Protagonist TherapeuticsPTGX
13F holders, Q4 2025 (December 31)At the end of Q4 2025, 316 institutions reported holding Protagonist Therapeutics Inc. (PTGX) in their 13F filings, up 41 from Q3 2025. 65 opened new positions and 38 sold out. The largest holders were BlackRock, Inc. ($848.6M), Farallon Capital Management, L.L.C. ($536.6M) and Vanguard Group Inc. ($472.8M). 10 famous investors held it, including Stanley Druckenmiller (0.3% of Duquesne Family Office's portfolio), George Soros (0.2% of Soros Fund Management's portfolio) and Ken Griffin (0.1% of Citadel Advisors's portfolio).
- Company
- Protagonist Therapeutics Inc.
- CUSIP
- 74366E102
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 65 | $260.2M |
| Exits | 38 | $472.6M |
All 13F filers, Q3 2025 → Q4 2025: 11,274,975 shares bought and 11,743,581 shares sold, net −468,606 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 316 holders
| BlackRock, Inc. | 0.01% | Add +3.3% | 9,715,999 | $848.6M |
| Farallon Capital Management, L.L.C. | 2.79% | Reduce -0.8% | 6,144,006 | $536.6M |
| Vanguard Group Inc. | 0.01% | Add +27.2% | 5,413,690 | $472.8M |
| RTW Investments, LP | 4.43% | Reduce -12.1% | 5,059,053 | $441.9M |
| State Street Corp. | 0.01% | Add +1.1% | 3,199,729 | $279.5M |
| Wellington Management Group LLP | 0.05% | Add +66.2% | 3,171,423 | $277.0M |
| UBS Group AG | 0.05% | Add +46.1% | 2,770,021 | $241.9M |
| Janus Henderson Group PLC | 0.10% | Add +140.7% | 2,649,981 | $231.4M |
| Johnson & Johnson | 38.54% | No change | 2,449,183 | $213.9M |
| Invesco Ltd. | 0.01% | Add +56.2% | 1,567,840 | $136.9M |
| Geode Capital Management, LLC | 0.01% | Add +2.6% | 1,452,928 | $126.9M |
| Woodline Partners LP | 0.48% | Reduce -2.0% | 1,408,772 | $123.0M |
| T. Rowe Price Associates Inc. | 0.01% | Add +14.8% | 1,400,738 | $122.3M |
| Perceptive Advisors LLC | 2.17% | Add +31.1% | 1,350,425 | $117.9M |
| Citadel Advisors | 0.07% | Add +373.6% | 1,126,687 | $98.4M |
| Driehaus Capital Management LLC | 0.65% | Reduce -3.6% | 1,099,170 | $96.0M |
| ADAR1 Capital Management, LLC | 6.85% | Add +6.1% | 1,049,168 | $91.6M |
| Marshall Wace, LLP | 0.09% | Reduce -5.6% | 1,024,925 | $89.5M |
| Goldman Sachs Group Inc. | 0.01% | Add +22.9% | 961,149 | $83.9M |
| Morgan Stanley | 0.00% | Add +14.4% | 879,024 | $76.8M |
| Bank of America Corp. | 0.01% | Add +4.5% | 867,580 | $75.8M |
| Northern Trust Corp. | 0.01% | Reduce -4.7% | 575,118 | $50.2M |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 4.43% | New | 571,825 | $49.9M |
| Charles Schwab Investment Management Inc. | 0.01% | Add +0.7% | 556,762 | $48.6M |
| FMR LLC | 0.00% | Add +3.7% | 539,878 | $47.2M |
| American Century Companies Inc. | 0.02% | Reduce -10.8% | 535,423 | $46.8M |
| Pictet Asset Management Holding SA | 0.04% | Reduce -35.6% | 529,631 | $46.3M |
| Clearbridge Investments, LLC | 0.03% | New | 489,842 | $42.8M |
| Commodore Capital LP | 2.62% | Reduce -56.1% | 450,000 | $39.3M |
| Dimensional Fund Advisors LP | 0.01% | Reduce -5.5% | 414,415 | $36.2M |
| 683 Capital Management, LLC | 2.91% | Reduce -6.6% | 380,669 | $33.2M |
| Voya Investment Management LLC | 0.04% | Add +19.9% | 366,165 | $32.0M |
| Bank of New York Mellon Corp | 0.01% | Reduce -3.5% | 350,388 | $30.6M |
| Principal Financial Group Inc. | 0.02% | Add +6.7% | 347,932 | $30.4M |
| Jennison Associates LLC | 0.02% | New | 331,164 | $28.9M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.03% | Reduce -26.8% | 330,804 | $28.9M |
| Adage Capital Partners Gp, L.L.C. | 0.03% | Reduce -67.6% | 232,836 | $20.3M |
| NEXTBio Capital Management LP | 11.76% | — | 229,619 | $20.1M |
| Kennedy Capital Management LLC | 0.41% | Add +6.2% | 221,444 | $19.3M |
| Holocene Advisors, LP | 0.04% | New | 210,019 | $18.3M |
| Skandinaviska Enskilda Banken AB (publ) | 0.07% | Add +160.9% | 205,574 | $18.0M |
| Public Sector Pension Investment Board | 0.06% | Reduce -10.8% | 203,426 | $17.8M |
| Alyeska Investment Group, L.P. | 0.05% | New | 199,523 | $17.4M |
| MPM Bioimpact LLC | 1.99% | New | 199,471 | $17.4M |
| AIHC Capital Management Ltd | 15.54% | — | 189,823 | $16.6M |
| Barclays PLC | 0.01% | Add +9.5% | 187,642 | $16.4M |
| Raymond James Financial Inc. | 0.00% | Reduce -38.3% | 181,503 | $15.8M |
| Nan Fung Trinity (hk) Ltd. | 1.25% | Add +24.7% | 180,670 | $15.8M |
| Affinity Asset Advisors, LLC | 1.11% | Reduce -22.0% | 172,125 | $15.0M |
| Boxer Capital Management, LLC | 3.25% | Add +54.5% | 170,000 | $14.8M |
| Ameriprise Financial Inc. | 0.00% | Add +10.7% | 169,518 | $14.8M |
| Duquesne Family Office | 0.33% | No change | 159,700 | $13.9M |
| TD Asset Management Inc | 0.01% | Add +5.5% | 158,730 | $13.9M |
| JPMorgan Chase & Co. | 0.00% | Reduce -38.5% | 155,300 | $13.6M |
| Rhumbline Advisers | 0.01% | Reduce -5.5% | 154,950 | $13.5M |
| Qube Research & Technologies Ltd | 0.02% | New | 153,876 | $13.4M |
| Legal & General Group Plc | 0.00% | Reduce -4.3% | 149,164 | $13.0M |
| Segall Bryant & Hamill, LLC | 0.15% | Add +4.8% | 129,060 | $11.3M |
| Nuveen, LLC | 0.00% | Reduce -2.0% | 125,861 | $11.0M |
| Panagora Asset Management Inc. | 0.04% | Reduce -15.7% | 125,384 | $11.0M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.02% | Add +26.3% | 114,036 | $10.0M |
| Manufacturers Life Insurance Company, The | 0.01% | Reduce -16.1% | 113,340 | $9.9M |
| Prudential Financial Inc. | 0.01% | Reduce -12.7% | 110,360 | $9.6M |
| Hudson Bay Capital Management LP | 0.06% | New | 109,615 | $9.6M |
| Deutsche Bank AG | 0.00% | Reduce -10.0% | 105,460 | $9.2M |
| Opaleye Management Inc. | 1.21% | No change | 105,000 | $9.2M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -5.2% | 104,528 | $9.1M |
| Soros Fund Management | 0.16% | New | 100,000 | $8.7M |
| Neuberger Berman Group LLC | 0.01% | Reduce -20.2% | 98,473 | $8.6M |
| Swiss National Bank | 0.01% | Add +2.2% | 98,200 | $8.6M |
| BNP Paribas Financial Markets | 0.01% | Add +644.2% | 97,764 | $8.5M |
| Citigroup Inc. | 0.01% | Reduce -37.8% | 94,909 | $8.3M |
| Axiom Investors LLC | 0.07% | Add +11.7% | 89,468 | $7.8M |
| Atika Capital Management LLC | 1.05% | Add +3.6% | 86,000 | $7.5M |
| Moody Aldrich Partners LLC | 1.31% | Reduce -43.6% | 80,623 | $7.0M |
| Victory Capital Management Inc. | 0.00% | Reduce -5.8% | 80,571 | $7.0M |
| Informed Momentum Co LLC | 0.76% | Reduce -2.0% | 78,498 | $6.9M |
| Franklin Resources Inc. | 0.00% | Reduce -7.8% | 76,442 | $6.7M |
| Great Lakes Advisors, LLC | 0.05% | Reduce -17.1% | 73,966 | $6.5M |
| HighVista Strategies LLC | 1.65% | Reduce -39.6% | 73,545 | $6.4M |
| Alliancebernstein L.P. | 0.00% | Reduce -71.9% | 73,222 | $6.4M |
| Knott David M Jr | 2.95% | Reduce -12.1% | 73,000 | $6.4M |
| EFG International AG | 0.12% | — | 72,623 | $6.3M |
| Wells Fargo & Company | 0.00% | Add +49.9% | 71,645 | $6.3M |
| Fisher Asset Management | 0.00% | New | 65,114 | $5.7M |
| Rafferty Asset Management, LLC | 0.02% | Reduce -14.9% | 63,661 | $5.6M |
| Stempoint Capital LP | 0.89% | Add +23.9% | 59,430 | $5.2M |
| Eagle Health Investments LP | 1.10% | New | 57,300 | $5.0M |
| Quinn Opportunity Partners LLC | 0.21% | New | 55,259 | $4.8M |
| Birchview Capital, LP | 2.81% | Add +14.6% | 55,000 | $4.8M |
| Bessemer Group Inc. | 0.01% | Add +1167.0% | 54,162 | $4.7M |
| Silvercrest Asset Management Group LLC | 0.03% | No change | 53,217 | $4.6M |
| KVP Capital Advisors, LP | 4.78% | — | 53,000 | $4.6M |
| Eversept Partners, LP | 0.26% | New | 52,961 | $4.6M |
| Pentwater Capital Management LP | 0.03% | New | 50,000 | $4.4M |
| CANADA LIFE ASSURANCE Co | 0.01% | Add +2.5% | 49,640 | $4.3M |
| New York State Teachers Retirement System | 0.01% | Reduce -0.4% | 49,350 | $4.3M |
| Northwestern Mutual Wealth Management Co. | 0.00% | Reduce -17.0% | 48,894 | $4.3M |
| California State Teachers Retirement System | 0.00% | Add +1.3% | 48,033 | $4.2M |
| First Trust Advisors LP | 0.00% | Reduce -25.9% | 46,454 | $4.1M |
| J. Goldman & Co LP | 0.16% | Add +156.4% | 46,325 | $4.0M |
| SummitTX Capital, L.P. | 0.11% | Add +34.2% | 42,266 | $3.7M |
| Creative Planning | 0.00% | Add +13.9% | 41,254 | $3.6M |
| Thrivent Financial for Lutherans | 0.01% | Reduce -4.3% | 40,380 | $3.5M |
| LMR Partners LLP | 0.04% | New | 40,000 | $3.5M |
| State of Alaska, Department of Revenue | 0.04% | Add +29.5% | 38,099 | $3.3M |
| Elmind Capital, LP | 0.98% | — | 38,000 | $3.3M |
| Sei Investments Co. | 0.00% | Reduce -15.1% | 37,346 | $3.3M |
| Aquatic Capital Management LLC | 0.09% | New | 36,615 | $3.2M |
| Exchange Traded Concepts, LLC | 0.03% | Add +4.4% | 35,039 | $3.1M |
| State of Wisconsin Investment Board | 0.01% | Reduce -15.0% | 34,786 | $3.0M |
| Jane Street Group, LLC | 0.00% | Reduce -22.6% | 34,307 | $3.0M |
| Deeter Investments LLP | 0.62% | — | 300,000 | $2.9M |
| MetLife Investment Management, LLC | 0.01% | Reduce -4.2% | 32,440 | $2.8M |
| Illinois Municipal Retirement Fund | 0.03% | Reduce -5.8% | 31,244 | $2.7M |
| Guggenheim Capital LLC | 0.02% | Add +67.3% | 31,096 | $2.7M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -0.3% | 30,789 | $2.7M |
| Louisiana State Employees Retirement System | 0.04% | No change | 26,900 | $2.3M |
| Verition Fund Management LLC | 0.01% | New | 26,792 | $2.3M |
| Teachers Retirement System of the State of Kentucky | 0.02% | Add +53.4% | 26,528 | $2.3M |
| Keystone Investors Pte Ltd. | 0.21% | New | 26,390 | $2.3M |
| Parkman Healthcare Partners LLC | 0.22% | Reduce -58.0% | 25,973 | $2.3M |
| Profund Advisors LLC | 0.07% | Add +40.9% | 25,574 | $2.2M |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.01% | Add +62.8% | 25,400 | $2.2M |
| Artia Global Partners LP | 0.32% | No change | 22,951 | $2.0M |
| Diadema Partners LP | 1.18% | Reduce -55.6% | 22,700 | $2.0M |
| Intech Investment Management LLC | 0.02% | Add +3.9% | 22,485 | $2.0M |
| State of Tennessee, Department of Treasury | 0.01% | Reduce -11.2% | 23,526 | $1.9M |
| Orbimed Advisors LLC | 0.04% | New | 21,700 | $1.9M |
| Gotham Asset Management | 0.01% | Reduce -2.7% | 21,595 | $1.9M |
| Campbell & CO Investment Adviser LLC | 0.09% | New | 21,054 | $1.8M |
| Natixis Advisors, LLC | 0.00% | Add +21.6% | 20,495 | $1.8M |
| Polen Capital Management LLC | 0.01% | Add +0.1% | 20,349 | $1.8M |
| SG Americas Securities, LLC | 0.00% | Reduce -51.5% | 19,997 | $1.7M |
| Handelsbanken Fonder AB | 0.01% | Add +5.3% | 19,900 | $1.7M |
| New York State Common Retirement Fund | 0.00% | Reduce -6.1% | 18,382 | $1.6M |
| Nomura Holdings Inc. | 0.00% | New | 17,521 | $1.5M |
| Millennium Management | 0.00% | Reduce -86.4% | 17,391 | $1.5M |
| Headlands Technologies LLC | 0.12% | New | 17,079 | $1.5M |
| Amalgamated Bank | 0.01% | Add +1.4% | 17,063 | $1.5M |
| Royce & Associates LP | 0.01% | No change | 16,989 | $1.5M |
| State of New Jersey Common Pension Fund D | 0.01% | Reduce -55.3% | 16,987 | $1.5M |
| Bellevue Group AG | 0.03% | Reduce -19.6% | 16,543 | $1.4M |
| Pathstone Holdings, LLC | 0.01% | Add +23.0% | 16,441 | $1.4M |
| State Board of Administration of Florida Retirement System | 0.00% | No change | 16,303 | $1.4M |
| STRS Ohio | 0.01% | Reduce -10.7% | 15,900 | $1.4M |
| Police & Firemen's Retirement System of New Jersey | 0.01% | Reduce -1.8% | 15,834 | $1.4M |
| Yousif Capital Management, LLC | 0.01% | Reduce -11.6% | 16,281 | $1.4M |
| Envestnet Asset Management Inc. | 0.00% | Reduce -39.5% | 14,673 | $1.3M |
| Commonwealth of Pennsylvania Public School Empls Retrmt SYS | 0.01% | Reduce -2.3% | 14,548 | $1.3M |
| ProShare Advisors LLC | 0.00% | Add +6.8% | 14,084 | $1.2M |
| Arizona State Retirement System | 0.01% | Reduce -4.4% | 14,025 | $1.2M |
| China Universal Asset Management Co., Ltd. | 0.09% | Reduce -13.3% | 13,787 | $1.2M |
| Erste Asset Management GmbH | 0.01% | No change | 13,500 | $1.2M |
| Oregon Public Employees Retirement Fund | 0.01% | Add +1.5% | 13,393 | $1.2M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | New | 13,270 | $1.2M |
| Comerica Bank | 0.00% | Reduce -20.7% | 13,005 | $1.1M |
| Allianz Asset Management GmbH | 0.00% | Reduce -33.9% | 13,000 | $1.1M |
| Jain Global LLC | 0.01% | Reduce -13.5% | 12,850 | $1.1M |
| Glenmede Trust Co. NA | 0.01% | — | 12,755 | $1.1M |
| Hussman Strategic Advisors, Inc. | 0.27% | Reduce -40.0% | 12,600 | $1.1M |
| Susquehanna International Group, LLP | 0.00% | Reduce -81.4% | 11,762 | $1.0M |
| WINTON GROUP Ltd | 0.03% | Reduce -38.2% | 11,471 | $1.0M |
| Franklin Street Advisors Inc. | 0.06% | No change | 11,300 | $987K |
| KLP Kapitalforvaltning As | 0.00% | Add +1.9% | 10,600 | $926K |
| Cache Advisors, LLC | 0.11% | No change | 10,143 | $886K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | No change | 10,073 | $880K |
| Dymon Asia Capital (singapore) Pte. LTD. | 0.19% | New | 10,000 | $873K |
| Cerity Partners LLC | 0.00% | Add +5.0% | 9,049 | $790K |
| FORA Capital, LLC | 0.10% | Add +147.8% | 9,130 | $788K |
| Maryland State Retirement & Pension System | 0.02% | Add +2.3% | 8,603 | $751K |
| AlphaCentric Advisors LLC | 0.74% | — | 8,549 | $747K |
| Baron Capital (BAMCO) | 0.00% | New | 8,300 | $725K |
| Renaissance Technologies | 0.00% | New | 8,167 | $713K |
| Seven Fleet Capital Management LP | 0.47% | — | 8,000 | $699K |
| Persistent Asset Partners Ltd | 0.33% | Reduce -32.9% | 7,908 | $691K |
| Tudor Investment Corporation | 0.00% | New | 7,718 | $674K |
| Mariner, LLC | 0.00% | Reduce -43.8% | 7,620 | $666K |
| Horizon Investments, LLC | 0.01% | New | 7,461 | $652K |
| Teacher Retirement System of Texas | 0.00% | Reduce -39.3% | 7,350 | $642K |
| HighTower Advisors, LLC | 0.00% | Reduce -17.3% | 7,127 | $622K |
| Cambria Investment Management, L.P. | 0.04% | Reduce -36.4% | 6,960 | $608K |
| AQR Capital Management | 0.00% | Reduce -18.9% | 6,954 | $607K |
| Mutual of America Capital Management LLC | 0.01% | Add +2.5% | 6,716 | $587K |
| Fox Run Management, L.L.C. | 0.09% | Add +114.4% | 6,654 | $581K |
| Palumbo Wealth Management LLC | 0.14% | Add +20.4% | 6,340 | $554K |
| PSP Research LLC | 0.47% | — | 6,121 | $535K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 6,001 | $524K |
| Caprock Group, LLC | 0.01% | Add +3.3% | 5,991 | $523K |
| Fieldview Capital Management, LLC | 0.09% | New | 5,841 | $510K |
| Russell Investments Group, Ltd. | 0.00% | Reduce -3.4% | 5,723 | $500K |
| Aviva PLC | 0.00% | Reduce -28.0% | 5,609 | $490K |
| DekaBank Deutsche Girozentrale | 0.00% | No change | 15,800 | $489K |
| Kestra Advisory Services, LLC | 0.00% | Reduce -1.6% | 5,142 | $449K |
| Algert Global LLC | 0.01% | New | 5,090 | $445K |
| Arrowstreet Capital, Limited Partnership | 0.00% | New | 5,076 | $443K |
| Taconic Capital Advisors LP | 0.16% | New | 5,000 | $437K |
| Jefferies Financial Group Inc. | 0.00% | Reduce -99.4% | 5,000 | $437K |
| Quantinno Capital Management LP | 0.00% | Add +22.3% | 4,948 | $432K |
| Ameritas Investment Partners, Inc. | 0.01% | Reduce -2.8% | 4,725 | $413K |
| Advisors Asset Management, Inc. | 0.01% | Reduce -0.0% | 4,704 | $411K |
| Cornerstone Investment Partners, LLC | 0.02% | Add +0.0% | 4,634 | $405K |
| Xponance LLC | 0.00% | Add +1.2% | 4,588 | $401K |
| Ensign Peak Advisors, Inc | 0.00% | Reduce -59.2% | 4,486 | $392K |
| Orion Porfolio Solutions, LLC | 0.00% | Reduce -36.5% | 4,396 | $384K |
| US Bancorp \de | 0.00% | Reduce -24.9% | 4,395 | $384K |
| O'shaughnessy Asset Management, LLC | 0.00% | New | 4,369 | $382K |
| Brooklyn Investment Group | 0.02% | New | 4,331 | $381K |
| Los Angeles Capital Management LLC | 0.00% | New | 4,727 | $368K |
| Osaic Holdings, Inc. | 0.00% | Add +202.0% | 4,201 | $367K |
| Vident Advisory, LLC | 0.00% | Reduce -17.3% | 4,191 | $366K |
| New Vernon Capital Holdings II LLC | 0.17% | Reduce -42.5% | 4,137 | $361K |
| King Wealth Management Group | 0.04% | Reduce -33.3% | 4,000 | $349K |
| Allspring Global Investments Holdings, LLC | 0.00% | New | 3,985 | $347K |
| Crossmark Global Holdings, Inc. | 0.01% | Reduce -0.1% | 3,960 | $346K |
| Cibc World Markets Corp. | 0.00% | — | 3,851 | $336K |
| Bank of Montreal | 0.00% | Reduce -1.4% | 3,808 | $332K |
| Nisa Investment Advisors, LLC | 0.00% | Reduce -5.1% | 3,780 | $330K |
| Vestcor Inc | 0.01% | Reduce -25.0% | 3,765 | $329K |
| Abacus Wealth Partners, LLC | 0.03% | New | 3,763 | $329K |
| M&T Bank Corp | 0.00% | New | 3,753 | $328K |
| Velan Capital Investment Management LP | 0.19% | No change | 3,700 | $323K |
| Burney Co./ | 0.01% | Reduce -27.3% | 3,680 | $321K |
| Mackenzie Financial Corp. | 0.00% | Reduce -10.2% | 3,648 | $318K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Add +8.3% | 3,573 | $312K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Add +1.2% | 3,554 | $292K |
| Rockefeller Capital Management L.P. | 0.00% | Add +10.5% | 3,292 | $288K |
| LPL Financial LLC | 0.00% | Reduce -34.6% | 3,265 | $285K |
| Certuity, LLC | 0.02% | Reduce -28.3% | 3,251 | $284K |
| Royal Bank of Canada | 0.00% | Reduce -95.5% | 3,183 | $278K |
| AlphaGrep UK Ltd | 0.09% | — | 3,070 | $268K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +26.3% | 3,038 | $265K |
| Vise Technologies, Inc. | 0.01% | New | 2,996 | $262K |
| Lanark Financial, Inc. | 0.02% | Add +0.6% | 2,977 | $260K |
| PNC Financial Services Group, Inc. | 0.00% | Add +8.1% | 2,959 | $258K |
| Pinnacle Wealth Planning Services, Inc. | 0.03% | New | 2,864 | $250K |
| Evergreen Capital Management LLC | 0.01% | New | 2,812 | $246K |
| Virtus Investment Advisers, LLC | 0.07% | Add +38.1% | 2,790 | $244K |
| New Age Alpha Advisors, LLC | 0.01% | New | 2,784 | $243K |
| Captrust Financial Advisors | 0.00% | Reduce -17.5% | 2,732 | $239K |
| GAMMA Investing LLC | 0.01% | Add +62.1% | 2,672 | $233K |
| CIBC Asset Management Inc | 0.00% | New | 2,667 | $233K |
| Sumitomo Mitsui Trust Group, Inc. | 0.00% | New | 2,560 | $224K |
| Highland Capital Management, LLC | 0.01% | New | 2,462 | $215K |
| Swiss Life Asset Management Ltd | 0.00% | New | 2,431 | $212K |
| State of Wyoming | 0.02% | New | 2,070 | $181K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -46.1% | 2,047 | $179K |
| Smartleaf Asset Management LLC | 0.01% | Add +23.1% | 1,727 | $151K |
| AlphaQuest LLC | 0.01% | Reduce -0.1% | 1,617 | $141K |
| KBC Group NV | 0.00% | No change | 1,574 | $137K |
| Quadrant Capital Group LLC | 0.00% | Add +8.5% | 1,467 | $128K |
| Covestor Ltd | 0.07% | Add +45.1% | 1,437 | $125K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -8.3% | 1,227 | $107K |
| Truvestments Capital LLC | 0.02% | Add +60.8% | 1,161 | $101K |
| Canton Hathaway, LLC | 0.02% | New | 1,000 | $87K |
| Hantz Financial Services, Inc. | 0.00% | Add +222.4% | 951 | $83K |
| CFG Wealth Management Services, Inc. | 0.05% | — | 602 | $53K |
| Cwm, LLC | 0.00% | No change | 556 | $49K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +3.5% | 559 | $49K |
| Summit Securities Group LLC | 0.01% | New | 500 | $44K |
| Salomon & Ludwin, LLC | 0.00% | Reduce -1.4% | 436 | $37K |
| Sterling Capital Management LLC | 0.00% | Add +168.1% | 378 | $33K |
| UMB Bank, n.a. | 0.00% | Add +29.1% | 333 | $29K |
| Fifth Third Bancorp | 0.00% | Add +6.5% | 327 | $29K |
| Greenline Wealth Management LLC | 0.03% | — | 304 | $27K |
| Farther Finance Advisors, LLC | 0.00% | Add +110.6% | 297 | $26K |
| Assetmark, Inc. | 0.00% | Add +1.8% | 285 | $25K |
| Sound Income Strategies, LLC | 0.00% | New | 284 | $23K |
| Clearstead Advisors, LLC | 0.00% | Add +11.0% | 222 | $19K |
| Daiwa Securities Group Inc. | 0.00% | No change | 190 | $17K |
| Kemnay Advisory Services Inc. | 0.00% | New | 181 | $16K |
| Larson Financial Group LLC | 0.00% | Add +11.0% | 171 | $15K |
| Signaturefd, LLC | 0.00% | Add +9.4% | 163 | $14K |
| Matrix Trust Co | 0.00% | New | 143 | $12K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | No change | 119 | $10K |
| Bare Financial Services, Inc | 0.00% | Add +223.5% | 110 | $10K |
| Parallel Advisors, LLC | 0.00% | Add +6.9% | 109 | $10K |
| SageView Advisory Group, LLC | 0.00% | New | 106 | $9K |
| Danske Bank A/S | 0.00% | No change | 100 | $9K |
| MAI Capital Management | 0.00% | Add +12.8% | 97 | $8K |
| WPG Advisers, LLC | 0.01% | Add +23.1% | 96 | $8K |
| Rothschild Investment LLC | 0.00% | Add +1.2% | 86 | $8K |
| Parkside Financial Bank & Trust | 0.00% | Add +86.7% | 84 | $7K |
| Bell Investment Advisors, Inc | 0.00% | No change | 81 | $7K |
| Brown Brothers Harriman & Co. | 0.00% | No change | 81 | $7K |
| Annis Gardner Whiting Capital Advisors, LLC | 0.00% | No change | 76 | $7K |
| SBI Securities Co., Ltd. | 0.00% | New | 70 | $6K |
| Sankala Group LLC | 0.00% | — | 60 | $6K |
| Raffa Wealth Management, LLC | 0.00% | No change | 60 | $5K |
| Jones Financial Companies LLLP | 0.00% | Add +130.0% | 46 | $4K |
| Torren Management, LLC | 0.00% | — | 39 | $3K |
| Wolff Wiese Magana LLC | 0.00% | No change | 35 | $3K |
| Farmers & Merchants Investments Inc. | 0.00% | No change | 35 | $3K |
| Huntington National Bank | 0.00% | Reduce -10.3% | 35 | $3K |
| Marquette Asset Management, LLC | 0.00% | No change | 28 | $2K |
| Versant Capital Management, Inc | 0.00% | No change | 27 | $2K |
| Picton Mahoney Asset Management | 0.00% | No change | 25 | $2K |
| Elyxium Wealth, LLC | 0.00% | New | 22 | $2K |
| Physician Wealth Advisors, Inc. | 0.00% | Add +133.3% | 21 | $2K |
| ORG Partners LLC | 0.00% | New | 19 | $2K |
| Triumph Capital Management | 0.00% | New | 18 | $2K |
| CIBC Private Wealth Group LLC | 0.00% | New | 13 | $1K |
| Ankerstar Wealth, LLC | 0.00% | — | 12 | $1K |
| Arax Advisory Partners | 0.00% | Reduce -89.1% | 10 | $874 |
| Trust Co | 0.00% | New | 7 | $611 |
| Flagship Harbor Advisors, LLC | 0.00% | New | 6 | $524 |
| Gilpin Wealth Management, LLC | 0.00% | — | 5 | $437 |
| Kilter Group LLC | 0.00% | No change | 4 | $350 |
| DecisionPoint Financial, LLC | 0.00% | No change | 4 | $350 |
| Abound Wealth Management | 0.00% | No change | 4 | $350 |
| TD Capital Management LLC | 0.00% | New | 4 | $349 |
| Root Financial Partners, LLC | 0.00% | New | 3 | $262 |
| Harbour Investments, Inc. | 0.00% | New | 2 | $175 |
| Hughes Financial Services, LLC | 0.00% | New | 2 | $175 |
| Keating Financial Advisory Services, Inc. | 0.00% | — | 2 | $175 |
| Avion Wealth | 0.00% | New | 6 | $0 |
"% of holder's portfolio" is PTGX's weight in each manager's 13F, not the share of Protagonist Therapeutics Inc. the manager owns.