Protagonist TherapeuticsPTGX
13F holders, Q4 2025 (December 31)316holders +41
65new positions
38sold out
10famous investors
$86.99avg. 13F price*
At the end of Q4 2025, 316 institutions reported holding Protagonist Therapeutics Inc. (PTGX) in their 13F filings, up 41 from Q3 2025. 65 opened new positions and 38 sold out. The largest holders were BlackRock, Inc. ($848.6M), Farallon Capital Management, L.L.C. ($536.6M) and Vanguard Group Inc. ($472.8M). 10 famous investors held it, including Stanley Druckenmiller (0.3% of Duquesne Family Office's portfolio), George Soros (0.2% of Soros Fund Management's portfolio) and Ken Griffin (0.1% of Citadel Advisors's portfolio).
- Company
- Protagonist Therapeutics Inc.
- CUSIP
- 74366E102
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 65 | $260.2M |
| Exits | 38 | $472.6M |
All 13F filers, Q3 2025 → Q4 2025: 11,274,975 shares bought and 11,743,581 shares sold, net −468,606 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 316 holders
| BlackRock, Inc. | 0.01% | Add +3.3% | 9,715,999 | $848.6M |
| Farallon Capital Management, L.L.C. | 2.79% | Reduce -0.8% | 6,144,006 | $536.6M |
| Vanguard Group Inc. | 0.01% | Add +27.2% | 5,413,690 | $472.8M |
| RTW Investments, LP | 4.43% | Reduce -12.1% | 5,059,053 | $441.9M |
| State Street Corp. | 0.01% | Add +1.1% | 3,199,729 | $279.5M |
| Wellington Management Group LLP | 0.05% | Add +66.2% | 3,171,423 | $277.0M |
| UBS Group AG | 0.05% | Add +46.1% | 2,770,021 | $241.9M |
| Janus Henderson Group PLC | 0.10% | Add +140.7% | 2,649,981 | $231.4M |
| Johnson & Johnson | 38.54% | No change | 2,449,183 | $213.9M |
| Invesco Ltd. | 0.01% | Add +56.2% | 1,567,840 | $136.9M |
| Geode Capital Management, LLC | 0.01% | Add +2.6% | 1,452,928 | $126.9M |
| Woodline Partners LP | 0.48% | Reduce -2.0% | 1,408,772 | $123.0M |
| T. Rowe Price Associates Inc. | 0.01% | Add +14.8% | 1,400,738 | $122.3M |
| Perceptive Advisors LLC | 2.17% | Add +31.1% | 1,350,425 | $117.9M |
| Citadel Advisors | 0.07% | Add +373.6% | 1,126,687 | $98.4M |
| Driehaus Capital Management LLC | 0.65% | Reduce -3.6% | 1,099,170 | $96.0M |
| ADAR1 Capital Management, LLC | 6.85% | Add +6.1% | 1,049,168 | $91.6M |
| Marshall Wace, LLP | 0.09% | Reduce -5.6% | 1,024,925 | $89.5M |
| Goldman Sachs Group Inc. | 0.01% | Add +22.9% | 961,149 | $83.9M |
| Morgan Stanley | 0.00% | Add +14.4% | 879,024 | $76.8M |
| Bank of America Corp. | 0.01% | Add +4.5% | 867,580 | $75.8M |
| Northern Trust Corp. | 0.01% | Reduce -4.7% | 575,118 | $50.2M |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 4.43% | New | 571,825 | $49.9M |
| Charles Schwab Investment Management Inc. | 0.01% | Add +0.7% | 556,762 | $48.6M |
| FMR LLC | 0.00% | Add +3.7% | 539,878 | $47.2M |
| American Century Companies Inc. | 0.02% | Reduce -10.8% | 535,423 | $46.8M |
| Pictet Asset Management Holding SA | 0.04% | Reduce -35.6% | 529,631 | $46.3M |
| Clearbridge Investments, LLC | 0.03% | New | 489,842 | $42.8M |
| Commodore Capital LP | 2.62% | Reduce -56.1% | 450,000 | $39.3M |
| Dimensional Fund Advisors LP | 0.01% | Reduce -5.5% | 414,415 | $36.2M |
| 683 Capital Management, LLC | 2.91% | Reduce -6.6% | 380,669 | $33.2M |
| Voya Investment Management LLC | 0.04% | Add +19.9% | 366,165 | $32.0M |
| Bank of New York Mellon Corp | 0.01% | Reduce -3.5% | 350,388 | $30.6M |
| Principal Financial Group Inc. | 0.02% | Add +6.7% | 347,932 | $30.4M |
| Jennison Associates LLC | 0.02% | New | 331,164 | $28.9M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.03% | Reduce -26.8% | 330,804 | $28.9M |
| Adage Capital Partners Gp, L.L.C. | 0.03% | Reduce -67.6% | 232,836 | $20.3M |
| NEXTBio Capital Management LP | 11.76% | — | 229,619 | $20.1M |
| Kennedy Capital Management LLC | 0.41% | Add +6.2% | 221,444 | $19.3M |
| Holocene Advisors, LP | 0.04% | New | 210,019 | $18.3M |
| Skandinaviska Enskilda Banken AB (publ) | 0.07% | Add +160.9% | 205,574 | $18.0M |
| Public Sector Pension Investment Board | 0.06% | Reduce -10.8% | 203,426 | $17.8M |
| Alyeska Investment Group, L.P. | 0.05% | New | 199,523 | $17.4M |
| MPM Bioimpact LLC | 1.99% | New | 199,471 | $17.4M |
| AIHC Capital Management Ltd | 15.54% | — | 189,823 | $16.6M |
| Barclays PLC | 0.01% | Add +9.5% | 187,642 | $16.4M |
| Raymond James Financial Inc. | 0.00% | Reduce -38.3% | 181,503 | $15.8M |
| Nan Fung Trinity (hk) Ltd. | 1.25% | Add +24.7% | 180,670 | $15.8M |
| Affinity Asset Advisors, LLC | 1.11% | Reduce -22.0% | 172,125 | $15.0M |
| Boxer Capital Management, LLC | 3.25% | Add +54.5% | 170,000 | $14.8M |
| Ameriprise Financial Inc. | 0.00% | Add +10.7% | 169,518 | $14.8M |
| Duquesne Family Office | 0.33% | No change | 159,700 | $13.9M |
| TD Asset Management Inc | 0.01% | Add +5.5% | 158,730 | $13.9M |
| JPMorgan Chase & Co. | 0.00% | Reduce -38.5% | 155,300 | $13.6M |
| Rhumbline Advisers | 0.01% | Reduce -5.5% | 154,950 | $13.5M |
| Qube Research & Technologies Ltd | 0.02% | New | 153,876 | $13.4M |
| Legal & General Group Plc | 0.00% | Reduce -4.3% | 149,164 | $13.0M |
| Segall Bryant & Hamill, LLC | 0.15% | Add +4.8% | 129,060 | $11.3M |
| Nuveen, LLC | 0.00% | Reduce -2.0% | 125,861 | $11.0M |
| Panagora Asset Management Inc. | 0.04% | Reduce -15.7% | 125,384 | $11.0M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.02% | Add +26.3% | 114,036 | $10.0M |
| Manufacturers Life Insurance Company, The | 0.01% | Reduce -16.1% | 113,340 | $9.9M |
| Prudential Financial Inc. | 0.01% | Reduce -12.7% | 110,360 | $9.6M |
| Hudson Bay Capital Management LP | 0.06% | New | 109,615 | $9.6M |
| Deutsche Bank AG | 0.00% | Reduce -10.0% | 105,460 | $9.2M |
| Opaleye Management Inc. | 1.21% | No change | 105,000 | $9.2M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -5.2% | 104,528 | $9.1M |
| Soros Fund Management | 0.16% | New | 100,000 | $8.7M |
| Neuberger Berman Group LLC | 0.01% | Reduce -20.2% | 98,473 | $8.6M |
| Swiss National Bank | 0.01% | Add +2.2% | 98,200 | $8.6M |
| BNP Paribas Financial Markets | 0.01% | Add +644.2% | 97,764 | $8.5M |
| Citigroup Inc. | 0.01% | Reduce -37.8% | 94,909 | $8.3M |
| Axiom Investors LLC | 0.07% | Add +11.7% | 89,468 | $7.8M |
| Atika Capital Management LLC | 1.05% | Add +3.6% | 86,000 | $7.5M |
| Moody Aldrich Partners LLC | 1.31% | Reduce -43.6% | 80,623 | $7.0M |
| Victory Capital Management Inc. | 0.00% | Reduce -5.8% | 80,571 | $7.0M |
| Informed Momentum Co LLC | 0.76% | Reduce -2.0% | 78,498 | $6.9M |
| Franklin Resources Inc. | 0.00% | Reduce -7.8% | 76,442 | $6.7M |
| Great Lakes Advisors, LLC | 0.05% | Reduce -17.1% | 73,966 | $6.5M |
| HighVista Strategies LLC | 1.65% | Reduce -39.6% | 73,545 | $6.4M |
| Alliancebernstein L.P. | 0.00% | Reduce -71.9% | 73,222 | $6.4M |
| Knott David M Jr | 2.95% | Reduce -12.1% | 73,000 | $6.4M |
| EFG International AG | 0.12% | — | 72,623 | $6.3M |
| Wells Fargo & Company | 0.00% | Add +49.9% | 71,645 | $6.3M |
| Fisher Asset Management | 0.00% | New | 65,114 | $5.7M |
| Rafferty Asset Management, LLC | 0.02% | Reduce -14.9% | 63,661 | $5.6M |
| Stempoint Capital LP | 0.89% | Add +23.9% | 59,430 | $5.2M |
| Eagle Health Investments LP | 1.10% | New | 57,300 | $5.0M |
| Quinn Opportunity Partners LLC | 0.21% | New | 55,259 | $4.8M |
| Birchview Capital, LP | 2.81% | Add +14.6% | 55,000 | $4.8M |
| Bessemer Group Inc. | 0.01% | Add +1167.0% | 54,162 | $4.7M |
| Silvercrest Asset Management Group LLC | 0.03% | No change | 53,217 | $4.6M |
| KVP Capital Advisors, LP | 4.78% | — | 53,000 | $4.6M |
| Eversept Partners, LP | 0.26% | New | 52,961 | $4.6M |
| Pentwater Capital Management LP | 0.03% | New | 50,000 | $4.4M |
| CANADA LIFE ASSURANCE Co | 0.01% | Add +2.5% | 49,640 | $4.3M |
| New York State Teachers Retirement System | 0.01% | Reduce -0.4% | 49,350 | $4.3M |
| Northwestern Mutual Wealth Management Co. | 0.00% | Reduce -17.0% | 48,894 | $4.3M |
| California State Teachers Retirement System | 0.00% | Add +1.3% | 48,033 | $4.2M |
| First Trust Advisors LP | 0.00% | Reduce -25.9% | 46,454 | $4.1M |
"% of holder's portfolio" is PTGX's weight in each manager's 13F, not the share of Protagonist Therapeutics Inc. the manager owns.