Amylyx PharmaceuticalsAMLX
13F holders, Q4 2024 (December 31)122holders +12
27new positions
19sold out
6famous investors
$3.78avg. 13F price*
At the end of Q4 2024, 122 institutions reported holding Amylyx Pharmaceuticals Inc. (AMLX) in their 13F filings, up 12 from Q3 2024. 27 opened new positions and 19 sold out. The largest holders were Perceptive Advisors LLC ($25.6M), TCG Crossover Management, LLC ($17.6M) and Vanguard Group Inc. ($10.2M). 6 famous investors held it, including Ken Griffin (0.0% of Citadel Advisors's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Amylyx Pharmaceuticals Inc.
- CUSIP
- 03237H101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2024 → Q4 2024
| Institutions | Total Value | |
|---|---|---|
| New Positions | 27 | $8.0M |
| Exits | 19 | $7.7M |
All 13F filers, Q3 2024 → Q4 2024: 12,921,058 shares bought and 8,132,342 shares sold, net +4,788,716 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 122 holders
| Perceptive Advisors LLC | 0.71% | Add +218.7% | 6,774,348 | $25.6M |
| TCG Crossover Management, LLC | 1.72% | No change | 4,643,812 | $17.6M |
| Vanguard Group Inc. | 0.00% | Reduce -12.8% | 2,692,489 | $10.2M |
| Bank of America Corp. | 0.00% | Add +165.9% | 2,426,263 | $9.2M |
| BlackRock, Inc. | 0.00% | Reduce -10.6% | 2,278,934 | $8.6M |
| Almitas Capital LLC | 1.69% | Add +2.2% | 2,032,370 | $7.7M |
| Citadel Advisors | 0.01% | Add +3.8% | 1,970,704 | $7.4M |
| 683 Capital Management, LLC | 0.80% | Reduce -3.5% | 1,930,000 | $7.3M |
| Goldman Sachs Group Inc. | 0.00% | Add +15.2% | 1,859,896 | $7.0M |
| Boxer Capital Management, LLC | 0.56% | — | 1,750,000 | $6.6M |
| Aberdeen Group plc | 0.01% | Reduce -12.7% | 1,722,805 | $6.5M |
| Nantahala Capital Management, LLC | 0.38% | Add +3.4% | 1,452,153 | $5.5M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.02% | Add +43.4% | 1,263,353 | $4.8M |
| Saturn V Capital Management LP | 1.32% | New | 889,073 | $3.4M |
| Susquehanna International Group, LLP | 0.00% | Add +113.8% | 868,382 | $3.3M |
| Alyeska Investment Group, L.P. | 0.01% | Reduce -59.3% | 823,420 | $3.1M |
| Qube Research & Technologies Ltd | 0.00% | Add +324.5% | 780,566 | $3.0M |
| Jane Street Group, LLC | 0.00% | Add +122.4% | 765,475 | $2.9M |
| FMR LLC | 0.00% | Add +230.9% | 731,356 | $2.8M |
| Two Sigma Investments, LP | 0.01% | Add +77.4% | 651,517 | $2.5M |
| UBS Group AG | 0.00% | Add +180.9% | 643,524 | $2.4M |
| Acadian Asset Management LLC | 0.01% | Reduce -65.4% | 611,926 | $2.3M |
| Citigroup Inc. | 0.00% | Add +6.0% | 609,324 | $2.3M |
| Millennium Management | 0.00% | Add +30.1% | 594,236 | $2.2M |
| Deutsche Bank AG | 0.00% | No change | 570,857 | $2.2M |
| Geode Capital Management, LLC | 0.00% | Add +3.1% | 567,903 | $2.1M |
| Walleye Capital LLC | 0.02% | Reduce -22.6% | 518,784 | $2.0M |
| Cubist Systematic Strategies, LLC | 0.03% | Add +862.5% | 472,397 | $1.8M |
| Renaissance Technologies | 0.00% | Add +70.9% | 464,400 | $1.8M |
| Morgan Stanley | 0.00% | Reduce -2.9% | 464,220 | $1.8M |
| Orbimed Advisors LLC | 0.03% | New | 348,000 | $1.3M |
| Jacobs Levy Equity Management, Inc. | 0.00% | Reduce -34.2% | 314,939 | $1.2M |
| D. E. Shaw & Co. | 0.00% | Reduce -55.6% | 306,744 | $1.2M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -1.1% | 298,949 | $1.1M |
| Aldebaran Capital, LLC | 0.95% | Reduce -2.6% | 262,753 | $993K |
| Two Sigma Advisers, LP | 0.00% | Reduce -22.0% | 241,400 | $912K |
| State Street Corp. | 0.00% | Add +41.0% | 218,383 | $825K |
| Wellington Management Group LLP | 0.00% | New | 209,708 | $793K |
| Federated Hermes, Inc. | 0.00% | Add +8.6% | 202,316 | $765K |
| Ikarian Capital, LLC | 0.22% | Reduce -26.7% | 201,187 | $760K |
| Schonfeld Strategic Advisors LLC | 0.00% | Add +16.5% | 193,931 | $733K |
| AQR Capital Management | 0.00% | Reduce -71.0% | 188,386 | $712K |
| Marshall Wace, LLP | 0.00% | Reduce -35.0% | 184,678 | $698K |
| Alpha Wave Global, LP | 0.26% | Reduce -77.8% | 148,627 | $562K |
| Bridgeway Capital Management, LLC | 0.01% | Add +12.7% | 146,500 | $554K |
| Bank of Montreal | 0.00% | No change | 143,512 | $542K |
| Kennondale Capital Management LLC | 0.55% | — | 134,445 | $508K |
| Mackenzie Financial Corp. | 0.00% | Add +234.9% | 111,310 | $421K |
| Northern Trust Corp. | 0.00% | Add +11.8% | 106,564 | $403K |
| ExodusPoint Capital Management, LP | 0.00% | New | 106,237 | $402K |
| Jump Financial, LLC | 0.01% | New | 104,342 | $394K |
| Man Group plc | 0.00% | Reduce -23.5% | 100,059 | $378K |
| Tang Capital Management LLC | 0.03% | No change | 100,000 | $378K |
| Hennion & Walsh Asset Management, Inc. | 0.02% | Reduce -20.9% | 90,619 | $343K |
| Boothbay Fund Management, LLC | 0.01% | Reduce -5.8% | 80,543 | $304K |
| Squarepoint Ops LLC | 0.00% | Add +56.8% | 75,284 | $285K |
| Barclays PLC | 0.00% | Reduce -11.5% | 74,845 | $283K |
| Point72 Asia (Singapore) Pte. Ltd. | 0.07% | Reduce -12.8% | 72,863 | $275K |
| OMERS ADMINISTRATION Corp | 0.00% | New | 66,000 | $249K |
| American Century Companies Inc. | 0.00% | Add +181.8% | 59,310 | $224K |
| T. Rowe Price Associates Inc. | 0.00% | Add +3.8% | 57,700 | $219K |
| JPMorgan Chase & Co. | 0.00% | Reduce -60.4% | 55,606 | $210K |
| Alps Advisors Inc. | 0.00% | New | 55,430 | $210K |
| Dimensional Fund Advisors LP | 0.00% | New | 54,114 | $205K |
| XTX Topco Ltd | 0.02% | Add +12.0% | 53,376 | $202K |
| Mariner, LLC | 0.00% | Reduce -10.3% | 50,539 | $191K |
| Ameriprise Financial Inc. | 0.00% | New | 50,428 | $191K |
| Balyasny Asset Management L.P. | 0.00% | Reduce -1.3% | 50,248 | $190K |
| Group One Trading LLC | 0.01% | Reduce -61.4% | 49,899 | $189K |
| Landscape Capital Management, L.L.C. | 0.02% | New | 49,661 | $188K |
| Jefferies Financial Group Inc. | 0.00% | No change | 46,200 | $175K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +377.0% | 45,987 | $174K |
| Guggenheim Capital LLC | 0.00% | Add +132.9% | 35,868 | $136K |
| Centiva Capital, LP | 0.00% | New | 33,831 | $128K |
| Tudor Investment Corporation | 0.00% | New | 33,687 | $127K |
| Parsons Capital Management Inc. | 0.00% | Reduce -1.4% | 21,645 | $82K |
| Marex Group Ltd | 0.00% | Reduce -50.0% | 20,000 | $76K |
| Brown Advisory Inc. | 0.00% | Reduce -0.1% | 19,930 | $75K |
| Wedbush Securities Inc. | 0.00% | New | 19,914 | $75K |
| Prudential Financial Inc. | 0.00% | No change | 19,400 | $73K |
| Simplex Trading, LLC | 0.00% | Reduce -84.0% | 17,819 | $67K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Add +6.8% | 17,724 | $67K |
| Engineers Gate Manager LP | 0.00% | New | 17,637 | $67K |
| State of Wyoming | 0.01% | Reduce -37.6% | 16,077 | $61K |
| SG Americas Securities, LLC | 0.00% | Reduce -72.2% | 15,958 | $60K |
| Y-Intercept (Hong Kong) Ltd | 0.00% | New | 14,809 | $56K |
| China Universal Asset Management Co., Ltd. | 0.01% | Add +11.0% | 14,535 | $55K |
| EntryPoint Capital, LLC | 0.02% | New | 13,909 | $53K |
| Rpo LLC | 0.07% | New | 12,136 | $46K |
| Alpine Global Management, LLC | 0.02% | New | 12,017 | $45K |
| Royal Bank of Canada | 0.00% | Add +0.2% | 11,874 | $45K |
| Bank of Nova Scotia | 0.00% | Add +11.1% | 11,884 | $45K |
| Fox Run Management, L.L.C. | 0.01% | New | 11,788 | $45K |
| HSBC Holdings PLC | 0.00% | Reduce -81.3% | 11,566 | $43K |
| Vident Advisory, LLC | 0.00% | Reduce -30.3% | 10,862 | $41K |
| Gsa Capital Partners LLP | 0.00% | New | 10,639 | $40K |
| R Squared Ltd | 0.02% | — | 6,370 | $24K |
| Russell Investments Group, Ltd. | 0.00% | Reduce -27.5% | 5,069 | $19K |
| Point72 (DIFC) Ltd | 0.00% | New | 4,796 | $18K |
| US Bancorp \de | 0.00% | New | 4,000 | $15K |
| Advisors Asset Management, Inc. | 0.00% | Reduce -49.0% | 3,902 | $15K |
| Walleye Trading LLC | 0.00% | New | 2,649 | $10K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Reduce -7.2% | 2,284 | $9K |
| Arax Advisory Partners | 0.00% | No change | 2,193 | $8K |
| Steward Partners Investment Advisory, LLC | 0.00% | No change | 2,000 | $8K |
| Loring Wolcott & Coolidge Fiduciary Advisors LLP | 0.00% | No change | 1,803 | $6K |
| GF Fund Management Co. LTD. | 0.00% | — | 1,439 | $5K |
| BNP Paribas Financial Markets | 0.00% | New | 1,149 | $4K |
| Oliver Lagore Vanvalin Investment Group | 0.00% | Reduce -31.3% | 1,100 | $4K |
| Cwm, LLC | 0.00% | No change | 890 | $3K |
| Osaic Holdings, Inc. | 0.00% | Add +196.7% | 638 | $2K |
| Dunhill Financial, LLC | 0.00% | No change | 600 | $2K |
| Nisa Investment Advisors, LLC | 0.00% | Reduce -33.6% | 495 | $2K |
| Global Retirement Partners, LLC | 0.00% | New | 400 | $2K |
| Wells Fargo & Company | 0.00% | No change | 300 | $1K |
| Daiwa Securities Group Inc. | 0.00% | No change | 266 | $1K |
| Harbour Investments, Inc. | 0.00% | New | 90 | $340 |
| Catherine Avery Investment Management LLC | 0.00% | — | 87 | $329 |
| Salem Investment Counselors Inc. | 0.00% | No change | 55 | $208 |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -44.8% | 53 | $200 |
| EverSource Wealth Advisors, LLC | 0.00% | New | 25 | $95 |
| SBI Securities Co., Ltd. | 0.00% | — | 1 | $4 |
"% of holder's portfolio" is AMLX's weight in each manager's 13F, not the share of Amylyx Pharmaceuticals Inc. the manager owns.