Rhythm PharmaceuticalsRYTM
13F holders, Q4 2025 (December 31)281holders +17
48new positions
39sold out
7famous investors
$107.05avg. 13F price*
At the end of Q4 2025, 281 institutions reported holding Rhythm Pharmaceuticals Inc. (RYTM) in their 13F filings, up 17 from Q3 2025. 48 opened new positions and 39 sold out. The largest holders were Ra Capital Management, L.P. ($713.6M), BlackRock, Inc. ($674.1M) and Vanguard Group Inc. ($664.8M). 7 famous investors held it, including Steve Cohen (0.1% of Point72 Asset Management's portfolio), Jim Simons / Peter Brown (0.1% of Renaissance Technologies's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Rhythm Pharmaceuticals Inc.
- CUSIP
- 76243J105
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 48 | $127.7M |
| Exits | 39 | $195.0M |
All 13F filers, Q3 2025 → Q4 2025: 7,739,927 shares bought and 5,908,810 shares sold, net +1,831,117 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 281 holders
| Ra Capital Management, L.P. | 7.32% | Add +17.4% | 6,666,837 | $713.6M |
| BlackRock, Inc. | 0.01% | Reduce -0.1% | 6,297,334 | $674.1M |
| Vanguard Group Inc. | 0.01% | Add +24.3% | 6,210,916 | $664.8M |
| Baker Bros. Advisors LP | 3.53% | No change | 5,604,483 | $599.9M |
| Primecap Management Co. | 0.28% | Reduce -18.4% | 3,478,669 | $372.4M |
| NEA Management Company, LLC | 15.88% | No change | 2,909,956 | $311.5M |
| Perceptive Advisors LLC | 5.01% | Add +4.4% | 2,546,391 | $272.6M |
| State Street Corp. | 0.01% | Add +8.4% | 2,198,615 | $235.3M |
| Goldman Sachs Group Inc. | 0.03% | Reduce -3.3% | 1,830,866 | $196.0M |
| FMR LLC | 0.01% | Reduce -20.5% | 1,706,317 | $182.6M |
| Federated Hermes, Inc. | 0.29% | Reduce -6.0% | 1,623,841 | $173.8M |
| T. Rowe Price Associates Inc. | 0.02% | Add +11.5% | 1,560,847 | $167.1M |
| JPMorgan Chase & Co. | 0.01% | Add +19.9% | 1,423,989 | $152.4M |
| Geode Capital Management, LLC | 0.01% | Add +0.9% | 1,375,729 | $147.3M |
| Driehaus Capital Management LLC | 0.93% | Reduce -7.1% | 1,285,222 | $137.6M |
| Westfield Capital Management Co. LP | 0.56% | Add +18.5% | 1,267,158 | $135.6M |
| Polar Capital Holdings Plc | 0.58% | Reduce -4.8% | 1,185,392 | $126.9M |
| Janus Henderson Group PLC | 0.05% | Reduce -3.0% | 1,126,125 | $120.6M |
| Checkpoint Capital L.P. | 33.65% | Add +29.9% | 992,200 | $106.2M |
| Capital Research Global Investors | 0.02% | Add +64.7% | 985,086 | $105.4M |
| Alliancebernstein L.P. | 0.03% | Reduce -5.0% | 930,233 | $99.6M |
| Jennison Associates LLC | 0.06% | Add +123.2% | 918,567 | $98.3M |
| Franklin Resources Inc. | 0.02% | Add +22.5% | 695,735 | $74.5M |
| Rock Springs Capital Management LP | 3.83% | Reduce -3.1% | 695,010 | $74.4M |
| Woodline Partners LP | 0.29% | Add +18.7% | 688,779 | $73.7M |
| Morgan Stanley | 0.00% | Add +40.0% | 651,402 | $69.7M |
| Adage Capital Partners Gp, L.L.C. | 0.10% | Add +14.3% | 621,585 | $66.5M |
| Lord, Abbett & Co. LLC | 0.21% | Add +7.6% | 619,542 | $66.3M |
| Pictet Asset Management Holding SA | 0.06% | Reduce -10.0% | 614,663 | $66.2M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.01% | Add +25.5% | 549,020 | $58.8M |
| Charles Schwab Investment Management Inc. | 0.01% | Add +0.9% | 532,447 | $57.0M |
| Clearbridge Investments, LLC | 0.04% | Add +4.4% | 506,109 | $54.2M |
| Loomis Sayles & Co. L P | 0.07% | Reduce -4.5% | 503,901 | $53.9M |
| Siren, L.L.C. | 1.60% | No change | 499,975 | $53.5M |
| Northern Trust Corp. | 0.01% | Reduce -4.4% | 488,216 | $52.3M |
| Integral Health Asset Management, LLC | 2.58% | Add +115.9% | 475,000 | $50.8M |
| Point72 Asset Management | 0.08% | New | 429,420 | $46.0M |
| UBS Group AG | 0.01% | Add +1.6% | 427,236 | $45.7M |
| Renaissance Technologies | 0.06% | Reduce -37.6% | 341,193 | $36.5M |
| Opaleye Management Inc. | 4.66% | Reduce -28.5% | 330,000 | $35.3M |
| Qube Research & Technologies Ltd | 0.05% | Add +30.2% | 310,919 | $33.3M |
| Bank of New York Mellon Corp | 0.01% | Add +65.1% | 301,080 | $32.2M |
| First Light Asset Management, LLC | 2.42% | Add +63.9% | 295,844 | $31.7M |
| Invesco Ltd. | 0.00% | Add +102.8% | 291,150 | $31.2M |
| Candriam S.C.A. | 0.15% | Add +29.8% | 287,907 | $30.8M |
| Sofinnova Investments, Inc. | 1.25% | Add +9.9% | 271,394 | $29.1M |
| Artisan Partners Limited Partnership | 0.04% | Add +11.3% | 263,591 | $28.2M |
| Ameriprise Financial Inc. | 0.01% | Add +89.3% | 261,160 | $28.0M |
| Wellington Management Group LLP | 0.00% | Add +922.0% | 250,156 | $26.8M |
| Voya Investment Management LLC | 0.03% | Add +12.8% | 249,874 | $26.7M |
| Orbimed Advisors LLC | 0.53% | Add +11.5% | 239,800 | $25.7M |
| Hood River Capital Management LLC | 0.28% | Add +0.5% | 237,043 | $25.4M |
| Bank of America Corp. | 0.00% | Reduce -3.7% | 224,484 | $24.0M |
| Logos Global Management LP | 1.36% | Reduce -5.0% | 190,000 | $20.3M |
| Millennium Management | 0.01% | Add +40.2% | 186,709 | $20.0M |
| BNP Paribas Financial Markets | 0.01% | Reduce -26.4% | 164,563 | $17.6M |
| Citadel Advisors | 0.01% | Add +15.6% | 153,322 | $16.4M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.04% | Add +23.2% | 149,373 | $16.0M |
| First Turn Management, LLC | 1.79% | New | 146,303 | $15.7M |
| M&G PLC | 0.08% | New | 137,074 | $14.7M |
| Silverarc Capital Management, LLC | 2.11% | Reduce -63.3% | 135,950 | $14.6M |
| Russell Investments Group, Ltd. | 0.02% | Reduce -14.9% | 134,180 | $14.4M |
| Barclays PLC | 0.01% | Reduce -7.7% | 131,436 | $14.1M |
| Deutsche Bank AG | 0.00% | Add +10.6% | 129,123 | $13.8M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.02% | Add +21.9% | 123,537 | $13.2M |
| Nuveen, LLC | 0.00% | Reduce -1.7% | 115,934 | $12.4M |
| Capital World Investors | 0.00% | New | 115,693 | $12.4M |
| Swiss National Bank | 0.01% | Add +8.8% | 111,300 | $11.9M |
| New York State Common Retirement Fund | 0.01% | Add +24.7% | 93,677 | $10.0M |
| First Trust Advisors LP | 0.01% | Add +9.4% | 88,505 | $9.5M |
| Algert Global LLC | 0.15% | Reduce -37.1% | 88,250 | $9.4M |
| Axiom Investors LLC | 0.08% | Add +0.6% | 83,554 | $8.9M |
| Zweig-DiMenna Associates LLC | 0.62% | New | 81,600 | $8.7M |
| SummitTX Capital, L.P. | 0.26% | Add +580.2% | 80,729 | $8.6M |
| ExodusPoint Capital Management, LP | 0.09% | New | 75,141 | $8.0M |
| Neuberger Berman Group LLC | 0.01% | Reduce -13.6% | 73,572 | $7.9M |
| Wells Fargo & Company | 0.00% | Add +54.1% | 72,617 | $7.8M |
| Balyasny Asset Management L.P. | 0.02% | Reduce -79.3% | 72,282 | $7.7M |
| Rhumbline Advisers | 0.01% | Reduce -13.2% | 71,212 | $7.6M |
| AQR Capital Management | 0.00% | Reduce -12.2% | 70,046 | $7.5M |
| NEXTBio Capital Management LP | 4.24% | — | 67,586 | $7.2M |
| Norges Bank | 0.00% | — | 66,213 | $7.1M |
| Castleark Management LLC | 0.20% | Add +51.6% | 64,479 | $6.9M |
| Voloridge Investment Management, LLC | 0.02% | Reduce -83.5% | 60,575 | $6.5M |
| Manufacturers Life Insurance Company, The | 0.01% | Reduce -2.1% | 59,609 | $6.4M |
| PDT Partners, LLC | 0.41% | Reduce -31.0% | 59,436 | $6.4M |
| Stempoint Capital LP | 1.08% | Reduce -35.6% | 58,915 | $6.3M |
| Informed Momentum Co LLC | 0.68% | Reduce -2.0% | 57,327 | $6.1M |
| Rafferty Asset Management, LLC | 0.02% | Reduce -0.4% | 55,526 | $5.9M |
| Legal & General Group Plc | 0.00% | Reduce -4.0% | 55,075 | $5.9M |
| TD Asset Management Inc | 0.00% | Reduce -7.6% | 55,050 | $5.9M |
| California State Teachers Retirement System | 0.01% | Add +9.4% | 53,537 | $5.7M |
| Granahan Investment Management, LLC | 0.24% | Add +7.5% | 53,452 | $5.7M |
| Prudential Financial Inc. | 0.01% | Reduce -27.2% | 53,145 | $5.7M |
| ADAR1 Capital Management, LLC | 0.41% | Add +3.6% | 51,349 | $5.5M |
| Nan Fung Group Holdings Ltd | 4.71% | No change | 49,120 | $5.3M |
| Victory Capital Management Inc. | 0.00% | Add +5.8% | 45,381 | $4.9M |
| WCM Investment Management, LLC | 0.01% | Reduce -6.1% | 44,805 | $4.8M |
| Harvest Investment Services, LLC | 0.89% | Reduce -8.7% | 43,953 | $4.7M |
| HighVista Strategies LLC | 1.18% | Add +14.4% | 42,867 | $4.6M |
"% of holder's portfolio" is RYTM's weight in each manager's 13F, not the share of Rhythm Pharmaceuticals Inc. the manager owns.