Protagonist TherapeuticsPTGX
13F holders, Q3 2025 (September 30)275holders +2
39new positions
39sold out
5famous investors
$66.43avg. 13F price*
At the end of Q3 2025, 275 institutions reported holding Protagonist Therapeutics Inc. (PTGX) in their 13F filings, up 2 from Q2 2025. 39 opened new positions and 39 sold out. The largest holders were BlackRock, Inc. ($624.7M), Farallon Capital Management, L.L.C. ($411.6M) and RTW Investments, LP ($382.4M). 5 famous investors held it, including Stanley Druckenmiller (0.3% of Duquesne Family Office's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Protagonist Therapeutics Inc.
- CUSIP
- 74366E102
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 39 | $160.4M |
| Exits | 39 | $115.4M |
All 13F filers, Q2 2025 → Q3 2025: 7,111,527 shares bought and 7,391,773 shares sold, net −280,246 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 275 holders
| BlackRock, Inc. | 0.01% | Reduce -2.4% | 9,404,232 | $624.7M |
| Farallon Capital Management, L.L.C. | 2.33% | Add +0.4% | 6,196,006 | $411.6M |
| RTW Investments, LP | 4.71% | No change | 5,756,277 | $382.4M |
| Vanguard Group Inc. | 0.00% | Reduce -2.3% | 4,257,229 | $282.8M |
| State Street Corp. | 0.01% | Reduce -1.3% | 3,165,795 | $210.3M |
| BVF Inc. | 6.90% | Reduce -20.3% | 2,560,916 | $170.1M |
| Johnson & Johnson | 32.29% | No change | 2,449,183 | $162.7M |
| Wellington Management Group LLP | 0.02% | Add +83.9% | 1,908,446 | $126.8M |
| UBS Group AG | 0.02% | Reduce -24.2% | 1,896,008 | $126.0M |
| Deep Track Capital, LP | 3.18% | Reduce -47.1% | 1,715,691 | $114.0M |
| Woodline Partners LP | 0.45% | Add +51.9% | 1,438,247 | $95.5M |
| Geode Capital Management, LLC | 0.01% | Reduce -1.9% | 1,416,646 | $94.1M |
| T. Rowe Price Associates Inc. | 0.01% | Add +30.3% | 1,220,436 | $81.1M |
| Driehaus Capital Management LLC | 0.54% | Add +50.4% | 1,139,854 | $75.7M |
| Janus Henderson Group PLC | 0.03% | Add +146.4% | 1,100,821 | $73.2M |
| Marshall Wace, LLP | 0.08% | New | 1,085,564 | $72.1M |
| Perceptive Advisors LLC | 2.01% | Reduce -4.1% | 1,030,134 | $68.4M |
| Commodore Capital LP | 3.32% | Reduce -4.7% | 1,025,000 | $68.1M |
| Invesco Ltd. | 0.01% | Add +39.1% | 1,003,706 | $66.7M |
| ADAR1 Capital Management, LLC | 6.55% | Add +4.3% | 989,182 | $65.7M |
| Bank of America Corp. | 0.00% | Reduce -2.6% | 829,877 | $55.1M |
| Pictet Asset Management Holding SA | 0.05% | Add +9.3% | 822,212 | $54.6M |
| Jefferies Financial Group Inc. | 0.52% | Reduce -0.3% | 821,503 | $54.6M |
| Goldman Sachs Group Inc. | 0.01% | Add +0.6% | 781,711 | $51.9M |
| Morgan Stanley | 0.00% | Reduce -11.6% | 768,359 | $51.0M |
| Adage Capital Partners Gp, L.L.C. | 0.08% | Reduce -34.3% | 718,202 | $47.7M |
| Lynx1 Capital Management LP | 9.47% | Reduce -4.5% | 700,014 | $46.5M |
| Northern Trust Corp. | 0.01% | Reduce -1.9% | 603,222 | $40.1M |
| American Century Companies Inc. | 0.02% | Reduce -26.3% | 600,047 | $39.9M |
| Charles Schwab Investment Management Inc. | 0.01% | Reduce -3.9% | 552,877 | $36.7M |
| FMR LLC | 0.00% | Reduce -3.3% | 520,664 | $34.6M |
| Mangrove Partners Im, LLC | 2.64% | Add +21.0% | 478,413 | $31.8M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.08% | Add +1.3% | 451,766 | $30.0M |
| Focus Partners Wealth | 0.05% | New | 448,988 | $29.8M |
| Toronto Dominion Bank | 0.06% | No change | 445,440 | $29.6M |
| Dimensional Fund Advisors LP | 0.01% | Add +143.6% | 438,515 | $29.1M |
| 683 Capital Management, LLC | 2.58% | Reduce -8.4% | 407,500 | $27.1M |
| Bank of New York Mellon Corp | 0.00% | Reduce -6.4% | 363,261 | $24.1M |
| Principal Financial Group Inc. | 0.01% | Reduce -1.2% | 326,088 | $21.7M |
| Voya Investment Management LLC | 0.02% | Add +8.9% | 305,419 | $20.3M |
| Logos Global Management LP | 1.97% | New | 300,000 | $19.9M |
| Raymond James Financial Inc. | 0.01% | Reduce -5.7% | 294,296 | $19.6M |
| Alliancebernstein L.P. | 0.01% | Add +284.2% | 260,854 | $17.3M |
| JPMorgan Chase & Co. | 0.00% | Reduce -43.4% | 252,400 | $16.8M |
| Citadel Advisors | 0.01% | Add +774.5% | 237,881 | $15.8M |
| Public Sector Pension Investment Board | 0.06% | Add +8.0% | 228,146 | $15.2M |
| Affinity Asset Advisors, LLC | 1.41% | Reduce -49.9% | 220,600 | $14.7M |
| Kennedy Capital Management LLC | 0.31% | Add +54.5% | 208,437 | $13.8M |
| Barclays PLC | 0.00% | Reduce -19.2% | 171,406 | $11.4M |
| Rhumbline Advisers | 0.01% | Reduce -5.2% | 163,980 | $10.9M |
| Duquesne Family Office | 0.27% | New | 159,700 | $10.6M |
| Legal & General Group Plc | 0.00% | Reduce -6.2% | 155,829 | $10.4M |
| Ameriprise Financial Inc. | 0.00% | Reduce -9.0% | 153,191 | $10.2M |
| Citigroup Inc. | 0.01% | Add +95.7% | 152,580 | $10.1M |
| TD Asset Management Inc | 0.01% | Add +29.3% | 150,428 | $10.0M |
| Panagora Asset Management Inc. | 0.04% | Reduce -0.0% | 148,729 | $9.9M |
| Nan Fung Trinity (hk) Ltd. | 0.96% | Add +7.3% | 144,892 | $9.6M |
| Moody Aldrich Partners LLC | 1.80% | Reduce -16.1% | 143,060 | $9.5M |
| Manufacturers Life Insurance Company, The | 0.01% | Add +42.5% | 135,096 | $9.0M |
| Nuveen, LLC | 0.00% | Reduce -0.9% | 128,384 | $8.5M |
| Millennium Management | 0.01% | Add +739.7% | 127,560 | $8.5M |
| Prudential Financial Inc. | 0.01% | Add +63.3% | 126,403 | $8.4M |
| ExodusPoint Capital Management, LP | 0.12% | New | 124,929 | $8.3M |
| Neuberger Berman Group LLC | 0.01% | Add +31.8% | 123,377 | $8.2M |
| Segall Bryant & Hamill, LLC | 0.11% | Add +2.5% | 123,125 | $8.2M |
| HighVista Strategies LLC | 1.98% | Add +110.3% | 121,682 | $8.1M |
| Deutsche Bank AG | 0.00% | Add +5.4% | 117,212 | $7.8M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -54.7% | 110,229 | $7.3M |
| Boxer Capital Management, LLC | 2.33% | Add +83.3% | 110,000 | $7.3M |
| Opaleye Management Inc. | 0.99% | No change | 105,000 | $7.0M |
| Swiss National Bank | 0.00% | Add +2.5% | 96,100 | $6.4M |
| Schonfeld Strategic Advisors LLC | 0.04% | Add +23.5% | 95,190 | $6.3M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | Add +123.1% | 90,317 | $6.0M |
| Great Lakes Advisors, LLC | 0.05% | Reduce -36.0% | 89,171 | $5.9M |
| Victory Capital Management Inc. | 0.00% | Reduce -6.0% | 85,494 | $5.7M |
| Knott David M Jr | 2.31% | Add +3.8% | 83,000 | $5.5M |
| Atika Capital Management LLC | 0.47% | New | 83,000 | $5.5M |
| Franklin Resources Inc. | 0.00% | Add +0.4% | 82,918 | $5.5M |
| EFG Asset Management (North America) Corp. | 0.71% | Add +1.1% | 82,639 | $5.5M |
| Axiom Investors LLC | 0.04% | Add +56.4% | 80,113 | $5.3M |
| Skandinaviska Enskilda Banken AB (publ) | 0.02% | Reduce -4.8% | 78,796 | $5.2M |
| Informed Momentum Co LLC | 0.60% | Add +11.3% | 80,067 | $5.2M |
| Rafferty Asset Management, LLC | 0.02% | Reduce -7.1% | 74,827 | $5.0M |
| Royal Bank of Canada | 0.00% | Reduce -6.3% | 69,996 | $4.7M |
| Assenagon Asset Management S.A. | 0.01% | Reduce -28.4% | 65,756 | $4.4M |
| Susquehanna International Group, LLP | 0.01% | Reduce -11.3% | 63,188 | $4.2M |
| First Trust Advisors LP | 0.00% | Reduce -44.9% | 62,724 | $4.2M |
| Parkman Healthcare Partners LLC | 0.45% | Add +0.4% | 61,849 | $4.1M |
| Northwestern Mutual Wealth Management Co. | 0.00% | Reduce -25.4% | 58,894 | $3.9M |
| Silvercrest Asset Management Group LLC | 0.02% | Reduce -2.8% | 53,217 | $3.5M |
| Diadema Partners LP | 2.37% | Reduce -32.8% | 51,185 | $3.4M |
| New York State Teachers Retirement System | 0.01% | Reduce -11.1% | 49,550 | $3.3M |
| Birchview Capital, LP | 2.41% | No change | 48,000 | $3.2M |
| Stempoint Capital LP | 0.64% | Add +185.9% | 47,954 | $3.2M |
| Wells Fargo & Company | 0.00% | Add +14.7% | 47,794 | $3.2M |
| California State Teachers Retirement System | 0.00% | Reduce -7.3% | 47,437 | $3.2M |
| CANADA LIFE ASSURANCE Co | 0.00% | Reduce -3.6% | 48,407 | $3.2M |
| Jane Street Group, LLC | 0.00% | New | 44,339 | $2.9M |
| Sei Investments Co. | 0.00% | Reduce -2.0% | 44,011 | $2.9M |
| Thrivent Financial for Lutherans | 0.01% | Reduce -7.4% | 42,188 | $2.8M |
"% of holder's portfolio" is PTGX's weight in each manager's 13F, not the share of Protagonist Therapeutics Inc. the manager owns.