Amylyx PharmaceuticalsAMLX
13F holders, Q1 2025 (March 31)136holders +14
31new positions
16sold out
6famous investors
$3.54avg. 13F price*
At the end of Q1 2025, 136 institutions reported holding Amylyx Pharmaceuticals Inc. (AMLX) in their 13F filings, up 14 from Q4 2024. 31 opened new positions and 16 sold out. The largest holders were Perceptive Advisors LLC ($27.9M), TCG Crossover Management, LLC ($21.0M) and Adage Capital Partners Gp, L.L.C. ($20.2M). 6 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and Steve Cohen (0.0% of Point72 Asset Management's portfolio).
- Company
- Amylyx Pharmaceuticals Inc.
- CUSIP
- 03237H101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2024 → Q1 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 31 | $48.3M |
| Exits | 16 | $3.2M |
All 13F filers, Q4 2024 → Q1 2025: 28,887,960 shares bought and 4,793,495 shares sold, net +24,094,465 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 136 holders
| Perceptive Advisors LLC | 0.99% | Add +16.2% | 7,874,348 | $27.9M |
| TCG Crossover Management, LLC | 2.87% | Add +28.0% | 5,943,812 | $21.0M |
| Adage Capital Partners Gp, L.L.C. | 0.04% | New | 5,697,605 | $20.2M |
| Vanguard Group Inc. | 0.00% | Add +52.9% | 4,116,512 | $14.6M |
| Millennium Management | 0.01% | Add +418.6% | 3,081,853 | $10.9M |
| Nantahala Capital Management, LLC | 0.86% | Add +102.1% | 2,934,405 | $10.4M |
| Citadel Advisors | 0.01% | Add +39.9% | 2,757,776 | $9.8M |
| Aberdeen Group plc | 0.02% | Add +41.1% | 2,430,358 | $8.6M |
| Saturn V Capital Management LP | 4.33% | Add +172.9% | 2,426,436 | $8.6M |
| 683 Capital Management, LLC | 0.95% | Add +24.9% | 2,411,400 | $8.5M |
| BlackRock, Inc. | 0.00% | Add +4.8% | 2,387,409 | $8.5M |
| Almitas Capital LLC | 2.50% | Add +4.4% | 2,122,597 | $7.5M |
| Goldman Sachs Group Inc. | 0.00% | Add +7.7% | 2,002,961 | $7.1M |
| Great Point Partners LLC | 3.49% | New | 1,811,996 | $6.4M |
| Boxer Capital Management, LLC | 1.86% | No change | 1,750,000 | $6.2M |
| Woodline Partners LP | 0.04% | New | 1,609,447 | $5.7M |
| ADAR1 Capital Management, LLC | 1.03% | New | 1,471,587 | $5.2M |
| Susquehanna International Group, LLP | 0.01% | Add +69.4% | 1,470,925 | $5.2M |
| UBS Group AG | 0.00% | Add +115.8% | 1,388,427 | $4.9M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.02% | Reduce -5.0% | 1,199,691 | $4.2M |
| FMR LLC | 0.00% | Add +58.3% | 1,157,988 | $4.1M |
| Qube Research & Technologies Ltd | 0.01% | Add +20.8% | 942,891 | $3.3M |
| Point72 Asset Management | 0.01% | New | 916,966 | $3.2M |
| PFM Health Sciences, LP | 0.23% | New | 834,135 | $3.0M |
| Geode Capital Management, LLC | 0.00% | Add +42.0% | 806,161 | $2.9M |
| Bank of America Corp. | 0.00% | Reduce -67.3% | 794,354 | $2.8M |
| Two Sigma Investments, LP | 0.01% | Add +17.0% | 762,053 | $2.7M |
| Alyeska Investment Group, L.P. | 0.01% | Reduce -8.9% | 750,412 | $2.7M |
| Two Sigma Advisers, LP | 0.01% | Add +169.2% | 649,800 | $2.3M |
| Deutsche Bank AG | 0.00% | No change | 570,857 | $2.0M |
| Renaissance Technologies | 0.00% | Add +10.9% | 515,100 | $1.8M |
| Morgan Stanley | 0.00% | Add +2.2% | 474,418 | $1.7M |
| Citigroup Inc. | 0.00% | Reduce -24.0% | 463,240 | $1.6M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +24.7% | 372,853 | $1.3M |
| Orbimed Advisors LLC | 0.03% | No change | 348,000 | $1.2M |
| Rock Springs Capital Management LP | 0.07% | New | 343,228 | $1.2M |
| Jane Street Group, LLC | 0.00% | Reduce -56.7% | 331,185 | $1.2M |
| Wellington Management Group LLP | 0.00% | Add +38.6% | 290,682 | $1.0M |
| D. E. Shaw & Co. | 0.00% | Reduce -12.0% | 270,006 | $956K |
| Allostery Investments LP | 1.36% | New | 266,099 | $942K |
| State Street Corp. | 0.00% | Add +19.9% | 261,783 | $927K |
| Aldebaran Capital, LLC | 0.87% | Reduce -1.3% | 259,253 | $918K |
| Walleye Capital LLC | 0.01% | Reduce -51.6% | 250,888 | $888K |
| Marshall Wace, LLP | 0.00% | Add +33.9% | 247,275 | $875K |
| Acadian Asset Management LLC | 0.00% | Reduce -60.4% | 242,107 | $855K |
| Federated Hermes, Inc. | 0.00% | Add +0.2% | 202,785 | $718K |
| Kennondale Capital Management LLC | 0.78% | Add +50.8% | 202,743 | $718K |
| Alpha Wave Global, LP | 0.30% | Add +26.0% | 187,311 | $663K |
| OMERS ADMINISTRATION Corp | 0.01% | Add +157.0% | 169,600 | $600K |
| Bridgeway Capital Management, LLC | 0.01% | Add +6.3% | 155,700 | $551K |
| Balyasny Asset Management L.P. | 0.00% | Add +195.7% | 148,559 | $526K |
| Bank of Montreal | 0.00% | No change | 143,512 | $508K |
| Northern Trust Corp. | 0.00% | Add +30.8% | 139,332 | $493K |
| Barclays PLC | 0.00% | Add +83.6% | 137,405 | $486K |
| HRT Financial LP | 0.00% | New | 127,998 | $453K |
| Dimensional Fund Advisors LP | 0.00% | Add +128.4% | 123,576 | $438K |
| Schonfeld Strategic Advisors LLC | 0.00% | Reduce -39.6% | 117,140 | $415K |
| American Century Companies Inc. | 0.00% | Add +80.4% | 107,014 | $379K |
| Tang Capital Management LLC | 0.02% | No change | 100,000 | $354K |
| Cantor Fitzgerald, L. P. | 0.01% | New | 100,000 | $354K |
| Man Group plc | 0.00% | Reduce -12.7% | 87,352 | $309K |
| Hennion & Walsh Asset Management, Inc. | 0.01% | Reduce -8.2% | 83,236 | $295K |
| Cubist Systematic Strategies, LLC | 0.00% | Reduce -82.4% | 83,130 | $294K |
| Jacobs Levy Equity Management, Inc. | 0.00% | Reduce -75.5% | 77,091 | $273K |
| Squarepoint Ops LLC | 0.00% | Add +0.8% | 75,849 | $269K |
| Jain Global LLC | 0.01% | New | 73,942 | $262K |
| Alps Advisors Inc. | 0.00% | Add +21.9% | 67,597 | $239K |
| ExodusPoint Capital Management, LP | 0.00% | Reduce -44.0% | 59,491 | $211K |
| T. Rowe Price Associates Inc. | 0.00% | No change | 57,700 | $205K |
| Algert Global LLC | 0.01% | New | 57,133 | $202K |
| JPMorgan Chase & Co. | 0.00% | Reduce -2.8% | 54,069 | $191K |
| Mariner, LLC | 0.00% | Add +0.7% | 50,906 | $180K |
| Jefferies Financial Group Inc. | 0.00% | No change | 46,200 | $164K |
| Invesco Ltd. | 0.00% | New | 45,694 | $162K |
| Group One Trading LLC | 0.01% | Reduce -13.4% | 43,234 | $153K |
| LMR Partners LLP | 0.00% | New | 43,228 | $153K |
| Point72 Asia (Singapore) Pte. Ltd. | 0.04% | Reduce -40.7% | 43,200 | $153K |
| Quantessence Capital LLC | 0.04% | New | 40,134 | $142K |
| XTX Topco Ltd | 0.01% | Reduce -25.9% | 39,542 | $140K |
| Guggenheim Capital LLC | 0.00% | Add +5.4% | 37,796 | $134K |
| Tudor Investment Corporation | 0.00% | Reduce -0.8% | 33,428 | $118K |
| Centiva Capital, LP | 0.01% | Reduce -16.6% | 28,222 | $100K |
| Cannon Global Investment Management, LLC | 0.25% | New | 25,500 | $90K |
| SG Americas Securities, LLC | 0.00% | Add +58.0% | 25,210 | $89K |
| Verition Fund Management LLC | 0.00% | New | 24,013 | $85K |
| Gsa Capital Partners LLP | 0.01% | Add +117.0% | 23,085 | $82K |
| Paloma Partners Management Co | 0.03% | New | 22,242 | $79K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Add +22.8% | 21,756 | $77K |
| Parsons Capital Management Inc. | 0.00% | No change | 21,645 | $77K |
| Premier Path Wealth Partners, LLC | 0.01% | New | 20,265 | $72K |
| Marex Group Ltd | 0.00% | No change | 20,000 | $71K |
| Brown Advisory Inc. | 0.00% | No change | 19,930 | $71K |
| China Universal Asset Management Co., Ltd. | 0.01% | Add +18.3% | 17,188 | $61K |
| Capstone Investment Advisors, LLC | 0.00% | New | 16,150 | $57K |
| State of Wyoming | 0.01% | Reduce -1.0% | 15,920 | $56K |
| Prudential Financial Inc. | 0.00% | Reduce -21.6% | 15,200 | $54K |
| Catalyst Funds Management Pty Ltd | 0.01% | New | 14,905 | $53K |
| HSBC Holdings PLC | 0.00% | Add +24.7% | 14,419 | $51K |
| Engineers Gate Manager LP | 0.00% | Reduce -24.1% | 13,382 | $47K |
| Two Sigma Securities, LLC | 0.01% | New | 13,301 | $47K |
"% of holder's portfolio" is AMLX's weight in each manager's 13F, not the share of Amylyx Pharmaceuticals Inc. the manager owns.