Amylyx PharmaceuticalsAMLX
13F holders, Q4 2025 (December 31)180holders +11
36new positions
27sold out
7famous investors
$12.08avg. 13F price*
At the end of Q4 2025, 180 institutions reported holding Amylyx Pharmaceuticals Inc. (AMLX) in their 13F filings, up 11 from Q3 2025. 36 opened new positions and 27 sold out. The largest holders were FMR LLC ($199.5M), BlackRock, Inc. ($109.4M) and Perceptive Advisors LLC ($100.1M). 7 famous investors held it, including Steve Cohen (0.0% of Point72 Asset Management's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Amylyx Pharmaceuticals Inc.
- CUSIP
- 03237H101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 36 | $42.9M |
| Exits | 27 | $72.3M |
All 13F filers, Q3 2025 → Q4 2025: 21,179,955 shares bought and 18,746,581 shares sold, net +2,433,374 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 180 holders
| FMR LLC | 0.01% | Add +45.2% | 16,518,419 | $199.5M |
| BlackRock, Inc. | 0.00% | Add +26.8% | 9,054,431 | $109.4M |
| Perceptive Advisors LLC | 1.84% | Reduce -7.5% | 8,284,882 | $100.1M |
| TCG Crossover Management, LLC | 2.50% | No change | 6,243,812 | $75.4M |
| Vanguard Group Inc. | 0.00% | Add +10.1% | 5,804,912 | $70.1M |
| Commodore Capital LP | 4.54% | Add +38.6% | 5,650,000 | $68.3M |
| Saturn V Capital Management LP | 9.97% | Reduce -2.4% | 4,496,487 | $54.3M |
| Janus Henderson Group PLC | 0.02% | Add +76.1% | 4,465,872 | $54.0M |
| First Light Asset Management, LLC | 3.10% | Reduce -0.0% | 3,355,539 | $40.5M |
| Driehaus Capital Management LLC | 0.26% | Add +28.4% | 3,109,503 | $37.6M |
| Adage Capital Partners Gp, L.L.C. | 0.05% | Reduce -59.3% | 2,777,055 | $33.5M |
| Goldman Sachs Group Inc. | 0.00% | Add +30.0% | 2,613,221 | $31.6M |
| Morgan Stanley | 0.00% | Add +21.0% | 2,359,824 | $28.5M |
| Geode Capital Management, LLC | 0.00% | Add +19.5% | 2,165,534 | $26.2M |
| Almitas Capital LLC | 5.67% | No change | 2,122,597 | $25.6M |
| State Street Corp. | 0.00% | Add +27.7% | 2,069,884 | $25.0M |
| Great Point Partners LLC | 6.85% | Add +2.9% | 1,750,000 | $21.1M |
| 683 Capital Management, LLC | 1.75% | Reduce -6.3% | 1,650,000 | $19.9M |
| Eventide Asset Management, LLC | 0.29% | Add +0.0% | 1,513,148 | $18.3M |
| Bank of America Corp. | 0.00% | Add +211.1% | 1,336,010 | $16.1M |
| Deutsche Bank AG | 0.01% | Reduce -2.4% | 1,333,236 | $16.1M |
| Franklin Resources Inc. | 0.00% | New | 1,200,096 | $14.5M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.03% | Reduce -9.3% | 1,004,021 | $12.1M |
| Logos Global Management LP | 0.76% | Reduce -34.5% | 950,000 | $11.5M |
| Northern Trust Corp. | 0.00% | Add +14.1% | 937,764 | $11.3M |
| ADAR1 Capital Management, LLC | 0.80% | Add +2.8% | 890,356 | $10.8M |
| Balyasny Asset Management L.P. | 0.02% | Reduce -41.8% | 858,684 | $10.4M |
| Woodline Partners LP | 0.04% | Add +0.0% | 845,408 | $10.2M |
| Nantahala Capital Management, LLC | 0.60% | Reduce -10.7% | 835,684 | $10.1M |
| Boxer Capital Management, LLC | 2.12% | Reduce -11.1% | 800,000 | $9.7M |
| Dimensional Fund Advisors LP | 0.00% | Add +51.3% | 771,248 | $9.3M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +10.5% | 712,990 | $8.6M |
| Stempoint Capital LP | 1.17% | Add +104.1% | 565,140 | $6.8M |
| UBS Group AG | 0.00% | Reduce -61.3% | 543,323 | $6.6M |
| Sofinnova Investments, Inc. | 0.27% | New | 527,099 | $6.4M |
| Silverarc Capital Management, LLC | 0.88% | Reduce -27.7% | 506,242 | $6.1M |
| Ameriprise Financial Inc. | 0.00% | Add +276.3% | 502,366 | $6.1M |
| Rock Springs Capital Management LP | 0.31% | No change | 499,764 | $6.0M |
| Federated Hermes, Inc. | 0.01% | Add +115.4% | 457,412 | $5.5M |
| Qube Research & Technologies Ltd | 0.01% | Add +147.1% | 412,873 | $5.0M |
| Cormorant Asset Management, LP | 0.27% | Reduce -20.0% | 400,000 | $4.8M |
| Parkman Healthcare Partners LLC | 0.44% | Reduce -34.1% | 381,760 | $4.6M |
| Patient Square Capital LP | 0.91% | Add +10.7% | 350,000 | $4.2M |
| Citadel Advisors | 0.00% | Add +47.0% | 344,968 | $4.2M |
| Two Sigma Investments, LP | 0.01% | Add +249.9% | 344,401 | $4.2M |
| Point72 Asset Management | 0.01% | Reduce -88.0% | 335,000 | $4.0M |
| Acuta Capital Partners, LLC | 2.73% | No change | 333,258 | $4.0M |
| Two Sigma Advisers, LP | 0.01% | Add +129.7% | 328,401 | $4.0M |
| Alpha Wave Global, LP | 0.47% | Reduce -2.9% | 317,678 | $3.8M |
| Barclays PLC | 0.00% | Reduce -28.7% | 295,177 | $3.6M |
| Nuveen, LLC | 0.00% | Add +77.0% | 283,948 | $3.4M |
| Tetragon Partners GP Ltd | 0.69% | Add +5.7% | 272,828 | $3.3M |
| Jane Street Group, LLC | 0.00% | New | 263,235 | $3.2M |
| Acadian Asset Management LLC | 0.01% | Reduce -30.8% | 254,328 | $3.1M |
| HighVista Strategies LLC | 0.74% | New | 238,812 | $2.9M |
| Wellington Management Group LLP | 0.00% | Reduce -4.4% | 225,782 | $2.7M |
| SummitTX Capital, L.P. | 0.08% | Add +30.0% | 218,399 | $2.6M |
| Bank of New York Mellon Corp | 0.00% | Add +18.8% | 217,347 | $2.6M |
| Aldebaran Capital, LLC | 2.15% | Reduce -2.9% | 198,508 | $2.4M |
| Renaissance Technologies | 0.00% | Add +867.3% | 192,500 | $2.3M |
| XTX Topco Ltd | 0.06% | New | 189,673 | $2.3M |
| Invesco Ltd. | 0.00% | Reduce -78.3% | 175,914 | $2.1M |
| Swiss National Bank | 0.00% | New | 161,700 | $2.0M |
| Voloridge Investment Management, LLC | 0.01% | New | 153,363 | $1.9M |
| Wells Fargo & Company | 0.00% | Add +56.2% | 146,309 | $1.8M |
| Atom Investors LP | 0.13% | New | 139,422 | $1.7M |
| Bank of Montreal | 0.00% | Reduce -3.6% | 138,525 | $1.7M |
| PFM Health Sciences, LP | 0.17% | Reduce -69.2% | 134,549 | $1.6M |
| Numerai GP LLC | 0.16% | Add +67.8% | 112,648 | $1.4M |
| Elmind Capital, LP | 0.40% | — | 112,000 | $1.4M |
| T. Rowe Price Associates Inc. | 0.00% | Add +7.1% | 107,548 | $1.3M |
| Rhumbline Advisers | 0.00% | Add +0.6% | 99,274 | $1.2M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | New | 98,838 | $1.2M |
| Alps Advisors Inc. | 0.01% | New | 90,172 | $1.1M |
| State of Wisconsin Investment Board | 0.00% | Add +506.4% | 84,144 | $1.0M |
| California State Teachers Retirement System | 0.00% | Add +1726.1% | 79,090 | $955K |
| Campbell & CO Investment Adviser LLC | 0.05% | Add +221.7% | 78,763 | $951K |
| Squarepoint Ops LLC | 0.00% | New | 76,562 | $925K |
| D. E. Shaw & Co. | 0.00% | Add +6.3% | 73,224 | $885K |
| Legal & General Group Plc | 0.00% | Add +8.0% | 72,612 | $877K |
| Alliancebernstein L.P. | 0.00% | No change | 71,500 | $864K |
| Susquehanna International Group, LLP | 0.00% | New | 68,892 | $832K |
| JPMorgan Chase & Co. | 0.00% | Add +85.7% | 66,547 | $804K |
| Russell Investments Group, Ltd. | 0.00% | Add +18.1% | 65,438 | $790K |
| Kennondale Capital Management LLC | 0.47% | Reduce -50.8% | 53,423 | $645K |
| Informed Momentum Co LLC | 0.07% | Reduce -29.1% | 53,256 | $643K |
| Sei Investments Co. | 0.00% | New | 52,856 | $639K |
| MetLife Investment Management, LLC | 0.00% | Add +15.7% | 49,654 | $600K |
| Trexquant Investment LP | 0.01% | Reduce -78.4% | 48,112 | $581K |
| Millennium Management | 0.00% | Reduce -88.9% | 46,455 | $561K |
| Mariner, LLC | 0.00% | Reduce -3.5% | 46,342 | $560K |
| PSP Research LLC | 0.47% | — | 44,223 | $534K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +28.6% | 41,166 | $497K |
| Citigroup Inc. | 0.00% | Reduce -0.1% | 38,032 | $459K |
| Gsa Capital Partners LLP | 0.04% | Reduce -29.5% | 36,758 | $444K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +1782.3% | 35,877 | $433K |
| Fox Run Management, L.L.C. | 0.07% | New | 35,409 | $428K |
| Intech Investment Management LLC | 0.00% | Add +64.2% | 32,006 | $387K |
| Persistent Asset Partners Ltd | 0.18% | Add +35.9% | 31,147 | $376K |
| Headlands Technologies LLC | 0.03% | New | 30,543 | $369K |
"% of holder's portfolio" is AMLX's weight in each manager's 13F, not the share of Amylyx Pharmaceuticals Inc. the manager owns.