SepternaSEPN
13F holders, Q3 2025 (September 30)82holders −7
10new positions
16sold out
1famous investor
$18.81avg. 13F price*
At the end of Q3 2025, 82 institutions reported holding Septerna Inc. (SEPN) in their 13F filings, down 7 from Q2 2025. 10 opened new positions and 16 sold out. The largest holders were Ra Capital Management, L.P. ($131.6M), TRV GP V, LLC ($116.9M) and Driehaus Capital Management LLC ($92.5M). One famous investor held it Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Septerna Inc.
- CUSIP
- 81734D104
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 10 | $4.5M |
| Exits | 16 | $5.1M |
All 13F filers, Q2 2025 → Q3 2025: 1,921,439 shares bought and 1,790,291 shares sold, net +131,148 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 82 holders
| Ra Capital Management, L.P. | 1.62% | No change | 6,995,858 | $131.6M |
| TRV GP V, LLC | 33.07% | No change | 6,215,591 | $116.9M |
| Driehaus Capital Management LLC | 0.66% | Add +5.1% | 4,919,896 | $92.5M |
| TRV GP Vi, LLC | 72.26% | No change | 4,211,659 | $79.2M |
| BVF Inc. | 3.06% | Reduce -8.7% | 4,015,790 | $75.5M |
| Samsara Biocapital, LLC | 7.73% | No change | 3,149,128 | $59.2M |
| Siren, L.L.C. | 1.62% | No change | 2,202,514 | $41.4M |
| Vanguard Group Inc. | 0.00% | Add +7.4% | 1,518,757 | $28.6M |
| BlackRock, Inc. | 0.00% | Add +5.0% | 1,459,795 | $27.5M |
| Goldman Sachs Group Inc. | 0.00% | Add +2.7% | 1,454,720 | $27.4M |
| Avoro Capital Advisors LLC | 0.33% | Add +8.1% | 1,337,500 | $25.2M |
| ADAR1 Capital Management, LLC | 2.21% | Add +38.9% | 1,176,491 | $22.1M |
| Venrock Adviser, LLC | 0.65% | Add +13.0% | 610,808 | $11.5M |
| Casdin Capital, LLC | 0.87% | No change | 553,268 | $10.4M |
| Geode Capital Management, LLC | 0.00% | Add +11.8% | 545,701 | $10.3M |
| Perceptive Advisors LLC | 0.30% | No change | 541,450 | $10.2M |
| State Street Corp. | 0.00% | Add +13.2% | 418,960 | $7.9M |
| Millennium Management | 0.01% | Add +639.6% | 384,200 | $7.2M |
| Catalio Capital Management, LP | 1.02% | No change | 294,360 | $5.5M |
| Checkpoint Capital L.P. | 1.78% | Reduce -51.7% | 283,158 | $5.3M |
| Woodline Partners LP | 0.03% | No change | 282,585 | $5.3M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | No change | 222,702 | $4.2M |
| Sio Capital Management, LLC | 0.90% | Reduce -67.6% | 189,199 | $3.6M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +20.8% | 186,904 | $3.5M |
| Invesco Ltd. | 0.00% | Add +1396.4% | 177,070 | $3.3M |
| Northern Trust Corp. | 0.00% | Add +8.4% | 167,345 | $3.1M |
| Two Sigma Investments, LP | 0.00% | Add +18.9% | 92,334 | $1.7M |
| Rangeley Capital, LLC | 1.59% | Add +50.2% | 88,000 | $1.7M |
| Logos Global Management LP | 0.16% | Reduce -23.5% | 83,548 | $1.6M |
| Walleye Capital LLC | 0.01% | New | 80,341 | $1.5M |
| UBS Group AG | 0.00% | Reduce -18.4% | 59,046 | $1.1M |
| Longaeva Partners L.P. | 0.23% | New | 57,064 | $1.1M |
| Morgan Stanley | 0.00% | Reduce -35.8% | 54,458 | $1.0M |
| Bank of New York Mellon Corp | 0.00% | Add +6.5% | 51,631 | $971K |
| Bank of America Corp. | 0.00% | Reduce -48.1% | 51,495 | $969K |
| Jacobs Levy Equity Management, Inc. | 0.00% | New | 35,778 | $673K |
| Alyeska Investment Group, L.P. | 0.00% | No change | 35,000 | $658K |
| Barclays PLC | 0.00% | Reduce -15.7% | 30,102 | $566K |
| Rhumbline Advisers | 0.00% | Reduce -3.4% | 27,604 | $519K |
| T. Rowe Price Associates Inc. | 0.00% | Add +10.1% | 27,424 | $516K |
| American Century Companies Inc. | 0.00% | New | 25,283 | $476K |
| Nuveen, LLC | 0.00% | Reduce -58.7% | 23,961 | $451K |
| Alliancebernstein L.P. | 0.00% | No change | 22,100 | $416K |
| Two Sigma Advisers, LP | 0.00% | New | 20,700 | $389K |
| Wells Fargo & Company | 0.00% | Add +36.9% | 20,147 | $379K |
| Verition Fund Management LLC | 0.00% | New | 20,131 | $379K |
| Soleus Capital Management, L.P. | 0.02% | Reduce -75.8% | 18,260 | $343K |
| Deutsche Bank AG | 0.00% | Add +16.6% | 14,135 | $266K |
| MetLife Investment Management, LLC | 0.00% | No change | 13,685 | $257K |
| Osaic Holdings, Inc. | 0.00% | Add +5910.8% | 12,863 | $242K |
| PharVision Advisers, LLC | 0.13% | Add +17.5% | 11,932 | $224K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -16.3% | 9,791 | $184K |
| JPMorgan Chase & Co. | 0.00% | Reduce -13.5% | 8,736 | $164K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Add +45.6% | 5,175 | $97K |
| BNP Paribas Financial Markets | 0.00% | Add +88.0% | 4,155 | $78K |
| Covestor Ltd | 0.04% | Add +55.8% | 3,620 | $68K |
| FMR LLC | 0.00% | Add +38.4% | 3,438 | $65K |
| New York State Common Retirement Fund | 0.00% | No change | 2,900 | $55K |
| Legal & General Group Plc | 0.00% | No change | 1,945 | $37K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 1,944 | $37K |
| Russell Investments Group, Ltd. | 0.00% | New | 1,896 | $36K |
| Quarry LP | 0.01% | Reduce -51.8% | 1,736 | $33K |
| Group One Trading LLC | 0.00% | Add +114.1% | 1,689 | $32K |
| Sterling Capital Management LLC | 0.00% | Add +155.6% | 1,475 | $28K |
| California State Teachers Retirement System | 0.00% | Add +0.1% | 1,371 | $26K |
| Royal Bank of Canada | 0.00% | Reduce -41.1% | 1,083 | $20K |
| Signaturefd, LLC | 0.00% | No change | 966 | $18K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -56.9% | 959 | $18K |
| Cwm, LLC | 0.00% | Add +1.4% | 884 | $17K |
| GAMMA Investing LLC | 0.00% | Add +39.3% | 804 | $15K |
| Amalgamated Bank | 0.00% | No change | 634 | $12K |
| US Bancorp \de | 0.00% | No change | 265 | $5K |
| Versant Capital Management, Inc | 0.00% | New | 261 | $5K |
| Citigroup Inc. | 0.00% | Reduce -96.5% | 249 | $5K |
| PNC Financial Services Group, Inc. | 0.00% | New | 198 | $4K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 143 | $3K |
| Fortitude Family Office, LLC | 0.00% | No change | 71 | $1K |
| Arax Advisory Partners | 0.00% | New | 63 | $1K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +186.4% | 63 | $1K |
| SBI Securities Co., Ltd. | 0.00% | No change | 50 | $941 |
| Rothschild Investment LLC | 0.00% | No change | 30 | $564 |
| National Bank of Canada | 0.00% | No change | 8 | $150 |
"% of holder's portfolio" is SEPN's weight in each manager's 13F, not the share of Septerna Inc. the manager owns.