Orbimed Advisors LLC

In its 13F for Q2 2024 (holdings as of June 30, 2024, filed August 14, 2024), Orbimed Advisors LLC reported 108 stock positions worth $5.0 billion. Its top holding was Sinovac Biotech (SVA) at 6.8% of the portfolio, followed by Eli Lilly (LLY, 6.1%) and Edgewise Therapeutics (EWTX, 5.4%). Compared with Q1 2024, it opened 9 new positions, sold out of 13, added to 22 and reduced 21. The biggest buy was a new position in Alnylam Pharmaceuticals (ALNY) and the biggest sale Biomarin Pharmaceutical (BMRN, shares −98%).

Most Recent 13F
Q2 2026
Location
New York, NY
CIK
0001055951
Portfolio Value
$5.0B (Q2 2024)
SEC Filing
0001172661-24-003539 ↗ filed Aug 14, 2024

Holdings Value

0$2.0B$4.0B$6.0B Q1 2024: $5.4B Q1 2024 Q2 2024: $5.0B $5.0B Q2 2024 Q3 2024: $5.5B Q3 2024 Q4 2024: $4.8B Q4 2024 Q1 2025: $4.2B Q1 2025 Q2 2025: $4.0B Q2 2025 Q3 2025: $4.2B Q3 2025 Q4 2025: $4.9B Q4 2025 Q1 2026: $4.4B Q1 2026 Q2 2026: $5.3B Q2 2026

Holdings 108 stocks · $5.0B
SVA Sinovac Biotech Ltd. 6.76% 2,718,735 $340.0M No change
LLY Eli Lilly & Co. 6.08% 337,600 $305.7M Reduce -6.4%
EWTX Edgewise Therapeutics Inc. 5.38% 15,021,721 $270.5M No change
BSX Boston Scientific Corp. 5.01% 3,273,000 $252.1M No change
ISRG Intuitive Surgical Inc. 4.36% 493,100 $219.4M No change
BIIB Biogen Inc. 4.15% 900,900 $208.8M No change
ELVN Enliven Therapeutics Inc. 3.70% 7,959,538 $186.0M Reduce -11.5%
MRK Merck & Co. Inc. 3.24% 1,316,000 $162.9M No change
THC Tenet Healthcare Corp. 3.10% 1,173,300 $156.1M No change
JANX Janux Therapeutics Inc. 2.48% 2,979,828 $124.8M Reduce -30.3%
IONS Ionis Pharmaceuticals Inc. 2.25% 2,372,333 $113.1M Add +17.9%
SRPT Sarepta Therapeutics Inc. 2.03% 646,000 $102.1M Reduce -7.4%
SYK Stryker Corp. 1.82% 269,000 $91.5M No change
ELV Elevance Health Inc. 1.81% 168,100 $91.1M No change
ARGX Argenx SE - ADR 1.79% 209,100 $89.9M Add +37.9%
IRON Disc Medicine Inc. 1.60% 1,785,571 $80.5M Add +4.9%
SPRY Ars Pharmaceuticals Inc. 1.56% 9,240,887 $78.6M No change
THRD Third Harmonic Bio Inc. 1.49% 5,779,071 $75.1M No change
NTRA Natera Inc. 1.48% 687,500 $74.4M Reduce -23.6%
TMO Thermo Fisher Scientific Inc. 1.45% 132,000 $73.0M No change
VRTX Vertex Pharmaceuticals Inc. 1.41% 151,000 $70.8M Add +23.1%
SWTX Springworks Therapeutics Inc. 1.28% 1,707,331 $64.3M No change
NBIX Neurocrine Biosciences Inc. 1.23% 448,200 $61.7M Add +5.9%
ALNY Alnylam Pharmaceuticals Inc. 1.21% 250,300 $60.8M New
PCVX Vaxcyte Inc. 1.19% 795,900 $60.1M Reduce -25.4%
KROS Keros Therapeutics Inc. 1.15% 1,268,734 $58.0M No change
CRNX Crinetics Pharmaceuticals Inc. 1.14% 1,280,800 $57.4M Reduce -7.5%
UNH Unitedhealth Group Inc. 1.13% 112,000 $57.0M Add +60.0%
AVBP Arrivent Biopharma Inc. 1.12% 3,027,328 $56.2M No change
ICLR Icon PLC 1.08% 174,100 $54.6M No change
TERN Terns Pharmaceuticals Inc. 1.03% 7,619,135 $51.9M No change
APLS Apellis Pharmaceuticals Inc. 0.99% 1,302,800 $50.0M Add +0.4%
EVH Evolent Health Inc. Class A 0.99% 2,605,615 $49.8M No change
XTNT Xtant Medical Holdings Inc. 0.92% 73,114,592 $46.1M No change
CYTK Cytokinetics Inc. 0.88% 812,906 $44.0M Add +19.1%
AMGN Amgen Inc. 0.84% 134,900 $42.1M Add +112.8%
SIBN Si-Bone Inc. 0.83% 3,229,977 $41.8M Add +1.8%
PRLD Prelude Therapeutics Inc. 0.83% 10,909,256 $41.6M No change
VRNA Verona Pharma Ltd. 0.82% 2,861,801 $41.4M Reduce -15.8%
QTTB Q32 Bio Inc. 0.80% 2,252,987 $40.4M No change
ITGR Integer Holdings Corp. 0.80% 349,221 $40.4M New
SNDX Syndax Pharmaceuticals Inc. 0.79% 1,925,300 $39.5M Add +10.1%
GERN Geron Corp. 0.75% 8,930,252 $37.9M Reduce -30.7%
XENE Xenon Pharmaceuticals Inc. 0.67% 862,362 $33.6M Add +56.8%
DXCM Dexcom Inc. 0.65% 289,900 $32.9M Add +106.6%
0 0.64% 12,048,773 $32.1M No change
RYTM Rhythm Pharmaceuticals Inc. 0.58% 704,842 $28.9M No change
RNAM Avidity Biosciences Inc. 0.57% 706,475 $28.9M Reduce -28.9%
EXAS Exact Sciences Corp. 0.56% 672,416 $28.4M Add +378.9%
NPCE Neuropace Inc. 0.51% 3,406,335 $25.8M Reduce -14.9%
DYN Dyne Therapeutics Inc. 0.50% 708,400 $25.0M No change
VERA Vera Therapeutics Inc. 0.49% 675,872 $24.5M No change
SCPH Scpharmaceuticals Inc. 0.48% 5,559,528 $24.2M No change
REGN Regeneron Pharmaceuticals 0.48% 22,800 $24.0M No change
MLYS Mineralys Therapeutics Inc. 0.47% 2,021,424 $23.7M No change
IMTX Immatics NV 0.46% 2,006,381 $23.3M Add +13.4%
HRTX Heron Therapeutics Inc. 0.45% 6,512,866 $22.8M Reduce -35.6%
CMPX Compass Therapeutics Inc. 0.44% 22,362,850 $22.4M No change
MORF Morphic Holding Inc. 0.41% 612,500 $20.9M Add +9.7%
VIR Vir Biotechnology Inc. 0.41% 2,320,102 $20.6M Add +262.5%
CGEM Cullinan Therapeutics Inc. 0.40% 1,147,655 $20.0M Add +121.7%
SLRN Acelyrin Inc. 0.35% 4,001,711 $17.6M No change
APGE Apogee Therapeutics Inc. 0.30% 379,130 $14.9M Reduce -47.3%
NMRA Neumora Therapeutics Inc. 0.29% 1,500,000 $14.7M No change
ACET Adicet Bio Inc. 0.28% 11,447,140 $13.9M No change
ADCT Adc Therapeutics SA 0.27% 4,316,824 $13.6M New
CRVS Corvus Pharmaceuticals Inc. 0.25% 6,943,654 $12.6M No change
ABCL Abcellera Biologics Inc. 0.25% 4,180,768 $12.4M No change
TYRA Tyra Biosciences Inc. 0.24% 768,638 $12.3M No change
TELA Tela Bio Inc. 0.23% 2,457,542 $11.6M Reduce -13.3%
ALXO Alx Oncology Holdings Inc. 0.23% 1,894,462 $11.4M Reduce -30.3%
RPTX Repare Therapeutics Inc. 0.22% 3,322,488 $11.0M No change
PMVP PMV Pharmaceuticals Inc. 0.21% 6,475,291 $10.5M No change
LXRX Lexicon Pharmaceuticals Inc. 0.20% 5,846,100 $9.8M Add +65.0%
LYEL Lyell Immunopharma Inc. 0.18% 6,405,098 $9.3M Add +3110.6%
MRUS Merus NV 0.18% 156,100 $9.2M New
SRRK Scholar Rock Holding Corp. 0.18% 1,074,382 $8.9M Reduce -69.9%
TSBX Turnstone Biologics Corp. 0.16% 3,099,265 $8.1M No change
PASG Passage Bio Inc. 0.16% 10,124,576 $8.0M No change
PGNY Progyny Inc. 0.15% 259,900 $7.4M Add +129.4%
CCCC C4 Therapeutics Inc. 0.14% 1,513,058 $7.0M New
IKENA ONCOLOGY INC 0.12% 3,539,358 $5.8M No change
FOLD Amicus Therapeutics Inc. 0.11% 570,300 $5.7M No change
KRYS Krystal Biotech Inc. 0.11% 29,966 $5.5M Reduce -19.4%
NSPR Inspiremd Inc. 0.11% 2,133,405 $5.3M No change
CATX Perspective Therapeutics Inc. 0.10% 492,670 $4.9M New
GPCR Structure Therapeutics Inc. 0.10% 125,000 $4.9M New
NKTX Nkarta Inc. 0.09% 800,000 $4.7M No change
BIOMX INC 0.09% 13,773,653 $4.6M Add +204.9%
VSTM Verastem Inc. 0.09% 1,529,115 $4.6M No change
FATE Fate Therapeutics Inc. 0.09% 1,355,352 $4.4M No change
XFOR X4 Pharmaceuticals Inc. 0.08% 7,133,515 $4.1M No change
IVVD Invivyd Inc. 0.05% 2,425,800 $2.7M Reduce -9.8%
MIST Milestone Pharmaceuticals Inc. 0.05% 2,000,000 $2.6M No change
ELEV Elevation Oncology Inc. 0.05% 941,275 $2.5M No change
TGTX TG Therapeutics Inc. 0.05% 133,200 $2.4M New
BMRN Biomarin Pharmaceutical Inc. 0.04% 26,100 $2.1M Reduce -98.0%
CMMB Chemomab Therapeutics Ltd. 0.04% 2,241,273 $2.0M Reduce 0.0%
ORIC Oric Pharmaceuticals Inc. 0.04% 287,100 $2.0M No change
NXTC Nextcure Inc. 0.04% 1,141,200 $1.8M No change
APLM Apollomics Inc. 0.04% 8,565,456 $1.8M No change
VIGL Vigil Neuroscience Inc. 0.04% 448,891 $1.8M No change
DVAX Dynavax Technologies Corp. 0.03% 113,500 $1.3M No change
KEZAR LIFE SCIENCES INC 0.02% 1,927,000 $1.2M No change
LAKESHORE BIOPHARMA CO LTD 0.02% 1,404,280 $910K Reduce -8.5%
TRAW Traws Pharma Inc. 0.01% 1,045,261 $467K New
XERS Xeris Biopharma Holdings Inc. 0.00% 80,420 $181K No change
OMIC Singular Genomics Systems Inc. 0.00% 18,023 $152K No change

Options reported separately and not counted above: SOLV calls ($10.6M), SRPT calls ($7.9M), PFE calls ($7.0M), SIBN calls ($3.2M), MRUS calls ($3.0M), GERN calls ($2.5M).

Portfolio Sells Q1 2024 → Q2 2024
BMRN Biomarin Pharmaceutical Inc. Reduce -98.0% 0.04% −2.01
ALPN Alpine Immune Sciences Inc. Sold out 0.00% −1.95
SRRK Scholar Rock Holding Corp. Reduce -69.9% 0.18% −0.99
ESPR Esperion Therapeutics Inc. Sold out 0.00% −0.67
APGE Apogee Therapeutics Inc. Reduce -47.3% 0.30% −0.58
PRAX Praxis Precision Medicines I Sold out 0.00% −0.52
JANX Janux Therapeutics Inc. Reduce -30.3% 2.48% −0.47
NPCE Neuropace Inc. Reduce -14.9% 0.51% −0.46
KNTE Kinnate Biopharma Inc. Sold out 0.00% −0.39
ARWR Arrowhead Pharmaceuticals Inc. Sold out 0.00% −0.39
ALXO Alx Oncology Holdings Inc. Reduce -30.3% 0.23% −0.33
AEROVATE THERAPEUTICS INC Sold out 0.00% −0.31
VTYX Ventyx Biosciences Inc. Sold out 0.00% −0.19
VRNA Verona Pharma Ltd. Reduce -15.8% 0.82% −0.18
IVVD Invivyd Inc. Reduce -9.8% 0.05% −0.17
TXG 10X Genomics Inc. Class A Sold out 0.00% −0.16
PCVX Vaxcyte Inc. Reduce -25.4% 1.19% −0.14
CATX Perspective Therapeutics Inc. Sold out 0.00% −0.14
CTMX Cytomx Therapeutics Inc. Sold out 0.00% −0.14
TELA Tela Bio Inc. Reduce -13.3% 0.23% −0.07
HRTX Heron Therapeutics Inc. Reduce -35.6% 0.45% −0.06
CRNX Crinetics Pharmaceuticals Inc. Reduce -7.5% 1.14% −0.05
BOLT Bolt Biotherapeutics Inc. Sold out 0.00% −0.04
NTRA Natera Inc. Reduce -23.6% 1.48% −0.03
GERN Geron Corp. Reduce -30.7% 0.75% −0.03
CALC Calcimedica Inc. Sold out 0.00% −0.02
KRYS Krystal Biotech Inc. Reduce -19.4% 0.11% −0.01
AFIB Acutus Medical Inc. Sold out 0.00% −0.01
LAKESHORE BIOPHARMA CO LTD Reduce -8.5% 0.02% −0.00
CMMB Chemomab Therapeutics Ltd. Reduce 0.0% 0.04% +0.01
RNAM Avidity Biosciences Inc. Reduce -28.9% 0.57% +0.11
SRPT Sarepta Therapeutics Inc. Reduce -7.4% 2.03% +0.37
ELVN Enliven Therapeutics Inc. Reduce -11.5% 3.70% +0.79
LLY Eli Lilly & Co. Reduce -6.4% 6.08% +0.92

Portfolio Buys Q1 2024 → Q2 2024
ALNY Alnylam Pharmaceuticals Inc. New 1.21% +1.21
ITGR Integer Holdings Corp. New 0.80% +0.80
ARGX Argenx SE - ADR Add +37.9% 1.79% +0.69
IONS Ionis Pharmaceuticals Inc. Add +17.9% 2.25% +0.65
AMGN Amgen Inc. Add +112.8% 0.84% +0.51
UNH Unitedhealth Group Inc. Add +60.0% 1.13% +0.50
VRTX Vertex Pharmaceuticals Inc. Add +23.1% 1.41% +0.47
EXAS Exact Sciences Corp. Add +378.9% 0.56% +0.39
DXCM Dexcom Inc. Add +106.6% 0.65% +0.30
VIR Vir Biotechnology Inc. Add +262.5% 0.41% +0.29
ADCT Adc Therapeutics SA New 0.27% +0.27
CGEM Cullinan Therapeutics Inc. Add +121.7% 0.40% +0.24
XENE Xenon Pharmaceuticals Inc. Add +56.8% 0.67% +0.23
MRUS Merus NV New 0.18% +0.18
LYEL Lyell Immunopharma Inc. Add +3110.6% 0.18% +0.18
NBIX Neurocrine Biosciences Inc. Add +5.9% 1.23% +0.16
CCCC C4 Therapeutics Inc. New 0.14% +0.14
IMTX Immatics NV Add +13.4% 0.46% +0.12
CATX Perspective Therapeutics Inc. New 0.10% +0.10
GPCR Structure Therapeutics Inc. New 0.10% +0.10
PGNY Progyny Inc. Add +129.4% 0.15% +0.07
BIOMX INC Add +204.9% 0.09% +0.05
MORF Morphic Holding Inc. Add +9.7% 0.41% +0.05
TGTX TG Therapeutics Inc. New 0.05% +0.05
LXRX Lexicon Pharmaceuticals Inc. Add +65.0% 0.20% +0.04
SNDX Syndax Pharmaceuticals Inc. Add +10.1% 0.79% +0.02
TRAW Traws Pharma Inc. New 0.01% +0.01
CYTK Cytokinetics Inc. Add +19.1% 0.88% −0.00
SIBN Si-Bone Inc. Add +1.8% 0.83% −0.12
IRON Disc Medicine Inc. Add +4.9% 1.60% −0.35
APLS Apellis Pharmaceuticals Inc. Add +0.4% 0.99% −0.41

Options Activity Q1 2024 → Q2 2024
SOLV Solventum Corp. call New 200,000 $10.6M
APLS Apellis Pharmaceuticals Inc. call Sold out 150,000 $8.8Mbefore exit
SRPT Sarepta Therapeutics Inc. call New 50,000 $7.9M
PFE Pfizer Inc. call New 250,000 $7.0M
MRUS Merus NV call New 50,000 $3.0M
GERN Geron Corp. call New 600,000 $2.5M

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 117$5.3BEWTX, ELVN, LLY, MBX, SVA
Q1 2026 105$4.4BEWTX, ELVN, LLY, SVA, BSX
Q4 2025 104$4.9BEWTX, LLY, BSX, SVA, EW
Q3 2025 98$4.2BEWTX, BSX, LLY, SVA, ELVN
Q2 2025 97$4.0BSVA, BSX, LLY, EWTX, ELVN
Q1 2025 106$4.2BSVA, EWTX, BSX, LLY, ELVN
Q4 2024 111$4.8BEWTX, SVA, BSX, LLY, ISRG
Q3 2024 109$5.5BEWTX, SVA, LLY, BSX, ISRG
Q2 2024 108$5.0BSVA, LLY, EWTX, BSX, ISRG
Q1 2024 112$5.4BSVA, LLY, EWTX, BSX, ISRG