Rhythm PharmaceuticalsRYTM
13F holders, Q3 2025 (September 30)264holders +37
56new positions
16sold out
6famous investors
$100.99avg. 13F price*
At the end of Q3 2025, 264 institutions reported holding Rhythm Pharmaceuticals Inc. (RYTM) in their 13F filings, up 37 from Q2 2025. 56 opened new positions and 16 sold out. The largest holders were BlackRock, Inc. ($636.5M), Ra Capital Management, L.P. ($573.8M) and Baker Bros. Advisors LP ($566.0M). 6 famous investors held it, including Jim Simons / Peter Brown (0.1% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Rhythm Pharmaceuticals Inc.
- CUSIP
- 76243J105
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 56 | $209.9M |
| Exits | 16 | $23.8M |
All 13F filers, Q2 2025 → Q3 2025: 9,124,126 shares bought and 4,561,713 shares sold, net +4,562,413 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 264 holders
| BlackRock, Inc. | 0.01% | Add +0.6% | 6,302,215 | $636.5M |
| Ra Capital Management, L.P. | 7.07% | Add +2.2% | 5,681,359 | $573.8M |
| Baker Bros. Advisors LP | 4.10% | No change | 5,604,483 | $566.0M |
| Vanguard Group Inc. | 0.01% | Add +39.2% | 4,996,427 | $504.6M |
| Primecap Management Co. | 0.33% | Reduce -12.6% | 4,262,859 | $430.5M |
| NEA Management Company, LLC | 16.13% | No change | 2,909,956 | $293.9M |
| Perceptive Advisors LLC | 7.22% | Add +0.8% | 2,438,969 | $246.3M |
| FMR LLC | 0.01% | Add +9.8% | 2,145,183 | $216.6M |
| State Street Corp. | 0.01% | Add +6.3% | 2,028,651 | $204.9M |
| Goldman Sachs Group Inc. | 0.03% | Add +9.2% | 1,893,663 | $191.2M |
| Federated Hermes, Inc. | 0.31% | Add +2.5% | 1,727,885 | $174.5M |
| T. Rowe Price Associates Inc. | 0.02% | Add +4.4% | 1,399,897 | $141.4M |
| Driehaus Capital Management LLC | 1.00% | Add +9.0% | 1,383,775 | $139.7M |
| Geode Capital Management, LLC | 0.01% | Add +3.9% | 1,362,829 | $137.7M |
| Polar Capital Holdings Plc | 0.61% | Reduce -0.5% | 1,244,932 | $125.7M |
| JPMorgan Chase & Co. | 0.01% | Add +51.6% | 1,188,069 | $120.0M |
| Janus Henderson Group PLC | 0.05% | Reduce -17.8% | 1,160,887 | $117.2M |
| Westfield Capital Management Co. LP | 0.45% | Reduce -34.4% | 1,069,004 | $108.0M |
| Alkeon Capital Management LLC | 0.46% | No change | 1,017,700 | $102.8M |
| Alliancebernstein L.P. | 0.03% | Add +1493.8% | 979,682 | $98.9M |
| Checkpoint Capital L.P. | 25.84% | Reduce -27.9% | 763,707 | $77.1M |
| Rock Springs Capital Management LP | 4.25% | Reduce -16.7% | 717,102 | $72.4M |
| Pictet Asset Management Holding SA | 0.07% | Add +64.1% | 683,017 | $69.0M |
| Capital Research Global Investors | 0.01% | New | 598,247 | $60.4M |
| Woodline Partners LP | 0.28% | Add +12.8% | 580,183 | $58.6M |
| Lord, Abbett & Co. LLC | 0.18% | Add +182.0% | 575,984 | $58.2M |
| Franklin Resources Inc. | 0.01% | Add +4.4% | 567,782 | $57.3M |
| Renaissance Technologies | 0.07% | Add +73.6% | 546,593 | $55.2M |
| Adage Capital Partners Gp, L.L.C. | 0.09% | Add +59.5% | 544,000 | $54.9M |
| Charles Schwab Investment Management Inc. | 0.01% | Add +14.4% | 527,922 | $53.3M |
| Loomis Sayles & Co. L P | 0.06% | Reduce -10.8% | 527,439 | $53.3M |
| Northern Trust Corp. | 0.01% | Add +0.1% | 510,906 | $51.6M |
| Siren, L.L.C. | 1.98% | Add +22.0% | 499,975 | $50.5M |
| Clearbridge Investments, LLC | 0.04% | Add +55.1% | 484,732 | $49.0M |
| Morgan Stanley | 0.00% | Reduce -11.3% | 465,190 | $47.0M |
| Opaleye Management Inc. | 6.64% | Reduce -2.8% | 461,700 | $46.6M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.01% | Add +92.2% | 437,472 | $44.2M |
| UBS Group AG | 0.01% | Add +66.4% | 420,336 | $42.4M |
| Jennison Associates LLC | 0.02% | New | 411,550 | $41.6M |
| Silverarc Capital Management, LLC | 5.41% | Reduce -7.7% | 369,996 | $37.4M |
| Voloridge Investment Management, LLC | 0.12% | Add +8.7% | 368,263 | $37.2M |
| Balyasny Asset Management L.P. | 0.07% | Add +547.1% | 350,008 | $35.3M |
| Sofinnova Investments, Inc. | 1.53% | Reduce -57.9% | 246,966 | $24.9M |
| Qube Research & Technologies Ltd | 0.03% | Reduce -0.6% | 238,819 | $24.1M |
| Artisan Partners Limited Partnership | 0.03% | Add +35.7% | 236,841 | $23.9M |
| Hood River Capital Management LLC | 0.28% | Reduce -56.6% | 235,836 | $23.8M |
| Bank of America Corp. | 0.00% | Add +5.0% | 233,150 | $23.5M |
| Assenagon Asset Management S.A. | 0.03% | Reduce -5.8% | 224,128 | $22.6M |
| BNP Paribas Financial Markets | 0.02% | Add +118.8% | 223,681 | $22.6M |
| Candriam S.C.A. | 0.12% | Reduce -29.0% | 221,863 | $22.4M |
| Voya Investment Management LLC | 0.03% | Reduce -9.2% | 221,593 | $22.4M |
| Integral Health Asset Management, LLC | 1.62% | Add +83.3% | 220,000 | $22.2M |
| Orbimed Advisors LLC | 0.52% | Reduce -13.4% | 215,152 | $21.7M |
| Comerica Bank | 0.08% | Reduce -30.6% | 209,325 | $21.1M |
| Logos Global Management LP | 2.00% | Add +53.9% | 200,000 | $20.2M |
| Bank of New York Mellon Corp | 0.00% | Reduce -0.9% | 182,365 | $18.4M |
| First Light Asset Management, LLC | 1.72% | New | 180,484 | $18.2M |
| Marshall Wace, LLP | 0.02% | Reduce -54.3% | 171,834 | $17.4M |
| Russell Investments Group, Ltd. | 0.02% | Add +20.4% | 157,678 | $15.9M |
| Invesco Ltd. | 0.00% | Add +108.3% | 143,555 | $14.5M |
| Barclays PLC | 0.01% | Reduce -59.5% | 142,385 | $14.4M |
| Algert Global LLC | 0.24% | Add +133.0% | 140,284 | $14.2M |
| Ameriprise Financial Inc. | 0.00% | Reduce -20.3% | 137,967 | $13.9M |
| Millennium Management | 0.01% | Reduce -32.8% | 133,161 | $13.4M |
| Citadel Advisors | 0.01% | New | 132,626 | $13.4M |
| Man Group plc | 0.03% | New | 129,330 | $13.1M |
| Royal Bank of Canada | 0.00% | Reduce -35.9% | 125,786 | $12.7M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.04% | Add +5.3% | 121,260 | $12.2M |
| Nuveen, LLC | 0.00% | Reduce -3.2% | 117,964 | $11.9M |
| Deutsche Bank AG | 0.00% | Add +217.4% | 116,742 | $11.8M |
| Ensign Peak Advisors, Inc | 0.02% | Add +531.7% | 111,544 | $11.3M |
| Swiss National Bank | 0.01% | Add +12.9% | 102,300 | $10.3M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.02% | Add +6.1% | 101,372 | $10.2M |
| Stempoint Capital LP | 1.86% | Reduce -48.3% | 91,444 | $9.2M |
| PDT Partners, LLC | 0.55% | Reduce -11.8% | 86,136 | $8.7M |
| Neuberger Berman Group LLC | 0.01% | Reduce -1.2% | 85,117 | $8.6M |
| Axiom Investors LLC | 0.06% | Add +58.3% | 83,031 | $8.4M |
| Rhumbline Advisers | 0.01% | Reduce -6.2% | 82,068 | $8.3M |
| First Trust Advisors LP | 0.01% | Add +9.8% | 80,903 | $8.2M |
| AQR Capital Management | 0.01% | Add +62.7% | 79,780 | $8.1M |
| New York State Common Retirement Fund | 0.01% | Add +28.2% | 75,131 | $7.6M |
| Prudential Financial Inc. | 0.01% | Add +929.0% | 73,010 | $7.4M |
| Panagora Asset Management Inc. | 0.03% | Reduce -45.9% | 64,614 | $6.5M |
| Manufacturers Life Insurance Company, The | 0.01% | Reduce -10.6% | 60,917 | $6.2M |
| TD Asset Management Inc | 0.00% | Add +6.4% | 59,564 | $6.0M |
| Informed Momentum Co LLC | 0.67% | New | 58,480 | $5.8M |
| Legal & General Group Plc | 0.00% | Add +8.9% | 57,376 | $5.8M |
| Rafferty Asset Management, LLC | 0.02% | Add +8.0% | 55,734 | $5.6M |
| Walleye Capital LLC | 0.05% | New | 50,181 | $5.1M |
| Granahan Investment Management, LLC | 0.21% | Add +20.8% | 49,728 | $5.0M |
| ADAR1 Capital Management, LLC | 0.50% | Add +9.2% | 49,571 | $5.0M |
| Nan Fung Group Holdings Ltd | 8.32% | No change | 49,120 | $5.0M |
| California State Teachers Retirement System | 0.01% | Add +14.0% | 48,934 | $4.9M |
| PFM Health Sciences, LP | 0.42% | New | 48,162 | $4.9M |
| Harvest Investment Services, LLC | 0.98% | Add +211.3% | 48,140 | $4.9M |
| WCM Investment Management, LLC | 0.01% | New | 47,733 | $4.8M |
| Wells Fargo & Company | 0.00% | Add +11.3% | 47,134 | $4.8M |
| Hennion & Walsh Asset Management, Inc. | 0.16% | Reduce -12.4% | 44,731 | $4.5M |
| Raymond James Financial Inc. | 0.00% | Add +318.1% | 44,093 | $4.5M |
| Victory Capital Management Inc. | 0.00% | Add +164.0% | 42,883 | $4.3M |
"% of holder's portfolio" is RYTM's weight in each manager's 13F, not the share of Rhythm Pharmaceuticals Inc. the manager owns.