| SWTX Springworks Therapeutics Inc. | 8.32% | 3,421,541 | $168.4M | No change |
| CYTK Cytokinetics Inc. | 7.27% | 2,100,000 | $147.2M | No change |
| RVMD Revolution Medicines Inc. | 6.81% | 4,279,464 | $137.9M | No change |
| TYRA Tyra Biosciences Inc. | 5.22% | 6,448,359 | $105.8M | No change |
| APLS Apellis Pharmaceuticals Inc. | 5.01% | 1,726,000 | $101.5M | No change |
| IDYA Ideaya Biosciences Inc. | 4.77% | 2,202,812 | $96.7M | No change |
| MRUS Merus NV | 4.23% | 1,900,000 | $85.6M | No change |
| SRPT Sarepta Therapeutics Inc. | 4.16% | 650,000 | $84.1M | No change |
| NUVL Nuvalent Inc. Class A | 4.15% | 1,120,192 | $84.1M | No change |
| ONC Beone Medicines Ltd.-ADR filed as BEIGENE LTD | 3.86% | 500,000 | $78.2M | No change |
| TNGX Tango Therapeutics Inc. | 3.22% | 8,198,642 | $65.1M | No change |
| NKTX Nkarta Inc. | 2.99% | 5,607,350 | $60.6M | Add +289.4% |
| FATE Fate Therapeutics Inc. | 2.98% | 8,215,910 | $60.3M | Add +1543.2% |
| RNAM Avidity Biosciences Inc. | 2.18% | 1,727,388 | $44.1M | Add +54.0% |
| AKRO Akero Therapeutics Inc. | 2.09% | 1,676,733 | $42.4M | No change |
| RCKT Rocket Pharmaceuticals Inc. | 1.95% | 1,466,051 | $39.5M | No change |
| ARGX Argenx SE - ADR | 1.94% | 100,000 | $39.4M | Reduce -37.5% |
| LEGN Legend Biotech Corp.-ADR | 1.66% | 600,000 | $33.7M | No change |
| AXSM Axsome Therapeutics Inc. | 1.58% | 400,000 | $31.9M | No change |
| RCUS Arcus Biosciences Inc. | 1.49% | 1,602,200 | $30.2M | No change |
| ANAB Anaptysbio Inc. | 1.45% | 1,300,000 | $29.3M | No change |
| IMVT Immunovant Inc. | 1.32% | 825,000 | $26.7M | Reduce -17.5% |
| XENE Xenon Pharmaceuticals Inc. | 1.28% | 600,000 | $25.8M | No change |
| ARVN Arvinas Inc. | 1.24% | 608,614 | $25.1M | No change |
| ITOS Iteos Therapeutics Inc. | 1.22% | 1,804,058 | $24.6M | No change |
| VKTX Viking Therapeutics Inc. | 1.22% | 300,000 | $24.6M | New |
| ORIC Oric Pharmaceuticals Inc. | 1.18% | 1,732,571 | $23.8M | No change |
| KURA Kura Oncology Inc. | 1.05% | 1,000,000 | $21.3M | New |
| GERN Geron Corp. | 0.98% | 6,000,000 | $19.8M | Add +100.0% |
| DAWN Day One Biopharmaceuticals I | 0.97% | 1,189,943 | $19.7M | No change |
| THRD Third Harmonic Bio Inc. | 0.93% | 2,000,000 | $18.9M | Add +166.7% |
| KALV Kalvista Pharmaceuticals Inc. | 0.93% | 1,590,000 | $18.9M | Reduce -3.6% |
| ALLO Allogene Therapeutics Inc. | 0.85% | 3,850,000 | $17.2M | New |
| GPCR Structure Therapeutics Inc. | 0.85% | 400,000 | $17.1M | No change |
| PRTA Prothena Corp. PLC | 0.84% | 690,000 | $17.1M | Add +3.8% |
| SANA Sana Biotechnology Inc. | 0.76% | 1,545,000 | $15.4M | New |
| RLAY Relay Therapeutics Inc. | 0.75% | 1,819,132 | $15.1M | No change |
| PSTX Poseida Therapeutics Inc. | 0.71% | 4,475,000 | $14.3M | New |
| ENGN Engene Holdings Inc. | 0.61% | 727,900 | $12.3M | New |
| PRLD Prelude Therapeutics Inc. | 0.60% | 2,568,287 | $12.2M | No change |
| ELVN Enliven Therapeutics Inc. | 0.58% | 671,358 | $11.8M | Add +3.9% |
| IOVA Iovance Biotherapeutics Inc. | 0.55% | 750,000 | $11.1M | Reduce -46.4% |
| JSPR Jasper Therapeutics Inc. | 0.51% | 350,000 | $10.3M | New |
| BOLD Boundless Bio Inc. | 0.50% | 711,329 | $10.1M | New |
| SYRE Spyre Therapeutics Inc. | 0.47% | 250,000 | $9.5M | No change |
| IPSC Century Therapeutics Inc. | 0.36% | 1,750,000 | $7.3M | New |
| ZNTL Zentalis Pharmaceuticals Inc. | 0.35% | 450,000 | $7.1M | No change |
| AMLX Amylyx Pharmaceuticals Inc. | 0.21% | 1,500,000 | $4.3M | New |
| ABSI Absci Corp. | 0.20% | 700,000 | $4.0M | New |
| ATRA Atara Biotherapeutics Inc. | 0.14% | 4,150,000 | $2.9M | New |
| BDTX Black Diamond Therapeutics I | 0.13% | 506,000 | $2.6M | No change |
| DIREXION SHS ETF TR | 0.13% | 350,000 | $2.6M | New |
| BCAB Bioatla Inc. | 0.12% | 686,347 | $2.4M | No change |
| OBIO Orchestra Biomed Holdings Inc. | 0.06% | 238,193 | $1.3M | No change |
| TARA Protara Therapeutic Inc. | 0.04% | 209,227 | $839K | No change |
| MIST Milestone Pharmaceuticals Inc. | 0.03% | 309,007 | $553K | No change |
| DBV TECHNOLOGIES S A | 0.02% | 500,000 | $375K | No change |