Opko HealthOPK
13F holders, Q4 2025 (December 31)221holders −12
24new positions
33sold out
6famous investors
$1.26avg. 13F price*
At the end of Q4 2025, 221 institutions reported holding Opko Health Inc. (OPK) in their 13F filings, down 12 from Q3 2025. 24 opened new positions and 33 sold out. The largest holders were Rubric Capital Management LP ($60.2M), BlackRock, Inc. ($43.9M) and Vanguard Group Inc. ($40.9M). 6 famous investors held it, including Ken Griffin (0.0% of Citadel Advisors's portfolio), Mario Gabelli (0.0% of GAMCO Investors's portfolio) and Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio).
- Company
- Opko Health Inc.
- CUSIP
- 68375N103
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 24 | $5.0M |
| Exits | 33 | $3.3M |
All 13F filers, Q3 2025 → Q4 2025: 15,522,472 shares bought and 12,175,243 shares sold, net +3,347,229 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 221 holders
| Rubric Capital Management LP | 0.72% | No change | 47,791,243 | $60.2M |
| BlackRock, Inc. | 0.00% | Add +5.1% | 34,852,030 | $43.9M |
| Vanguard Group Inc. | 0.00% | Reduce -13.5% | 32,457,788 | $40.9M |
| Geode Capital Management, LLC | 0.00% | Add +0.6% | 11,061,318 | $13.9M |
| State Street Corp. | 0.00% | Reduce -0.5% | 8,951,762 | $11.3M |
| Goldman Sachs Group Inc. | 0.00% | Add +150.9% | 5,986,913 | $7.5M |
| UBS Group AG | 0.00% | Add +12.1% | 5,352,784 | $6.7M |
| Whitefort Capital Management, LP | 1.69% | Reduce -13.2% | 4,253,340 | $5.4M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -2.0% | 3,692,650 | $4.7M |
| Northern Trust Corp. | 0.00% | Reduce -6.0% | 3,438,312 | $4.3M |
| Citadel Advisors | 0.00% | Add +921.0% | 2,857,433 | $3.6M |
| AWM Investment Company, Inc. | 0.26% | Reduce -4.5% | 2,100,000 | $2.6M |
| AQR Capital Management | 0.00% | Reduce -29.5% | 2,026,957 | $2.6M |
| Jane Street Group, LLC | 0.00% | Add +575.5% | 1,775,336 | $2.2M |
| Dimensional Fund Advisors LP | 0.00% | Reduce -3.4% | 1,611,318 | $2.0M |
| Washington Growth Strategies LLC | 1.10% | No change | 1,356,124 | $1.7M |
| Y.D. More Investments Ltd | 0.08% | Reduce -12.8% | 1,306,452 | $1.7M |
| PFG Investments, LLC | 0.08% | Reduce -1.3% | 1,320,391 | $1.7M |
| Bank of New York Mellon Corp | 0.00% | Add +2.6% | 1,310,094 | $1.7M |
| Voya Investment Management LLC | 0.00% | Reduce -9.5% | 1,102,174 | $1.4M |
| Morgan Stanley | 0.00% | Add +9.5% | 917,353 | $1.2M |
| Clearstead Advisors, LLC | 0.01% | New | 882,367 | $1.1M |
| Tejara Capital Ltd | 0.46% | No change | 877,941 | $1.1M |
| Swiss National Bank | 0.00% | No change | 845,755 | $1.1M |
| Nuveen, LLC | 0.00% | No change | 841,836 | $1.1M |
| Invesco Ltd. | 0.00% | Reduce -23.2% | 781,672 | $985K |
| Two Sigma Investments, LP | 0.00% | Reduce -41.5% | 734,747 | $926K |
| HRT Financial LP | 0.00% | New | 675,483 | $851K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | No change | 673,565 | $849K |
| Barclays PLC | 0.00% | Add +12.8% | 663,236 | $836K |
| Assenagon Asset Management S.A. | 0.00% | Reduce -5.5% | 652,066 | $835K |
| Commonwealth Equity Services, LLC | 0.00% | Add +8.3% | 641,456 | $808K |
| Gsa Capital Partners LLP | 0.07% | New | 621,328 | $783K |
| Bank of America Corp. | 0.00% | Reduce -52.9% | 618,259 | $779K |
| JPMorgan Chase & Co. | 0.00% | Add +9.9% | 579,778 | $731K |
| Rhumbline Advisers | 0.00% | Reduce -7.9% | 511,479 | $644K |
| Wells Fargo & Company | 0.00% | Add +36.8% | 468,518 | $590K |
| Legal & General Group Plc | 0.00% | Add +17.2% | 453,265 | $571K |
| Alliancebernstein L.P. | 0.00% | Reduce -5.7% | 448,190 | $565K |
| Susquehanna International Group, LLP | 0.00% | Add +46.8% | 437,287 | $551K |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | Add +9.6% | 430,630 | $543K |
| California State Teachers Retirement System | 0.00% | Add +0.4% | 417,088 | $526K |
| Two Sigma Securities, LLC | 0.06% | Add +209.2% | 374,468 | $472K |
| T. Rowe Price Associates Inc. | 0.00% | Add +7.0% | 367,191 | $463K |
| XTX Topco Ltd | 0.01% | New | 342,757 | $432K |
| Deutsche Bank AG | 0.00% | Add +18.4% | 325,889 | $411K |
| EntryPoint Capital, LLC | 0.15% | Add +695.9% | 309,024 | $389K |
| Millennium Management | 0.00% | New | 265,268 | $334K |
| Royal Bank of Canada | 0.00% | Reduce -4.3% | 261,020 | $329K |
| Tudor Investment Corporation | 0.00% | No change | 244,821 | $308K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -3.0% | 229,590 | $289K |
| Janus Henderson Group PLC | 0.00% | No change | 206,314 | $259K |
| Balyasny Asset Management L.P. | 0.00% | New | 198,821 | $251K |
| Mirabella Financial Services LLP | 0.03% | New | 193,722 | $244K |
| Two Sigma Advisers, LP | 0.00% | Reduce -44.4% | 191,201 | $241K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -0.0% | 191,104 | $241K |
| State Board of Administration of Florida Retirement System | 0.00% | No change | 176,260 | $222K |
| MetLife Investment Management, LLC | 0.00% | Reduce -15.2% | 175,676 | $221K |
| GAMCO Investors | 0.00% | No change | 175,000 | $221K |
| Gabelli Funds LLC | 0.00% | No change | 170,000 | $214K |
| Intech Investment Management LLC | 0.00% | Add +11.4% | 159,652 | $201K |
| Ieq Capital, LLC | 0.00% | Reduce -43.2% | 157,779 | $199K |
| ProShare Advisors LLC | 0.00% | Add +122.2% | 156,354 | $197K |
| Zazove Associates LLC | 0.34% | Reduce -27.8% | 150,000 | $189K |
| Teton Advisors, LLC | 0.12% | Reduce -1.4% | 140,000 | $176K |
| Van Eck Associates Corp. | 0.00% | Add +22.5% | 137,019 | $173K |
| Quantbot Technologies LP | 0.01% | New | 122,747 | $155K |
| Comerica Bank | 0.00% | Add +7.1% | 120,000 | $151K |
| Graham Capital Management, L.P. | 0.01% | Add +21.6% | 119,654 | $151K |
| Highline Wealth Partners LLC | 0.04% | No change | 116,681 | $147K |
| Virtu Financial LLC | 0.01% | New | 115,298 | $145K |
| New York State Common Retirement Fund | 0.00% | Reduce -12.7% | 114,301 | $144K |
| Arizona State Retirement System | 0.00% | Reduce -11.5% | 113,834 | $143K |
| Glenmede Trust Co. NA | 0.00% | — | 113,483 | $143K |
| Y-Intercept (Hong Kong) Ltd | 0.00% | New | 112,930 | $142K |
| SIH Partners, LLLP | 0.01% | Reduce -30.5% | 104,334 | $131K |
| Qube Research & Technologies Ltd | 0.00% | New | 102,763 | $129K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 102,397 | $129K |
| RPg Family Wealth Advisory, LLC | 0.03% | No change | 98,990 | $125K |
| Ameriprise Financial Inc. | 0.00% | Add +1.1% | 96,242 | $121K |
| Simplex Trading, LLC | 0.00% | Reduce -37.6% | 93,881 | $118K |
| Quadrature Capital Ltd | 0.00% | New | 91,702 | $116K |
| KLP Kapitalforvaltning As | 0.00% | Add +22.6% | 90,700 | $114K |
| BNP Paribas Financial Markets | 0.00% | Reduce -23.6% | 90,433 | $114K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | Reduce -7.0% | 89,721 | $113K |
| Headlands Technologies LLC | 0.01% | Add +96.6% | 88,962 | $112K |
| 360 Financial, Inc. | 0.03% | Reduce -4.4% | 87,300 | $110K |
| Brevan Howard Capital Management LP | 0.00% | New | 85,348 | $108K |
| Osaic Holdings, Inc. | 0.00% | Reduce -13.2% | 75,315 | $95K |
| Cwm, LLC | 0.00% | Reduce -44.6% | 69,147 | $87K |
| World Investment Advisors | 0.00% | Add +63.8% | 66,520 | $84K |
| Cascade Financial Partners, LLC | 0.01% | No change | 66,490 | $84K |
| Pictet Asset Management Holding SA | 0.00% | No change | 65,495 | $83K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 61,502 | $77K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Reduce -24.1% | 57,529 | $76K |
| Wellington Grp LLC | 0.03% | — | 60,000 | $76K |
| Cetera Investment Advisers | 0.00% | Add +0.2% | 59,163 | $75K |
| Mercer Global Advisors Inc. | 0.00% | Reduce -24.2% | 59,026 | $74K |
| Kestra Private Wealth Services, LLC | 0.00% | No change | 58,450 | $74K |
| Creative Planning | 0.00% | Reduce -28.1% | 58,061 | $73K |
| Private Advisor Group, LLC | 0.00% | No change | 55,301 | $70K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | No change | 55,140 | $69K |
| CANADA LIFE ASSURANCE Co | 0.00% | No change | 54,068 | $68K |
| SG Americas Securities, LLC | 0.00% | Reduce -37.9% | 54,022 | $68K |
| Teacher Retirement System of Texas | 0.00% | Reduce -35.2% | 52,815 | $67K |
| Transcend Capital Advisors, LLC | 0.01% | Add +0.3% | 52,741 | $66K |
| First Manhattan Co. Llc. | 0.00% | No change | 51,750 | $65K |
| Verition Fund Management LLC | 0.00% | Reduce -36.3% | 50,650 | $64K |
| Farmers National Bank | 0.01% | No change | 50,300 | $63K |
| Victory Capital Management Inc. | 0.00% | Add +9.0% | 45,025 | $57K |
| Mariner, LLC | 0.00% | Reduce -38.8% | 42,225 | $53K |
| RK Asset Management, LLC | 0.05% | No change | 40,485 | $51K |
| Captrust Financial Advisors | 0.00% | Reduce -41.0% | 40,120 | $51K |
| Hollencrest Capital Management | 0.00% | Reduce -55.6% | 40,000 | $50K |
| Caitong International Asset Management Co., Ltd | 0.01% | Add +1056.9% | 39,232 | $49K |
| Raymond James Financial Inc. | 0.00% | Reduce -37.7% | 38,744 | $49K |
| HighTower Advisors, LLC | 0.00% | Reduce -7.3% | 37,453 | $47K |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -35.1% | 37,000 | $47K |
| Choreo, LLC | 0.00% | No change | 33,757 | $44K |
| Waverly Advisors, LLC | 0.00% | New | 34,727 | $44K |
| Russell Investments Group, Ltd. | 0.00% | No change | 34,690 | $44K |
| Xponance LLC | 0.00% | Add +0.6% | 32,361 | $41K |
| Operose Advisors LLC | 0.01% | No change | 32,000 | $40K |
| Diversify Wealth Management, LLC | 0.00% | No change | 30,000 | $40K |
| STRS Ohio | 0.00% | No change | 31,900 | $40K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 31,889 | $40K |
| IPG Investment Advisors LLC | 0.01% | No change | 30,000 | $38K |
| Orion Porfolio Solutions, LLC | 0.00% | Reduce -0.3% | 30,000 | $38K |
| Fisher Asset Management | 0.00% | No change | 30,000 | $38K |
| EP Wealth Advisors, LLC | 0.00% | — | 29,446 | $37K |
| Atom Investors LP | 0.00% | Reduce -32.5% | 28,258 | $36K |
| Cibc World Markets Corp. | 0.00% | — | 27,225 | $34K |
| Mackenzie Financial Corp. | 0.00% | No change | 25,843 | $34K |
| State of Wisconsin Investment Board | 0.00% | Reduce -32.4% | 26,437 | $33K |
| Prudential Financial Inc. | 0.00% | Reduce -51.9% | 26,366 | $33K |
| Cim Investment Management Inc. | 0.01% | No change | 25,804 | $33K |
| SlateStone Wealth, LLC | 0.00% | No change | 25,770 | $32K |
| Arrow Financial Corp | 0.00% | No change | 25,000 | $32K |
| Sterling Capital Management LLC | 0.00% | Reduce -16.5% | 23,720 | $30K |
| LPL Financial LLC | 0.00% | Reduce -27.4% | 22,458 | $28K |
| CIBC Asset Management Inc | 0.00% | No change | 21,918 | $28K |
| StoneX Group Inc. | 0.00% | New | 21,599 | $27K |
| Zacks Investment Management | 0.00% | New | 21,322 | $27K |
| Sax Wealth Advisors, LLC | 0.00% | Reduce -0.4% | 20,298 | $26K |
| Capital Advisors Inc. | 0.00% | No change | 370,000 | $25K |
| Cumberland Advisors Inc. | 0.01% | No change | 19,500 | $25K |
| Swiss Life Asset Management Ltd | 0.00% | No change | 19,164 | $24K |
| Westmount Partners, LLC | 0.01% | Add +12.1% | 18,550 | $23K |
| Principal Financial Group Inc. | 0.00% | Reduce -38.2% | 17,752 | $22K |
| Quantinno Capital Management LP | 0.00% | New | 17,716 | $22K |
| Cerity Partners LLC | 0.00% | Reduce -49.7% | 17,382 | $22K |
| Cibc World Market Inc. | 0.00% | Reduce -42.4% | 17,228 | $22K |
| Shufro Rose & Co. LLC | 0.00% | No change | 17,000 | $21K |
| Caprock Group, LLC | 0.00% | No change | 16,770 | $21K |
| Citigroup Inc. | 0.00% | Reduce -49.5% | 16,542 | $21K |
| Commons Capital, LLC | 0.01% | No change | 16,300 | $21K |
| Sigma Planning Corp | 0.00% | No change | 15,807 | $20K |
| Stifel Financial Corp. | 0.00% | Reduce -8.9% | 15,358 | $19K |
| Jump Financial, LLC | 0.00% | New | 15,277 | $19K |
| Key Financial Inc | 0.00% | Add +38.6% | 15,250 | $19K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | No change | 14,823 | $19K |
| Sanctuary Advisors, LLC | 0.00% | Reduce -5.8% | 14,758 | $19K |
| Colony Family Offices, LLC | 0.00% | No change | 14,729 | $19K |
| Jones Financial Companies LLLP | 0.00% | No change | 14,125 | $18K |
| FMR LLC | 0.00% | Reduce -14.9% | 14,087 | $18K |
| Formidable Asset Management, LLC | 0.00% | Reduce -21.0% | 11,296 | $18K |
| Amalgamated Bank | 0.00% | Add +16.4% | 12,929 | $16K |
| Mill Creek Capital Advisors, LLC | 0.00% | No change | 12,383 | $16K |
| Traphagen Investment Advisors LLC | 0.00% | No change | 11,680 | $15K |
| Focus Partners Advisor Solutions, LLC | 0.00% | Reduce -35.3% | 11,664 | $15K |
| Compound Planning, Inc. | 0.00% | New | 11,500 | $14K |
| HBK Sorce Advisory LLC | 0.00% | Reduce -18.3% | 11,057 | $14K |
| ExodusPoint Capital Management, LP | 0.00% | New | 10,637 | $13K |
| Diversified Trust Co. | 0.00% | No change | 10,374 | $13K |
| Sei Investments Co. | 0.00% | No change | 10,163 | $13K |
| MRP Capital Investments, LLC | 0.01% | No change | 10,000 | $13K |
| Greenbush Financial Group, LLC | 0.00% | No change | 10,000 | $13K |
| KLCM Advisors, Inc. | 0.00% | No change | 10,000 | $13K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -57.6% | 9,128 | $12K |
| Aventura Private Wealth, LLC | 0.00% | No change | 8,400 | $11K |
| Allworth Financial LP | 0.00% | Add +36.2% | 8,151 | $10K |
| Steward Partners Investment Advisory, LLC | 0.00% | No change | 7,110 | $9K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.00% | Add +60.0% | 6,045 | $8K |
| National Bank of Canada | 0.00% | No change | 6,200 | $8K |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -17.2% | 5,625 | $7K |
| CIBC Private Wealth Group LLC | 0.00% | New | 5,000 | $6K |
| Altshuler Shaham Ltd | 0.00% | Add +190.8% | 3,292 | $4K |
| Gables Capital Management Inc. | 0.00% | No change | 3,000 | $4K |
| Smartleaf Asset Management LLC | 0.00% | No change | 2,757 | $4K |
| Essential Partners LLC | 0.00% | Reduce -68.1% | 1,716 | $2K |
| CoreCap Advisors, LLC | 0.00% | No change | 1,600 | $2K |
| Aster Capital Management (DIFC) Ltd | 0.00% | Reduce -69.9% | 1,408 | $2K |
| Optiver Holding B.V. | 0.00% | Reduce -49.5% | 1,393 | $2K |
| Nisa Investment Advisors, LLC | 0.00% | Reduce -70.7% | 1,312 | $2K |
| Godfrey Financial Associates, Inc. | 0.00% | — | 1,250 | $2K |
| PFS Partners, LLC | 0.00% | No change | 1,100 | $1K |
| Salomon & Ludwin, LLC | 0.00% | Reduce -3.1% | 921 | $1K |
| True Wealth Design, LLC | 0.00% | Add +0.7% | 872 | $1K |
| US Bancorp \de | 0.00% | Reduce -54.5% | 500 | $630 |
| Rothschild Investment LLC | 0.00% | Reduce -33.9% | 449 | $566 |
| IFP Advisors, Inc | 0.00% | Reduce -29.3% | 432 | $544 |
| Rockefeller Capital Management L.P. | 0.00% | Reduce -71.4% | 401 | $505 |
| Pittenger & Anderson Inc. | 0.00% | No change | 250 | $315 |
| Northwestern Mutual Wealth Management Co. | 0.00% | Add +0.4% | 228 | $287 |
| Hilton Head Capital Partners, LLC | 0.00% | — | 200 | $252 |
| Medallion Wealth Advisors, LLC | 0.00% | No change | 200 | $252 |
| Harbor Investment Advisory, LLC | 0.00% | No change | 180 | $227 |
| Farther Finance Advisors, LLC | 0.00% | Add +10700.0% | 108 | $135 |
| Root Financial Partners, LLC | 0.00% | No change | 100 | $126 |
| Boreal Capital Management LLC | 0.00% | No change | 69 | $87 |
| Transamerica Financial Advisors, LLC | 0.00% | Reduce -70.0% | 56 | $71 |
| Larson Financial Group LLC | 0.00% | No change | 40 | $50 |
| Dunhill Financial, LLC | 0.00% | New | 9 | $11 |
| Darwin Wealth Management, LLC | 0.00% | No change | 5 | $6 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -96.2% | 2 | $3 |
| Atlantic Union Bankshares Corp | 0.00% | New | 1 | $2 |
| Crewe Advisors LLC | 0.00% | No change | 1 | $2 |
| LRI Investments, LLC | 0.00% | No change | 1 | $1 |
| Centerpoint Advisors, LLC | 0.00% | No change | 100 | $0 |
| Covestor Ltd | 0.00% | Reduce -77.2% | 72 | $0 |
| Motiv8 Investments LLC | 0.00% | New | 300 | $0 |
"% of holder's portfolio" is OPK's weight in each manager's 13F, not the share of Opko Health Inc. the manager owns.