Amylyx PharmaceuticalsAMLX
13F holders, Q2 2025 (June 30)131holders −5
30new positions
36sold out
6famous investors
$6.41avg. 13F price*
At the end of Q2 2025, 131 institutions reported holding Amylyx Pharmaceuticals Inc. (AMLX) in their 13F filings, down 5 from Q1 2025. 30 opened new positions and 36 sold out. The largest holders were Adage Capital Partners Gp, L.L.C. ($56.4M), Perceptive Advisors LLC ($50.7M) and TCG Crossover Management, LLC ($38.1M). 6 famous investors held it, including Steve Cohen (0.1% of Point72 Asset Management's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Amylyx Pharmaceuticals Inc.
- CUSIP
- 03237H101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2025 → Q2 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 30 | $22.6M |
| Exits | 36 | $9.1M |
All 13F filers, Q1 2025 → Q2 2025: 21,617,265 shares bought and 13,827,492 shares sold, net +7,789,773 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 131 holders
| Adage Capital Partners Gp, L.L.C. | 0.10% | Add +54.5% | 8,800,000 | $56.4M |
| Perceptive Advisors LLC | 1.90% | Add +0.4% | 7,902,365 | $50.7M |
| TCG Crossover Management, LLC | 4.35% | No change | 5,943,812 | $38.1M |
| BlackRock, Inc. | 0.00% | Add +130.8% | 5,510,189 | $35.3M |
| Point72 Asset Management | 0.07% | Add +394.7% | 4,536,266 | $29.1M |
| Vanguard Group Inc. | 0.00% | Add +9.3% | 4,498,028 | $28.8M |
| Saturn V Capital Management LP | 8.47% | Add +34.4% | 3,260,570 | $20.9M |
| FMR LLC | 0.00% | Add +163.2% | 3,048,019 | $19.5M |
| Nantahala Capital Management, LLC | 1.33% | No change | 2,934,405 | $18.8M |
| 683 Capital Management, LLC | 1.49% | Reduce -10.4% | 2,160,000 | $13.8M |
| Almitas Capital LLC | 3.44% | No change | 2,122,597 | $13.6M |
| Great Point Partners LLC | 8.34% | Add +10.4% | 2,000,000 | $12.8M |
| Geode Capital Management, LLC | 0.00% | Add +109.9% | 1,692,413 | $10.9M |
| Millennium Management | 0.01% | Reduce -50.9% | 1,512,058 | $9.7M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -35.2% | 1,297,982 | $8.3M |
| Driehaus Capital Management LLC | 0.06% | New | 1,264,997 | $8.1M |
| UBS Group AG | 0.00% | Reduce -9.7% | 1,253,344 | $8.0M |
| Citadel Advisors | 0.01% | Reduce -54.9% | 1,242,927 | $8.0M |
| Boxer Capital Management, LLC | 3.95% | Reduce -30.0% | 1,225,000 | $7.9M |
| ADAR1 Capital Management, LLC | 1.27% | Reduce -18.1% | 1,205,101 | $7.7M |
| Woodline Partners LP | 0.04% | Reduce -25.4% | 1,200,290 | $7.7M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.03% | Reduce -3.8% | 1,154,485 | $7.4M |
| State Street Corp. | 0.00% | Add +285.4% | 1,008,909 | $6.5M |
| Northern Trust Corp. | 0.00% | Add +488.6% | 820,164 | $5.3M |
| Aberdeen Group plc | 0.01% | Reduce -69.6% | 738,657 | $4.7M |
| PFM Health Sciences, LP | 0.42% | Reduce -12.2% | 732,256 | $4.7M |
| Parkman Healthcare Partners LLC | 0.48% | New | 650,000 | $4.2M |
| Schonfeld Strategic Advisors LLC | 0.03% | Add +451.9% | 646,443 | $4.1M |
| Deutsche Bank AG | 0.00% | Add +8.1% | 616,919 | $4.0M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +57.8% | 588,411 | $3.8M |
| Invesco Ltd. | 0.00% | Add +1184.4% | 586,883 | $3.8M |
| Acadian Asset Management LLC | 0.01% | Add +135.1% | 569,083 | $3.6M |
| Two Sigma Investments, LP | 0.01% | Reduce -26.7% | 558,846 | $3.6M |
| Rock Springs Capital Management LP | 0.20% | Add +45.6% | 499,764 | $3.2M |
| Morgan Stanley | 0.00% | Add +2.6% | 486,893 | $3.1M |
| Two Sigma Advisers, LP | 0.01% | Reduce -27.7% | 470,000 | $3.0M |
| Bank of America Corp. | 0.00% | Reduce -43.1% | 451,808 | $2.9M |
| Qube Research & Technologies Ltd | 0.00% | Reduce -53.5% | 438,026 | $2.8M |
| Renaissance Technologies | 0.00% | Reduce -23.1% | 396,200 | $2.5M |
| Dimensional Fund Advisors LP | 0.00% | Add +202.4% | 373,739 | $2.4M |
| Orbimed Advisors LLC | 0.05% | Reduce -10.0% | 313,200 | $2.0M |
| Wellington Management Group LLP | 0.00% | Reduce -0.7% | 288,618 | $1.9M |
| Alpha Wave Global, LP | 0.19% | Add +47.3% | 275,842 | $1.8M |
| J. Goldman & Co LP | 0.05% | New | 258,600 | $1.7M |
| Y-Intercept (Hong Kong) Ltd | 0.04% | New | 240,379 | $1.5M |
| Tetragon Partners GP Ltd | 0.40% | New | 218,750 | $1.4M |
| Aldebaran Capital, LLC | 1.38% | Reduce -16.0% | 217,827 | $1.4M |
| Federated Hermes, Inc. | 0.00% | Add +0.6% | 203,930 | $1.3M |
| Jane Street Group, LLC | 0.00% | Reduce -43.5% | 186,986 | $1.2M |
| Gsa Capital Partners LLP | 0.08% | Add +638.7% | 170,533 | $1.1M |
| Nuveen, LLC | 0.00% | New | 155,536 | $997K |
| D. E. Shaw & Co. | 0.00% | Reduce -43.9% | 151,502 | $971K |
| Bank of New York Mellon Corp | 0.00% | New | 150,837 | $967K |
| Bank of Montreal | 0.00% | No change | 143,512 | $920K |
| American Century Companies Inc. | 0.00% | Add +25.6% | 134,380 | $861K |
| Barclays PLC | 0.00% | Reduce -5.2% | 130,274 | $835K |
| Cubist Systematic Strategies, LLC | 0.01% | Add +48.3% | 123,242 | $790K |
| Allostery Investments LP | 9.81% | Reduce -54.9% | 120,119 | $770K |
| Susquehanna International Group, LLP | 0.00% | Reduce -92.5% | 110,846 | $711K |
| Rhumbline Advisers | 0.00% | New | 100,576 | $645K |
| Tang Capital Management LLC | 0.03% | No change | 100,000 | $641K |
| Informed Momentum Co LLC | 0.10% | New | 99,960 | $641K |
| Ameriprise Financial Inc. | 0.00% | Add +643.6% | 95,219 | $610K |
| Kennondale Capital Management LLC | 0.62% | Reduce -53.1% | 95,165 | $610K |
| T. Rowe Price Associates Inc. | 0.00% | Add +58.4% | 91,392 | $586K |
| JPMorgan Chase & Co. | 0.00% | Add +62.7% | 87,989 | $564K |
| Hennion & Walsh Asset Management, Inc. | 0.01% | Reduce -31.7% | 56,831 | $364K |
| Cantor Fitzgerald, L. P. | 0.01% | Reduce -50.0% | 50,000 | $321K |
| Mariner, LLC | 0.00% | Reduce -4.4% | 48,668 | $312K |
| Jump Financial, LLC | 0.00% | New | 47,800 | $306K |
| Centiva Capital, LP | 0.02% | Add +61.1% | 45,464 | $291K |
| MetLife Investment Management, LLC | 0.00% | New | 42,929 | $275K |
| Squarepoint Ops LLC | 0.00% | Reduce -46.4% | 40,643 | $261K |
| Wells Fargo & Company | 0.00% | Add +12600.3% | 38,101 | $244K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 37,987 | $243K |
| Intech Investment Management LLC | 0.00% | New | 36,315 | $233K |
| Guggenheim Capital LLC | 0.00% | Reduce -5.4% | 35,752 | $229K |
| Graham Capital Management, L.P. | 0.01% | New | 34,153 | $219K |
| Citigroup Inc. | 0.00% | Reduce -93.3% | 31,098 | $199K |
| Alliancebernstein L.P. | 0.00% | New | 30,600 | $196K |
| Quadrature Capital Ltd | 0.00% | Add +130.9% | 29,430 | $188K |
| Manufacturers Life Insurance Company, The | 0.00% | New | 25,999 | $167K |
| Group One Trading LLC | 0.01% | Reduce -40.2% | 25,856 | $166K |
| Bridgeway Capital Management, LLC | 0.00% | Reduce -83.5% | 25,700 | $165K |
| Los Angeles Capital Management LLC | 0.00% | New | 23,320 | $149K |
| New York State Common Retirement Fund | 0.00% | New | 21,900 | $140K |
| Parsons Capital Management Inc. | 0.01% | No change | 21,645 | $139K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Reduce -2.9% | 21,123 | $135K |
| Premier Path Wealth Partners, LLC | 0.02% | No change | 20,265 | $130K |
| Marex Group Ltd | 0.00% | No change | 20,000 | $128K |
| Brown Advisory Inc. | 0.00% | No change | 19,930 | $128K |
| Voya Investment Management LLC | 0.00% | New | 19,476 | $125K |
| China Universal Asset Management Co., Ltd. | 0.01% | Add +4.2% | 17,904 | $115K |
| ProShare Advisors LLC | 0.00% | New | 17,551 | $113K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | New | 15,992 | $103K |
| Prudential Financial Inc. | 0.00% | Add +2.8% | 15,620 | $100K |
| Royal Bank of Canada | 0.00% | Add +2.4% | 12,133 | $78K |
| Tudor Investment Corporation | 0.00% | Reduce -63.9% | 12,073 | $77K |
| Valeo Financial Advisors, LLC | 0.00% | No change | 10,000 | $64K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +9.8% | 7,467 | $48K |
"% of holder's portfolio" is AMLX's weight in each manager's 13F, not the share of Amylyx Pharmaceuticals Inc. the manager owns.