Rhythm PharmaceuticalsRYTM

13F holders, Q3 2025 (September 30)
264holders +37
56new positions
16sold out
6famous investors
$100.99avg. 13F price*

At the end of Q3 2025, 264 institutions reported holding Rhythm Pharmaceuticals Inc. (RYTM) in their 13F filings, up 37 from Q2 2025. 56 opened new positions and 16 sold out. The largest holders were BlackRock, Inc. ($636.5M), Ra Capital Management, L.P. ($573.8M) and Baker Bros. Advisors LP ($566.0M). 6 famous investors held it, including Jim Simons / Peter Brown (0.1% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).

Company
Rhythm Pharmaceuticals Inc.
CUSIP
76243J105
Latest filing quarter
Q2 2026

History

Number of 13F holders

0100200300400 Q1 2024: 167Q1 2024Q2 2024: 165Q2 2024Q3 2024: 176Q3 2024Q4 2024: 203Q4 2024Q1 2025: 228Q1 2025Q2 2025: 227Q2 2025Q3 2025: 264Q3 2025Q4 2025: 281Q4 2025Q1 2026: 285Q1 2026Q2 2026: 304Q2 2026

Total Exit/New Position Q2 2025 → Q3 2025

InstitutionsTotal Value
New Positions56$209.9M
Exits16$23.8M

All 13F filers, Q2 2025 → Q3 2025: 9,124,126 shares bought and 4,561,713 shares sold, net +4,562,413 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.

Ownership 264 holders

BlackRock, Inc. 0.01% Add +0.6% 6,302,215 $636.5M
Ra Capital Management, L.P. 7.07% Add +2.2% 5,681,359 $573.8M
Baker Bros. Advisors LP 4.10% No change 5,604,483 $566.0M
Vanguard Group Inc. 0.01% Add +39.2% 4,996,427 $504.6M
Primecap Management Co. 0.33% Reduce -12.6% 4,262,859 $430.5M
NEA Management Company, LLC 16.13% No change 2,909,956 $293.9M
Perceptive Advisors LLC 7.22% Add +0.8% 2,438,969 $246.3M
FMR LLC 0.01% Add +9.8% 2,145,183 $216.6M
State Street Corp. 0.01% Add +6.3% 2,028,651 $204.9M
Goldman Sachs Group Inc. 0.03% Add +9.2% 1,893,663 $191.2M
Federated Hermes, Inc. 0.31% Add +2.5% 1,727,885 $174.5M
T. Rowe Price Associates Inc. 0.02% Add +4.4% 1,399,897 $141.4M
Driehaus Capital Management LLC 1.00% Add +9.0% 1,383,775 $139.7M
Geode Capital Management, LLC 0.01% Add +3.9% 1,362,829 $137.7M
Polar Capital Holdings Plc 0.61% Reduce -0.5% 1,244,932 $125.7M
JPMorgan Chase & Co. 0.01% Add +51.6% 1,188,069 $120.0M
Janus Henderson Group PLC 0.05% Reduce -17.8% 1,160,887 $117.2M
Westfield Capital Management Co. LP 0.45% Reduce -34.4% 1,069,004 $108.0M
Alkeon Capital Management LLC 0.46% No change 1,017,700 $102.8M
Alliancebernstein L.P. 0.03% Add +1493.8% 979,682 $98.9M
Checkpoint Capital L.P. 25.84% Reduce -27.9% 763,707 $77.1M
Rock Springs Capital Management LP 4.25% Reduce -16.7% 717,102 $72.4M
Pictet Asset Management Holding SA 0.07% Add +64.1% 683,017 $69.0M
Capital Research Global Investors 0.01% New 598,247 $60.4M
Woodline Partners LP 0.28% Add +12.8% 580,183 $58.6M
Lord, Abbett & Co. LLC 0.18% Add +182.0% 575,984 $58.2M
Franklin Resources Inc. 0.01% Add +4.4% 567,782 $57.3M
Renaissance Technologies 0.07% Add +73.6% 546,593 $55.2M
Adage Capital Partners Gp, L.L.C. 0.09% Add +59.5% 544,000 $54.9M
Charles Schwab Investment Management Inc. 0.01% Add +14.4% 527,922 $53.3M
Loomis Sayles & Co. L P 0.06% Reduce -10.8% 527,439 $53.3M
Northern Trust Corp. 0.01% Add +0.1% 510,906 $51.6M
Siren, L.L.C. 1.98% Add +22.0% 499,975 $50.5M
Clearbridge Investments, LLC 0.04% Add +55.1% 484,732 $49.0M
Morgan Stanley 0.00% Reduce -11.3% 465,190 $47.0M
Opaleye Management Inc. 6.64% Reduce -2.8% 461,700 $46.6M
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% Add +92.2% 437,472 $44.2M
UBS Group AG 0.01% Add +66.4% 420,336 $42.4M
Jennison Associates LLC 0.02% New 411,550 $41.6M
Silverarc Capital Management, LLC 5.41% Reduce -7.7% 369,996 $37.4M
Voloridge Investment Management, LLC 0.12% Add +8.7% 368,263 $37.2M
Balyasny Asset Management L.P. 0.07% Add +547.1% 350,008 $35.3M
Sofinnova Investments, Inc. 1.53% Reduce -57.9% 246,966 $24.9M
Qube Research & Technologies Ltd 0.03% Reduce -0.6% 238,819 $24.1M
Artisan Partners Limited Partnership 0.03% Add +35.7% 236,841 $23.9M
Hood River Capital Management LLC 0.28% Reduce -56.6% 235,836 $23.8M
Bank of America Corp. 0.00% Add +5.0% 233,150 $23.5M
Assenagon Asset Management S.A. 0.03% Reduce -5.8% 224,128 $22.6M
BNP Paribas Financial Markets 0.02% Add +118.8% 223,681 $22.6M
Candriam S.C.A. 0.12% Reduce -29.0% 221,863 $22.4M
Voya Investment Management LLC 0.03% Reduce -9.2% 221,593 $22.4M
Integral Health Asset Management, LLC 1.62% Add +83.3% 220,000 $22.2M
Orbimed Advisors LLC 0.52% Reduce -13.4% 215,152 $21.7M
Comerica Bank 0.08% Reduce -30.6% 209,325 $21.1M
Logos Global Management LP 2.00% Add +53.9% 200,000 $20.2M
Bank of New York Mellon Corp 0.00% Reduce -0.9% 182,365 $18.4M
First Light Asset Management, LLC 1.72% New 180,484 $18.2M
Marshall Wace, LLP 0.02% Reduce -54.3% 171,834 $17.4M
Russell Investments Group, Ltd. 0.02% Add +20.4% 157,678 $15.9M
Invesco Ltd. 0.00% Add +108.3% 143,555 $14.5M
Barclays PLC 0.01% Reduce -59.5% 142,385 $14.4M
Algert Global LLC 0.24% Add +133.0% 140,284 $14.2M
Ameriprise Financial Inc. 0.00% Reduce -20.3% 137,967 $13.9M
Millennium Management 0.01% Reduce -32.8% 133,161 $13.4M
Citadel Advisors 0.01% New 132,626 $13.4M
Man Group plc 0.03% New 129,330 $13.1M
Royal Bank of Canada 0.00% Reduce -35.9% 125,786 $12.7M
Connor, Clark & Lunn Investment Management Ltd. 0.04% Add +5.3% 121,260 $12.2M
Nuveen, LLC 0.00% Reduce -3.2% 117,964 $11.9M
Deutsche Bank AG 0.00% Add +217.4% 116,742 $11.8M
Ensign Peak Advisors, Inc 0.02% Add +531.7% 111,544 $11.3M
Swiss National Bank 0.01% Add +12.9% 102,300 $10.3M
Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% Add +6.1% 101,372 $10.2M
Stempoint Capital LP 1.86% Reduce -48.3% 91,444 $9.2M
PDT Partners, LLC 0.55% Reduce -11.8% 86,136 $8.7M
Neuberger Berman Group LLC 0.01% Reduce -1.2% 85,117 $8.6M
Axiom Investors LLC 0.06% Add +58.3% 83,031 $8.4M
Rhumbline Advisers 0.01% Reduce -6.2% 82,068 $8.3M
First Trust Advisors LP 0.01% Add +9.8% 80,903 $8.2M
AQR Capital Management 0.01% Add +62.7% 79,780 $8.1M
New York State Common Retirement Fund 0.01% Add +28.2% 75,131 $7.6M
Prudential Financial Inc. 0.01% Add +929.0% 73,010 $7.4M
Panagora Asset Management Inc. 0.03% Reduce -45.9% 64,614 $6.5M
Manufacturers Life Insurance Company, The 0.01% Reduce -10.6% 60,917 $6.2M
TD Asset Management Inc 0.00% Add +6.4% 59,564 $6.0M
Informed Momentum Co LLC 0.67% New 58,480 $5.8M
Legal & General Group Plc 0.00% Add +8.9% 57,376 $5.8M
Rafferty Asset Management, LLC 0.02% Add +8.0% 55,734 $5.6M
Walleye Capital LLC 0.05% New 50,181 $5.1M
Granahan Investment Management, LLC 0.21% Add +20.8% 49,728 $5.0M
ADAR1 Capital Management, LLC 0.50% Add +9.2% 49,571 $5.0M
Nan Fung Group Holdings Ltd 8.32% No change 49,120 $5.0M
California State Teachers Retirement System 0.01% Add +14.0% 48,934 $4.9M
PFM Health Sciences, LP 0.42% New 48,162 $4.9M
Harvest Investment Services, LLC 0.98% Add +211.3% 48,140 $4.9M
WCM Investment Management, LLC 0.01% New 47,733 $4.8M
Wells Fargo & Company 0.00% Add +11.3% 47,134 $4.8M
Hennion & Walsh Asset Management, Inc. 0.16% Reduce -12.4% 44,731 $4.5M
Raymond James Financial Inc. 0.00% Add +318.1% 44,093 $4.5M
Victory Capital Management Inc. 0.00% Add +164.0% 42,883 $4.3M
Hillsdale Investment Management Inc. 0.13% New 42,600 $4.3M
Castleark Management LLC 0.12% New 42,539 $4.3M
Aquatic Capital Management LLC 0.08% Add +974.9% 42,490 $4.3M
State of Wisconsin Investment Board 0.01% Add +14.2% 40,776 $4.1M
Kennedy Capital Management LLC 0.09% Reduce -30.8% 39,575 $4.0M
HighVista Strategies LLC 0.93% Add +33.5% 37,482 $3.8M
Harbor Capital Advisors, Inc. 0.29% Reduce -57.0% 37,205 $3.8M
Trexquant Investment LP 0.04% Add +424.6% 37,161 $3.8M
Canada Pension Plan Investment Board 0.00% New 37,000 $3.7M
Cinctive Capital Management LP 0.18% Reduce -50.4% 35,156 $3.6M
Jain Global LLC 0.05% Add +798.4% 35,110 $3.5M
Rhenman & Partners Asset Management AB 0.39% New 35,000 $3.5M
Silvercrest Asset Management Group LLC 0.02% Reduce -30.1% 34,084 $3.4M
Alps Advisors Inc. 0.02% Reduce -3.5% 33,000 $3.3M
Sei Investments Co. 0.00% Reduce -4.5% 31,658 $3.2M
Penserra Capital Management LLC 0.04% New 30,436 $3.1M
MetLife Investment Management, LLC 0.01% Reduce -6.3% 30,362 $3.1M
Samsara Biocapital, LLC 0.40% Reduce -40.0% 30,285 $3.1M
Lazard Asset Management LLC 0.00% Reduce -69.6% 30,239 $3.1M
Dark Forest Capital Management LP 0.11% Reduce -17.8% 28,639 $2.9M
Dimensional Fund Advisors LP 0.00% New 28,378 $2.9M
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% Reduce -16.2% 27,122 $2.7M
Voleon Capital Management LP 0.07% New 26,897 $2.7M
Aberdeen Group plc 0.00% Reduce -60.5% 26,740 $2.7M
Creative Planning 0.00% Add +44.8% 24,945 $2.5M
Wellington Management Group LLP 0.00% Add +9.2% 24,477 $2.5M
Intech Investment Management LLC 0.02% Reduce -11.4% 24,312 $2.5M
Wedge Capital Management L L P 0.04% Reduce -25.8% 22,244 $2.2M
State of New Jersey Common Pension Fund D 0.01% Reduce -31.1% 20,919 $2.1M
EFG Asset Management (North America) Corp. 0.26% New 20,269 $2.0M
Burkehill Global Management, LP 0.12% New 20,000 $2.0M
SG Americas Securities, LLC 0.01% Add +216.2% 19,554 $2.0M
Captrust Financial Advisors 0.00% Add +4.5% 18,258 $1.8M
Schroder Investment Management Group 0.00% Add +2.4% 18,042 $1.8M
Quantedge Capital Pte Ltd 0.98% New 17,800 $1.8M
Los Angeles Capital Management LLC 0.01% Add +331.8% 16,721 $1.7M
Arizona State Retirement System 0.01% Add +12.9% 15,614 $1.6M
Handelsbanken Fonder AB 0.01% No change 15,521 $1.6M
STRS Ohio 0.01% Reduce -14.9% 14,800 $1.5M
State Board of Administration of Florida Retirement System 0.00% Reduce -0.1% 14,650 $1.5M
Police & Firemen's Retirement System of New Jersey 0.01% Add +18.2% 14,606 $1.5M
Stifel Financial Corp. 0.00% Reduce -20.5% 14,455 $1.5M
CANADA LIFE ASSURANCE Co 0.00% Add +24.3% 14,395 $1.4M
Advisors Asset Management, Inc. 0.02% Add +4.3% 14,178 $1.4M
Engineers Gate Manager LP 0.02% Reduce -22.1% 13,775 $1.4M
Nisa Investment Advisors, LLC 0.01% Add +956.9% 13,254 $1.3M
Citigroup Inc. 0.00% Reduce -61.9% 13,080 $1.3M
Teacher Retirement System of Texas 0.01% Add +1.5% 12,960 $1.3M
Principal Financial Group Inc. 0.00% Reduce -3.6% 12,598 $1.3M
Profund Advisors LLC 0.04% Add +10.7% 12,457 $1.3M
Fred Alger Management, LLC 0.00% New 12,335 $1.2M
Allianz Asset Management GmbH 0.00% No change 12,100 $1.2M
SummitTX Capital, L.P. 0.05% Reduce -53.4% 11,869 $1.2M
China Universal Asset Management Co., Ltd. 0.10% Reduce -8.9% 11,642 $1.2M
ProShare Advisors LLC 0.00% Reduce -16.5% 11,299 $1.1M
KLP Kapitalforvaltning As 0.00% Add +7.8% 11,000 $1.1M
Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% Add +11.1% 10,726 $1.1M
Cannon Financial Strategists, Inc. 0.14% No change 10,000 $1.0M
Toth Financial Advisory Corp. 0.11% No change 10,000 $1.0M
Fiduciary Trust Co 0.01% No change 10,000 $1.0M
Bellevue Group AG 0.02% Reduce -56.7% 9,053 $914K
Rockefeller Capital Management L.P. 0.00% New 8,868 $896K
Entropy Technologies, LP 0.06% New 8,502 $859K
Readystate Asset Management LP 0.08% Reduce -66.1% 8,365 $845K
Aigen Investment Management, LP 0.13% Add +95.2% 8,225 $831K
E. Ohman J:or Asset Management AB 0.02% No change 8,213 $829K
Leo Wealth, LLC 0.10% Reduce -41.5% 7,867 $794K
Inceptionr LLC 0.18% New 7,482 $756K
Virtus Investment Advisers, LLC 0.20% No change 7,052 $712K
VIRGINIA RETIREMENT SYSTEMS ET Al 0.00% New 6,700 $677K
Exchange Traded Concepts, LLC 0.01% New 6,386 $645K
Arrowstreet Capital, Limited Partnership 0.00% New 6,307 $637K
Jasper Ridge Partners, L.P. 0.01% No change 5,639 $569K
CIBC Bancorp USA Inc. 0.00% — 5,569 $562K
Oxford Asset Management LLP 0.18% New 5,538 $559K
DNB Asset Management AS 0.00% New 5,528 $558K
Public Employees Retirement Association of Colorado 0.00% No change 5,463 $552K
Quantbot Technologies LP 0.01% New 4,981 $503K
Gotham Asset Management 0.00% Add +0.1% 4,855 $490K
O'shaughnessy Asset Management, LLC 0.00% Add +39.1% 4,836 $488K
Mackenzie Financial Corp. 0.00% Reduce -0.3% 4,398 $444K
Ameritas Investment Partners, Inc. 0.01% Reduce -21.3% 4,365 $441K
PNC Financial Services Group, Inc. 0.00% Reduce -23.9% 4,217 $426K
Xponance LLC 0.00% Reduce -2.6% 4,162 $420K
LPL Financial LLC 0.00% Reduce -17.0% 3,990 $403K
Gsa Capital Partners LLP 0.03% Reduce -36.1% 3,897 $394K
Freestone Capital Holdings, LLC 0.01% No change 3,700 $374K
FORA Capital, LLC 0.06% New 3,599 $363K
Mariner, LLC 0.00% Reduce -16.8% 3,597 $363K
D. E. Shaw & Co. 0.00% Reduce -85.2% 3,585 $362K
Avior Wealth Management, LLC 0.01% Reduce -37.2% 3,541 $358K
Capstone Investment Advisors, LLC 0.00% New 3,497 $353K
Two Sigma Advisers, LP 0.00% Reduce -66.0% 3,300 $333K
JGP Global Gestao de Recursos Ltda. 0.19% Reduce -14.9% 3,253 $329K
Susquehanna International Group, LLP 0.00% Reduce -96.0% 3,104 $313K
Cim Investment Management Inc. 0.08% New 2,993 $302K
Jane Street Group, LLC 0.00% New 2,968 $300K
Cerity Partners LLC 0.00% New 2,964 $299K
Cwm, LLC 0.00% Reduce -6.4% 2,892 $292K
Chicago Partners Investment Group LLC 0.01% Reduce -21.2% 2,455 $279K
B. Riley Wealth Advisors, Inc. 0.01% New 2,675 $270K
Tidal Investments LLC 0.00% New 2,664 $269K
Mirae Asset Global Investments Co., Ltd. 0.00% Add +4.5% 2,568 $259K
Quantinno Capital Management LP 0.00% New 2,558 $258K
Fox Run Management, L.L.C. 0.04% New 2,517 $254K
Integrated Wealth Concepts LLC 0.00% New 2,491 $252K
Swiss Life Asset Management Ltd 0.00% New 2,461 $249K
Centaurus Financial, Inc. 0.01% New 2,389 $241K
Guggenheim Capital LLC 0.00% New 2,285 $231K
Empowered Funds, LLC 0.00% New 2,145 $217K
American Century Companies Inc. 0.00% New 2,077 $210K
Vanguard Personalized Indexing Management, LLC 0.00% New 2,068 $209K
EntryPoint Capital, LLC 0.08% New 1,993 $201K
RWC Asset Management LLP 0.01% New 1,988 $201K
Elevation Wealth Partners, LLC 0.07% No change 1,971 $199K
MAI Capital Management 0.00% New 1,857 $188K
Whittier Trust Co. 0.00% Add +2.9% 1,811 $179K
Tower Research Capital LLC (TRC) 0.00% Reduce -71.3% 1,753 $177K
KBC Group NV 0.00% No change 1,707 $172K
Amalgamated Bank 0.00% Reduce -10.0% 1,693 $171K
GF Fund Management Co. LTD. 0.00% Reduce -9.2% 1,429 $144K
AlphaQuest LLC 0.01% Reduce -5.4% 1,391 $140K
Bayforest Capital Ltd 0.06% Add +909.5% 1,171 $118K
Osaic Holdings, Inc. 0.00% Add +0.1% 980 $100K
State of Wyoming 0.01% Reduce -10.4% 954 $96K
Arax Advisory Partners 0.00% Add +40.0% 781 $79K
Bank of Montreal 0.00% New 715 $72K
BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.00% Add +18.1% 497 $50K
Global Retirement Partners, LLC 0.00% No change 400 $40K
Clearstead Advisors, LLC 0.00% Reduce -32.4% 399 $40K
Optiver Holding B.V. 0.00% Add +65.2% 365 $37K
Farther Finance Advisors, LLC 0.00% Add +1110.3% 351 $35K
Smartleaf Asset Management LLC 0.00% Add +97.2% 286 $29K
GAMMA Investing LLC 0.00% Add +15.2% 243 $25K
Signaturefd, LLC 0.00% Add +3.6% 232 $23K
Jones Financial Companies LLLP 0.00% Add +1.3% 234 $23K
Daiwa Securities Group Inc. 0.00% Reduce -7.0% 213 $22K
Essential Partners LLC 0.01% Add +65.0% 198 $20K
SBI Securities Co., Ltd. 0.00% Add +17.9% 198 $20K
True Wealth Design, LLC 0.00% No change 147 $15K
US Bancorp \de 0.00% No change 146 $15K
Covestor Ltd 0.01% Add +2600.0% 135 $14K
Truvestments Capital LLC 0.00% No change 138 $14K
Allworth Financial LP 0.00% Add +104.7% 131 $13K
Sterling Capital Management LLC 0.00% Reduce -3.8% 127 $13K
AdvisorNet Financial, Inc 0.00% New 105 $11K
Rothschild Investment LLC 0.00% Reduce -19.1% 85 $9K
Bessemer Group Inc. 0.00% No change 66 $7K
EverSource Wealth Advisors, LLC 0.00% Add +1.5% 66 $7K
WPG Advisers, LLC 0.00% No change 57 $6K
Quadrant Capital Group LLC 0.00% New 42 $4K
Aster Capital Management (DIFC) Ltd 0.00% New 40 $4K
Versant Capital Management, Inc 0.00% No change 36 $4K
Parkside Financial Bank & Trust 0.00% No change 33 $3K
ORG Partners LLC 0.00% Add +33.3% 32 $3K
Larson Financial Group LLC 0.00% New 28 $3K
Parallel Advisors, LLC 0.00% Add +31.6% 25 $3K
J.Safra Asset Management Corp 0.00% New 20 $2K
Advisory Services Network, LLC 0.00% New 19 $2K
IFP Advisors, Inc 0.00% Add +26.7% 19 $2K
Bare Financial Services, Inc 0.00% Add +80.0% 18 $2K
Physician Wealth Advisors, Inc. 0.00% No change 16 $2K
CVA Family Office, LLC 0.00% No change 12 $1K
Wealthspire Advisors, LLC 0.00% New 1 $101

"% of holder's portfolio" is RYTM's weight in each manager's 13F, not the share of Rhythm Pharmaceuticals Inc. the manager owns.