| TCG Crossover Management, LLC | 29.70% | Add +17.4% | 7,111,596 | $603.8M |
| UBS Group AG | 0.07% | Add +2561.0% | 4,461,262 | $378.8M |
| Darwin Global Management, Ltd. | 7.33% | New | 3,164,501 | $263.7M |
| Point72 Asset Management | 0.58% | Add +1642.5% | 2,925,352 | $248.4M |
| Cormorant Asset Management, LP | 11.42% | Reduce -8.4% | 1,950,000 | $165.6M |
| Paradigm Biocapital Advisors LP | 3.93% | New | 1,564,196 | $132.8M |
| Morgan Stanley | 0.01% | Add +209.4% | 1,470,717 | $124.9M |
| Caligan Partners LP | 17.10% | Reduce -13.3% | 1,451,924 | $123.3M |
| FMR LLC | 0.01% | New | 1,430,673 | $121.5M |
| ADAR1 Capital Management, LLC | 11.44% | Reduce -56.0% | 1,350,826 | $114.7M |
| Octagon Capital Advisors LP | 17.57% | Add +4.6% | 1,325,000 | $112.5M |
| Millennium Management | 0.08% | Reduce -12.1% | 1,100,030 | $93.4M |
| Vestal Point Capital, LP | 3.85% | New | 1,000,000 | $84.9M |
| Adage Capital Partners Gp, L.L.C. | 0.13% | New | 977,629 | $83.0M |
| Baker Bros. Advisors LP | 0.54% | New | 875,796 | $74.4M |
| Farallon Capital Management, L.L.C. | 0.39% | New | 805,000 | $68.3M |
| Saturn V Capital Management LP | 14.92% | Add +28.7% | 801,224 | $68.0M |
| Aberdeen Group plc | 0.11% | Add +10.8% | 787,417 | $66.9M |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 4.80% | New | 731,523 | $62.1M |
| Fairmount Funds Management LLC | 5.45% | New | 713,434 | $60.6M |
| Citadel Advisors | 0.05% | Reduce -45.6% | 681,785 | $57.9M |
| Boothbay Fund Management, LLC | 1.35% | Reduce -31.3% | 597,931 | $50.8M |
| Venrock Adviser, LLC | 2.76% | Reduce -57.1% | 576,729 | $49.0M |
| BVF Inc. | 1.92% | New | 558,031 | $47.4M |
| Nantahala Capital Management, LLC | 2.93% | Reduce -62.4% | 557,564 | $47.3M |
| Silverarc Capital Management, LLC | 6.63% | New | 539,704 | $45.8M |
| Franklin Resources Inc. | 0.01% | Reduce -62.4% | 516,090 | $43.8M |
| T. Rowe Price Associates Inc. | 0.00% | New | 479,869 | $40.7M |
| Holocene Advisors, LP | 0.09% | New | 461,301 | $39.2M |
| Jefferies Financial Group Inc. | 0.37% | New | 457,325 | $38.8M |
| Ensign Peak Advisors, Inc | 0.06% | No change | 455,684 | $38.7M |
| Eversept Partners, LP | 2.77% | New | 426,499 | $36.2M |
| Logos Global Management LP | 3.48% | New | 415,000 | $35.2M |
| Eventide Asset Management, LLC | 0.55% | New | 396,904 | $33.7M |
| Ikarian Capital, LLC | 6.76% | New | 396,098 | $33.4M |
| Perceptive Advisors LLC | 0.97% | New | 388,608 | $33.0M |
| Orbimed Advisors LLC | 0.77% | New | 380,000 | $32.3M |
| Frazier Life Sciences Management, L.P. | 0.96% | New | 378,300 | $32.1M |
| Affinity Asset Advisors, LLC | 2.93% | Add +260.0% | 360,000 | $30.6M |
| Vivo Capital, LLC | 2.45% | New | 359,305 | $30.5M |
| Janus Henderson Group PLC | 0.01% | New | 354,734 | $30.1M |
| RTW Investments, LP | 0.37% | New | 350,000 | $29.7M |
| Lord, Abbett & Co. LLC | 0.09% | New | 336,706 | $28.6M |
| Woodline Partners LP | 0.12% | Add +69.2% | 311,042 | $26.4M |
| First Turn Management, LLC | 3.72% | New | 291,820 | $24.8M |
| Evergreen Quality Fund GP, Ltd. | 0.54% | New | 288,600 | $24.5M |
| Artia Global Partners LP | 3.37% | New | 225,453 | $19.1M |
| Pictet Asset Management Holding SA | 0.02% | New | 196,836 | $16.7M |
| Marshall Wace, LLP | 0.02% | New | 189,704 | $16.1M |
| HighVista Strategies LLC | 3.84% | Add +260.6% | 184,468 | $15.7M |
| Bronte Capital Management Pty Ltd. | 1.35% | New | 156,747 | $14.9M |
| Stempoint Capital LP | 2.85% | Add +89.5% | 166,273 | $14.1M |
| Catalio Capital Management, LP | 2.54% | New | 162,141 | $13.8M |
| Balyasny Asset Management L.P. | 0.03% | New | 160,220 | $13.6M |
| Patient Square Capital LP | 3.45% | New | 151,833 | $12.9M |
| Great Point Partners LLC | 5.32% | Reduce -88.4% | 150,000 | $12.7M |
| Goldman Sachs Group Inc. | 0.00% | New | 135,626 | $11.5M |
| TimesSquare Capital Management, LLC | 0.16% | New | 128,023 | $10.9M |
| Boxer Capital Management, LLC | 3.25% | New | 120,000 | $10.2M |
| Apis Capital Advisors, LLC | 1.98% | New | 105,400 | $8.9M |
| Nan Fung Trinity (hk) Ltd. | 0.86% | New | 101,365 | $8.6M |
| Federated Hermes, Inc. | 0.01% | New | 99,500 | $8.4M |
| First Light Asset Management, LLC | 0.77% | New | 95,955 | $8.1M |
| Bank of America Corp. | 0.00% | Add +17734.5% | 95,593 | $8.1M |
| Hudson Bay Capital Management LP | 0.05% | New | 91,062 | $7.7M |
| Barclays PLC | 0.00% | Reduce -32.7% | 76,342 | $6.5M |
| Samsara Biocapital, LLC | 0.84% | New | 75,442 | $6.4M |
| LMR Partners LLP | 0.12% | New | 74,078 | $6.3M |
| Atika Capital Management LLC | 0.50% | New | 69,000 | $5.9M |
| Jane Street Group, LLC | 0.01% | New | 67,802 | $5.8M |
| Sei Investments Co. | 0.01% | New | 66,725 | $5.7M |
| Velan Capital Investment Management LP | 5.13% | New | 64,389 | $5.5M |
| Melqart Asset Management (UK) Ltd | 0.73% | New | 64,157 | $5.4M |
| Simplify Asset Management Inc. | 0.11% | New | 61,449 | $5.2M |
| Ameriprise Financial Inc. | 0.00% | New | 58,618 | $5.0M |
| Verition Fund Management LLC | 0.03% | New | 56,618 | $4.8M |
| Trexquant Investment LP | 0.05% | New | 56,420 | $4.8M |
| Parkman Healthcare Partners LLC | 0.51% | New | 55,197 | $4.7M |
| HRT Financial LP | 0.02% | New | 53,078 | $4.5M |
| J. Goldman & Co LP | 0.17% | Reduce -23.1% | 51,893 | $4.4M |
| Erste Asset Management GmbH | 0.04% | New | 50,000 | $4.2M |
| TD Asset Management Inc | 0.00% | New | 46,486 | $3.9M |
| Russell Investments Group, Ltd. | 0.00% | New | 41,894 | $3.6M |
| Diadema Partners LP | 2.45% | New | 41,620 | $3.5M |
| Resolute Capital Asset Partners LLC | 1.78% | New | 40,000 | $3.4M |
| Findell Capital Management LLC | 1.55% | New | 40,000 | $3.4M |
| Cantor Fitzgerald, L. P. | 0.06% | New | 35,000 | $3.0M |
| Susquehanna International Group, LLP | 0.00% | New | 34,614 | $2.9M |
| Longaeva Partners L.P. | 0.60% | New | 32,886 | $2.8M |
| Tudor Investment Corporation | 0.02% | New | 32,883 | $2.8M |
| Quinn Opportunity Partners LLC | 0.19% | New | 31,000 | $2.6M |
| Privium Fund Management B.V. | 0.46% | New | 30,412 | $2.6M |
| Tetragon Partners GP Ltd | 0.62% | New | 30,000 | $2.5M |
| Geode Capital Management, LLC | 0.00% | Add +77.5% | 29,852 | $2.5M |
| LPL Financial LLC | 0.00% | New | 29,247 | $2.5M |
| D. E. Shaw & Co. | 0.00% | New | 27,537 | $2.3M |
| Manufacturers Life Insurance Company, The | 0.00% | New | 26,136 | $2.2M |
| SummitTX Capital, L.P. | 0.09% | New | 25,820 | $2.2M |
| Greenland Capital Management LP | 0.34% | New | 25,039 | $2.1M |
| Optiver Holding B.V. | 0.03% | New | 23,104 | $2.0M |
| Envestnet Asset Management Inc. | 0.00% | New | 20,300 | $1.7M |
| Nicholas Investment Partners, LP | 0.14% | New | 19,428 | $1.6M |
| Virtu Financial LLC | 0.09% | New | 19,095 | $1.6M |
| Guggenheim Capital LLC | 0.01% | Add +7.2% | 17,258 | $1.5M |
| Voleon Capital Management LP | 0.03% | New | 16,757 | $1.4M |
| Acadian Asset Management LLC | 0.00% | New | 16,608 | $1.4M |
| Baron Capital (BAMCO) | 0.00% | New | 14,000 | $1.2M |
| Progeny 3, Inc. | 0.05% | New | 12,240 | $1.0M |
| Himension Capital (singapore) Pte. LTD. | 0.06% | New | 11,962 | $1.0M |
| Voya Investment Management LLC | 0.00% | New | 11,515 | $978K |
| Jain Global LLC | 0.01% | New | 11,099 | $942K |
| Dymon Asia Capital (singapore) Pte. LTD. | 0.34% | New | 10,000 | $849K |
| Gilder Gagnon Howe & Co. LLC | 0.01% | New | 9,824 | $834K |
| Persistent Asset Partners Ltd | 0.59% | New | 9,604 | $815K |
| XTX Topco Ltd | 0.04% | Reduce -48.7% | 9,332 | $792K |
| Scientech Research LLC | 0.28% | New | 9,294 | $789K |
| Cubist Systematic Strategies, LLC | 0.01% | New | 9,107 | $773K |
| Mariner, LLC | 0.00% | New | 7,894 | $670K |
| Schonfeld Strategic Advisors LLC | 0.00% | New | 7,260 | $616K |
| Rangeley Capital, LLC | 0.49% | New | 6,000 | $509K |
| Colonial River Investments, LLC | 0.14% | New | 4,349 | $369K |
| Axxcess Wealth Management, LLC | 0.01% | New | 4,349 | $369K |
| Crossmark Global Holdings, Inc. | 0.00% | New | 3,775 | $320K |
| Integrated Wealth Concepts LLC | 0.00% | New | 3,633 | $308K |
| Marex Group Ltd | 0.00% | New | 3,402 | $289K |
| FNY Investment Advisers, LLC | 0.09% | New | 3,250 | $275K |
| Oppenheimer Asset Management Inc. | 0.00% | New | 3,101 | $263K |
| Truist Financial Corp. | 0.00% | New | 3,089 | $262K |
| Bank of Hawaii | 0.01% | New | 3,006 | $255K |
| Royal Bank of Canada | 0.00% | New | 2,955 | $251K |
| New York State Common Retirement Fund | 0.00% | New | 2,919 | $248K |
| Allianz Asset Management GmbH | 0.00% | New | 2,900 | $246K |
| Legato Capital Management LLC | 0.02% | New | 2,554 | $217K |
| Stonepine Capital Management, LLC | 0.17% | New | 2,500 | $212K |
| Ashton Thomas Securities, LLC | 0.03% | New | 2,500 | $212K |
| Moody Aldrich Partners LLC | 0.04% | New | 2,438 | $207K |
| Group One Trading LLC | 0.00% | New | 1,805 | $153K |
| BNP Paribas Financial Markets | 0.00% | Reduce -83.1% | 1,800 | $153K |
| Covestor Ltd | 0.05% | New | 1,136 | $96K |
| Rhumbline Advisers | 0.00% | Add +4.1% | 1,021 | $87K |
| IQ EQ FUND MANAGEMENT (SINGAPORE) PRIVATE Ltd | 0.10% | New | 900 | $76K |
| Wells Fargo & Company | 0.00% | New | 717 | $61K |
| GAMMA Investing LLC | 0.00% | Reduce -1.1% | 638 | $54K |
| Hantz Financial Services, Inc. | 0.00% | New | 611 | $52K |
| First Horizon Corp. | 0.00% | — | 428 | $36K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +4612.5% | 377 | $32K |
| HighMark Wealth Management LLC | 0.01% | New | 280 | $24K |
| WPG Advisers, LLC | 0.01% | New | 201 | $17K |
| PNC Financial Services Group, Inc. | 0.00% | New | 141 | $12K |
| Steward Partners Investment Advisory, LLC | 0.00% | New | 106 | $9K |
| Financial Management Professionals, Inc. | 0.00% | No change | 100 | $8K |
| US Bancorp \de | 0.00% | New | 76 | $6K |
| LRI Investments, LLC | 0.00% | New | 75 | $6K |
| Private Trust Co. NA | 0.00% | New | 70 | $6K |
| Grove Bank & Trust | 0.00% | New | 62 | $5K |
| Caitong International Asset Management Co., Ltd | 0.00% | New | 52 | $4K |
| Citigroup Inc. | 0.00% | Reduce -100.0% | 51 | $4K |
| Global Retirement Partners, LLC | 0.00% | New | 50 | $4K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 43 | $4K |
| Osaic Holdings, Inc. | 0.00% | New | 37 | $3K |
| Principal Securities, Inc. | 0.00% | Reduce -41.7% | 21 | $2K |
| MAI Capital Management | 0.00% | New | 16 | $1K |
| Allworth Financial LP | 0.00% | New | 16 | $1K |
| Jones Financial Companies LLLP | 0.00% | New | 13 | $1K |
| Farther Finance Advisors, LLC | 0.00% | New | 8 | $679 |