Pyxis OncologyPYXS
13F holders, Q4 2025 (December 31)79holders +6
19new positions
14sold out
4famous investors
$1.15avg. 13F price*
At the end of Q4 2025, 79 institutions reported holding Pyxis Oncology Inc. (PYXS) in their 13F filings, up 6 from Q3 2025. 19 opened new positions and 14 sold out. The largest holders were Pfizer Inc ($8.1M), Laurion Capital Management LP ($5.5M) and GordonMD Global Investments LP ($4.7M). 4 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Steve Cohen (0.0% of Point72 Asset Management's portfolio).
- Company
- Pyxis Oncology Inc.
- CUSIP
- 747324101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 19 | $2.5M |
| Exits | 14 | $12.5M |
All 13F filers, Q3 2025 → Q4 2025: 5,272,841 shares bought and 6,030,382 shares sold, net −757,541 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 79 holders
| Pfizer Inc | 3.42% | No change | 7,032,770 | $8.1M |
| Laurion Capital Management LP | 0.39% | Add +32.3% | 4,796,479 | $5.5M |
| GordonMD Global Investments LP | 3.40% | — | 4,121,870 | $4.7M |
| Vanguard Group Inc. | 0.00% | Add +7.9% | 2,335,768 | $2.7M |
| Palo Alto Investors LP | 0.17% | No change | 1,037,421 | $1.2M |
| 683 Capital Management, LLC | 0.09% | Add +69.9% | 891,910 | $1.0M |
| Jane Street Group, LLC | 0.00% | Add +158.8% | 786,010 | $904K |
| BlackRock, Inc. | 0.00% | Add +14.7% | 784,077 | $902K |
| Millennium Management | 0.00% | Reduce -8.9% | 743,107 | $855K |
| Renaissance Technologies | 0.00% | Add +26.4% | 728,380 | $838K |
| Atle Fund Management AB | 0.23% | New | 617,245 | $710K |
| Bank of America Corp. | 0.00% | Reduce -4.6% | 587,851 | $676K |
| Geode Capital Management, LLC | 0.00% | Add +6.0% | 577,211 | $664K |
| Longaeva Partners L.P. | 0.07% | No change | 503,214 | $579K |
| UBS Group AG | 0.00% | Add +5.1% | 392,766 | $452K |
| Marshall Wace, LLP | 0.00% | New | 389,764 | $448K |
| Decheng Capital LLC | 0.05% | No change | 326,810 | $376K |
| ExodusPoint Capital Management, LP | 0.00% | New | 317,769 | $365K |
| XTX Topco Ltd | 0.01% | Add +1533.0% | 289,033 | $332K |
| Citadel Advisors | 0.00% | Reduce -27.8% | 243,589 | $280K |
| State Street Corp. | 0.00% | Add +19.6% | 241,637 | $278K |
| Point72 Asset Management | 0.00% | New | 188,136 | $216K |
| Graham Capital Management, L.P. | 0.01% | New | 183,942 | $212K |
| Bank of New York Mellon Corp | 0.00% | No change | 165,044 | $190K |
| Qube Research & Technologies Ltd | 0.00% | Add +373.3% | 145,813 | $168K |
| NewEdge Wealth, LLC | 0.00% | No change | 116,006 | $133K |
| Susquehanna International Group, LLP | 0.00% | Reduce -21.2% | 108,414 | $125K |
| Two Sigma Investments, LP | 0.00% | Add +126.9% | 105,528 | $121K |
| Northern Trust Corp. | 0.00% | Add +1.2% | 101,948 | $117K |
| Quadrature Capital Ltd | 0.00% | New | 100,536 | $116K |
| Morgan Stanley | 0.00% | Reduce -16.3% | 89,222 | $103K |
| Goldman Sachs Group Inc. | 0.00% | Reduce -31.3% | 86,145 | $99K |
| Toronto Dominion Bank | 0.00% | New | 75,000 | $86K |
| Bridgeway Capital Management, LLC | 0.00% | Reduce -5.2% | 72,700 | $84K |
| OMERS ADMINISTRATION Corp | 0.00% | New | 67,000 | $77K |
| Cable Car Capital, LP | 0.00% | No change | 61,606 | $71K |
| Barclays PLC | 0.00% | Add +1939.3% | 60,385 | $69K |
| Royal Bank of Canada | 0.00% | Reduce -28.8% | 55,551 | $64K |
| J. Derek Lewis & Associates Inc. | 0.01% | — | 53,000 | $61K |
| Dimensional Fund Advisors LP | 0.00% | Add +37.1% | 50,066 | $58K |
| University of Chicago | 0.03% | No change | 48,731 | $56K |
| Velan Capital Investment Management LP | 0.03% | Reduce -27.3% | 40,000 | $46K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -35.0% | 39,755 | $46K |
| HRT Financial LP | 0.00% | Add +157.5% | 39,649 | $45K |
| LPL Financial LLC | 0.00% | Add +150.7% | 35,102 | $40K |
| American Century Companies Inc. | 0.00% | New | 31,936 | $37K |
| Lighthouse Investment Partners, LLC | 0.00% | New | 28,860 | $33K |
| Avanza Fonder AB | 0.00% | New | 27,345 | $31K |
| Cetera Investment Advisers | 0.00% | Reduce -1.8% | 27,260 | $31K |
| Maia Wealth LLC | 0.01% | New | 21,959 | $30K |
| BNP Paribas Financial Markets | 0.00% | Add +1314.0% | 24,279 | $28K |
| Engineers Gate Manager LP | 0.00% | New | 22,816 | $26K |
| Two Sigma Advisers, LP | 0.00% | Reduce -56.9% | 22,624 | $26K |
| Fox Run Management, L.L.C. | 0.00% | New | 22,566 | $26K |
| Osaic Holdings, Inc. | 0.00% | Add +13.2% | 17,224 | $20K |
| Jefferies Financial Group Inc. | 0.00% | New | 16,000 | $18K |
| FMR LLC | 0.00% | Reduce -16.8% | 12,858 | $15K |
| Paces Ferry Wealth Advisors, LLC | 0.01% | New | 11,440 | $13K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -16.7% | 10,810 | $12K |
| NewEdge Advisors, LLC | 0.00% | Add +4000.0% | 10,250 | $12K |
| China Universal Asset Management Co., Ltd. | 0.00% | Reduce -6.7% | 10,146 | $12K |
| Simplex Trading, LLC | 0.00% | Add +31.7% | 9,790 | $11K |
| Balyasny Asset Management L.P. | 0.00% | New | 8,227 | $9K |
| Winthrop Capital Management, LLC | 0.00% | No change | 6,000 | $7K |
| JPMorgan Chase & Co. | 0.00% | Add +22.2% | 5,514 | $6K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +26.2% | 3,026 | $3K |
| Citigroup Inc. | 0.00% | Add +126.5% | 2,902 | $3K |
| Wells Fargo & Company | 0.00% | Add +701.8% | 2,285 | $3K |
| Federated Hermes, Inc. | 0.00% | New | 1,894 | $2K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -4.3% | 1,277 | $1K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 961 | $1K |
| Physician Wealth Advisors, Inc. | 0.00% | No change | 943 | $1K |
| Jones Financial Companies LLLP | 0.00% | No change | 500 | $575 |
| Cornerstone Financial Management LLC | 0.00% | — | 172 | $198 |
| US Bancorp \de | 0.00% | New | 94 | $108 |
| Arax Advisory Partners | 0.00% | No change | 14 | $16 |
| Northwestern Mutual Wealth Management Co. | 0.00% | No change | 12 | $14 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -50.0% | 1 | $1 |
| Cwm, LLC | 0.00% | Reduce -83.1% | 70 | $0 |
"% of holder's portfolio" is PYXS's weight in each manager's 13F, not the share of Pyxis Oncology Inc. the manager owns.