Boxer Capital, LLC

In its 13F for Q3 2024 (holdings as of September 30, 2024, filed November 14, 2024), Boxer Capital, LLC reported 66 stock positions worth $2.0 billion. Its top holding was Revolution Medicines (RVMD) at 9.5% of the portfolio, followed by Tyra Biosciences (TYRA, 7.4%) and Nuvalent Class A (NUVL, 5.6%). Compared with Q2 2024, it opened 12 new positions, sold out of 5, added to 1 and reduced 5. The biggest buy was a new position in Instil Bio (TIL) and the biggest sale Nkarta (NKTX, shares −28%).

Most Recent 13F
Q4 2024
Location
San Diego, CA
CIK
0001465837
Portfolio Value
$2.0B (Q3 2024)
SEC Filing
0000895345-24-000585 ↗ filed Nov 14, 2024

Holdings Value

0$500.0M$1.0B$1.5B$2.0B$2.5B Q1 2024: $2.0B Q1 2024 Q2 2024: $1.9B Q2 2024 Q3 2024: $2.0B $2.0B Q3 2024 Q4 2024: $0 Q4 2024

Holdings 66 stocks · $2.0B
RVMD Revolution Medicines Inc. 9.52% 4,279,464 $194.1M No change
TYRA Tyra Biosciences Inc. 7.44% 6,448,359 $151.6M No change
NUVL Nuvalent Inc. Class A 5.62% 1,120,192 $114.6M No change
ONC Beone Medicines Ltd.-ADR filed as BEIGENE LTD 5.51% 500,000 $112.3M No change
CYTK Cytokinetics Inc. 5.44% 2,100,000 $110.9M No change
SWTX Springworks Therapeutics Inc. 5.38% 3,421,541 $109.6M No change
MRUS Merus NV 4.66% 1,900,000 $94.9M No change
SRPT Sarepta Therapeutics Inc. 3.98% 650,000 $81.2M No change
RNAM Avidity Biosciences Inc. 3.89% 1,727,388 $79.3M No change
IDYA Ideaya Biosciences Inc. 3.42% 2,202,812 $69.8M No change
TNGX Tango Therapeutics Inc. 3.10% 8,198,642 $63.1M No change
ARGX Argenx SE - ADR 2.66% 100,000 $54.2M No change
APLS Apellis Pharmaceuticals Inc. 2.44% 1,726,000 $49.8M No change
AKRO Akero Therapeutics Inc. 2.36% 1,676,733 $48.1M No change
ANAB Anaptysbio Inc. 2.14% 1,300,000 $43.5M No change
AXSM Axsome Therapeutics Inc. 1.76% 400,000 $35.9M No change
ITOS Iteos Therapeutics Inc. 1.48% 2,946,915 $30.1M No change
LEGN Legend Biotech Corp.-ADR 1.43% 600,000 $29.2M No change
GERN Geron Corp. 1.34% 6,000,000 $27.2M No change
THRD Third Harmonic Bio Inc. 1.33% 2,000,000 $27.1M No change
RCKT Rocket Pharmaceuticals Inc. 1.33% 1,466,051 $27.1M No change
RCUS Arcus Biosciences Inc. 1.20% 1,602,200 $24.5M No change
TIL Instil Bio Inc. 1.17% 355,500 $23.9M New
XENE Xenon Pharmaceuticals Inc. 1.16% 600,000 $23.6M No change
IMVT Immunovant Inc. 1.15% 825,000 $23.5M No change
KYMR Kymera Therapeutics Inc. 1.05% 450,000 $21.3M New
SYRE Spyre Therapeutics Inc. 1.01% 696,480 $20.5M No change
KURA Kura Oncology Inc. 0.96% 1,000,000 $19.5M No change
KALV Kalvista Pharmaceuticals Inc. 0.90% 1,590,000 $18.4M No change
NKTX Nkarta Inc. 0.89% 4,029,606 $18.2M Reduce -28.1%
ORIC Oric Pharmaceuticals Inc. 0.87% 1,732,571 $17.8M No change
GPCR Structure Therapeutics Inc. 0.86% 400,000 $17.6M No change
FATE Fate Therapeutics Inc. 0.85% 4,960,910 $17.4M Reduce -39.6%
ELVN Enliven Therapeutics Inc. 0.84% 671,358 $17.1M No change
REPL Replimune Group Inc. 0.83% 1,536,341 $16.8M No change
DAWN Day One Biopharmaceuticals I 0.81% 1,189,943 $16.6M No change
CGEM Cullinan Therapeutics Inc. 0.75% 907,895 $15.2M Add +38.0%
ARVN Arvinas Inc. 0.74% 608,614 $15.0M No change
CLYM Climb Bio Inc. filed as ELIEM THERAPEUTICS INC 0.65% 2,603,190 $13.3M No change
RLAY Relay Therapeutics Inc. 0.63% 1,819,132 $12.9M No change
NRIX Nurix Therapeutics Inc. 0.62% 563,067 $12.7M New
PRTA Prothena Corp. PLC 0.57% 690,000 $11.5M No change
QURE Uniqure NV 0.54% 2,225,000 $11.0M New
APGE Apogee Therapeutics Inc. 0.52% 179,000 $10.5M New
OLMA Olema Pharmaceuticals Inc. 0.38% 650,000 $7.8M No change
IOVA Iovance Biotherapeutics Inc. 0.35% 750,000 $7.0M No change
IPSC Century Therapeutics Inc. 0.33% 3,900,000 $6.7M Reduce -20.4%
JSPR Jasper Therapeutics Inc. 0.32% 350,000 $6.6M No change
SANA Sana Biotechnology Inc. 0.32% 1,545,000 $6.4M No change
TERN Terns Pharmaceuticals Inc. 0.31% 752,000 $6.3M New
SRRK Scholar Rock Holding Corp. 0.29% 750,000 $6.0M New
PSTX Poseida Therapeutics Inc. 0.28% 2,000,000 $5.7M Reduce -55.3%
SMMT Summit Therapeutics Inc. 0.27% 250,000 $5.5M New
ENGN Engene Holdings Inc. 0.24% 727,900 $4.8M No change
PRLD Prelude Therapeutics Inc. 0.17% 1,708,187 $3.5M Reduce -33.5%
BCAX Bicara Therapeutics Inc. 0.17% 135,000 $3.4M New
MERSANA THERAPEUTICS INC 0.17% 1,817,000 $3.4M New
BOLD Boundless Bio Inc. 0.12% 711,329 $2.5M No change
BDTX Black Diamond Therapeutics I 0.11% 506,000 $2.2M No change
ZNTL Zentalis Pharmaceuticals Inc. 0.08% 450,000 $1.7M No change
TARA Protara Therapeutic Inc. 0.07% 811,627 $1.5M No change
OBIO Orchestra Biomed Holdings Inc. 0.06% 238,193 $1.2M No change
ZURA Zura Bio Ltd. 0.06% 300,000 $1.2M New
BCAB Bioatla Inc. 0.06% 686,347 $1.2M No change
MIST Milestone Pharmaceuticals Inc. 0.02% 309,007 $470K No change
DBV TECHNOLOGIES S A 0.01% 250,000 $175K New
Other holdings (2): bonds, preferreds, convertibles and warrants · $27K (not counted above)
SecurityClassShares / PrincipalValueChange
NUVB.WS Nuvation Bio Inc. -CW27 *W EXP 02/10/202 266,666$26KNo change
SRZNW Surrozen Inc.-CW25 *W EXP 08/01/203 66,666$1KNo change

Total filed on the 13F, all lines: $2.0B.

Portfolio Sells Q2 2024 → Q3 2024
NKTX Nkarta Inc. Reduce -28.1% 0.89% −0.85
FATE Fate Therapeutics Inc. Reduce -39.6% 0.85% −0.57
ALLO Allogene Therapeutics Inc. Sold out 0.00% −0.47
PSTX Poseida Therapeutics Inc. Reduce -55.3% 0.28% −0.41
PRLD Prelude Therapeutics Inc. Reduce -33.5% 0.17% −0.34
IPSC Century Therapeutics Inc. Reduce -20.4% 0.33% −0.33
AMLX Amylyx Pharmaceuticals Inc. Sold out 0.00% −0.15
ABSI Absci Corp. Sold out 0.00% −0.11
ATRA Atara Biotherapeutics Inc. Sold out 0.00% −0.07
DBV TECHNOLOGIES S A Sold out 0.00% −0.01

Portfolio Buys Q2 2024 → Q3 2024
TIL Instil Bio Inc. New 1.17% +1.17
KYMR Kymera Therapeutics Inc. New 1.05% +1.05
NRIX Nurix Therapeutics Inc. New 0.62% +0.62
QURE Uniqure NV New 0.54% +0.54
APGE Apogee Therapeutics Inc. New 0.52% +0.52
TERN Terns Pharmaceuticals Inc. New 0.31% +0.31
SRRK Scholar Rock Holding Corp. New 0.29% +0.29
SMMT Summit Therapeutics Inc. New 0.27% +0.27
BCAX Bicara Therapeutics Inc. New 0.17% +0.17
MERSANA THERAPEUTICS INC New 0.17% +0.17
CGEM Cullinan Therapeutics Inc. Add +38.0% 0.75% +0.14
ZURA Zura Bio Ltd. New 0.06% +0.06
DBV TECHNOLOGIES S A New 0.01% +0.01

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q4 2024 0$0
Q3 2024 66$2.0BRVMD, TYRA, NUVL, ONC, CYTK
Q2 2024 59$1.9BRVMD, SWTX, CYTK, MRUS, TYRA
Q1 2024 57$2.0BSWTX, CYTK, RVMD, TYRA, APLS