Structure TherapeuticsGPCR
13F holders, Q1 2025 (March 31)150holders −14
23new positions
36sold out
5famous investors
$17.53avg. 13F price*
At the end of Q1 2025, 150 institutions reported holding Structure Therapeutics Inc. (GPCR) in their 13F filings, down 14 from Q4 2024. 23 opened new positions and 36 sold out. The largest holders were Wellington Management Group LLP ($134.9M), FMR LLC ($101.8M) and Janus Henderson Group PLC ($86.1M). 5 famous investors held it, including Ken Griffin (0.0% of Citadel Advisors's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Steve Cohen (0.0% of Point72 Asset Management's portfolio).
- Company
- Structure Therapeutics Inc.
- CUSIP
- 86366E106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2024 → Q1 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 23 | $13.6M |
| Exits | 36 | $45.1M |
All 13F filers, Q4 2024 → Q1 2025: 4,244,794 shares bought and 8,971,311 shares sold, net −4,726,517 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 150 holders
| Wellington Management Group LLP | 0.03% | Add +0.1% | 7,791,183 | $134.9M |
| FMR LLC | 0.01% | Reduce -3.2% | 5,883,707 | $101.8M |
| Janus Henderson Group PLC | 0.05% | Add +4.7% | 4,355,194 | $86.1M |
| Deep Track Capital, LP | 2.30% | Add +46.4% | 4,100,000 | $71.0M |
| Capital Research Global Investors | 0.01% | Reduce -38.8% | 2,164,145 | $37.5M |
| Vestal Point Capital, LP | 2.21% | Add +3.7% | 1,788,990 | $31.0M |
| BVF Inc. | 1.25% | No change | 1,771,417 | $30.7M |
| Capital International Investors | 0.01% | Reduce 0.0% | 1,619,026 | $28.0M |
| Ra Capital Management, L.P. | 0.44% | No change | 1,517,418 | $26.3M |
| Ameriprise Financial Inc. | 0.01% | Add +4.3% | 1,481,809 | $25.7M |
| Driehaus Capital Management LLC | 0.21% | Reduce -38.1% | 1,272,743 | $22.0M |
| Federated Hermes, Inc. | 0.04% | Reduce -42.8% | 1,170,948 | $20.3M |
| FIL Ltd | 0.02% | Reduce -11.5% | 1,150,440 | $19.9M |
| Rock Springs Capital Management LP | 1.13% | Add +4.8% | 1,132,979 | $19.6M |
| TCG Crossover Management, LLC | 2.51% | No change | 1,063,000 | $18.4M |
| Citadel Advisors | 0.02% | Reduce -32.9% | 992,340 | $17.2M |
| Millennium Management | 0.01% | Add +5.2% | 790,159 | $13.7M |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -44.3% | 777,173 | $13.5M |
| Principal Financial Group Inc. | 0.01% | Reduce -4.3% | 756,707 | $13.1M |
| Franklin Resources Inc. | 0.00% | Add +0.3% | 740,152 | $12.8M |
| Catalio Capital Management, LP | 3.02% | Add +23.8% | 704,864 | $12.2M |
| Casdin Capital, LLC | 0.99% | No change | 700,000 | $12.1M |
| Morgan Stanley | 0.00% | Add +78.8% | 692,439 | $12.0M |
| Orbimed Advisors LLC | 0.27% | No change | 652,028 | $11.3M |
| BlackRock, Inc. | 0.00% | Reduce -7.2% | 566,505 | $9.8M |
| American Century Companies Inc. | 0.01% | Reduce -16.7% | 510,201 | $8.8M |
| Readystate Asset Management LP | 0.76% | Add +129.9% | 481,241 | $8.3M |
| Logos Global Management LP | 1.31% | Reduce -39.3% | 425,000 | $7.4M |
| Foresite Capital Management VI LLC | 3.98% | No change | 420,000 | $7.3M |
| Invesco Ltd. | 0.00% | Add +6.1% | 394,386 | $6.8M |
| Handelsbanken Fonder AB | 0.03% | Add +130.3% | 380,000 | $6.6M |
| Deerfield Management Company, L.P. | 0.15% | No change | 373,407 | $6.5M |
| Baker Bros. Advisors LP | 0.07% | No change | 361,565 | $6.3M |
| HSG Holding Ltd | 0.36% | No change | 266,062 | $6.2M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -44.3% | 324,435 | $5.6M |
| Camber Capital Management LP | 0.32% | No change | 300,000 | $5.2M |
| Monashee Investment Management LLC | 0.61% | Add +121.9% | 292,862 | $5.1M |
| Ikarian Capital, LLC | 1.49% | Reduce -7.0% | 264,085 | $4.6M |
| Aberdeen Group plc | 0.01% | Add +45.2% | 248,899 | $4.3M |
| ArrowMark Colorado Holdings LLC | 0.07% | Add +5.3% | 245,186 | $4.2M |
| UBS Group AG | 0.00% | Reduce -2.4% | 238,197 | $4.1M |
| Point72 Asset Management | 0.01% | Reduce -51.9% | 229,431 | $4.0M |
| Bellevue Group AG | 0.09% | Reduce -54.3% | 221,715 | $3.8M |
| Candriam S.C.A. | 0.02% | Reduce -0.6% | 214,063 | $3.7M |
| Pier Capital, LLC | 0.62% | Add +60.3% | 212,520 | $3.7M |
| Balyasny Asset Management L.P. | 0.01% | New | 202,483 | $3.5M |
| Silverarc Capital Management, LLC | 0.68% | Add +23.4% | 188,069 | $3.3M |
| Woodline Partners LP | 0.02% | Reduce -47.5% | 175,424 | $3.0M |
| Nantahala Capital Management, LLC | 0.24% | Reduce -23.7% | 168,553 | $2.9M |
| Susquehanna Fundamental Investments, LLC | 0.05% | New | 157,961 | $2.7M |
| CCG Wealth Management, LLC | 1.55% | No change | 150,000 | $2.6M |
| JPMorgan Chase & Co. | 0.00% | Add +315.4% | 134,239 | $2.3M |
| First Light Asset Management, LLC | 0.26% | Reduce -66.8% | 132,380 | $2.3M |
| Jane Street Group, LLC | 0.00% | Add +4.0% | 120,703 | $2.1M |
| Trexquant Investment LP | 0.02% | Add +127.6% | 120,340 | $2.1M |
| Citigroup Inc. | 0.00% | Add +41.7% | 104,975 | $1.8M |
| Exome Asset Management LLC | 1.60% | Reduce -32.3% | 102,944 | $1.8M |
| Zimmer Partners, LP | 0.04% | Add +77.1% | 100,776 | $1.7M |
| Point72 Europe (London) LLP | 0.11% | Add +188.7% | 90,697 | $1.6M |
| Sphera Funds Management LTD. | 0.36% | New | 84,000 | $1.5M |
| Banque Pictet & Cie SA | 0.02% | Add +10.2% | 81,766 | $1.4M |
| Capital Fund Management S.A. | 0.02% | Add +18.6% | 79,656 | $1.4M |
| Boothbay Fund Management, LLC | 0.05% | Reduce -7.0% | 77,294 | $1.3M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Reduce -32.6% | 76,863 | $1.3M |
| Platinum Investment Management Ltd. | 0.08% | No change | 74,900 | $1.3M |
| Rhenman & Partners Asset Management AB | 0.14% | New | 70,000 | $1.2M |
| Susquehanna International Group, LLP | 0.00% | Reduce -0.1% | 68,167 | $1.2M |
| DAFNA Capital Management LLC | 0.29% | Add +66.2% | 59,000 | $1.0M |
| Macquarie Group Ltd. | 0.00% | No change | 58,000 | $1.0M |
| Bank of America Corp. | 0.00% | Add +2.3% | 55,438 | $960K |
| Cubist Systematic Strategies, LLC | 0.01% | New | 54,816 | $949K |
| Bank of Montreal | 0.00% | Add +6.1% | 53,235 | $921K |
| Group One Trading LLC | 0.04% | Add +126.8% | 48,917 | $847K |
| Geode Capital Management, LLC | 0.00% | Add +0.1% | 45,737 | $792K |
| TD Asset Management Inc | 0.00% | Reduce -50.9% | 43,686 | $756K |
| Alps Advisors Inc. | 0.00% | Reduce -7.0% | 43,080 | $746K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -30.1% | 40,737 | $705K |
| PFM Health Sciences, LP | 0.06% | New | 40,400 | $699K |
| TrueMark Investments, LLC | 0.18% | Reduce -6.9% | 39,217 | $679K |
| Exchange Traded Concepts, LLC | 0.01% | Reduce -3.7% | 38,923 | $674K |
| ADAR1 Capital Management, LLC | 0.12% | Add +0.8% | 35,619 | $617K |
| Sofinnova Investments, Inc. | 0.05% | Add +67.3% | 34,952 | $605K |
| Sectoral Asset Management Inc. | 0.45% | Reduce -31.6% | 33,695 | $583K |
| Osaic Holdings, Inc. | 0.00% | Add +1.9% | 31,390 | $543K |
| Jump Financial, LLC | 0.01% | New | 30,710 | $532K |
| Marshall Wace, LLP | 0.00% | Reduce -94.8% | 30,626 | $530K |
| Wexford Capital LP | 0.14% | Reduce -63.2% | 30,102 | $521K |
| Nomura Asset Management Co. Ltd. | 0.00% | Reduce -21.5% | 28,974 | $502K |
| Voya Investment Management LLC | 0.00% | No change | 25,940 | $449K |
| Prelude Capital Management, LLC | 0.04% | Reduce -19.9% | 25,628 | $444K |
| Jain Global LLC | 0.01% | New | 23,639 | $409K |
| HRT Financial LP | 0.00% | New | 22,859 | $395K |
| Tema ETFs LLC | 0.12% | Reduce -49.1% | 22,590 | $391K |
| NEOS Investment Management LLC | 0.01% | Reduce -49.1% | 22,590 | $391K |
| Quinn Opportunity Partners LLC | 0.03% | Add +83.3% | 22,000 | $381K |
| Simplex Trading, LLC | 0.01% | Add +18.8% | 20,604 | $356K |
| Verition Fund Management LLC | 0.00% | New | 19,582 | $339K |
| Mariner, LLC | 0.00% | Reduce -26.4% | 18,051 | $312K |
| Teachers Retirement System of the State of Kentucky | 0.00% | No change | 17,651 | $306K |
| HighVista Strategies LLC | 0.12% | No change | 17,561 | $304K |
| Renaissance Technologies | 0.00% | New | 15,800 | $273K |
| Quantbot Technologies LP | 0.01% | New | 14,401 | $249K |
| Good Life Advisors, LLC | 0.02% | New | 13,000 | $225K |
| China Universal Asset Management Co., Ltd. | 0.02% | Reduce -5.4% | 11,951 | $207K |
| Graham Capital Management, L.P. | 0.01% | New | 11,908 | $206K |
| D. E. Shaw & Co. | 0.00% | New | 11,661 | $202K |
| Brandywine Managers, LLC | 0.23% | No change | 11,057 | $191K |
| State Street Corp. | 0.00% | Add +2.0% | 10,740 | $186K |
| Bleichroeder LP | 0.05% | No change | 10,000 | $173K |
| PEAK6 LLC | 0.01% | No change | 9,445 | $163K |
| Caption Management, LLC | 0.01% | Add +65.3% | 9,256 | $160K |
| Wells Fargo & Company | 0.00% | Reduce -27.3% | 7,345 | $127K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | New | 5,915 | $102K |
| Barclays PLC | 0.00% | Reduce -95.4% | 5,312 | $92K |
| Virtus Investment Advisers, LLC | 0.02% | New | 5,177 | $90K |
| BNP Paribas Financial Markets | 0.00% | Reduce -59.7% | 4,518 | $78K |
| ANTIPODES PARTNERS Ltd | 0.00% | Add +310.7% | 4,247 | $74K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +3.3% | 3,685 | $73K |
| Royal Bank of Canada | 0.00% | Reduce -97.0% | 3,711 | $64K |
| Jones Financial Companies LLLP | 0.00% | Reduce -25.6% | 3,146 | $62K |
| PNC Financial Services Group, Inc. | 0.00% | Add +4.4% | 3,421 | $59K |
| Penserra Capital Management LLC | 0.00% | Add +9.8% | 3,411 | $59K |
| Headlands Technologies LLC | 0.01% | Reduce -18.1% | 3,408 | $59K |
| National Bank of Canada | 0.00% | Add +1448.2% | 2,957 | $51K |
| Steward Partners Investment Advisory, LLC | 0.00% | Add +19.0% | 2,516 | $44K |
| Assetmark, Inc. | 0.00% | Reduce -9.4% | 2,057 | $36K |
| GF Fund Management Co. LTD. | 0.00% | Add +21.9% | 1,525 | $26K |
| FNY Investment Advisers, LLC | 0.01% | Reduce -20.0% | 1,200 | $20K |
| SVB Wealth LLC | 0.00% | New | 836 | $14K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -85.4% | 595 | $10K |
| GAMMA Investing LLC | 0.00% | Reduce -55.9% | 507 | $9K |
| Rhumbline Advisers | 0.00% | No change | 450 | $8K |
| Caitong International Asset Management Co., Ltd | 0.00% | Add +102.2% | 376 | $7K |
| North Star Investment Management Corp. | 0.00% | No change | 330 | $6K |
| Daiwa Securities Group Inc. | 0.00% | No change | 226 | $4K |
| Private Wealth Management Group, LLC | 0.00% | New | 196 | $3K |
| Wolff Wiese Magana LLC | 0.00% | New | 134 | $2K |
| Cwm, LLC | 0.00% | No change | 100 | $2K |
| Signaturefd, LLC | 0.00% | No change | 100 | $2K |
| CoreCap Advisors, LLC | 0.00% | No change | 77 | $1K |
| Clearstead Advisors, LLC | 0.00% | No change | 67 | $1K |
| Washington Trust Advisors, Inc. | 0.00% | No change | 41 | $710 |
| Mather Group, Llc. | 0.00% | New | 35 | $606 |
| Federation des caisses Desjardins du Quebec | 0.00% | No change | 20 | $346 |
| US Bancorp \de | 0.00% | Reduce -87.1% | 13 | $225 |
| MAI Capital Management | 0.00% | New | 10 | $174 |
| Larson Financial Group LLC | 0.00% | New | 9 | $156 |
| Cullen/Frost Bankers, Inc. | 0.00% | No change | 8 | $138 |
| Huntington National Bank | 0.00% | No change | 2 | $35 |
| Point72 Asia (Singapore) Pte. Ltd. | 0.00% | No change | 1 | $17 |
"% of holder's portfolio" is GPCR's weight in each manager's 13F, not the share of Structure Therapeutics Inc. the manager owns.