Krystal BiotechKRYS
13F holders, Q4 2025 (December 31)334holders +50
62new positions
26sold out
9famous investors
$246.50avg. 13F price*
At the end of Q4 2025, 334 institutions reported holding Krystal Biotech Inc. (KRYS) in their 13F filings, up 50 from Q3 2025. 62 opened new positions and 26 sold out. The largest holders were FMR LLC ($1.1B), BlackRock, Inc. ($970.8M) and Avoro Capital Advisors LLC ($712.2M). 9 famous investors held it, including Ken Griffin (0.1% of Citadel Advisors's portfolio), Ray Dalio (0.0% of Bridgewater Associates's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Krystal Biotech Inc.
- CUSIP
- 501147102
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 62 | $44.8M |
| Exits | 26 | $29.0M |
All 13F filers, Q3 2025 → Q4 2025: 1,945,989 shares bought and 1,904,798 shares sold, net +41,191 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 334 holders
| FMR LLC | 0.05% | Add +0.2% | 4,349,628 | $1.1B |
| BlackRock, Inc. | 0.02% | Add +2.7% | 3,937,817 | $970.8M |
| Avoro Capital Advisors LLC | 7.00% | Add +4.0% | 2,888,888 | $712.2M |
| Vanguard Group Inc. | 0.01% | Reduce -0.5% | 2,778,845 | $685.1M |
| State Street Corp. | 0.01% | Reduce -3.8% | 1,342,303 | $330.9M |
| Soleus Capital Management, L.P. | 9.84% | Reduce -7.6% | 941,059 | $232.0M |
| Capital World Investors | 0.03% | Add +0.0% | 809,500 | $199.6M |
| Redmile Group, LLC | 12.30% | Add +2.5% | 677,705 | $167.1M |
| Hood River Capital Management LLC | 1.66% | Add +1.1% | 613,302 | $151.2M |
| Geode Capital Management, LLC | 0.01% | Add +0.1% | 611,878 | $150.9M |
| T. Rowe Price Associates Inc. | 0.01% | Add +13.5% | 529,955 | $130.7M |
| Dimensional Fund Advisors LP | 0.03% | Reduce -7.7% | 492,968 | $121.5M |
| Frazier Life Sciences Management, L.P. | 3.24% | Reduce -29.1% | 488,460 | $120.4M |
| Bellevue Group AG | 1.92% | Add +31174.6% | 410,323 | $101.2M |
| Citadel Advisors | 0.07% | Reduce -39.3% | 386,505 | $95.3M |
| William Blair Investment Management, LLC | 0.26% | Add +152.1% | 376,340 | $92.8M |
| Goldman Sachs Group Inc. | 0.01% | Reduce -15.7% | 293,525 | $72.4M |
| Norges Bank | 0.01% | — | 284,573 | $70.2M |
| Northern Trust Corp. | 0.01% | Reduce -0.3% | 247,443 | $61.0M |
| First Trust Advisors LP | 0.04% | Reduce -1.3% | 245,276 | $60.5M |
| Charles Schwab Investment Management Inc. | 0.01% | Reduce -0.0% | 242,774 | $59.9M |
| Morgan Stanley | 0.00% | Reduce -5.6% | 221,481 | $54.6M |
| Janus Henderson Group PLC | 0.02% | Add +2078.9% | 219,440 | $54.1M |
| Braidwell LP | 1.91% | Reduce -61.2% | 202,101 | $49.8M |
| Bank of America Corp. | 0.00% | Add +38.3% | 190,807 | $47.0M |
| Nuveen, LLC | 0.01% | Reduce -4.2% | 189,094 | $46.6M |
| Marshall Wace, LLP | 0.04% | Add +42.5% | 183,754 | $45.3M |
| Principal Financial Group Inc. | 0.02% | Add +15.6% | 165,074 | $40.7M |
| UBS Group AG | 0.01% | Add +22.6% | 159,595 | $39.3M |
| Pictet Asset Management Holding SA | 0.04% | Reduce -20.5% | 156,568 | $38.6M |
| Bank of New York Mellon Corp | 0.01% | Reduce -2.7% | 151,313 | $37.3M |
| Woodline Partners LP | 0.14% | No change | 150,616 | $37.1M |
| JPMorgan Chase & Co. | 0.00% | Reduce -8.0% | 134,624 | $33.2M |
| Franklin Resources Inc. | 0.01% | Add +533.1% | 125,675 | $31.0M |
| Orbimed Advisors LLC | 0.60% | Add +16.6% | 119,800 | $29.5M |
| Handelsbanken Fonder AB | 0.08% | Add +58.4% | 105,800 | $26.1M |
| Voya Investment Management LLC | 0.03% | Add +10.0% | 103,261 | $25.5M |
| TimesSquare Capital Management, LLC | 0.36% | Reduce -17.8% | 97,400 | $24.0M |
| S Squared Technology, LLC | 9.19% | Reduce -11.9% | 96,215 | $23.7M |
| Public Sector Pension Investment Board | 0.07% | Reduce -11.0% | 89,362 | $22.0M |
| C WorldWide Group Holding A/S | 0.37% | No change | 85,809 | $21.2M |
| Segall Bryant & Hamill, LLC | 0.28% | Reduce -2.4% | 83,246 | $20.5M |
| Raymond James Financial Inc. | 0.01% | Add +18.9% | 76,538 | $19.0M |
| Biondo Investment Advisors, LLC | 2.03% | Add +31.3% | 68,130 | $16.8M |
| Rhumbline Advisers | 0.01% | Reduce -5.8% | 66,436 | $16.4M |
| Legal & General Group Plc | 0.00% | Reduce -3.7% | 63,361 | $15.6M |
| Act Capital Management, LLC | 12.06% | — | 60,500 | $14.9M |
| Barclays PLC | 0.01% | Reduce -20.9% | 60,062 | $14.8M |
| Invesco Ltd. | 0.00% | Reduce -10.3% | 60,008 | $14.8M |
| TD Asset Management Inc | 0.01% | Add +20.1% | 54,142 | $13.3M |
| BNP Paribas Financial Markets | 0.01% | Add +487.3% | 53,911 | $13.3M |
| Ameriprise Financial Inc. | 0.00% | Reduce -6.2% | 52,345 | $12.9M |
| Skandinaviska Enskilda Banken AB (publ) | 0.05% | Reduce -22.1% | 46,732 | $11.5M |
| Swiss National Bank | 0.01% | Add +2.1% | 42,900 | $10.6M |
| Palisades Investment Partners, LLC | 3.98% | Add +3.3% | 42,765 | $10.5M |
| Manufacturers Life Insurance Company, The | 0.01% | Add +17.9% | 40,629 | $10.1M |
| Aberdeen Group plc | 0.01% | Reduce -33.7% | 39,360 | $9.7M |
| Corient Private Wealth LP | 0.01% | Reduce -2.0% | 38,346 | $9.5M |
| Mutual of America Capital Management LLC | 0.10% | Reduce -1.8% | 37,269 | $9.2M |
| Federated Hermes, Inc. | 0.01% | Add +44.0% | 34,541 | $8.5M |
| Atle Fund Management AB | 2.66% | Reduce -19.8% | 33,853 | $8.3M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -83.4% | 33,617 | $8.3M |
| Sei Investments Co. | 0.01% | Add +38.1% | 32,310 | $8.0M |
| Wells Fargo & Company | 0.00% | Add +60.6% | 31,572 | $7.8M |
| Alliancebernstein L.P. | 0.00% | Add +5.4% | 31,529 | $7.8M |
| New York State Common Retirement Fund | 0.01% | Add +16.1% | 31,342 | $7.7M |
| Citigroup Inc. | 0.01% | Add +210.3% | 29,943 | $7.4M |
| Castleark Management LLC | 0.21% | New | 29,260 | $7.2M |
| Russell Investments Group, Ltd. | 0.01% | Add +9.1% | 28,954 | $7.1M |
| Prudential Financial Inc. | 0.01% | Add +6.0% | 27,015 | $6.7M |
| Victory Capital Management Inc. | 0.00% | Reduce -51.7% | 26,461 | $6.5M |
| Granite Investment Partners, LLC | 0.38% | New | 25,760 | $6.4M |
| Rhenman & Partners Asset Management AB | 0.58% | Add +112.8% | 25,000 | $6.2M |
| Informed Momentum Co LLC | 0.68% | New | 24,667 | $6.1M |
| Rafferty Asset Management, LLC | 0.02% | Reduce -29.9% | 24,268 | $6.0M |
| EFG International AG | 0.11% | — | 23,569 | $5.8M |
| Deutsche Bank AG | 0.00% | Add +5.0% | 22,450 | $5.5M |
| CANADA LIFE ASSURANCE Co | 0.01% | Add +3.2% | 22,087 | $5.4M |
| Elmind Capital, LP | 1.60% | — | 22,000 | $5.4M |
| California State Teachers Retirement System | 0.01% | Reduce -1.4% | 20,583 | $5.1M |
| Bessemer Group Inc. | 0.01% | Add +13497.3% | 20,260 | $5.0M |
| ADAR1 Capital Management, LLC | 0.37% | Add +8.1% | 20,014 | $4.9M |
| GW&K Investment Management, LLC | 0.04% | Add +86.6% | 19,581 | $4.8M |
| SG Americas Securities, LLC | 0.01% | Add +469.9% | 18,909 | $4.7M |
| Fiera Capital Corp | 0.01% | Add +25.2% | 18,857 | $4.6M |
| State of Alaska, Department of Revenue | 0.05% | Add +25.4% | 17,902 | $4.4M |
| Thrivent Financial for Lutherans | 0.01% | Reduce -4.6% | 17,734 | $4.4M |
| 1832 Asset Management L.P. | 0.01% | New | 17,600 | $4.3M |
| Perceptive Advisors LLC | 0.08% | Reduce -50.0% | 17,500 | $4.3M |
| Decheng Capital LLC | 0.57% | Reduce -46.4% | 17,300 | $4.3M |
| Pinnacle Financial Partners, Inc. | 0.03% | — | 16,983 | $4.2M |
| Verition Fund Management LLC | 0.02% | Reduce -45.8% | 16,969 | $4.2M |
| Evolutionary Tree Capital Management, LLC | 4.81% | Add +34.9% | 16,811 | $4.1M |
| State Board of Administration of Florida Retirement System | 0.01% | Add +172.4% | 15,756 | $3.9M |
| New York State Teachers Retirement System | 0.01% | Add +0.6% | 15,650 | $3.9M |
| Ikarian Capital, LLC | 0.47% | Reduce -39.3% | 14,814 | $3.7M |
| Millennium Management | 0.00% | Reduce -90.1% | 14,658 | $3.6M |
| State of Wisconsin Investment Board | 0.01% | Reduce -50.7% | 14,466 | $3.6M |
| AQR Capital Management | 0.00% | Reduce -29.7% | 14,157 | $3.5M |
| Creative Planning | 0.00% | Add +19.6% | 13,881 | $3.4M |
"% of holder's portfolio" is KRYS's weight in each manager's 13F, not the share of Krystal Biotech Inc. the manager owns.