Apellis PharmaceuticalsAPLS

13F holders, Q2 2025 (June 30)
247holders −8
39new positions
49sold out
6famous investors
$17.32avg. 13F price*

At the end of Q2 2025, 247 institutions reported holding Apellis Pharmaceuticals Inc. (APLS) in their 13F filings, down 8 from Q1 2025. 39 opened new positions and 49 sold out. The largest holders were Avoro Capital Advisors LLC ($211.6M), EcoR1 Capital, LLC ($205.9M) and Vanguard Group Inc. ($175.8M). 6 famous investors held it, including Cliff Asness (0.1% of AQR Capital Management's portfolio), Joel Greenblatt (0.0% of Gotham Asset Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).

Company
Apellis Pharmaceuticals Inc.
CUSIP
03753U106
Latest filing quarter
Q2 2026

History

Number of 13F holders

0100200300400 Q1 2024: 302Q1 2024Q2 2024: 263Q2 2024Q3 2024: 265Q3 2024Q4 2024: 260Q4 2024Q1 2025: 255Q1 2025Q2 2025: 247Q2 2025Q3 2025: 273Q3 2025Q4 2025: 280Q4 2025Q1 2026: 324Q1 2026Q2 2026: 1Q2 2026

Total Exit/New Position Q1 2025 → Q2 2025

InstitutionsTotal Value
New Positions39$65.6M
Exits49$96.4M

All 13F filers, Q1 2025 → Q2 2025: 20,772,156 shares bought and 17,257,692 shares sold, net +3,514,464 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.

Ownership 247 holders

Avoro Capital Advisors LLC 3.71% No change 12,222,222 $211.6M
EcoR1 Capital, LLC 12.22% No change 11,895,808 $205.9M
Vanguard Group Inc. 0.00% Add +0.2% 10,154,751 $175.8M
Morgan Stanley 0.01% Add +1.3% 9,752,201 $168.8M
Wellington Management Group LLP 0.03% Reduce -27.0% 8,976,962 $155.4M
Deep Track Capital, LP 3.90% Add +40.0% 7,000,000 $121.2M
BlackRock, Inc. 0.00% Add +1.2% 6,404,999 $110.9M
AQR Capital Management 0.09% Add +46.6% 5,976,414 $103.5M
UBS Group AG 0.02% Add +44.7% 4,735,311 $82.0M
State Street Corp. 0.00% Reduce -9.6% 3,562,721 $61.7M
Montanova Capital, LLC 1.88% Add +74.8% 2,878,000 $49.8M
Marshall Wace, LLP 0.06% Add +11373.8% 2,704,837 $46.8M
Jennison Associates LLC 0.03% Add +7.4% 2,661,823 $46.1M
Siren, L.L.C. 2.31% No change 2,578,396 $44.6M
Bank of America Corp. 0.00% Reduce -22.5% 2,426,628 $42.0M
Norges Bank 0.01% Add +50.4% 2,367,224 $41.0M
Geode Capital Management, LLC 0.00% Add +2.3% 1,995,271 $34.5M
Amundi 0.01% Add +386.7% 1,604,105 $28.6M
Deutsche Bank AG 0.01% Reduce -15.8% 1,496,296 $25.9M
Orbimed Advisors LLC 0.65% Add +3.5% 1,482,300 $25.7M
Polar Capital Holdings Plc 0.12% Reduce -14.3% 1,352,175 $23.4M
BNP Paribas Financial Markets 0.02% Add +16.9% 1,298,459 $22.5M
Braidwell LP 0.93% Reduce -32.1% 1,121,034 $19.4M
Wells Fargo & Company 0.00% Add +22470.4% 1,043,655 $18.1M
Charles Schwab Investment Management Inc. 0.00% Add +2.6% 989,143 $17.1M
Octagon Capital Advisors LP 3.43% Reduce -56.9% 903,500 $15.6M
Camber Capital Management LP 2.05% New 850,000 $14.7M
Royal Bank of Canada 0.00% Add +0.3% 797,585 $13.8M
Ameriprise Financial Inc. 0.00% Add +60.8% 750,161 $13.0M
Bank of Nova Scotia 0.02% New 594,812 $10.3M
Jefferies Financial Group Inc. 0.17% Reduce -3.5% 578,205 $10.0M
Jump Financial, LLC 0.12% Add +110.3% 558,668 $9.7M
Ossiam 0.11% New 555,953 $9.6M
Capitolis Liquid Global Markets LLC 0.07% New 544,600 $9.4M
Woodline Partners LP 0.05% Add +142.6% 530,923 $9.2M
Northern Trust Corp. 0.00% Add +1.4% 525,882 $9.1M
Schroder Investment Management Group 0.01% Add +91.9% 485,615 $8.4M
Hudson Bay Capital Management LP 0.06% Add +52.9% 475,000 $8.2M
Nuveen, LLC 0.00% Reduce -4.7% 469,253 $8.1M
Voloridge Investment Management, LLC 0.03% Add +84.7% 468,710 $8.1M
Citadel Advisors 0.01% Add +97.5% 442,560 $7.7M
683 Capital Management, LLC 0.76% Add +23.1% 410,000 $7.1M
Two Sigma Investments, LP 0.01% Add +54.8% 406,913 $7.0M
Pictet Asset Management Holding SA 0.01% Add +10.6% 348,349 $6.1M
Ieq Capital, LLC 0.04% Add +18.9% 346,923 $6.0M
Canada Pension Plan Investment Board 0.01% Reduce -67.9% 336,800 $5.8M
Squarepoint Ops LLC 0.01% Reduce -25.6% 329,392 $5.7M
Susquehanna International Group, LLP 0.01% Add +1014.1% 328,726 $5.7M
Trexquant Investment LP 0.06% Reduce -14.9% 327,421 $5.7M
ING Groep NV 0.03% Add +67.4% 308,300 $5.3M
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% Add +35.6% 301,939 $5.2M
Barclays PLC 0.00% Add +43.2% 273,912 $4.7M
Two Sigma Advisers, LP 0.01% Add +33.9% 256,800 $4.4M
D. E. Shaw & Co. 0.00% New 251,069 $4.3M
Jane Street Group, LLC 0.01% Reduce -3.9% 246,199 $4.3M
Bank of New York Mellon Corp 0.00% Reduce -26.1% 243,327 $4.2M
JPMorgan Chase & Co. 0.00% Reduce -44.6% 234,801 $4.1M
Caption Management, LLC 0.37% Add +1824.1% 230,888 $4.0M
Edgestream Partners, L.P. 0.11% Reduce -9.5% 218,392 $3.8M
Goldman Sachs Group Inc. 0.00% Reduce -29.8% 215,999 $3.7M
Fiduciary Trust Co 0.04% Reduce -0.4% 202,536 $3.5M
Millennium Management 0.00% Reduce -55.2% 202,452 $3.5M
Aquatic Capital Management LLC 0.06% Reduce -18.1% 176,704 $3.1M
Invesco Ltd. 0.00% Reduce -74.1% 166,135 $2.9M
Y-Intercept (Hong Kong) Ltd 0.07% Add +455.4% 164,275 $2.8M
PDT Partners, LLC 0.16% Reduce -18.0% 160,058 $2.8M
Bank of Montreal 0.00% Add +0.7% 159,613 $2.8M
Algert Global LLC 0.06% Reduce -54.5% 154,113 $2.7M
Prudential Financial Inc. 0.00% Reduce -29.3% 154,010 $2.7M
Voya Investment Management LLC 0.00% Add +20.1% 150,593 $2.6M
Rafferty Asset Management, LLC 0.01% Reduce -20.1% 143,852 $2.5M
Swiss National Bank 0.00% Add +8.4% 143,800 $2.5M
Steward Partners Investment Advisory, LLC 0.02% Add +15.4% 140,975 $2.4M
Citigroup Inc. 0.00% Reduce -66.8% 138,451 $2.4M
California Public Employees Retirement System 0.00% Add +6.3% 134,637 $2.3M
Cwm, LLC 0.01% Add +29.9% 127,584 $2.2M
Rhumbline Advisers 0.00% Reduce -2.0% 122,002 $2.1M
Gotham Asset Management 0.01% Add +247.8% 119,229 $2.1M
Connor, Clark & Lunn Investment Management Ltd. 0.01% Reduce -10.0% 118,724 $2.1M
J. Safra Sarasin Holding AG 0.03% Add +145.6% 115,684 $2.0M
Cerity Partners LLC 0.00% Add +110.8% 114,745 $2.0M
Sphera Funds Management LTD. 0.52% Reduce -37.0% 114,346 $2.0M
HRT Financial LP 0.01% New 107,200 $1.9M
Wealth Enhancement Advisory Services, LLC 0.00% Add +43.5% 100,666 $1.8M
EFG Asset Management (North America) Corp. 0.26% Add +166.8% 105,024 $1.8M
Dark Forest Capital Management LP 0.07% New 104,725 $1.8M
Exome Asset Management LLC 1.41% New 98,600 $1.7M
Legal & General Group Plc 0.00% Add +21.5% 96,050 $1.7M
Verition Fund Management LLC 0.01% Reduce -13.5% 95,605 $1.7M
State of Wisconsin Investment Board 0.00% Add +11.6% 94,404 $1.6M
J. Goldman & Co LP 0.05% New 93,574 $1.6M
Rhenman & Partners Asset Management AB 0.20% Add +230.1% 93,250 $1.6M
T. Rowe Price Associates Inc. 0.00% Add +1.6% 92,151 $1.6M
State Board of Administration of Florida Retirement System 0.00% Reduce -0.5% 91,408 $1.6M
Natixis 0.01% Reduce -86.2% 90,666 $1.6M
California State Teachers Retirement System 0.00% Add +47.1% 87,929 $1.5M
HighVista Strategies LLC 0.55% Reduce -20.3% 86,663 $1.5M
Rock Springs Capital Management LP 0.09% Add +5.4% 84,300 $1.5M
Schonfeld Strategic Advisors LLC 0.01% Reduce -53.7% 83,916 $1.5M
Walleye Capital LLC 0.01% Reduce -74.4% 81,270 $1.4M
Bleakley Financial Group, LLC 0.03% Add +5.4% 77,088 $1.3M
Ikarian Capital, LLC 0.43% No change 75,000 $1.3M
Raymond James Financial Inc. 0.00% Add +43.3% 74,466 $1.3M
Mackenzie Financial Corp. 0.00% Add +78.6% 74,165 $1.3M
Phocas Financial Corp. 0.18% New 71,599 $1.2M
Alps Advisors Inc. 0.01% New 67,761 $1.2M
Landscape Capital Management, L.L.C. 0.09% Add +65.5% 64,521 $1.1M
New York State Common Retirement Fund 0.00% Add +20.6% 58,879 $1.0M
PNC Financial Services Group, Inc. 0.00% Add +0.8% 58,856 $1.0M
Engineers Gate Manager LP 0.01% Add +39.2% 58,718 $1.0M
HSBC Holdings PLC 0.00% Add +131.6% 57,898 $1.0M
Bayforest Capital Ltd 0.43% Add +8.2% 56,639 $980K
Healthcare of Ontario Pension Plan Trust Fund 0.00% New 56,000 $969K
Simplex Trading, LLC 0.03% New 55,934 $968K
Pallas Capital Advisors LLC 0.04% Add +28.9% 54,849 $949K
DekaBank Deutsche Girozentrale 0.00% No change 55,000 $921K
Treasurer of the State of North Carolina 0.00% Add +2.8% 50,358 $872K
T. Rowe Price Investment Management, Inc. 0.00% Add +3.3% 49,308 $854K
Hennion & Walsh Asset Management, Inc. 0.03% Add +11.0% 49,014 $848K
Cinctive Capital Management LP 0.05% New 47,700 $826K
SG Americas Securities, LLC 0.00% Reduce -87.7% 45,103 $781K
Voleon Capital Management LP 0.04% Add +42.9% 43,139 $747K
Graham Capital Management, L.P. 0.02% Add +53.1% 43,091 $746K
Erste Asset Management GmbH 0.01% No change 42,000 $732K
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% Add +38.6% 40,984 $710K
Police & Firemen's Retirement System of New Jersey 0.01% Add +6.2% 40,954 $709K
Wealthedge Investment Advisors, LLC 0.28% New 38,572 $668K
Guggenheim Capital LLC 0.01% Add +8.8% 38,453 $666K
Mariner, LLC 0.00% Add +179.4% 36,330 $629K
Janus Henderson Group PLC 0.00% No change 34,412 $595K
Public Employees Retirement System of Ohio 0.00% Add +1.5% 33,470 $579K
Alliancebernstein L.P. 0.00% Reduce -28.9% 31,929 $553K
Prelude Capital Management, LLC 0.05% New 31,139 $539K
Handelsbanken Fonder AB 0.00% Reduce -1.3% 30,200 $523K
Focus Partners Wealth 0.00% Add +35.6% 29,676 $514K
Captrust Financial Advisors 0.00% Add +0.9% 29,532 $511K
Ensign Peak Advisors, Inc 0.00% No change 29,397 $509K
Profund Advisors LLC 0.02% Reduce -19.6% 28,676 $496K
VIRGINIA RETIREMENT SYSTEMS ET Al 0.00% Add +12.2% 27,665 $479K
First Trust Advisors LP 0.00% Reduce -86.7% 26,538 $459K
Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% Add +56.4% 25,273 $437K
China Universal Asset Management Co., Ltd. 0.04% Add +0.3% 25,243 $437K
Parallax Volatility Advisers, L.P. 0.02% Reduce -13.8% 24,443 $423K
Focus Partners Advisor Solutions, LLC 0.01% Add +47.0% 24,350 $422K
Essential Partners LLC 0.17% — 23,902 $414K
Toronto Dominion Bank 0.00% Reduce -85.5% 23,437 $406K
Virtus Investment Advisers, LLC 0.14% Add +110.4% 23,073 $399K
Boothbay Fund Management, LLC 0.01% No change 22,997 $398K
Sei Investments Co. 0.00% New 22,359 $387K
Arizona State Retirement System 0.00% Add +12.5% 21,983 $381K
Manufacturers Life Insurance Company, The 0.00% Reduce -11.9% 21,973 $380K
Creative Planning 0.00% New 21,838 $378K
AlphaQuest LLC 0.04% Reduce -62.1% 21,240 $368K
Two Sigma Securities, LLC 0.05% New 21,168 $366K
Merit Financial Group, LLC 0.00% Reduce -37.5% 21,096 $365K
Corton Capital Inc. 0.42% New 21,011 $364K
Mercer Global Advisors Inc. 0.00% Reduce -3.8% 20,941 $362K
Teacher Retirement System of Texas 0.00% Add +9.9% 20,287 $351K
FMR LLC 0.00% Reduce -98.7% 19,292 $334K
Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% Reduce -3.8% 19,128 $331K
Xponance LLC 0.00% Add +14.1% 18,358 $318K
HAP Trading, LLC 0.14% New 17,937 $310K
Duncan Williams Asset Management, LLC 0.09% Reduce -19.5% 17,005 $294K
ADAR1 Capital Management, LLC 0.05% No change 17,000 $294K
Quadrature Capital Ltd 0.01% New 16,798 $291K
Group One Trading LLC 0.01% Reduce -44.1% 16,778 $290K
Brighton Jones LLC 0.01% New 16,539 $286K
Wolverine Trading, LLC 0.01% Add +20.6% 16,198 $282K
E Fund Management Co., Ltd. 0.01% Reduce -4.6% 16,057 $278K
Sherbrooke Park Advisers LLC 0.12% New 15,939 $276K
KLP Kapitalforvaltning As 0.00% Add +20.0% 15,600 $270K
Victory Capital Management Inc. 0.00% Reduce -92.8% 15,575 $270K
Birchview Capital, LP 0.24% No change 14,000 $242K
Fox Run Management, L.L.C. 0.04% Reduce -11.1% 13,967 $242K
Empowered Funds, LLC 0.00% New 13,487 $233K
Integrated Wealth Concepts LLC 0.00% New 12,583 $218K
111 Capital 0.04% Reduce -26.4% 12,400 $215K
Capstone Investment Advisors, LLC 0.00% New 11,700 $203K
Compagnie Lombard Odier SCmA 0.00% No change 11,000 $190K
Renaissance Technologies 0.00% New 10,988 $190K
Acadian Asset Management LLC 0.00% Reduce -58.0% 10,082 $174K
Eastern Bank 0.00% Reduce -53.5% 10,000 $173K
Russell Investments Group, Ltd. 0.00% Reduce -74.5% 9,925 $172K
Wexford Capital LP 0.04% New 9,139 $158K
Public Employees Retirement Association of Colorado 0.00% No change 8,362 $145K
Amalgamated Bank 0.00% Add +11.9% 8,111 $140K
Headlands Technologies LLC 0.01% Add +748.8% 6,892 $119K
MetLife Investment Management, LLC 0.00% Add +1.8% 6,703 $116K
CANADA LIFE ASSURANCE Co 0.00% No change 6,189 $107K
EverSource Wealth Advisors, LLC 0.00% Add +338.5% 5,429 $94K
Quarry LP 0.02% New 5,000 $87K
Mirae Asset Global Investments Co., Ltd. 0.00% Add +15.6% 4,855 $84K
Covestor Ltd 0.05% Add +15.1% 4,600 $80K
CIBC Private Wealth Group LLC 0.00% Reduce -81.4% 3,504 $61K
GF Fund Management Co. LTD. 0.00% No change 3,185 $55K
Clearstead Advisors, LLC 0.00% Add +71.8% 3,111 $54K
US Bancorp \de 0.00% Add +30.3% 3,056 $53K
Osaic Holdings, Inc. 0.00% Add +141.2% 2,682 $47K
STRS Ohio 0.00% New 2,577 $45K
KBC Group NV 0.00% Reduce -39.9% 2,313 $40K
Parallel Advisors, LLC 0.00% Add +80.0% 1,924 $33K
Tower Research Capital LLC (TRC) 0.00% Reduce -75.9% 1,567 $27K
Allworth Financial LP 0.00% Add +519.0% 1,337 $23K
Leonteq Securities AG 0.00% No change 1,221 $21K
Signaturefd, LLC 0.00% Add +204.8% 1,198 $21K
IFP Advisors, Inc 0.00% Add +752.4% 1,074 $19K
Lazard Asset Management LLC 0.00% Reduce -71.2% 1,024 $17K
Walleye Trading LLC 0.00% New 761 $13K
Jones Financial Companies LLLP 0.00% Add +10.7% 664 $12K
Aster Capital Management (DIFC) Ltd 0.00% New 617 $11K
Versant Capital Management, Inc 0.00% Add +263.9% 604 $10K
Atlantic Private Wealth, LLC 0.01% No change 600 $10K
Northwestern Mutual Wealth Management Co. 0.00% Reduce -1.0% 600 $10K
BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.00% New 594 $10K
True Wealth Design, LLC 0.00% Add +139.2% 567 $10K
Future Financial Wealth Managment LLC 0.01% No change 500 $9K
Archer Investment Corp 0.00% No change 500 $9K
Quintet Private Bank (Europe) S.A. 0.00% No change 452 $8K
Daiwa Securities Group Inc. 0.00% No change 429 $7K
Comerica Bank 0.00% Add +20.2% 315 $5K
Brooklyn Investment Group 0.00% Add +13.7% 241 $4K
Sterling Capital Management LLC 0.00% Reduce -54.0% 165 $3K
Caitong International Asset Management Co., Ltd 0.00% Add +216.7% 152 $3K
Evelyn Partners Investment Management LLP 0.00% No change 150 $3K
MassMutual Private Wealth & Trust, FSB 0.00% New 106 $2K
TD Private Client Wealth LLC 0.00% Add +75.9% 102 $2K
Financial Gravity Companies, Inc. 0.00% — 100 $2K
Mitsubishi UFJ Asset Management Co., Ltd. 0.00% No change 97 $2K
Brown Brothers Harriman & Co. 0.00% New 95 $2K
SBI Securities Co., Ltd. 0.00% Add +2.3% 91 $2K
GAMMA Investing LLC 0.00% Reduce -83.3% 78 $1K
Farther Finance Advisors, LLC 0.00% Reduce -86.9% 66 $1K
Sachetta, LLC 0.00% New 60 $1K
Capital Analysts, LLC 0.00% No change 57 $1K
Nisa Investment Advisors, LLC 0.00% No change 50 $866
Parkside Financial Bank & Trust 0.00% Add +620.0% 36 $624
CENTRAL TRUST Co 0.00% No change 27 $468
TFC Financial Management, Inc. 0.00% New 23 $399
Activest Wealth Management 0.00% Add +0.0% 23 $398
SouthState Bank Corp 0.00% Reduce -25.0% 15 $260
Assetmark, Inc. 0.00% Reduce -99.1% 11 $190
Clearstead Trust, LLC 0.00% Reduce -80.4% 10 $174
MV Capital Management, Inc. 0.00% Add +33.3% 8 $139
Global Retirement Partners, LLC 0.00% — 6 $104
WPG Advisers, LLC 0.00% No change 5 $87
Manchester Capital Management LLC 0.00% No change 3 $52
Larson Financial Group LLC 0.00% New 3 $52

"% of holder's portfolio" is APLS's weight in each manager's 13F, not the share of Apellis Pharmaceuticals Inc. the manager owns.