Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 117 | $5.3B | EWTX, ELVN, LLY, MBX, SVA |
| Q1 2026 | 105 | $4.4B | EWTX, ELVN, LLY, SVA, BSX |
| Q4 2025 | 104 | $4.9B | EWTX, LLY, BSX, SVA, EW |
| Q3 2025 | 98 | $4.2B | EWTX, BSX, LLY, SVA, ELVN |
| Q2 2025 | 97 | $4.0B | SVA, BSX, LLY, EWTX, ELVN |
| Q1 2025 | 106 | $4.2B | SVA, EWTX, BSX, LLY, ELVN |
| Q4 2024 | 111 | $4.8B | EWTX, SVA, BSX, LLY, ISRG |
| Q3 2024 | 109 | $5.5B | EWTX, SVA, LLY, BSX, ISRG |
| Q2 2024 | 108 | $5.0B | SVA, LLY, EWTX, BSX, ISRG |
| Q1 2024 | 112 | $5.4B | SVA, LLY, EWTX, BSX, ISRG |