Stempoint Capital LP
In its 13F for Q4 2025 (holdings as of December 31, 2025, filed February 17, 2026), Stempoint Capital LP reported 75 stock positions worth $582.7 million. Its top holding was Abivax SA-ADR (ABVX) at 9.1% of the portfolio, followed by Scholar Rock (SRRK, 6.7%) and Centessa Pharmaceuticals (CNTA, 5.0%). Compared with Q3 2025, it opened 32 new positions, sold out of 33, added to 27 and reduced 16. The biggest buy was Abivax SA-ADR (ABVX, shares +136%) and the biggest sale Roivant Sciences (ROIV, shares −77%).
- Most Recent 13F
- Q2 2026
- Location
- NEW YORK, NY
- CIK
- 0001952142
- Portfolio Value
- $582.7M (Q4 2025)
- SEC Filing
- 0001420506-26-000490 ↗ filed Feb 17, 2026
Holdings Value
Holdings 75 stocks · $582.7M
| ABVX Abivax SA-ADR | 9.07% | 391,783 | $52.8M | Add +135.6% |
| SRRK Scholar Rock Holding Corp. | 6.70% | 886,893 | $39.1M | Add +22.1% |
| CNTA Centessa Pharmaceuticals Ltd. | 4.95% | 1,154,114 | $28.9M | Add +76.1% |
| SNDX Syndax Pharmaceuticals Inc. | 4.83% | 1,339,379 | $28.1M | Reduce -2.0% |
| GPCR Structure Therapeutics Inc. | 4.19% | 351,073 | $24.4M | Add +171.4% |
| ACLX Arcellx Inc. | 3.72% | 332,860 | $21.7M | Add +2826.0% |
| ROIV Roivant Sciences Ltd. | 3.60% | 966,698 | $21.0M | Reduce -77.0% |
| TERN Terns Pharmaceuticals Inc. | 2.98% | 429,198 | $17.3M | Add +378.9% |
| TWST Twist Bioscience Corp. | 2.82% | 518,355 | $16.4M | New |
| IMVT Immunovant Inc. | 2.81% | 644,959 | $16.4M | Reduce -59.4% |
| DYN Dyne Therapeutics Inc. | 2.80% | 835,200 | $16.3M | Add +76.0% |
| XENE Xenon Pharmaceuticals Inc. | 2.68% | 348,605 | $15.6M | Add +81.3% |
| SRZN Surrozen Inc. | 2.17% | 619,766 | $12.7M | Reduce -13.1% |
| CELC Celcuity Inc. | 2.03% | 118,333 | $11.8M | Reduce -13.4% |
| MLYS Mineralys Therapeutics Inc. | 1.81% | 290,049 | $10.5M | Add +83.5% |
| MDGL Madrigal Pharmaceuticals Inc. | 1.77% | 17,736 | $10.3M | Add +116.1% |
| ADPT Adaptive Biotechnologies | 1.69% | 606,825 | $9.9M | New |
| PALI Palisade Bio Inc. | 1.69% | 4,192,375 | $9.9M | New |
| CYTK Cytokinetics Inc. | 1.60% | 146,978 | $9.3M | New |
| EWTX Edgewise Therapeutics Inc. | 1.54% | 360,876 | $9.0M | New |
| DRUG Bright Minds Biosciences Inc. | 1.30% | 97,340 | $7.6M | New |
| NKTR Nektar Therapeutics | 1.29% | 178,274 | $7.5M | Add +235.1% |
| JNJ Johnson & Johnson | 1.24% | 35,000 | $7.2M | New |
| DNLI Denali Therapeutics Inc. | 1.19% | 419,058 | $6.9M | Reduce -75.8% |
| AMLX Amylyx Pharmaceuticals Inc. | 1.17% | 565,140 | $6.8M | Add +104.1% |
| CLPT Clearpoint Neuro Inc. | 1.13% | 481,858 | $6.6M | Add +2793.9% |
| ARQT Arcutis Biotherapeutics Inc. | 1.12% | 224,740 | $6.5M | Reduce -45.4% |
| EYPT Eyepoint Inc. | 1.11% | 353,849 | $6.5M | New |
| IMTX Immatics NV | 1.10% | 610,308 | $6.4M | New |
| OCUL Ocular Therapeutix Inc. | 1.09% | 522,693 | $6.3M | Add +45.4% |
| RYTM Rhythm Pharmaceuticals Inc. | 1.08% | 58,915 | $6.3M | Reduce -35.6% |
| PRAX Praxis Precision Medicines I | 1.07% | 21,067 | $6.2M | New |
| APGE Apogee Therapeutics Inc. | 1.04% | 80,574 | $6.1M | New |
| INCY Incyte Corp. | 1.04% | 61,435 | $6.1M | Add +40.4% |
| IDYA Ideaya Biosciences Inc. | 0.96% | 161,659 | $5.6M | Reduce -56.5% |
| ASMB Assembly Biosciences Inc. | 0.91% | 156,728 | $5.3M | Add +137.0% |
| MAZE Maze Therapeutics Inc. | 0.90% | 125,877 | $5.2M | New |
| PTGX Protagonist Therapeutics Inc. | 0.89% | 59,430 | $5.2M | Add +23.9% |
| LLY Eli Lilly & Co. | 0.88% | 4,759 | $5.1M | New |
| TRVI Trevi Therapeutics Inc. | 0.86% | 399,557 | $5.0M | Add +13.9% |
| RVMD Revolution Medicines Inc. | 0.85% | 62,032 | $4.9M | Reduce -66.5% |
| VRDN Viridian Therapeutics Inc. | 0.82% | 154,320 | $4.8M | New |
| ABUS Arbutus Biopharma Corp. | 0.81% | 986,751 | $4.7M | Add +380.4% |
| MLTX Moonlake Immunotherapeutics | 0.79% | 348,401 | $4.6M | New |
| CTMX Cytomx Therapeutics Inc. | 0.76% | 1,036,311 | $4.4M | New |
| XFOR X4 Pharmaceuticals Inc. | 0.62% | 898,465 | $3.6M | Add +61.8% |
| WHWK Whitehawk Therapeutics Inc. | 0.61% | 1,458,807 | $3.5M | Add +244.0% |
| DNTH Dianthus Therapeutics Inc. | 0.56% | 79,284 | $3.3M | Add +91.6% |
| ASND Ascendis Pharma A/S | 0.54% | 14,842 | $3.2M | Reduce -2.0% |
| RGEN Repligen Corp. | 0.44% | 15,707 | $2.6M | New |
| NAMS Newamsterdam Pharma Co. NV | 0.44% | 73,106 | $2.6M | Reduce -51.5% |
| MBX MBX Biosciences Inc. | 0.43% | 78,553 | $2.5M | Add +4.7% |
| QUINCE THERAPEUTICS INC | 0.42% | 739,264 | $2.5M | New |
| AVTX Avalo Therapeutics Inc. | 0.42% | 135,552 | $2.5M | New |
| IVVD Invivyd Inc. | 0.42% | 989,822 | $2.4M | Add +255.3% |
| MGTX Meiragtx Holdings PLC | 0.39% | 287,689 | $2.3M | Add +251.4% |
| IVA Inventiva SA - ADR | 0.37% | 467,242 | $2.2M | Add +1415.8% |
| ABBV Abbvie Inc. | 0.37% | 9,325 | $2.1M | New |
| ADCT Adc Therapeutics SA | 0.30% | 502,570 | $1.8M | Add +77.4% |
| MPLT Maplight Therapeutics Inc. | 0.30% | 100,000 | $1.8M | New |
| PHVS Pharvaris NV | 0.28% | 58,389 | $1.6M | New |
| LEGN Legend Biotech Corp.-ADR | 0.27% | 73,328 | $1.6M | New |
| BLTE Belite Bio Inc. - ADR | 0.25% | 9,163 | $1.5M | New |
| XLO Xilio Therapeutics Inc. | 0.22% | 2,030,028 | $1.3M | New |
| EVMN Evommune Inc. | 0.20% | 68,196 | $1.2M | New |
| BBOT Bridgebio Oncology Therapeut | 0.19% | 86,517 | $1.1M | Reduce -53.6% |
| SYRE Spyre Therapeutics Inc. | 0.18% | 32,377 | $1.1M | New |
| QURE Uniqure NV | 0.18% | 43,485 | $1.0M | Reduce -91.7% |
| TSHA Taysha Gene Therapies Inc. | 0.17% | 182,130 | $1.0M | Reduce -78.3% |
| GLUE Monte Rosa Therapeutics Inc. | 0.17% | 61,577 | $966K | New |
| SABS Sab Biotherapeutics Inc. | 0.09% | 146,558 | $548K | New |
| VNDA Vanda Pharmaceuticals Inc. | 0.09% | 58,989 | $520K | New |
| CAPR Capricor Therapeutics Inc. | 0.09% | 17,853 | $515K | New |
| KTTA Pasithea Therapeutics Corp. | 0.08% | 355,082 | $458K | New |
| VTGN Vistagen Therapeutics Inc. | 0.02% | 616,749 | $142K | Reduce -75.2% |
Options reported separately and not counted above: SRRK calls ($485K), CNTA calls ($26K).
Portfolio Sells Q3 2025 → Q4 2025
| ROIV Roivant Sciences Ltd. | Reduce -77.0% | 3.60% | −9.21 |
| QURE Uniqure NV | Reduce -91.7% | 0.18% | −5.97 |
| DNLI Denali Therapeutics Inc. | Reduce -75.8% | 1.19% | −3.89 |
| WVE Wave Life Sciences Ltd. | Sold out | 0.00% | −3.11 |
| BHVN Biohaven Ltd. | Sold out | 0.00% | −3.08 |
| CDTX Cidara Therapeutics Inc. | Sold out | 0.00% | −2.94 |
| IMVT Immunovant Inc. | Reduce -59.4% | 2.81% | −2.35 |
| ARGX Argenx SE - ADR | Sold out | 0.00% | −1.85 |
| RZLT Rezolute Inc. | Sold out | 0.00% | −1.74 |
| GHRS GH Research PLC | Sold out | 0.00% | −1.57 |
| VTGN Vistagen Therapeutics Inc. | Reduce -75.2% | 0.02% | −1.54 |
| ALKS Alkermes PLC | Sold out | 0.00% | −1.46 |
| BBIO Bridgebio Pharma Inc. | Sold out | 0.00% | −1.33 |
| INSM Insmed Inc. | Sold out | 0.00% | −1.26 |
| AKRO Akero Therapeutics Inc. | Sold out | 0.00% | −1.16 |
| IDYA Ideaya Biosciences Inc. | Reduce -56.5% | 0.96% | −1.08 |
| JAZZ Jazz Pharmaceuticals PLC | Sold out | 0.00% | −1.04 |
| RNAM Avidity Biosciences Inc. | Sold out | 0.00% | −1.00 |
| RVMD Revolution Medicines Inc. | Reduce -66.5% | 0.85% | −0.90 |
| RYTM Rhythm Pharmaceuticals Inc. | Reduce -35.6% | 1.08% | −0.78 |
| TECX Tectonic Therapeutic Inc. | Sold out | 0.00% | −0.60 |
| HROW Harrow Inc. | Sold out | 0.00% | −0.56 |
| EQ Equillium Inc. | Sold out | 0.00% | −0.55 |
| UTHR United Therapeutics Corp. | Sold out | 0.00% | −0.53 |
| CGON CG Oncology Inc. | Sold out | 0.00% | −0.51 |
| QQQ Invesco QQQ Trust Series 1 | Sold out | 0.00% | −0.46 |
| ARQT Arcutis Biotherapeutics Inc. | Reduce -45.4% | 1.12% | −0.45 |
| NAMS Newamsterdam Pharma Co. NV | Reduce -51.5% | 0.44% | −0.42 |
| TNGX Tango Therapeutics Inc. | Sold out | 0.00% | −0.42 |
| ORIC Oric Pharmaceuticals Inc. | Sold out | 0.00% | −0.40 |
| TSHA Taysha Gene Therapies Inc. | Reduce -78.3% | 0.17% | −0.38 |
| PEPG Pepgen Inc. | Sold out | 0.00% | −0.36 |
| FRNM Freenome Inc. | Sold out | 0.00% | −0.32 |
| TARA Protara Therapeutic Inc. | Sold out | 0.00% | −0.32 |
| CMPS Compass Pathways PLC | Sold out | 0.00% | −0.32 |
| PYXS Pyxis Oncology Inc. | Sold out | 0.00% | −0.31 |
| BBOT Bridgebio Oncology Therapeut | Reduce -53.6% | 0.19% | −0.25 |
| MIND MEDICINE MINDMED INC | Sold out | 0.00% | −0.18 |
| ENTA Enanta Pharmaceuticals Inc. | Sold out | 0.00% | −0.18 |
| ZBIO Zenas Biopharma Inc. | Sold out | 0.00% | −0.17 |
| CRVS Corvus Pharmaceuticals Inc. | Sold out | 0.00% | −0.14 |
| KALV Kalvista Pharmaceuticals Inc. | Sold out | 0.00% | −0.14 |
| ARCT Arcturus Therapeutics Holdin | Sold out | 0.00% | −0.13 |
| VTYX Ventyx Biosciences Inc. | Sold out | 0.00% | −0.10 |
| ATAIBECKLEY INC | Sold out | 0.00% | −0.08 |
| ASND Ascendis Pharma A/S | Reduce -2.0% | 0.54% | −0.06 |
| SRZN Surrozen Inc. | Reduce -13.1% | 2.17% | +0.32 |
| SNDX Syndax Pharmaceuticals Inc. | Reduce -2.0% | 4.83% | +0.59 |
| CELC Celcuity Inc. | Reduce -13.4% | 2.03% | +0.66 |
Portfolio Buys Q3 2025 → Q4 2025
| ABVX Abivax SA-ADR | Add +135.6% | 9.07% | +6.22 |
| ACLX Arcellx Inc. | Add +2826.0% | 3.72% | +3.54 |
| GPCR Structure Therapeutics Inc. | Add +171.4% | 4.19% | +3.46 |
| TERN Terns Pharmaceuticals Inc. | Add +378.9% | 2.98% | +2.84 |
| TWST Twist Bioscience Corp. | New | 2.82% | +2.82 |
| CNTA Centessa Pharmaceuticals Ltd. | Add +76.1% | 4.95% | +1.75 |
| ADPT Adaptive Biotechnologies | New | 1.69% | +1.69 |
| PALI Palisade Bio Inc. | New | 1.69% | +1.69 |
| CYTK Cytokinetics Inc. | New | 1.60% | +1.60 |
| DYN Dyne Therapeutics Inc. | Add +76.0% | 2.80% | +1.59 |
| EWTX Edgewise Therapeutics Inc. | New | 1.54% | +1.54 |
| DRUG Bright Minds Biosciences Inc. | New | 1.30% | +1.30 |
| SRRK Scholar Rock Holding Corp. | Add +22.1% | 6.70% | +1.25 |
| JNJ Johnson & Johnson | New | 1.24% | +1.24 |
| XENE Xenon Pharmaceuticals Inc. | Add +81.3% | 2.68% | +1.12 |
| EYPT Eyepoint Inc. | New | 1.11% | +1.11 |
| IMTX Immatics NV | New | 1.10% | +1.10 |
| PRAX Praxis Precision Medicines I | New | 1.07% | +1.07 |
| CLPT Clearpoint Neuro Inc. | Add +2793.9% | 1.13% | +1.06 |
| APGE Apogee Therapeutics Inc. | New | 1.04% | +1.04 |
| MDGL Madrigal Pharmaceuticals Inc. | Add +116.1% | 1.77% | +1.01 |
| MAZE Maze Therapeutics Inc. | New | 0.90% | +0.90 |
| LLY Eli Lilly & Co. | New | 0.88% | +0.88 |
| VRDN Viridian Therapeutics Inc. | New | 0.82% | +0.82 |
| MLTX Moonlake Immunotherapeutics | New | 0.79% | +0.79 |
| CTMX Cytomx Therapeutics Inc. | New | 0.76% | +0.76 |
| NKTR Nektar Therapeutics | Add +235.1% | 1.29% | +0.68 |
| ABUS Arbutus Biopharma Corp. | Add +380.4% | 0.81% | +0.63 |
| MLYS Mineralys Therapeutics Inc. | Add +83.5% | 1.81% | +0.60 |
| ASMB Assembly Biosciences Inc. | Add +137.0% | 0.91% | +0.57 |
| WHWK Whitehawk Therapeutics Inc. | Add +244.0% | 0.61% | +0.44 |
| RGEN Repligen Corp. | New | 0.44% | +0.44 |
| QUINCE THERAPEUTICS INC | New | 0.42% | +0.42 |
| AVTX Avalo Therapeutics Inc. | New | 0.42% | +0.42 |
| AMLX Amylyx Pharmaceuticals Inc. | Add +104.1% | 1.17% | +0.41 |
| ABBV Abbvie Inc. | New | 0.37% | +0.37 |
| IVVD Invivyd Inc. | Add +255.3% | 0.42% | +0.36 |
| IVA Inventiva SA - ADR | Add +1415.8% | 0.37% | +0.34 |
| MPLT Maplight Therapeutics Inc. | New | 0.30% | +0.30 |
| INCY Incyte Corp. | Add +40.4% | 1.04% | +0.29 |
| PHVS Pharvaris NV | New | 0.28% | +0.28 |
| LEGN Legend Biotech Corp.-ADR | New | 0.27% | +0.27 |
| MGTX Meiragtx Holdings PLC | Add +251.4% | 0.39% | +0.26 |
| BLTE Belite Bio Inc. - ADR | New | 0.25% | +0.25 |
| PTGX Protagonist Therapeutics Inc. | Add +23.9% | 0.89% | +0.25 |
| OCUL Ocular Therapeutix Inc. | Add +45.4% | 1.09% | +0.24 |
| XFOR X4 Pharmaceuticals Inc. | Add +61.8% | 0.62% | +0.23 |
| DNTH Dianthus Therapeutics Inc. | Add +91.6% | 0.56% | +0.23 |
| XLO Xilio Therapeutics Inc. | New | 0.22% | +0.22 |
| TRVI Trevi Therapeutics Inc. | Add +13.9% | 0.86% | +0.21 |
Options Activity Q3 2025 → Q4 2025
| BHVN Biohaven Ltd. | call | Sold out | 480,000 | $1.2Mbefore exit |
| XBI SS SPDR S&P Biotech ETF | put | Sold out | 1,490,100 | $725Kbefore exit |
| SRRK Scholar Rock Holding Corp. | call | Add +1405.4% | 277,000 | $485K |
| IONS Ionis Pharmaceuticals Inc. | call | Sold out | 50,000 | $138Kbefore exit |
| CRSP Crispr Therapeutics AG | call | Sold out | 40,000 | $59Kbefore exit |
| SNDX Syndax Pharmaceuticals Inc. | call | Sold out | 100,000 | $55Kbefore exit |
| IMVT Immunovant Inc. | call | Sold out | 250,000 | $50Kbefore exit |
| ARKG ARK Genomic Revolution ETF | call | Sold out | 200,000 | $30Kbefore exit |
| CNTA Centessa Pharmaceuticals Ltd. | call | Reduce -56.5% | 75,000 | $26K |
| AKRO Akero Therapeutics Inc. | put | Sold out | 15,500 | $10Kbefore exit |
| ABUS Arbutus Biopharma Corp. | call | Sold out | 95,000 | $10Kbefore exit |
Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 73 | $577.9M | TNGX, ABVX, RVMD, ERAS, TYRA |
| Q1 2026Amended | 70 | $520.3M | SRRK, ABVX, SNDX, RVMD, IMVT |
| Q4 2025 | 75 | $582.7M | ABVX, SRRK, CNTA, SNDX, GPCR |
| Q3 2025 | 76 | $495.9M | ROIV, QURE, SRRK, IMVT, DNLI |
| Q2 2025 | 50 | $310.6M | SNDX, IMVT, SRRK, CNTA, MDGL |
| Q1 2025 | 52 | $313.1M | ROIV, SNDX, SRRK, ACLX, MRUS |
| Q4 2024 | 48 | $398.7M | SNDX, ROIV, IMVT, MRUS, CRNX |
| Q3 2024 | 50 | $333.4M | SNDX, ROIV, MRUS, IMVT, ARQT |
| Q2 2024Amended | 42 | $339.9M | SNDX, ROIV, IMVT, CRNX, MRUS |
| Q1 2024Amended | 45 | $374.3M | ROIV, CRNX, SNDX, ARQT, IMVT |