Pyxis OncologyPYXS
13F holders, Q3 2025 (September 30)73holders −1
14new positions
15sold out
4famous investors
$2.23avg. 13F price*
At the end of Q3 2025, 73 institutions reported holding Pyxis Oncology Inc. (PYXS) in their 13F filings, down 1 from Q2 2025. 14 opened new positions and 15 sold out. The largest holders were Pfizer Inc ($15.6M), Laurion Capital Management LP ($8.0M) and Tang Capital Management LLC ($5.5M). 4 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Pyxis Oncology Inc.
- CUSIP
- 747324101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 14 | $8.1M |
| Exits | 15 | $1.5M |
All 13F filers, Q2 2025 → Q3 2025: 4,521,217 shares bought and 5,149,386 shares sold, net −628,169 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 73 holders
| Pfizer Inc | 3.57% | No change | 7,032,770 | $15.6M |
| Laurion Capital Management LP | 1.19% | No change | 3,625,974 | $8.0M |
| Tang Capital Management LLC | 0.21% | No change | 2,500,000 | $5.5M |
| Vanguard Group Inc. | 0.00% | Add +0.7% | 2,163,962 | $4.8M |
| Perceptive Advisors LLC | 0.08% | New | 1,178,307 | $2.6M |
| Palo Alto Investors LP | 0.43% | No change | 1,037,421 | $2.3M |
| Millennium Management | 0.00% | Reduce -77.0% | 815,331 | $1.8M |
| Stempoint Capital LP | 0.31% | New | 689,538 | $1.5M |
| BlackRock, Inc. | 0.00% | Reduce -26.2% | 683,702 | $1.5M |
| Bank of America Corp. | 0.00% | Add +2690.9% | 615,922 | $1.4M |
| Renaissance Technologies | 0.00% | Add +37.9% | 576,336 | $1.3M |
| Geode Capital Management, LLC | 0.00% | Add +6.6% | 544,508 | $1.2M |
| 683 Capital Management, LLC | 0.11% | Reduce -3.7% | 525,000 | $1.2M |
| Longaeva Partners L.P. | 0.24% | New | 503,214 | $1.1M |
| Driehaus Capital Management LLC | 0.01% | New | 418,632 | $929K |
| UBS Group AG | 0.00% | Reduce -5.7% | 373,727 | $830K |
| Citadel Advisors | 0.00% | New | 337,359 | $749K |
| Decheng Capital LLC | 0.13% | No change | 326,810 | $726K |
| Jane Street Group, LLC | 0.00% | Reduce -9.6% | 303,700 | $674K |
| Schulhoff & Co. Inc. | 0.26% | No change | 275,000 | $611K |
| NewEdge Wealth, LLC | 0.01% | No change | 116,006 | $454K |
| State Street Corp. | 0.00% | Add +8.6% | 202,055 | $449K |
| Bank of New York Mellon Corp | 0.00% | No change | 165,044 | $366K |
| Pier 88 Investment Partners LLC | 0.37% | Reduce -58.7% | 151,730 | $337K |
| Diadema Partners LP | 0.23% | New | 150,000 | $333K |
| Susquehanna International Group, LLP | 0.00% | Add +20.3% | 137,531 | $305K |
| Goldman Sachs Group Inc. | 0.00% | Reduce -44.1% | 125,454 | $279K |
| Walleye Capital LLC | 0.00% | New | 119,561 | $265K |
| Morgan Stanley | 0.00% | Reduce -33.4% | 106,607 | $237K |
| Northern Trust Corp. | 0.00% | Reduce -1.4% | 100,773 | $224K |
| Royal Bank of Canada | 0.00% | Reduce -9.7% | 77,980 | $173K |
| Bridgeway Capital Management, LLC | 0.00% | Reduce -46.1% | 76,700 | $170K |
| Cable Car Capital, LP | 0.10% | No change | 61,606 | $137K |
| Commonwealth Equity Services, LLC | 0.00% | No change | 61,155 | $136K |
| Jacobs Levy Equity Management, Inc. | 0.00% | New | 60,333 | $134K |
| Velan Capital Investment Management LP | 0.11% | Add +37.5% | 55,000 | $122K |
| Two Sigma Advisers, LP | 0.00% | New | 52,524 | $117K |
| University of Chicago | 0.05% | No change | 48,731 | $108K |
| Two Sigma Investments, LP | 0.00% | New | 46,501 | $103K |
| Acadian Asset Management LLC | 0.00% | Add +127.4% | 43,082 | $94K |
| Dimensional Fund Advisors LP | 0.00% | No change | 36,516 | $81K |
| Persistent Asset Partners Ltd | 0.06% | New | 34,632 | $77K |
| Cubist Systematic Strategies, LLC | 0.00% | New | 33,061 | $73K |
| Qube Research & Technologies Ltd | 0.00% | Reduce -70.1% | 30,808 | $68K |
| Cetera Investment Advisers | 0.00% | Reduce -3.5% | 27,760 | $62K |
| Point72 Asia (Singapore) Pte. Ltd. | 0.01% | Reduce -6.1% | 18,057 | $40K |
| XTX Topco Ltd | 0.00% | Reduce -51.4% | 17,699 | $39K |
| Prudential Financial Inc. | 0.00% | New | 16,300 | $36K |
| FMR LLC | 0.00% | Reduce -83.7% | 15,455 | $34K |
| HRT Financial LP | 0.00% | Reduce -69.6% | 15,398 | $34K |
| LPL Financial LLC | 0.00% | Reduce -1.4% | 14,002 | $31K |
| AQR Capital Management | 0.00% | Reduce -84.1% | 13,832 | $31K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -11.4% | 12,982 | $29K |
| China Universal Asset Management Co., Ltd. | 0.00% | Reduce -12.6% | 10,871 | $24K |
| Osaic Holdings, Inc. | 0.00% | Reduce -14.1% | 15,221 | $19K |
| Simplex Trading, LLC | 0.00% | Reduce -41.1% | 7,433 | $16K |
| Winthrop Capital Management, LLC | 0.00% | No change | 6,000 | $13K |
| JPMorgan Chase & Co. | 0.00% | Add +118.2% | 4,513 | $10K |
| Barclays PLC | 0.00% | Reduce -39.0% | 2,961 | $7K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +0.2% | 2,398 | $5K |
| BNP Paribas Financial Markets | 0.00% | Reduce -6.3% | 1,717 | $4K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -6.7% | 1,334 | $3K |
| Citigroup Inc. | 0.00% | Reduce -85.7% | 1,281 | $3K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 961 | $2K |
| Physician Wealth Advisors, Inc. | 0.00% | No change | 943 | $2K |
| Jones Financial Companies LLLP | 0.00% | Reduce -66.7% | 500 | $1K |
| Cwm, LLC | 0.00% | Reduce -93.7% | 414 | $1K |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -26.6% | 434 | $964 |
| Wells Fargo & Company | 0.00% | Reduce -59.2% | 285 | $633 |
| NewEdge Advisors, LLC | 0.00% | No change | 250 | $555 |
| Arax Advisory Partners | 0.00% | New | 14 | $31 |
| Northwestern Mutual Wealth Management Co. | 0.00% | No change | 12 | $27 |
| SBI Securities Co., Ltd. | 0.00% | Add +100.0% | 2 | $4 |
"% of holder's portfolio" is PYXS's weight in each manager's 13F, not the share of Pyxis Oncology Inc. the manager owns.