Orbimed Advisors LLC

In its 13F for Q3 2024 (holdings as of September 30, 2024, filed November 14, 2024), Orbimed Advisors LLC reported 109 stock positions worth $5.5 billion. Its top holding was Edgewise Therapeutics (EWTX) at 7.3% of the portfolio, followed by Sinovac Biotech (SVA, 6.2%) and Eli Lilly (LLY, 5.5%). Compared with Q2 2024, it opened 17 new positions, sold out of 16, added to 21 and reduced 29. The biggest buy was a new position in MBX Biosciences (MBX) and the biggest sale Janux Therapeutics (JANX, shares −58%).

Most Recent 13F
Q2 2026
Location
New York, NY
CIK
0001055951
Portfolio Value
$5.5B (Q3 2024)
SEC Filing
0001172661-24-005167 ↗ filed Nov 14, 2024

Holdings Value

0$2.0B$4.0B$6.0B Q1 2024: $5.4B Q1 2024 Q2 2024: $5.0B Q2 2024 Q3 2024: $5.5B $5.5B Q3 2024 Q4 2024: $4.8B Q4 2024 Q1 2025: $4.2B Q1 2025 Q2 2025: $4.0B Q2 2025 Q3 2025: $4.2B Q3 2025 Q4 2025: $4.9B Q4 2025 Q1 2026: $4.4B Q1 2026 Q2 2026: $5.3B Q2 2026

Holdings 109 stocks · $5.5B
EWTX Edgewise Therapeutics Inc. 7.34% 15,021,721 $400.9M No change
SVA Sinovac Biotech Ltd. 6.22% 2,718,735 $340.0M No change
LLY Eli Lilly & Co. 5.47% 337,600 $299.1M No change
BSX Boston Scientific Corp. 5.02% 3,273,000 $274.3M No change
ISRG Intuitive Surgical Inc. 3.90% 433,800 $213.1M Reduce -12.0%
ELVN Enliven Therapeutics Inc. 3.72% 7,959,538 $203.3M No change
BIIB Biogen Inc. 2.88% 813,000 $157.6M Reduce -9.8%
MRK Merck & Co. Inc. 2.73% 1,316,000 $149.4M No change
THC Tenet Healthcare Corp. 2.38% 782,000 $130.0M Reduce -33.4%
SYK Stryker Corp. 2.28% 344,400 $124.4M Add +28.0%
SPRY Ars Pharmaceuticals Inc. 2.20% 8,288,510 $120.2M Reduce -10.3%
SRPT Sarepta Therapeutics Inc. 2.18% 954,500 $119.2M Add +47.8%
ARGX Argenx SE - ADR 2.03% 204,500 $110.9M Reduce -2.2%
UNH Unitedhealth Group Inc. 1.92% 179,000 $104.7M Add +59.8%
QTTB Q32 Bio Inc. 1.84% 2,252,987 $100.5M No change
MBX MBX Biosciences Inc. 1.81% 3,812,215 $99.0M New
IONS Ionis Pharmaceuticals Inc. 1.70% 2,324,447 $93.1M Reduce -2.0%
IRON Disc Medicine Inc. 1.61% 1,785,571 $87.7M No change
NTRA Natera Inc. 1.60% 687,500 $87.3M No change
AMGN Amgen Inc. 1.49% 252,300 $81.3M Add +87.0%
THRD Third Harmonic Bio Inc. 1.43% 5,779,071 $78.3M No change
ITGR Integer Holdings Corp. 1.37% 575,000 $74.8M Add +64.7%
AVBP Arrivent Biopharma Inc. 1.30% 3,027,328 $71.1M No change
VRTX Vertex Pharmaceuticals Inc. 1.29% 151,000 $70.2M No change
ALNY Alnylam Pharmaceuticals Inc. 1.26% 250,300 $68.8M No change
TERN Terns Pharmaceuticals Inc. 1.15% 7,562,971 $63.1M Reduce -0.7%
KROS Keros Therapeutics Inc. 1.08% 1,018,734 $59.2M Reduce -19.7%
JANX Janux Therapeutics Inc. 1.05% 1,258,566 $57.2M Reduce -57.8%
ELV Elevance Health Inc. 1.01% 106,200 $55.2M Reduce -36.8%
CRNX Crinetics Pharmaceuticals Inc. 0.98% 1,050,055 $53.7M Reduce -18.0%
TMO Thermo Fisher Scientific Inc. 0.96% 84,400 $52.2M Reduce -36.1%
XTNT Xtant Medical Holdings Inc. 0.90% 73,114,592 $49.4M No change
RNAM Avidity Biosciences Inc. 0.88% 1,044,805 $48.0M Add +47.9%
REGN Regeneron Pharmaceuticals 0.87% 45,200 $47.5M Add +98.3%
EVH Evolent Health Inc. Class A 0.86% 1,665,115 $47.1M Reduce -36.1%
EXAS Exact Sciences Corp. 0.85% 679,816 $46.3M Add +1.1%
SIBN Si-Bone Inc. 0.85% 3,305,801 $46.2M Add +2.4%
SWTX Springworks Therapeutics Inc. 0.82% 1,390,631 $44.6M Reduce -18.6%
PCVX Vaxcyte Inc. 0.81% 387,000 $44.2M Reduce -51.4%
CMPX Compass Therapeutics Inc. 0.75% 22,362,850 $41.1M No change
CYTK Cytokinetics Inc. 0.74% 766,906 $40.5M Reduce -5.7%
SNDX Syndax Pharmaceuticals Inc. 0.68% 1,925,300 $37.1M No change
CRVS Corvus Pharmaceuticals Inc. 0.67% 6,943,654 $36.7M No change
APLS Apellis Pharmaceuticals Inc. 0.67% 1,270,400 $36.6M Reduce -2.5%
XENE Xenon Pharmaceuticals Inc. 0.66% 911,420 $35.9M Add +5.7%
UHS Universal Health Services-B 0.65% 156,000 $35.7M New
ICLR Icon PLC 0.65% 123,900 $35.6M Reduce -28.8%
NBIX Neurocrine Biosciences Inc. 0.64% 302,220 $34.8M Reduce -32.6%
VERA Vera Therapeutics Inc. 0.55% 675,872 $29.9M No change
BIOA Bioage Labs Inc. 0.54% 1,423,470 $29.6M New
SCPH Scpharmaceuticals Inc. 0.51% 6,059,528 $27.6M Add +9.0%
VIR Vir Biotechnology Inc. 0.49% 3,573,000 $26.8M Add +54.0%
PHAT Phathom Pharmaceuticals Inc. 0.48% 1,449,073 $26.2M New
CGON CG Oncology Inc. 0.48% 691,114 $26.1M New
DYN Dyne Therapeutics Inc. 0.47% 708,400 $25.4M No change
CCCC C4 Therapeutics Inc. 0.46% 4,377,900 $25.0M Add +189.3%
MLYS Mineralys Therapeutics Inc. 0.44% 2,002,939 $24.3M Reduce -0.9%
NPCE Neuropace Inc. 0.43% 3,406,335 $23.7M No change
IMTX Immatics NV 0.42% 2,006,381 $22.9M No change
RYTM Rhythm Pharmaceuticals Inc. 0.42% 435,900 $22.8M Reduce -38.2%
0 0.42% 12,048,773 $22.8M No change
PRLD Prelude Therapeutics Inc. 0.41% 10,909,256 $22.6M No change
APGE Apogee Therapeutics Inc. 0.41% 379,130 $22.3M No change
NMRA Neumora Therapeutics Inc. 0.36% 1,500,000 $19.8M No change
SLRN Acelyrin Inc. 0.36% 4,001,711 $19.7M No change
CRBP Corbus Pharmaceuticals Holdi 0.34% 912,552 $18.8M New
TYRA Tyra Biosciences Inc. 0.33% 768,638 $18.1M No change
CGEM Cullinan Therapeutics Inc. 0.33% 1,070,055 $17.9M Reduce -6.8%
LXRX Lexicon Pharmaceuticals Inc. 0.32% 11,024,000 $17.3M Add +88.6%
GPCR Structure Therapeutics Inc. 0.31% 383,705 $16.8M Add +207.0%
ACET Adicet Bio Inc. 0.30% 11,447,140 $16.5M No change
MEDP Medpace Holdings Inc. 0.27% 44,900 $15.0M New
ADCT Adc Therapeutics SA 0.26% 4,533,801 $14.3M Add +5.0%
GILD Gilead Sciences Inc. 0.23% 151,700 $12.7M New
BNTX Biontech SE-ADR 0.22% 103,000 $12.2M New
ACAD Acadia Pharmaceuticals Inc. 0.22% 764,600 $11.8M New
RPTX Repare Therapeutics Inc. 0.21% 3,322,488 $11.4M No change
ABCL Abcellera Biologics Inc. 0.20% 4,180,768 $10.9M No change
PMVP PMV Pharmaceuticals Inc. 0.18% 6,475,291 $9.6M No change
AVTX Avalo Therapeutics Inc. 0.17% 967,000 $9.2M New
VSTM Verastem Inc. 0.16% 2,862,448 $8.6M Add +87.2%
LYEL Lyell Immunopharma Inc. 0.15% 6,086,001 $8.4M Reduce -5.0%
OSCR Oscar Health Inc. Class A 0.14% 351,618 $7.5M New
BCAX Bicara Therapeutics Inc. 0.13% 271,910 $6.9M New
PASG Passage Bio Inc. 0.13% 9,822,876 $6.9M Reduce -3.0%
PEPG Pepgen Inc. 0.12% 797,358 $6.8M New
NKTX Nkarta Inc. 0.12% 1,480,600 $6.7M Add +85.1%
IKENA ONCOLOGY INC 0.11% 3,539,358 $6.1M No change
FOLD Amicus Therapeutics Inc. 0.11% 570,300 $6.1M No change
SRRK Scholar Rock Holding Corp. 0.11% 742,300 $5.9M Reduce -30.9%
FATE Fate Therapeutics Inc. 0.11% 1,680,580 $5.9M Add +24.0%
NSPR Inspiremd Inc. 0.10% 2,133,405 $5.7M No change
LBPH Longboard Pharmaceuticals Inc. 0.10% 170,000 $5.7M New
TELA Tela Bio Inc. 0.10% 2,161,185 $5.5M Reduce -12.1%
XFOR X4 Pharmaceuticals Inc. 0.09% 7,133,515 $4.8M No change
KRYS Krystal Biotech Inc. 0.08% 23,500 $4.3M Reduce -21.6%
ARDT Ardent Health Inc. 0.07% 206,000 $3.8M New
TRAW Traws Pharma Inc. 0.07% 605,531 $3.6M Add +1348.3%
MIST Milestone Pharmaceuticals Inc. 0.06% 2,000,000 $3.0M No change
CMMB Chemomab Therapeutics Ltd. 0.05% 1,741,273 $2.7M Reduce -22.3%
TIL Instil Bio Inc. 0.04% 33,700 $2.3M New
BIOMX INC 0.03% 1,787,767 $1.8M Add +29.8%
IVVD Invivyd Inc. 0.03% 1,728,300 $1.8M Reduce -28.8%
TSBX Turnstone Biologics Corp. 0.03% 3,099,265 $1.7M No change
NXTC Nextcure Inc. 0.03% 1,141,200 $1.6M No change
VIGL Vigil Neuroscience Inc. 0.03% 448,891 $1.5M No change
KEZAR LIFE SCIENCES INC 0.03% 1,927,000 $1.5M No change
ELEV Elevation Oncology Inc. 0.01% 941,275 $565K No change
XERS Xeris Biopharma Holdings Inc. 0.00% 80,420 $229K No change

Options reported separately and not counted above: EVH calls ($7.3M), MRNA calls ($6.7M), SRPT calls ($6.2M), SOLV calls ($4.8M), RNAM calls ($4.6M), SIBN calls ($3.5M), FLNA puts ($2.8M), GERN calls ($1.8M), CCCC calls ($855K).

Portfolio Sells Q2 2024 → Q3 2024
JANX Janux Therapeutics Inc. Reduce -57.8% 1.05% −1.44
BIIB Biogen Inc. Reduce -9.8% 2.88% −1.27
VRNA Verona Pharma Ltd. Sold out 0.00% −0.82
ELV Elevance Health Inc. Reduce -36.8% 1.01% −0.80
GERN Geron Corp. Sold out 0.00% −0.75
THC Tenet Healthcare Corp. Reduce -33.4% 2.38% −0.72
DXCM Dexcom Inc. Sold out 0.00% −0.65
NBIX Neurocrine Biosciences Inc. Reduce -32.6% 0.64% −0.59
IONS Ionis Pharmaceuticals Inc. Reduce -2.0% 1.70% −0.54
TMO Thermo Fisher Scientific Inc. Reduce -36.1% 0.96% −0.50
SWTX Springworks Therapeutics Inc. Reduce -18.6% 0.82% −0.46
ISRG Intuitive Surgical Inc. Reduce -12.0% 3.90% −0.46
HRTX Heron Therapeutics Inc. Sold out 0.00% −0.45
ICLR Icon PLC Reduce -28.8% 0.65% −0.43
MORF Morphic Holding Inc. Sold out 0.00% −0.41
PCVX Vaxcyte Inc. Reduce -51.4% 0.81% −0.39
APLS Apellis Pharmaceuticals Inc. Reduce -2.5% 0.67% −0.32
ALXO Alx Oncology Holdings Inc. Sold out 0.00% −0.23
MRUS Merus NV Sold out 0.00% −0.18
CRNX Crinetics Pharmaceuticals Inc. Reduce -18.0% 0.98% −0.16
RYTM Rhythm Pharmaceuticals Inc. Reduce -38.2% 0.42% −0.16
PGNY Progyny Inc. Sold out 0.00% −0.15
CYTK Cytokinetics Inc. Reduce -5.7% 0.74% −0.13
TELA Tela Bio Inc. Reduce -12.1% 0.10% −0.13
EVH Evolent Health Inc. Class A Reduce -36.1% 0.86% −0.13
CATX Perspective Therapeutics Inc. Sold out 0.00% −0.10
CGEM Cullinan Therapeutics Inc. Reduce -6.8% 0.33% −0.07
KROS Keros Therapeutics Inc. Reduce -19.7% 1.08% −0.07
SRRK Scholar Rock Holding Corp. Reduce -30.9% 0.11% −0.07
TGTX TG Therapeutics Inc. Sold out 0.00% −0.05
BMRN Biomarin Pharmaceutical Inc. Sold out 0.00% −0.04
ORIC Oric Pharmaceuticals Inc. Sold out 0.00% −0.04
APLM Apollomics Inc. Sold out 0.00% −0.04
PASG Passage Bio Inc. Reduce -3.0% 0.13% −0.03
KRYS Krystal Biotech Inc. Reduce -21.6% 0.08% −0.03
LYEL Lyell Immunopharma Inc. Reduce -5.0% 0.15% −0.03
MLYS Mineralys Therapeutics Inc. Reduce -0.9% 0.44% −0.03
DVAX Dynavax Technologies Corp. Sold out 0.00% −0.03
IVVD Invivyd Inc. Reduce -28.8% 0.03% −0.02
LAKESHORE BIOPHARMA CO LTD Sold out 0.00% −0.02
OMIC Singular Genomics Systems Inc. Sold out 0.00% −0.00
CMMB Chemomab Therapeutics Ltd. Reduce -22.3% 0.05% +0.01
TERN Terns Pharmaceuticals Inc. Reduce -0.7% 1.15% +0.12
ARGX Argenx SE - ADR Reduce -2.2% 2.03% +0.24
SPRY Ars Pharmaceuticals Inc. Reduce -10.3% 2.20% +0.64

Portfolio Buys Q2 2024 → Q3 2024
MBX MBX Biosciences Inc. New 1.81% +1.81
UNH Unitedhealth Group Inc. Add +59.8% 1.92% +0.78
UHS Universal Health Services-B New 0.65% +0.65
AMGN Amgen Inc. Add +87.0% 1.49% +0.65
ITGR Integer Holdings Corp. Add +64.7% 1.37% +0.56
BIOA Bioage Labs Inc. New 0.54% +0.54
PHAT Phathom Pharmaceuticals Inc. New 0.48% +0.48
CGON CG Oncology Inc. New 0.48% +0.48
SYK Stryker Corp. Add +28.0% 2.28% +0.46
REGN Regeneron Pharmaceuticals Add +98.3% 0.87% +0.39
CRBP Corbus Pharmaceuticals Holdi New 0.34% +0.34
CCCC C4 Therapeutics Inc. Add +189.3% 0.46% +0.32
RNAM Avidity Biosciences Inc. Add +47.9% 0.88% +0.30
EXAS Exact Sciences Corp. Add +1.1% 0.85% +0.28
MEDP Medpace Holdings Inc. New 0.27% +0.27
GILD Gilead Sciences Inc. New 0.23% +0.23
BNTX Biontech SE-ADR New 0.22% +0.22
ACAD Acadia Pharmaceuticals Inc. New 0.22% +0.22
GPCR Structure Therapeutics Inc. Add +207.0% 0.31% +0.21
AVTX Avalo Therapeutics Inc. New 0.17% +0.17
SRPT Sarepta Therapeutics Inc. Add +47.8% 2.18% +0.15
OSCR Oscar Health Inc. Class A New 0.14% +0.14
BCAX Bicara Therapeutics Inc. New 0.13% +0.13
PEPG Pepgen Inc. New 0.12% +0.12
LXRX Lexicon Pharmaceuticals Inc. Add +88.6% 0.32% +0.12
LBPH Longboard Pharmaceuticals Inc. New 0.10% +0.10
VIR Vir Biotechnology Inc. Add +54.0% 0.49% +0.08
ARDT Ardent Health Inc. New 0.07% +0.07
VSTM Verastem Inc. Add +87.2% 0.16% +0.07
TRAW Traws Pharma Inc. Add +1348.3% 0.07% +0.06
TIL Instil Bio Inc. New 0.04% +0.04
NKTX Nkarta Inc. Add +85.1% 0.12% +0.03
SCPH Scpharmaceuticals Inc. Add +9.0% 0.51% +0.02
FATE Fate Therapeutics Inc. Add +24.0% 0.11% +0.02
SIBN Si-Bone Inc. Add +2.4% 0.85% +0.02
ADCT Adc Therapeutics SA Add +5.0% 0.26% −0.01
XENE Xenon Pharmaceuticals Inc. Add +5.7% 0.66% −0.01
BIOMX INC Add +29.8% 0.03% −0.06

Options Activity Q2 2024 → Q3 2024
EVH Evolent Health Inc. Class A call New 258,400 $7.3M
PFE Pfizer Inc. call Sold out 250,000 $7.0Mbefore exit
MRNA Moderna Inc. call New 100,000 $6.7M
SOLV Solventum Corp. call Reduce -65.3% 69,300 $4.8M
RNAM Avidity Biosciences Inc. call New 100,000 $4.6M
MRUS Merus NV call Sold out 50,000 $3.0Mbefore exit
FLNA Filana Therapeutics Inc. put New 95,000 $2.8M
GERN Geron Corp. call Reduce -33.3% 400,000 $1.8M
CCCC C4 Therapeutics Inc. call New 150,000 $855K

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 117$5.3BEWTX, ELVN, LLY, MBX, SVA
Q1 2026 105$4.4BEWTX, ELVN, LLY, SVA, BSX
Q4 2025 104$4.9BEWTX, LLY, BSX, SVA, EW
Q3 2025 98$4.2BEWTX, BSX, LLY, SVA, ELVN
Q2 2025 97$4.0BSVA, BSX, LLY, EWTX, ELVN
Q1 2025 106$4.2BSVA, EWTX, BSX, LLY, ELVN
Q4 2024 111$4.8BEWTX, SVA, BSX, LLY, ISRG
Q3 2024 109$5.5BEWTX, SVA, LLY, BSX, ISRG
Q2 2024 108$5.0BSVA, LLY, EWTX, BSX, ISRG
Q1 2024 112$5.4BSVA, LLY, EWTX, BSX, ISRG