Boxer Capital, LLC

In its 13F for Q2 2024 (holdings as of June 30, 2024, filed August 14, 2024), Boxer Capital, LLC reported 59 stock positions worth $1.9 billion. Its top holding was Revolution Medicines (RVMD) at 8.7% of the portfolio, followed by Springworks Therapeutics (SWTX, 6.8%) and Cytokinetics (CYTK, 6.0%). Compared with Q1 2024, it opened 4 new positions, sold out of 2, added to 4 and reduced 2. The biggest buy was Iteos Therapeutics (ITOS, shares +63%) and the biggest sale an exit from Viking Therapeutics (VKTX).

Most Recent 13F
Q4 2024
Location
San Diego, CA
CIK
0001465837
Portfolio Value
$1.9B (Q2 2024)
SEC Filing
0000895345-24-000355 ↗ filed Aug 14, 2024

Holdings Value

0$500.0M$1.0B$1.5B$2.0B$2.5B Q1 2024: $2.0B Q1 2024 Q2 2024: $1.9B $1.9B Q2 2024 Q3 2024: $2.0B Q3 2024 Q4 2024: $0 Q4 2024

Holdings 59 stocks · $1.9B
RVMD Revolution Medicines Inc. 8.75% 4,279,464 $166.1M No change
SWTX Springworks Therapeutics Inc. 6.79% 3,421,541 $128.9M No change
CYTK Cytokinetics Inc. 5.99% 2,100,000 $113.8M No change
MRUS Merus NV 5.92% 1,900,000 $112.4M No change
TYRA Tyra Biosciences Inc. 5.43% 6,448,359 $103.1M No change
SRPT Sarepta Therapeutics Inc. 5.41% 650,000 $102.7M No change
NUVL Nuvalent Inc. Class A 4.48% 1,120,192 $85.0M No change
IDYA Ideaya Biosciences Inc. 4.07% 2,202,812 $77.3M No change
ONC Beone Medicines Ltd.-ADR filed as BEIGENE LTD 3.76% 500,000 $71.3M No change
RNAM Avidity Biosciences Inc. 3.72% 1,727,388 $70.6M No change
TNGX Tango Therapeutics Inc. 3.70% 8,198,642 $70.3M No change
APLS Apellis Pharmaceuticals Inc. 3.49% 1,726,000 $66.2M No change
ITOS Iteos Therapeutics Inc. 2.30% 2,946,915 $43.7M Add +63.4%
ARGX Argenx SE - ADR 2.26% 100,000 $43.0M No change
AKRO Akero Therapeutics Inc. 2.07% 1,676,733 $39.3M No change
NKTX Nkarta Inc. 1.75% 5,607,350 $33.1M No change
ANAB Anaptysbio Inc. 1.72% 1,300,000 $32.6M No change
AXSM Axsome Therapeutics Inc. 1.70% 400,000 $32.2M No change
RCKT Rocket Pharmaceuticals Inc. 1.66% 1,466,051 $31.6M No change
FATE Fate Therapeutics Inc. 1.42% 8,215,910 $26.9M No change
LEGN Legend Biotech Corp.-ADR 1.40% 600,000 $26.6M No change
THRD Third Harmonic Bio Inc. 1.37% 2,000,000 $26.0M No change
GERN Geron Corp. 1.34% 6,000,000 $25.4M No change
RCUS Arcus Biosciences Inc. 1.29% 1,602,200 $24.4M No change
XENE Xenon Pharmaceuticals Inc. 1.23% 600,000 $23.4M No change
IMVT Immunovant Inc. 1.15% 825,000 $21.8M No change
KURA Kura Oncology Inc. 1.08% 1,000,000 $20.6M No change
KALV Kalvista Pharmaceuticals Inc. 0.99% 1,590,000 $18.7M No change
CLYM Climb Bio Inc. filed as ELIEM THERAPEUTICS INC 0.97% 2,603,190 $18.5M New
DAWN Day One Biopharmaceuticals I 0.86% 1,189,943 $16.4M No change
SYRE Spyre Therapeutics Inc. 0.86% 696,480 $16.4M Add +178.6%
ARVN Arvinas Inc. 0.85% 608,614 $16.2M No change
GPCR Structure Therapeutics Inc. 0.83% 400,000 $15.7M No change
ELVN Enliven Therapeutics Inc. 0.83% 671,358 $15.7M No change
PRTA Prothena Corp. PLC 0.75% 690,000 $14.2M No change
REPL Replimune Group Inc. 0.73% 1,536,341 $13.8M New
PSTX Poseida Therapeutics Inc. 0.69% 4,475,000 $13.1M No change
IPSC Century Therapeutics Inc. 0.66% 4,901,603 $12.5M Add +180.1%
ORIC Oric Pharmaceuticals Inc. 0.65% 1,732,571 $12.2M No change
RLAY Relay Therapeutics Inc. 0.62% 1,819,132 $11.9M No change
CGEM Cullinan Therapeutics Inc. 0.60% 657,895 $11.5M New
PRLD Prelude Therapeutics Inc. 0.52% 2,568,287 $9.8M No change
ALLO Allogene Therapeutics Inc. 0.47% 3,850,000 $9.0M No change
SANA Sana Biotechnology Inc. 0.44% 1,545,000 $8.4M No change
JSPR Jasper Therapeutics Inc. 0.42% 350,000 $7.9M No change
OLMA Olema Pharmaceuticals Inc. 0.37% 650,000 $7.0M New
ENGN Engene Holdings Inc. 0.36% 727,900 $6.9M No change
IOVA Iovance Biotherapeutics Inc. 0.32% 750,000 $6.0M No change
AMLX Amylyx Pharmaceuticals Inc. 0.15% 1,500,000 $2.9M No change
BOLD Boundless Bio Inc. 0.14% 711,329 $2.8M No change
BDTX Black Diamond Therapeutics I 0.12% 506,000 $2.4M No change
ABSI Absci Corp. 0.11% 700,000 $2.2M No change
OBIO Orchestra Biomed Holdings Inc. 0.10% 238,193 $1.9M No change
ZNTL Zentalis Pharmaceuticals Inc. 0.10% 450,000 $1.8M No change
TARA Protara Therapeutic Inc. 0.09% 811,627 $1.7M Add +287.9%
ATRA Atara Biotherapeutics Inc. 0.07% 166,000 $1.4M Reduce -96.0%
BCAB Bioatla Inc. 0.05% 686,347 $940K No change
MIST Milestone Pharmaceuticals Inc. 0.02% 309,007 $408K No change
DBV TECHNOLOGIES S A 0.01% 250,000 $200K Reduce -50.0%
Other holdings (2): bonds, preferreds, convertibles and warrants · $44K (not counted above)
SecurityClassShares / PrincipalValueChange
NUVB.WS Nuvation Bio Inc. -CW27 *W EXP 02/10/202 266,666$43KNo change
SRZNW Surrozen Inc.-CW25 *W EXP 08/01/203 66,666$1KNo change

Total filed on the 13F, all lines: $1.9B.

Portfolio Sells Q1 2024 → Q2 2024
VKTX Viking Therapeutics Inc. Sold out 0.00% −1.22
DIREXION SHS ETF TR Sold out 0.00% −0.13
ATRA Atara Biotherapeutics Inc. Reduce -96.0% 0.07% −0.07
DBV TECHNOLOGIES S A Reduce -50.0% 0.01% −0.01

Portfolio Buys Q1 2024 → Q2 2024
ITOS Iteos Therapeutics Inc. Add +63.4% 2.30% +1.09
CLYM Climb Bio Inc. New 0.97% +0.97
REPL Replimune Group Inc. New 0.73% +0.73
CGEM Cullinan Therapeutics Inc. New 0.60% +0.60
SYRE Spyre Therapeutics Inc. Add +178.6% 0.86% +0.39
OLMA Olema Pharmaceuticals Inc. New 0.37% +0.37
IPSC Century Therapeutics Inc. Add +180.1% 0.66% +0.30
TARA Protara Therapeutic Inc. Add +287.9% 0.09% +0.05

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q4 2024 0$0
Q3 2024 66$2.0BRVMD, TYRA, NUVL, ONC, CYTK
Q2 2024 59$1.9BRVMD, SWTX, CYTK, MRUS, TYRA
Q1 2024 57$2.0BSWTX, CYTK, RVMD, TYRA, APLS