SepternaSEPN
13F holders, Q4 2025 (December 31)122holders +40
41new positions
5sold out
4famous investors
$27.88avg. 13F price*
At the end of Q4 2025, 122 institutions reported holding Septerna Inc. (SEPN) in their 13F filings, up 40 from Q3 2025. 41 opened new positions and 5 sold out. The largest holders were Ra Capital Management, L.P. ($195.0M), TRV GP V, LLC ($173.3M) and Driehaus Capital Management LLC ($134.1M). 4 famous investors held it, including Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Septerna Inc.
- CUSIP
- 81734D104
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 41 | $58.6M |
| Exits | 5 | $10.8M |
All 13F filers, Q3 2025 → Q4 2025: 4,548,528 shares bought and 3,738,206 shares sold, net +810,322 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 122 holders
| Ra Capital Management, L.P. | 2.00% | No change | 6,995,858 | $195.0M |
| TRV GP V, LLC | 40.38% | No change | 6,215,591 | $173.3M |
| Driehaus Capital Management LLC | 0.91% | Reduce -2.2% | 4,809,470 | $134.1M |
| TRV GP Vi, LLC | 79.05% | No change | 4,211,659 | $117.4M |
| Samsara Biocapital, LLC | 9.06% | No change | 3,149,128 | $87.8M |
| Goldman Sachs Group Inc. | 0.01% | Add +86.6% | 2,715,129 | $75.7M |
| Siren, L.L.C. | 1.66% | Reduce -9.2% | 2,000,000 | $55.8M |
| BlackRock, Inc. | 0.00% | Add +23.4% | 1,801,328 | $50.2M |
| BVF Inc. | 1.61% | Reduce -57.1% | 1,720,782 | $48.0M |
| Vanguard Group Inc. | 0.00% | Reduce -0.7% | 1,508,195 | $42.0M |
| Avoro Capital Advisors LLC | 0.37% | No change | 1,337,500 | $37.3M |
| ADAR1 Capital Management, LLC | 2.41% | Reduce -1.6% | 1,157,611 | $32.3M |
| First Light Asset Management, LLC | 1.32% | New | 620,811 | $17.3M |
| Venrock Adviser, LLC | 0.84% | No change | 610,808 | $17.0M |
| Geode Capital Management, LLC | 0.00% | Add +5.0% | 572,734 | $16.0M |
| Casdin Capital, LLC | 0.96% | No change | 553,268 | $15.4M |
| Primecap Management Co. | 0.01% | New | 546,100 | $15.2M |
| State Street Corp. | 0.00% | Add +28.9% | 540,028 | $15.1M |
| Perceptive Advisors LLC | 0.22% | Reduce -20.0% | 433,160 | $12.1M |
| Woodline Partners LP | 0.04% | Add +36.4% | 385,310 | $10.7M |
| Soleus Capital Management, L.P. | 0.45% | Add +1999.5% | 383,368 | $10.7M |
| Catalio Capital Management, LP | 1.45% | No change | 294,360 | $8.2M |
| Marshall Wace, LLP | 0.01% | New | 226,901 | $6.3M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | No change | 222,702 | $6.2M |
| Kalehua Capital Management LLC | 5.36% | — | 194,544 | $5.4M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +0.2% | 187,241 | $5.2M |
| Invesco Ltd. | 0.00% | Reduce -8.5% | 162,014 | $4.5M |
| Northern Trust Corp. | 0.00% | Reduce -7.9% | 154,196 | $4.3M |
| Millennium Management | 0.00% | Reduce -72.0% | 107,463 | $3.0M |
| Morgan Stanley | 0.00% | Add +91.0% | 103,985 | $2.9M |
| Two Sigma Investments, LP | 0.00% | Add +0.5% | 92,809 | $2.6M |
| Federated Hermes, Inc. | 0.00% | New | 78,905 | $2.2M |
| HighVista Strategies LLC | 0.56% | New | 78,682 | $2.2M |
| Citadel Advisors | 0.00% | New | 75,945 | $2.1M |
| UBS Group AG | 0.00% | Add +16.6% | 68,817 | $1.9M |
| JPMorgan Chase & Co. | 0.00% | Add +682.3% | 68,338 | $1.9M |
| Rangeley Capital, LLC | 1.60% | Reduce -25.2% | 65,800 | $1.8M |
| Jacobs Levy Equity Management, Inc. | 0.01% | Add +71.5% | 61,370 | $1.7M |
| Bank of New York Mellon Corp | 0.00% | Add +7.2% | 55,332 | $1.5M |
| American Century Companies Inc. | 0.00% | Add +100.5% | 50,689 | $1.4M |
| Longaeva Partners L.P. | 0.17% | Reduce -12.6% | 49,902 | $1.4M |
| Numerai GP LLC | 0.15% | New | 45,866 | $1.3M |
| Jane Street Group, LLC | 0.00% | New | 44,070 | $1.2M |
| Trexquant Investment LP | 0.01% | New | 44,005 | $1.2M |
| Barclays PLC | 0.00% | Add +26.7% | 38,147 | $1.1M |
| ExodusPoint Capital Management, LP | 0.01% | New | 37,867 | $1.1M |
| Bank of America Corp. | 0.00% | Reduce -27.0% | 37,594 | $1.0M |
| Alyeska Investment Group, L.P. | 0.00% | No change | 35,000 | $976K |
| Algert Global LLC | 0.02% | New | 34,944 | $974K |
| Acadian Asset Management LLC | 0.00% | New | 30,877 | $858K |
| Wells Fargo & Company | 0.00% | Add +31.7% | 26,529 | $740K |
| Rhumbline Advisers | 0.00% | Reduce -4.3% | 26,419 | $737K |
| Nuveen, LLC | 0.00% | Add +7.7% | 25,798 | $719K |
| Two Sigma Advisers, LP | 0.00% | Add +24.1% | 25,700 | $717K |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -7.2% | 25,443 | $710K |
| Logos Global Management LP | 0.04% | Reduce -71.8% | 23,548 | $657K |
| XTX Topco Ltd | 0.02% | New | 23,315 | $650K |
| VARCOV Co. | 0.25% | — | 22,634 | $631K |
| Alliancebernstein L.P. | 0.00% | Reduce -11.3% | 19,600 | $546K |
| Tudor Investment Corporation | 0.00% | New | 18,053 | $503K |
| Franklin Resources Inc. | 0.00% | New | 16,852 | $470K |
| Russell Investments Group, Ltd. | 0.00% | Add +707.5% | 15,310 | $427K |
| Deutsche Bank AG | 0.00% | Add +5.3% | 14,879 | $415K |
| Squarepoint Ops LLC | 0.00% | New | 14,847 | $414K |
| STRS Ohio | 0.00% | New | 14,600 | $407K |
| Los Angeles Capital Management LLC | 0.00% | New | 18,550 | $399K |
| Ameriprise Financial Inc. | 0.00% | New | 14,090 | $393K |
| MetLife Investment Management, LLC | 0.00% | No change | 13,685 | $382K |
| Intech Investment Management LLC | 0.00% | New | 13,283 | $370K |
| Osaic Holdings, Inc. | 0.00% | Reduce -1.3% | 12,693 | $354K |
| Seven Fleet Capital Management LP | 0.22% | — | 11,445 | $319K |
| Dynamic Technology Lab Private Ltd | 0.07% | New | 10,810 | $301K |
| PharVision Advisers, LLC | 0.15% | Reduce -10.0% | 10,739 | $299K |
| Public Employees Retirement System of Ohio | 0.00% | New | 10,594 | $295K |
| Virtus Investment Advisers, LLC | 0.08% | New | 10,457 | $292K |
| China Universal Asset Management Co., Ltd. | 0.02% | New | 10,296 | $287K |
| Baader Bank Aktiengesellschaft | 0.02% | New | 10,000 | $279K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +1.5% | 9,934 | $277K |
| Atom Investors LP | 0.02% | New | 9,791 | $273K |
| Citigroup Inc. | 0.00% | Add +3739.8% | 9,561 | $267K |
| Graham Capital Management, L.P. | 0.01% | New | 8,971 | $250K |
| Jump Financial, LLC | 0.00% | New | 8,399 | $234K |
| Bank of Nova Scotia | 0.00% | New | 8,300 | $231K |
| AQR Capital Management | 0.00% | New | 7,826 | $218K |
| New York State Common Retirement Fund | 0.00% | Add +93.1% | 5,600 | $156K |
| BNP Paribas Financial Markets | 0.00% | Add +31.1% | 5,449 | $152K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 5,175 | $144K |
| Balyasny Asset Management L.P. | 0.00% | New | 3,571 | $100K |
| FMR LLC | 0.00% | Reduce -3.8% | 3,307 | $92K |
| Caitong International Asset Management Co., Ltd | 0.02% | New | 3,170 | $88K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | New | 2,176 | $61K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +124.8% | 2,156 | $60K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 1,944 | $54K |
| Legal & General Group Plc | 0.00% | No change | 1,945 | $54K |
| Covestor Ltd | 0.03% | Reduce -46.4% | 1,941 | $54K |
| California State Teachers Retirement System | 0.00% | Reduce -4.0% | 1,316 | $37K |
| Global Retirement Partners, LLC | 0.00% | New | 1,256 | $35K |
| Sterling Capital Management LLC | 0.00% | Reduce -16.5% | 1,232 | $34K |
| Signaturefd, LLC | 0.00% | Add +2.4% | 989 | $28K |
| Group One Trading LLC | 0.00% | Reduce -44.1% | 944 | $26K |
"% of holder's portfolio" is SEPN's weight in each manager's 13F, not the share of Septerna Inc. the manager owns.