Taysha Gene TherapiesTSHA
13F holders, Q4 2025 (December 31)195holders +40
59new positions
22sold out
6famous investors
$5.50avg. 13F price*
At the end of Q4 2025, 195 institutions reported holding Taysha Gene Therapies Inc. (TSHA) in their 13F filings, up 40 from Q3 2025. 59 opened new positions and 22 sold out. The largest holders were Ra Capital Management, L.P. ($129.6M), Avoro Capital Advisors LLC ($119.3M) and BlackRock, Inc. ($102.5M). 6 famous investors held it, including Steve Cohen (0.0% of Point72 Asset Management's portfolio), David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Taysha Gene Therapies Inc.
- CUSIP
- 877619106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 59 | $67.2M |
| Exits | 22 | $22.4M |
All 13F filers, Q3 2025 → Q4 2025: 39,301,619 shares bought and 34,631,989 shares sold, net +4,669,630 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 195 holders
| Ra Capital Management, L.P. | 1.33% | No change | 23,555,648 | $129.6M |
| Avoro Capital Advisors LLC | 1.17% | No change | 21,700,000 | $119.3M |
| BlackRock, Inc. | 0.00% | Add +13.9% | 18,643,129 | $102.5M |
| Morgan Stanley | 0.01% | Reduce -6.4% | 18,078,518 | $99.4M |
| RTW Investments, LP | 0.90% | Reduce -32.7% | 16,398,297 | $90.2M |
| Vestal Point Capital, LP | 2.77% | Add +150.0% | 13,750,000 | $75.6M |
| Goldman Sachs Group Inc. | 0.01% | Add +2.3% | 13,692,739 | $75.3M |
| FMR LLC | 0.00% | Reduce -7.3% | 13,528,366 | $74.4M |
| Vanguard Group Inc. | 0.00% | Add +3.3% | 13,267,805 | $73.0M |
| State Street Corp. | 0.00% | Add +49.1% | 10,790,084 | $59.3M |
| Siren, L.L.C. | 1.66% | Reduce -8.0% | 10,129,913 | $55.7M |
| Octagon Capital Advisors LP | 6.10% | Reduce -2.3% | 8,859,911 | $48.7M |
| Polar Capital Holdings Plc | 0.20% | Add +49.8% | 7,931,403 | $43.6M |
| Barclays PLC | 0.01% | Add +7.6% | 5,539,001 | $30.5M |
| Geode Capital Management, LLC | 0.00% | Add +4.1% | 5,387,026 | $29.6M |
| D. E. Shaw & Co. | 0.02% | Add +48.3% | 4,013,635 | $22.1M |
| Baker Bros. Advisors LP | 0.13% | No change | 4,004,756 | $22.0M |
| Point72 Asset Management | 0.03% | Reduce -47.2% | 3,868,682 | $21.3M |
| Healthcare of Ontario Pension Plan Trust Fund | 0.03% | New | 3,722,000 | $20.5M |
| Affinity Asset Advisors, LLC | 1.35% | Add +10.0% | 3,300,000 | $18.1M |
| Millennium Management | 0.01% | Reduce -21.0% | 3,178,863 | $17.5M |
| Deerfield Management Company, L.P. | 0.22% | Reduce -49.5% | 2,722,165 | $15.0M |
| ADAR1 Capital Management, LLC | 1.03% | Reduce -12.0% | 2,495,809 | $13.7M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +3.1% | 1,902,978 | $10.5M |
| Citadel Advisors | 0.01% | Add +405.0% | 1,854,855 | $10.2M |
| Norges Bank | 0.00% | — | 1,837,800 | $10.1M |
| B Group, Inc. | 7.34% | No change | 1,800,556 | $9.9M |
| Casdin Capital, LLC | 0.51% | New | 1,500,000 | $8.3M |
| Invesco Ltd. | 0.00% | Add +376.4% | 1,332,780 | $7.3M |
| GordonMD Global Investments LP | 5.25% | — | 1,330,901 | $7.3M |
| Adage Capital Partners Gp, L.L.C. | 0.01% | Reduce -60.1% | 1,328,000 | $7.3M |
| Rice Hall James & Associates, LLC | 0.38% | Add +119.8% | 1,270,645 | $7.0M |
| Northern Trust Corp. | 0.00% | Reduce -27.9% | 1,237,987 | $6.8M |
| Palo Alto Investors LP | 0.91% | Reduce -5.0% | 1,183,195 | $6.5M |
| Bank of America Corp. | 0.00% | Reduce -11.8% | 1,152,680 | $6.3M |
| Aberdeen Group plc | 0.01% | New | 1,021,063 | $5.6M |
| Superstring Capital Management LP | 2.89% | New | 980,768 | $5.4M |
| Informed Momentum Co LLC | 0.50% | New | 823,758 | $4.5M |
| Quantum Private Wealth, LLC | 1.32% | Reduce -0.3% | 819,715 | $4.5M |
| SG Americas Securities, LLC | 0.01% | Add +2271.8% | 781,474 | $4.3M |
| JPMorgan Chase & Co. | 0.00% | Add +161.4% | 774,412 | $4.3M |
| Sands Capital Alternatives, LLC | 0.77% | No change | 724,873 | $4.0M |
| Wellington Management Group LLP | 0.00% | Add +25.2% | 711,235 | $3.9M |
| Granahan Investment Management, LLC | 0.17% | Reduce -37.0% | 703,971 | $3.9M |
| Bank of New York Mellon Corp | 0.00% | Reduce -0.1% | 624,367 | $3.4M |
| Nuveen, LLC | 0.00% | Add +7.5% | 545,286 | $3.0M |
| Woodline Partners LP | 0.01% | No change | 500,000 | $2.8M |
| Dimensional Fund Advisors LP | 0.00% | Add +42.1% | 490,472 | $2.7M |
| Squarepoint Ops LLC | 0.01% | Add +137.8% | 471,577 | $2.6M |
| Ally Bridge Group (NY) LLC | 3.99% | Reduce -75.9% | 457,132 | $2.5M |
| Acuta Capital Partners, LLC | 1.70% | No change | 454,827 | $2.5M |
| HRT Financial LP | 0.01% | New | 409,254 | $2.3M |
| UBS Group AG | 0.00% | Reduce -40.1% | 383,043 | $2.1M |
| Sphera Funds Management LTD. | 0.42% | Reduce -9.8% | 368,146 | $2.0M |
| Two Sigma Investments, LP | 0.00% | Add +431.2% | 351,126 | $1.9M |
| Rafferty Asset Management, LLC | 0.01% | Add +43.8% | 344,784 | $1.9M |
| Boothbay Fund Management, LLC | 0.05% | Reduce -25.5% | 309,481 | $1.7M |
| Hennion & Walsh Asset Management, Inc. | 0.06% | New | 308,457 | $1.7M |
| Wells Fargo & Company | 0.00% | Add +110.3% | 305,086 | $1.7M |
| Capricorn Fund Managers Ltd | 0.40% | New | 300,000 | $1.6M |
| Focus Partners Wealth | 0.00% | New | 295,516 | $1.6M |
| American Century Companies Inc. | 0.00% | Add +648.4% | 288,535 | $1.6M |
| Ensign Peak Advisors, Inc | 0.00% | New | 275,111 | $1.5M |
| Swiss National Bank | 0.00% | New | 268,800 | $1.5M |
| Oracle Investment Management Inc. | 0.96% | New | 265,000 | $1.5M |
| Nomura Holdings Inc. | 0.00% | New | 259,339 | $1.4M |
| Rhumbline Advisers | 0.00% | Reduce -10.9% | 257,440 | $1.4M |
| Alps Advisors Inc. | 0.01% | New | 224,920 | $1.2M |
| Voya Investment Management LLC | 0.00% | Add +497.8% | 218,185 | $1.2M |
| Gsa Capital Partners LLP | 0.10% | Reduce -56.5% | 208,016 | $1.1M |
| Victory Capital Management Inc. | 0.00% | Add +664.7% | 195,764 | $1.1M |
| Stempoint Capital LP | 0.17% | Reduce -78.3% | 182,130 | $1.0M |
| Wexford Capital LP | 0.26% | Add +5067.2% | 180,853 | $995K |
| Alliancebernstein L.P. | 0.00% | No change | 179,640 | $988K |
| Palumbo Wealth Management LLC | 0.24% | Add +13.1% | 178,007 | $979K |
| BNP Paribas Financial Markets | 0.00% | Add +274.7% | 172,482 | $949K |
| Renaissance Technologies | 0.00% | New | 171,100 | $941K |
| AQR Capital Management | 0.00% | Add +11.8% | 168,862 | $929K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | New | 167,500 | $921K |
| Seven Fleet Capital Management LP | 0.62% | — | 167,223 | $920K |
| Privium Fund Management B.V. | 0.17% | Add +22.2% | 164,900 | $907K |
| Jane Street Group, LLC | 0.00% | Reduce -70.7% | 163,146 | $897K |
| Deutsche Bank AG | 0.00% | Add +30.9% | 160,779 | $884K |
| Polen Capital Management LLC | 0.00% | New | 156,586 | $861K |
| Chicago Partners Investment Group LLC | 0.02% | Add +1.5% | 166,541 | $776K |
| Two Sigma Advisers, LP | 0.00% | New | 139,581 | $768K |
| California State Teachers Retirement System | 0.00% | Add +1236.0% | 138,580 | $762K |
| Legal & General Group Plc | 0.00% | Add +475.2% | 133,146 | $732K |
| Profund Advisors LLC | 0.02% | Add +141.0% | 128,590 | $707K |
| Susquehanna International Group, LLP | 0.00% | Add +474.8% | 124,975 | $687K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +10.5% | 122,639 | $678K |
| T. Rowe Price Associates Inc. | 0.00% | Add +7.0% | 121,814 | $670K |
| MetLife Investment Management, LLC | 0.00% | Reduce -10.8% | 113,266 | $623K |
| State of Wisconsin Investment Board | 0.00% | Add +163.5% | 113,178 | $622K |
| Franklin Resources Inc. | 0.00% | No change | 108,399 | $596K |
| Prudential Financial Inc. | 0.00% | Add +206.0% | 86,730 | $477K |
| Intech Investment Management LLC | 0.00% | Add +3.6% | 71,069 | $391K |
| Canada Pension Plan Investment Board | 0.00% | New | 68,900 | $379K |
| Janus Henderson Group PLC | 0.00% | New | 69,000 | $378K |
| New York State Common Retirement Fund | 0.00% | Reduce -0.1% | 67,500 | $371K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | New | 67,477 | $371K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -4.0% | 67,085 | $369K |
| Red Reef Advisors LLC | 0.37% | — | 65,950 | $363K |
| Creative Planning | 0.00% | Add +21.1% | 63,235 | $348K |
| Citigroup Inc. | 0.00% | Add +88.1% | 63,015 | $347K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 57,168 | $314K |
| SummitTX Capital, L.P. | 0.01% | New | 56,595 | $311K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -4.5% | 55,657 | $306K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | Reduce -28.2% | 57,975 | $304K |
| Abacus Wealth Partners, LLC | 0.03% | New | 55,173 | $303K |
| Voloridge Investment Management, LLC | 0.00% | New | 54,785 | $301K |
| Lanark Financial, Inc. | 0.02% | New | 52,955 | $291K |
| ProShare Advisors LLC | 0.00% | Add +13.9% | 52,463 | $289K |
| Sei Investments Co. | 0.00% | New | 47,858 | $263K |
| Militia Capital Partners, LP | 0.10% | Reduce -30.4% | 46,500 | $256K |
| Virtus Investment Advisers, LLC | 0.07% | Add +7.0% | 45,946 | $253K |
| Williams & Novak, LLC | 0.19% | No change | 45,000 | $248K |
| Redwood Wealth Management Group, LLC | 0.10% | New | 44,700 | $246K |
| China Universal Asset Management Co., Ltd. | 0.02% | Reduce -6.7% | 44,635 | $245K |
| Group One Trading LLC | 0.01% | Add +2419.7% | 44,195 | $243K |
| First Manhattan Co. Llc. | 0.00% | Add +52.6% | 43,500 | $239K |
| Allianz Asset Management GmbH | 0.00% | New | 42,400 | $233K |
| Balyasny Asset Management L.P. | 0.00% | New | 42,070 | $231K |
| Axq Capital, LP | 0.05% | Reduce -23.9% | 37,804 | $208K |
| Arizona State Retirement System | 0.00% | New | 37,677 | $207K |
| J. Goldman & Co LP | 0.01% | New | 33,750 | $186K |
| Los Angeles Capital Management LLC | 0.00% | New | 32,918 | $162K |
| KLP Kapitalforvaltning As | 0.00% | New | 29,300 | $161K |
| Leonteq Securities AG | 0.01% | No change | 27,999 | $154K |
| Allegheny Financial Group | 0.02% | Add +75.7% | 26,350 | $145K |
| Caitong International Asset Management Co., Ltd | 0.03% | Add +698.3% | 25,577 | $141K |
| Jefferies Financial Group Inc. | 0.00% | Reduce -98.8% | 25,000 | $138K |
| Ethic Inc. | 0.00% | Reduce -11.8% | 22,735 | $125K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | Reduce -6.8% | 22,080 | $121K |
| Cetera Investment Advisers | 0.00% | Add +30.9% | 21,154 | $116K |
| Mangrove Partners Im, LLC | 0.01% | New | 20,546 | $113K |
| Envestnet Asset Management Inc. | 0.00% | New | 20,178 | $111K |
| Lee Financial Co | 0.01% | No change | 20,000 | $110K |
| Teacher Retirement System of Texas | 0.00% | New | 19,837 | $109K |
| Simplex Trading, LLC | 0.00% | Add +626.8% | 19,782 | $109K |
| Pictet Asset Management Holding SA | 0.00% | New | 19,318 | $106K |
| Scientech Research LLC | 0.06% | New | 18,176 | $100K |
| Raymond James Financial Inc. | 0.00% | New | 18,144 | $100K |
| Ameritas Investment Partners, Inc. | 0.00% | Add +12.8% | 17,672 | $97K |
| Xponance LLC | 0.00% | Add +3.9% | 17,218 | $95K |
| Russell Investments Group, Ltd. | 0.00% | Reduce -6.8% | 16,929 | $93K |
| Captrust Financial Advisors | 0.00% | New | 15,113 | $83K |
| Legato Capital Management LLC | 0.01% | New | 15,023 | $83K |
| Cibc World Markets Corp. | 0.00% | — | 14,612 | $80K |
| Bank of Montreal | 0.00% | Add +0.3% | 13,708 | $75K |
| Mackenzie Financial Corp. | 0.00% | Add +18.7% | 13,308 | $75K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +26.2% | 13,311 | $73K |
| Cwm, LLC | 0.00% | Add +1.6% | 13,093 | $72K |
| Principal Financial Group Inc. | 0.00% | Reduce -21.1% | 12,823 | $71K |
| CIBC Asset Management Inc | 0.00% | New | 11,959 | $66K |
| Panagora Asset Management Inc. | 0.00% | New | 11,574 | $64K |
| Guggenheim Capital LLC | 0.00% | New | 11,111 | $61K |
| Oppenheimer Asset Management Inc. | 0.00% | New | 10,773 | $59K |
| Capital Investment Advisors, LLC | 0.00% | No change | 10,000 | $55K |
| St Germain D J Co. Inc. | 0.00% | No change | 9,633 | $53K |
| Amalgamated Bank | 0.00% | Add +25.4% | 6,939 | $38K |
| Royal Bank of Canada | 0.00% | Reduce -98.9% | 6,302 | $34K |
| Nisa Investment Advisors, LLC | 0.00% | Reduce -6.1% | 5,512 | $30K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -8.3% | 5,383 | $30K |
| Rockefeller Capital Management L.P. | 0.00% | No change | 5,000 | $28K |
| Chung Wu Investment Group, LLC | 0.02% | New | 4,000 | $22K |
| Capital Advisors, Ltd. LLC | 0.00% | Reduce -2.5% | 77 | $12K |
| International Assets Investment Management, LLC | 0.00% | New | 2,000 | $11K |
| Sterling Capital Management LLC | 0.00% | Add +174.0% | 1,411 | $8K |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -19.4% | 1,054 | $6K |
| Optiver Holding B.V. | 0.00% | Reduce -58.8% | 934 | $5K |
| US Bancorp \de | 0.00% | No change | 912 | $5K |
| Daiwa Securities Group Inc. | 0.00% | Reduce -96.8% | 691 | $4K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -92.8% | 475 | $3K |
| Essential Partners LLC | 0.00% | No change | 327 | $2K |
| Parallel Advisors, LLC | 0.00% | No change | 280 | $2K |
| Osaic Holdings, Inc. | 0.00% | Add +106.7% | 277 | $2K |
| GAMMA Investing LLC | 0.00% | New | 276 | $2K |
| Sound Income Strategies, LLC | 0.00% | New | 325 | $1K |
| Allworth Financial LP | 0.00% | Add +3.7% | 223 | $1K |
| EverSource Wealth Advisors, LLC | 0.00% | No change | 91 | $501 |
| Bare Financial Services, Inc | 0.00% | New | 85 | $468 |
| Rothschild Investment LLC | 0.00% | New | 70 | $385 |
| Signaturefd, LLC | 0.00% | New | 60 | $330 |
| Farther Finance Advisors, LLC | 0.00% | No change | 55 | $303 |
| SageView Advisory Group, LLC | 0.00% | New | 49 | $270 |
| True Wealth Design, LLC | 0.00% | No change | 30 | $165 |
| Arax Advisory Partners | 0.00% | New | 21 | $116 |
| Tradewinds Capital Management, LLC | 0.00% | New | 20 | $110 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -6.3% | 15 | $83 |
| IFP Advisors, Inc | 0.00% | No change | 14 | $77 |
| MAI Capital Management | 0.00% | New | 8 | $44 |
| Northwestern Mutual Wealth Management Co. | 0.00% | New | 8 | $44 |
| Assetmark, Inc. | 0.00% | New | 8 | $44 |
| Hughes Financial Services, LLC | 0.00% | New | 4 | $22 |
"% of holder's portfolio" is TSHA's weight in each manager's 13F, not the share of Taysha Gene Therapies Inc. the manager owns.