| Ra Capital Management, L.P. | 2.13% | New | 6,995,858 | $160.2M |
| TRV GP V, LLC | 48.42% | — | 6,215,591 | $142.3M |
| TRV GP Vi, LLC | 61.75% | — | 3,152,456 | $72.2M |
| Samsara Biocapital, LLC | 8.70% | New | 2,768,520 | $63.4M |
| Driehaus Capital Management LLC | 0.49% | New | 2,589,553 | $59.3M |
| BVF Inc. | 1.90% | New | 2,452,024 | $56.2M |
| Siren, L.L.C. | 2.23% | New | 2,202,514 | $50.4M |
| Deep Track Capital, LP | 1.64% | New | 1,912,929 | $43.8M |
| BlackRock, Inc. | 0.00% | New | 1,677,135 | $38.4M |
| Goldman Sachs Group Inc. | 0.01% | New | 1,674,357 | $38.3M |
| Avoro Capital Advisors LLC | 0.36% | New | 1,110,000 | $25.4M |
| Janus Henderson Group PLC | 0.01% | New | 1,096,302 | $25.1M |
| Catalio Capital Management, LP | 5.13% | — | 1,024,245 | $23.5M |
| FMR LLC | 0.00% | New | 1,002,958 | $23.0M |
| Vanguard Group Inc. | 0.00% | New | 985,032 | $22.6M |
| Deerfield Management Company, L.P. | 0.42% | New | 861,814 | $19.7M |
| Perceptive Advisors LLC | 0.48% | New | 750,000 | $17.2M |
| Soleus Capital Management, L.P. | 1.17% | New | 675,409 | $15.5M |
| Cormorant Asset Management, LP | 0.70% | New | 560,000 | $12.8M |
| Casdin Capital, LLC | 0.85% | New | 553,268 | $12.7M |
| T. Rowe Price Associates Inc. | 0.00% | New | 518,588 | $11.9M |
| Citadel Advisors | 0.01% | New | 404,882 | $9.3M |
| Geode Capital Management, LLC | 0.00% | New | 380,577 | $8.7M |
| Woodline Partners LP | 0.05% | New | 300,000 | $6.9M |
| Adage Capital Partners Gp, L.L.C. | 0.01% | New | 300,000 | $6.9M |
| State Street Corp. | 0.00% | New | 272,776 | $6.2M |
| Sio Capital Management, LLC | 1.75% | New | 271,687 | $6.2M |
| ArrowMark Colorado Holdings LLC | 0.05% | New | 147,886 | $3.4M |
| Northern Trust Corp. | 0.00% | New | 147,776 | $3.4M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 139,616 | $3.2M |
| Logos Global Management LP | 0.36% | New | 134,202 | $3.1M |
| UBS Group AG | 0.00% | New | 108,453 | $2.5M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | — | 102,749 | $2.4M |
| Bank of America Corp. | 0.00% | New | 78,744 | $1.8M |
| TD Asset Management Inc | 0.00% | New | 69,460 | $1.6M |
| Morgan Stanley | 0.00% | New | 41,911 | $960K |
| Bank of New York Mellon Corp | 0.00% | New | 38,093 | $872K |
| JPMorgan Chase & Co. | 0.00% | New | 38,015 | $871K |
| Alyeska Investment Group, L.P. | 0.00% | New | 35,000 | $802K |
| Barclays PLC | 0.00% | New | 28,785 | $659K |
| Jane Street Group, LLC | 0.00% | New | 26,208 | $600K |
| Nuveen Asset Management, LLC | 0.00% | New | 23,961 | $549K |
| Verition Fund Management LLC | 0.00% | New | 22,695 | $520K |
| Manufacturers Life Insurance Company, The | 0.00% | New | 22,095 | $506K |
| Lindbrook Capital, LLC | 0.04% | New | 21,000 | $481K |
| Walleye Capital LLC | 0.00% | New | 20,204 | $463K |
| Rhumbline Advisers | 0.00% | New | 19,995 | $458K |
| M&T Bank Corp | 0.00% | New | 16,394 | $376K |
| Citigroup Inc. | 0.00% | New | 14,633 | $335K |
| Invesco Ltd. | 0.00% | New | 12,154 | $278K |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0.01% | New | 12,118 | $278K |
| MetLife Investment Management, LLC | 0.00% | New | 11,555 | $265K |
| Wells Fargo & Company | 0.00% | New | 10,651 | $244K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 10,519 | $241K |
| Deutsche Bank AG | 0.00% | New | 10,419 | $239K |
| Soros Fund Management | 0.01% | New | 10,000 | $229K |
| Zimmer Partners, LP | 0.00% | New | 10,000 | $229K |
| Corebridge Financial, Inc. | 0.00% | New | 9,236 | $212K |
| SG Americas Securities, LLC | 0.00% | New | 8,095 | $185K |
| STRS Ohio | 0.00% | New | 3,400 | $78K |
| PNC Financial Services Group, Inc. | 0.00% | New | 2,680 | $61K |
| BNP Paribas Financial Markets | 0.00% | New | 2,251 | $52K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 1,944 | $45K |
| Legal & General Group Plc | 0.00% | New | 1,840 | $42K |
| New York State Common Retirement Fund | 0.00% | New | 1,400 | $32K |
| Royal Bank of Canada | 0.00% | New | 1,398 | $32K |
| California State Teachers Retirement System | 0.00% | New | 1,370 | $31K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 1,093 | $25K |
| Amalgamated Bank | 0.00% | New | 634 | $15K |
| Sterling Capital Management LLC | 0.00% | New | 266 | $6K |
| GAMMA Investing LLC | 0.00% | New | 15 | $344 |