SepternaSEPN
13F holders, Q2 2025 (June 30)89holders +18
25new positions
6sold out
3famous investors
$10.57avg. 13F price*
At the end of Q2 2025, 89 institutions reported holding Septerna Inc. (SEPN) in their 13F filings, up 18 from Q1 2025. 25 opened new positions and 6 sold out. The largest holders were Ra Capital Management, L.P. ($73.9M), TRV GP V, LLC ($65.7M) and Driehaus Capital Management LLC ($49.5M). 3 famous investors held it, including Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Septerna Inc.
- CUSIP
- 81734D104
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2025 → Q2 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 25 | $13.4M |
| Exits | 6 | $854K |
All 13F filers, Q1 2025 → Q2 2025: 4,106,329 shares bought and 4,945,333 shares sold, net −839,004 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 89 holders
| Ra Capital Management, L.P. | 1.25% | No change | 6,995,858 | $73.9M |
| TRV GP V, LLC | 39.66% | No change | 6,215,591 | $65.7M |
| Driehaus Capital Management LLC | 0.40% | Add +49.9% | 4,680,431 | $49.5M |
| BVF Inc. | 1.66% | No change | 4,396,124 | $46.5M |
| TRV GP Vi, LLC | 69.32% | No change | 4,211,659 | $44.5M |
| Samsara Biocapital, LLC | 6.81% | No change | 3,149,128 | $33.3M |
| Siren, L.L.C. | 1.20% | No change | 2,202,514 | $23.3M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -2.3% | 1,416,314 | $15.0M |
| Vanguard Group Inc. | 0.00% | Add +42.1% | 1,414,363 | $14.9M |
| BlackRock, Inc. | 0.00% | Add +10.5% | 1,390,800 | $14.7M |
| Avoro Capital Advisors LLC | 0.23% | Reduce -7.5% | 1,237,500 | $13.1M |
| ADAR1 Capital Management, LLC | 1.47% | Add +17.5% | 847,227 | $9.0M |
| Checkpoint Capital L.P. | 2.89% | Reduce -28.9% | 586,473 | $6.2M |
| Sio Capital Management, LLC | 2.48% | Reduce -25.9% | 584,435 | $6.2M |
| Casdin Capital, LLC | 0.53% | No change | 553,268 | $5.8M |
| Perceptive Advisors LLC | 0.21% | New | 541,450 | $5.7M |
| Venrock Adviser, LLC | 0.43% | New | 540,453 | $5.7M |
| Geode Capital Management, LLC | 0.00% | Add +19.1% | 487,956 | $5.2M |
| State Street Corp. | 0.00% | Add +7.4% | 369,992 | $3.9M |
| Catalio Capital Management, LP | 0.65% | Reduce -71.3% | 294,360 | $3.1M |
| Woodline Partners LP | 0.02% | Reduce -51.5% | 282,585 | $3.0M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Add +116.7% | 222,702 | $2.4M |
| Susquehanna International Group, LLP | 0.00% | Add +560.5% | 166,506 | $1.8M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +30.7% | 154,781 | $1.6M |
| Northern Trust Corp. | 0.00% | Reduce -2.3% | 154,344 | $1.6M |
| Deep Track Capital, LP | 0.04% | Reduce -93.6% | 121,716 | $1.3M |
| Logos Global Management LP | 0.15% | Reduce -18.6% | 109,202 | $1.2M |
| Bank of America Corp. | 0.00% | Add +758.3% | 99,213 | $1.0M |
| Morgan Stanley | 0.00% | Reduce -6.8% | 84,860 | $897K |
| Two Sigma Investments, LP | 0.00% | Add +3.7% | 77,642 | $821K |
| Soleus Capital Management, L.P. | 0.06% | Reduce -90.0% | 75,456 | $798K |
| UBS Group AG | 0.00% | Reduce -69.8% | 72,335 | $765K |
| Rangeley Capital, LLC | 0.81% | Add +10.7% | 58,605 | $619K |
| Nuveen, LLC | 0.00% | Add +141.9% | 57,971 | $613K |
| Millennium Management | 0.00% | Reduce -88.1% | 51,944 | $549K |
| Bank of New York Mellon Corp | 0.00% | Add +26.4% | 48,489 | $513K |
| Barclays PLC | 0.00% | Add +57.1% | 35,706 | $377K |
| Alyeska Investment Group, L.P. | 0.00% | No change | 35,000 | $370K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | New | 28,700 | $303K |
| Rhumbline Advisers | 0.00% | Add +22.5% | 28,572 | $302K |
| T. Rowe Price Associates Inc. | 0.00% | Add +8.5% | 24,902 | $264K |
| Boothbay Fund Management, LLC | 0.01% | New | 24,142 | $255K |
| Gsa Capital Partners LLP | 0.02% | Add +28.6% | 23,527 | $249K |
| Simplex Trading, LLC | 0.01% | Add +78316.7% | 23,525 | $248K |
| XTX Topco Ltd | 0.01% | Reduce -40.2% | 22,330 | $236K |
| Alliancebernstein L.P. | 0.00% | New | 22,100 | $234K |
| Citadel Advisors | 0.00% | New | 17,774 | $188K |
| Tudor Investment Corporation | 0.00% | New | 16,761 | $177K |
| Wells Fargo & Company | 0.00% | Add +35.4% | 14,717 | $156K |
| MetLife Investment Management, LLC | 0.00% | New | 13,685 | $145K |
| CW Advisors, LLC | 0.00% | New | 12,589 | $133K |
| Intech Investment Management LLC | 0.00% | New | 12,200 | $129K |
| Deutsche Bank AG | 0.00% | Reduce -24.1% | 12,123 | $128K |
| Invesco Ltd. | 0.00% | Reduce -3.0% | 11,833 | $125K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +6.5% | 11,697 | $124K |
| Squarepoint Ops LLC | 0.00% | New | 10,737 | $113K |
| Quadrature Capital Ltd | 0.00% | New | 10,125 | $107K |
| PharVision Advisers, LLC | 0.15% | New | 10,152 | $107K |
| JPMorgan Chase & Co. | 0.00% | Add +15.0% | 10,101 | $107K |
| Citigroup Inc. | 0.00% | Reduce -81.2% | 7,173 | $76K |
| Quarry LP | 0.01% | New | 3,601 | $38K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 3,555 | $38K |
| STRS Ohio | 0.00% | No change | 3,400 | $36K |
| New York State Common Retirement Fund | 0.00% | No change | 2,900 | $31K |
| FMR LLC | 0.00% | Reduce -95.0% | 2,485 | $26K |
| Covestor Ltd | 0.01% | Add +38633.3% | 2,324 | $24K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +24.4% | 2,225 | $24K |
| BNP Paribas Financial Markets | 0.00% | Add +92.3% | 2,210 | $23K |
| Legal & General Group Plc | 0.00% | Add +5.7% | 1,945 | $21K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 1,944 | $21K |
| Royal Bank of Canada | 0.00% | Add +129.4% | 1,840 | $19K |
| California State Teachers Retirement System | 0.00% | Reduce -96.9% | 1,370 | $14K |
| Signaturefd, LLC | 0.00% | New | 966 | $10K |
| Cwm, LLC | 0.00% | Add +209.2% | 872 | $9K |
| Group One Trading LLC | 0.00% | New | 789 | $8K |
| Amalgamated Bank | 0.00% | No change | 634 | $7K |
| Caitong International Asset Management Co., Ltd | 0.00% | New | 605 | $6K |
| GAMMA Investing LLC | 0.00% | Add +33.0% | 577 | $6K |
| Sterling Capital Management LLC | 0.00% | Add +267.5% | 577 | $6K |
| US Bancorp \de | 0.00% | New | 265 | $3K |
| Raymond James Financial Inc. | 0.00% | New | 222 | $2K |
| Osaic Holdings, Inc. | 0.00% | New | 214 | $2K |
| Comerica Bank | 0.00% | New | 212 | $2K |
| Nisa Investment Advisors, LLC | 0.00% | Add +6.7% | 143 | $2K |
| Fortitude Family Office, LLC | 0.00% | New | 71 | $750 |
| SBI Securities Co., Ltd. | 0.00% | New | 50 | $529 |
| Rothschild Investment LLC | 0.00% | New | 30 | $317 |
| EverSource Wealth Advisors, LLC | 0.00% | New | 22 | $233 |
| National Bank of Canada | 0.00% | No change | 8 | $85 |
"% of holder's portfolio" is SEPN's weight in each manager's 13F, not the share of Septerna Inc. the manager owns.