SepternaSEPN
13F holders, Q1 2025 (March 31)71holders
19new positions
19sold out
1famous investor
$5.79avg. 13F price*
At the end of Q1 2025, 71 institutions reported holding Septerna Inc. (SEPN) in their 13F filings, unchanged from Q4 2024. 19 opened new positions and 19 sold out. The largest holders were Ra Capital Management, L.P. ($40.5M), TRV GP V, LLC ($36.0M) and BVF Inc. ($25.5M). One famous investor held it Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Septerna Inc.
- CUSIP
- 81734D104
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2024 → Q1 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 19 | $13.5M |
| Exits | 19 | $99.7M |
All 13F filers, Q4 2024 → Q1 2025: 7,731,641 shares bought and 6,570,551 shares sold, net +1,161,090 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 71 holders
| Ra Capital Management, L.P. | 0.68% | No change | 6,995,858 | $40.5M |
| TRV GP V, LLC | 28.77% | No change | 6,215,591 | $36.0M |
| BVF Inc. | 1.04% | Add +79.3% | 4,396,124 | $25.5M |
| TRV GP Vi, LLC | 58.10% | Add +33.6% | 4,211,659 | $24.4M |
| Samsara Biocapital, LLC | 3.25% | Add +13.8% | 3,149,128 | $18.2M |
| Driehaus Capital Management LLC | 0.17% | Add +20.6% | 3,122,608 | $18.1M |
| Siren, L.L.C. | 0.72% | No change | 2,202,514 | $12.8M |
| Deep Track Capital, LP | 0.36% | No change | 1,912,929 | $11.1M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -13.4% | 1,449,399 | $8.4M |
| Avoro Capital Advisors LLC | 0.12% | Add +20.5% | 1,337,500 | $7.7M |
| BlackRock, Inc. | 0.00% | Reduce -25.0% | 1,258,313 | $7.3M |
| Catalio Capital Management, LP | 1.47% | No change | 1,024,245 | $5.9M |
| Vanguard Group Inc. | 0.00% | Add +1.0% | 995,044 | $5.8M |
| Checkpoint Capital L.P. | 2.62% | New | 824,878 | $4.8M |
| Sio Capital Management, LLC | 1.38% | Add +190.3% | 788,670 | $4.6M |
| Soleus Capital Management, L.P. | 0.34% | Add +11.2% | 751,353 | $4.4M |
| ADAR1 Capital Management, LLC | 0.83% | New | 720,848 | $4.2M |
| Woodline Partners LP | 0.02% | Add +94.2% | 582,585 | $3.4M |
| Casdin Capital, LLC | 0.26% | No change | 553,268 | $3.2M |
| Millennium Management | 0.00% | New | 436,564 | $2.5M |
| Geode Capital Management, LLC | 0.00% | Add +7.6% | 409,640 | $2.4M |
| State Street Corp. | 0.00% | Add +26.3% | 344,604 | $2.0M |
| UBS Group AG | 0.00% | Add +121.2% | 239,930 | $1.4M |
| Northern Trust Corp. | 0.00% | Add +7.0% | 158,040 | $915K |
| Logos Global Management LP | 0.14% | No change | 134,202 | $777K |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -15.2% | 118,451 | $686K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | No change | 102,749 | $595K |
| Morgan Stanley | 0.00% | Add +117.2% | 91,044 | $527K |
| Two Sigma Investments, LP | 0.00% | New | 74,841 | $433K |
| Stonepine Capital Management, LLC | 0.38% | New | 68,084 | $394K |
| Rangeley Capital, LLC | 0.35% | New | 52,950 | $307K |
| FMR LLC | 0.00% | Reduce -95.0% | 49,778 | $288K |
| California State Teachers Retirement System | 0.00% | Add +3138.1% | 44,362 | $257K |
| Bank of New York Mellon Corp | 0.00% | Add +0.7% | 38,376 | $222K |
| Citigroup Inc. | 0.00% | Add +160.1% | 38,055 | $220K |
| XTX Topco Ltd | 0.01% | New | 37,350 | $216K |
| Alyeska Investment Group, L.P. | 0.00% | No change | 35,000 | $203K |
| Swiss National Bank | 0.00% | New | 30,100 | $174K |
| Susquehanna International Group, LLP | 0.00% | New | 25,209 | $146K |
| Nuveen, LLC | 0.00% | — | 23,961 | $139K |
| Rhumbline Advisers | 0.00% | Add +16.6% | 23,318 | $135K |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -95.6% | 22,957 | $133K |
| Barclays PLC | 0.00% | Reduce -21.0% | 22,733 | $132K |
| Lindbrook Capital, LLC | 0.01% | No change | 21,000 | $122K |
| Stoneridge Investment Partners LLC | 0.09% | New | 18,477 | $107K |
| Gsa Capital Partners LLP | 0.01% | New | 18,299 | $106K |
| Deutsche Bank AG | 0.00% | Add +53.3% | 15,968 | $92K |
| Chicago Partners Investment Group LLC | 0.00% | New | 10,954 | $77K |
| Invesco Ltd. | 0.00% | Add +0.4% | 12,202 | $71K |
| Bank of America Corp. | 0.00% | Reduce -85.3% | 11,559 | $67K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +4.5% | 10,987 | $64K |
| Wells Fargo & Company | 0.00% | Add +2.0% | 10,869 | $63K |
| Corebridge Financial, Inc. | 0.00% | Reduce -1.4% | 9,102 | $53K |
| JPMorgan Chase & Co. | 0.00% | Reduce -76.9% | 8,786 | $51K |
| KLP Kapitalforvaltning As | 0.00% | New | 8,400 | $49K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | New | 3,555 | $21K |
| STRS Ohio | 0.00% | No change | 3,400 | $20K |
| New York State Common Retirement Fund | 0.00% | Add +107.1% | 2,900 | $17K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 1,944 | $11K |
| Legal & General Group Plc | 0.00% | No change | 1,840 | $11K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +63.6% | 1,788 | $10K |
| BNP Paribas Financial Markets | 0.00% | Reduce -49.0% | 1,149 | $7K |
| Amalgamated Bank | 0.00% | No change | 634 | $4K |
| Royal Bank of Canada | 0.00% | Reduce -42.6% | 802 | $4K |
| GAMMA Investing LLC | 0.00% | Add +2793.3% | 434 | $3K |
| Cwm, LLC | 0.00% | New | 282 | $2K |
| Sterling Capital Management LLC | 0.00% | Reduce -41.0% | 157 | $909 |
| Nisa Investment Advisors, LLC | 0.00% | New | 134 | $776 |
| National Bank of Canada | 0.00% | New | 8 | $46 |
| Simplex Trading, LLC | 0.00% | New | 30 | $0 |
| Covestor Ltd | 0.00% | New | 6 | $0 |
"% of holder's portfolio" is SEPN's weight in each manager's 13F, not the share of Septerna Inc. the manager owns.