Taysha Gene TherapiesTSHA
13F holders, Q4 2025 (December 31)195holders +40
59new positions
22sold out
6famous investors
$5.50avg. 13F price*
At the end of Q4 2025, 195 institutions reported holding Taysha Gene Therapies Inc. (TSHA) in their 13F filings, up 40 from Q3 2025. 59 opened new positions and 22 sold out. The largest holders were Ra Capital Management, L.P. ($129.6M), Avoro Capital Advisors LLC ($119.3M) and BlackRock, Inc. ($102.5M). 6 famous investors held it, including Steve Cohen (0.0% of Point72 Asset Management's portfolio), David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Taysha Gene Therapies Inc.
- CUSIP
- 877619106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 59 | $67.2M |
| Exits | 22 | $22.4M |
All 13F filers, Q3 2025 → Q4 2025: 39,301,619 shares bought and 34,631,989 shares sold, net +4,669,630 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 195 holders
| Ra Capital Management, L.P. | 1.33% | No change | 23,555,648 | $129.6M |
| Avoro Capital Advisors LLC | 1.17% | No change | 21,700,000 | $119.3M |
| BlackRock, Inc. | 0.00% | Add +13.9% | 18,643,129 | $102.5M |
| Morgan Stanley | 0.01% | Reduce -6.4% | 18,078,518 | $99.4M |
| RTW Investments, LP | 0.90% | Reduce -32.7% | 16,398,297 | $90.2M |
| Vestal Point Capital, LP | 2.77% | Add +150.0% | 13,750,000 | $75.6M |
| Goldman Sachs Group Inc. | 0.01% | Add +2.3% | 13,692,739 | $75.3M |
| FMR LLC | 0.00% | Reduce -7.3% | 13,528,366 | $74.4M |
| Vanguard Group Inc. | 0.00% | Add +3.3% | 13,267,805 | $73.0M |
| State Street Corp. | 0.00% | Add +49.1% | 10,790,084 | $59.3M |
| Siren, L.L.C. | 1.66% | Reduce -8.0% | 10,129,913 | $55.7M |
| Octagon Capital Advisors LP | 6.10% | Reduce -2.3% | 8,859,911 | $48.7M |
| Polar Capital Holdings Plc | 0.20% | Add +49.8% | 7,931,403 | $43.6M |
| Barclays PLC | 0.01% | Add +7.6% | 5,539,001 | $30.5M |
| Geode Capital Management, LLC | 0.00% | Add +4.1% | 5,387,026 | $29.6M |
| D. E. Shaw & Co. | 0.02% | Add +48.3% | 4,013,635 | $22.1M |
| Baker Bros. Advisors LP | 0.13% | No change | 4,004,756 | $22.0M |
| Point72 Asset Management | 0.03% | Reduce -47.2% | 3,868,682 | $21.3M |
| Healthcare of Ontario Pension Plan Trust Fund | 0.03% | New | 3,722,000 | $20.5M |
| Affinity Asset Advisors, LLC | 1.35% | Add +10.0% | 3,300,000 | $18.1M |
| Millennium Management | 0.01% | Reduce -21.0% | 3,178,863 | $17.5M |
| Deerfield Management Company, L.P. | 0.22% | Reduce -49.5% | 2,722,165 | $15.0M |
| ADAR1 Capital Management, LLC | 1.03% | Reduce -12.0% | 2,495,809 | $13.7M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +3.1% | 1,902,978 | $10.5M |
| Citadel Advisors | 0.01% | Add +405.0% | 1,854,855 | $10.2M |
| Norges Bank | 0.00% | — | 1,837,800 | $10.1M |
| B Group, Inc. | 7.34% | No change | 1,800,556 | $9.9M |
| Casdin Capital, LLC | 0.51% | New | 1,500,000 | $8.3M |
| Invesco Ltd. | 0.00% | Add +376.4% | 1,332,780 | $7.3M |
| GordonMD Global Investments LP | 5.25% | — | 1,330,901 | $7.3M |
| Adage Capital Partners Gp, L.L.C. | 0.01% | Reduce -60.1% | 1,328,000 | $7.3M |
| Rice Hall James & Associates, LLC | 0.38% | Add +119.8% | 1,270,645 | $7.0M |
| Northern Trust Corp. | 0.00% | Reduce -27.9% | 1,237,987 | $6.8M |
| Palo Alto Investors LP | 0.91% | Reduce -5.0% | 1,183,195 | $6.5M |
| Bank of America Corp. | 0.00% | Reduce -11.8% | 1,152,680 | $6.3M |
| Aberdeen Group plc | 0.01% | New | 1,021,063 | $5.6M |
| Superstring Capital Management LP | 2.89% | New | 980,768 | $5.4M |
| Informed Momentum Co LLC | 0.50% | New | 823,758 | $4.5M |
| Quantum Private Wealth, LLC | 1.32% | Reduce -0.3% | 819,715 | $4.5M |
| SG Americas Securities, LLC | 0.01% | Add +2271.8% | 781,474 | $4.3M |
| JPMorgan Chase & Co. | 0.00% | Add +161.4% | 774,412 | $4.3M |
| Sands Capital Alternatives, LLC | 0.77% | No change | 724,873 | $4.0M |
| Wellington Management Group LLP | 0.00% | Add +25.2% | 711,235 | $3.9M |
| Granahan Investment Management, LLC | 0.17% | Reduce -37.0% | 703,971 | $3.9M |
| Bank of New York Mellon Corp | 0.00% | Reduce -0.1% | 624,367 | $3.4M |
| Nuveen, LLC | 0.00% | Add +7.5% | 545,286 | $3.0M |
| Woodline Partners LP | 0.01% | No change | 500,000 | $2.8M |
| Dimensional Fund Advisors LP | 0.00% | Add +42.1% | 490,472 | $2.7M |
| Squarepoint Ops LLC | 0.01% | Add +137.8% | 471,577 | $2.6M |
| Ally Bridge Group (NY) LLC | 3.99% | Reduce -75.9% | 457,132 | $2.5M |
| Acuta Capital Partners, LLC | 1.70% | No change | 454,827 | $2.5M |
| HRT Financial LP | 0.01% | New | 409,254 | $2.3M |
| UBS Group AG | 0.00% | Reduce -40.1% | 383,043 | $2.1M |
| Sphera Funds Management LTD. | 0.42% | Reduce -9.8% | 368,146 | $2.0M |
| Two Sigma Investments, LP | 0.00% | Add +431.2% | 351,126 | $1.9M |
| Rafferty Asset Management, LLC | 0.01% | Add +43.8% | 344,784 | $1.9M |
| Boothbay Fund Management, LLC | 0.05% | Reduce -25.5% | 309,481 | $1.7M |
| Hennion & Walsh Asset Management, Inc. | 0.06% | New | 308,457 | $1.7M |
| Wells Fargo & Company | 0.00% | Add +110.3% | 305,086 | $1.7M |
| Capricorn Fund Managers Ltd | 0.40% | New | 300,000 | $1.6M |
| Focus Partners Wealth | 0.00% | New | 295,516 | $1.6M |
| American Century Companies Inc. | 0.00% | Add +648.4% | 288,535 | $1.6M |
| Ensign Peak Advisors, Inc | 0.00% | New | 275,111 | $1.5M |
| Swiss National Bank | 0.00% | New | 268,800 | $1.5M |
| Oracle Investment Management Inc. | 0.96% | New | 265,000 | $1.5M |
| Nomura Holdings Inc. | 0.00% | New | 259,339 | $1.4M |
| Rhumbline Advisers | 0.00% | Reduce -10.9% | 257,440 | $1.4M |
| Alps Advisors Inc. | 0.01% | New | 224,920 | $1.2M |
| Voya Investment Management LLC | 0.00% | Add +497.8% | 218,185 | $1.2M |
| Gsa Capital Partners LLP | 0.10% | Reduce -56.5% | 208,016 | $1.1M |
| Victory Capital Management Inc. | 0.00% | Add +664.7% | 195,764 | $1.1M |
| Stempoint Capital LP | 0.17% | Reduce -78.3% | 182,130 | $1.0M |
| Wexford Capital LP | 0.26% | Add +5067.2% | 180,853 | $995K |
| Alliancebernstein L.P. | 0.00% | No change | 179,640 | $988K |
| Palumbo Wealth Management LLC | 0.24% | Add +13.1% | 178,007 | $979K |
| BNP Paribas Financial Markets | 0.00% | Add +274.7% | 172,482 | $949K |
| Renaissance Technologies | 0.00% | New | 171,100 | $941K |
| AQR Capital Management | 0.00% | Add +11.8% | 168,862 | $929K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | New | 167,500 | $921K |
| Seven Fleet Capital Management LP | 0.62% | — | 167,223 | $920K |
| Privium Fund Management B.V. | 0.17% | Add +22.2% | 164,900 | $907K |
| Jane Street Group, LLC | 0.00% | Reduce -70.7% | 163,146 | $897K |
| Deutsche Bank AG | 0.00% | Add +30.9% | 160,779 | $884K |
| Polen Capital Management LLC | 0.00% | New | 156,586 | $861K |
| Chicago Partners Investment Group LLC | 0.02% | Add +1.5% | 166,541 | $776K |
| Two Sigma Advisers, LP | 0.00% | New | 139,581 | $768K |
| California State Teachers Retirement System | 0.00% | Add +1236.0% | 138,580 | $762K |
| Legal & General Group Plc | 0.00% | Add +475.2% | 133,146 | $732K |
| Profund Advisors LLC | 0.02% | Add +141.0% | 128,590 | $707K |
| Susquehanna International Group, LLP | 0.00% | Add +474.8% | 124,975 | $687K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +10.5% | 122,639 | $678K |
| T. Rowe Price Associates Inc. | 0.00% | Add +7.0% | 121,814 | $670K |
| MetLife Investment Management, LLC | 0.00% | Reduce -10.8% | 113,266 | $623K |
| State of Wisconsin Investment Board | 0.00% | Add +163.5% | 113,178 | $622K |
| Franklin Resources Inc. | 0.00% | No change | 108,399 | $596K |
| Prudential Financial Inc. | 0.00% | Add +206.0% | 86,730 | $477K |
| Intech Investment Management LLC | 0.00% | Add +3.6% | 71,069 | $391K |
| Canada Pension Plan Investment Board | 0.00% | New | 68,900 | $379K |
| Janus Henderson Group PLC | 0.00% | New | 69,000 | $378K |
| New York State Common Retirement Fund | 0.00% | Reduce -0.1% | 67,500 | $371K |
"% of holder's portfolio" is TSHA's weight in each manager's 13F, not the share of Taysha Gene Therapies Inc. the manager owns.